Celiac Disease
Diarrhea, bloating, fatigue
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About Celiac Disease
Celiac disease is a serious autoimmune disorder triggered by the consumption of gluten, a protein found in wheat, barley, and other grains. When an individual with this condition ingests gluten, their body launches an immune response that damages the villi, which are tiny, finger-like projections lining the small intestine. This damage impairs the intestine's ability to absorb nutrients from food, eventually leading to malnourishment and a variety of symptoms, from weakened bones to mood changes and even miscarriage.
The condition, also known as celiac sprue, nontropical sprue, or gluten-sensitive enteropathy, is often undiagnosed. Researchers believe that as few as 20% of people with celiac disease receive a proper diagnosis, largely because the damage to the intestine progresses slowly and symptoms can vary greatly from person to person.
While celiac disease itself is not typically life-threatening, if left untreated, it can lead to serious complications. Untreated celiac disease also increases the risk of developing certain types of cancer.
Medical term: Celiac Disease
Probiotics
Verified Supplement
Why it works:
Restore a healthier gut microbiota / correct dysbiosis. People with CeD often show altered intestinal microbiota (lower bifidobacteria, altered lactobacilli). Replenishing benefici...
Instructions:
Important: there are no universally accepted clinical guidelines that recommend a single probiotic strain/dose as standard CeD therapy. Most clinical work treats probiotics as adju...
Warnings:
Probiotics are generally well tolerated in healthy people, but there are important cautions:. • Not...
Studies:
Systematic reviews / meta-analyses / reviewsFrontiers review...
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Burdock Root
Verified Herb
Why it works:
There is no high-quality clinical evidence that burdock root (Arctium lappa) treats or cures celiac disease. Some laboratory and animal studies show burdock has anti-inflammatory,...
Instructions:
No randomized controlled trials (RCTs) or human clinical trials were found showing burdock root treats celiac disease or heals gluten-related intestinal damage. Searches of trial r...
Warnings:
(The list below shows the strongest available literature on burdock biology and general trials — non...
Studies:
Because there are no standardized, evidence-based dosing pro...
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Gluten-free diet (GFD)
Verified Practice
Why it works:
Pathophysiology: In celiac disease, gluten (proteins in wheat, barley, rye, and hybrids like triticale) triggers an autoimmune response that damages small-bowel villi. Removing glu...
Instructions:
1) Make it strict and lifelong. • Avoid: wheat (all Triticum species), barley, rye, and their crossbreeds (e.g., triticale). giboardreview.com. • Work with a dietitian experienced...
Warnings:
Hidden gluten & cross-contact. • Risk: sauces, soups, processed meats, shared fryers/surfaces.. • Ac...
Studies:
Symptom, serology, and histologyMucosal recovery in adults o...
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Iron
Verified Mineral
Why it works:
Iron supplementation is effective for celiac disease because iron deficiency anemia (IDA) is the most frequent extra-intestinal manifestation of celiac disease, with a prevalence b...
Instructions:
Dosing Guidelines: In children, the recommended iron dose is 2–6 mg/kg/day in terms of elemental iron. In adolescents and adults, it is 100–200 mg daily Iron Deficiency Anemia in C...
Warnings:
Major Contraindications: Patients with iron-overloaded states such as hereditary hemochromatosis, he...
Studies:
Sucrosomial Iron Study (2018): 43 subjects with celiac disea...
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Folate
Verified Vitamin
Why it works:
Folate (vitamin B9 / folic acid) is not a cure for celiac disease — the only disease-modifying treatment for celiac disease is a strict gluten-free diet. However, folate is effecti...
Instructions:
Before starting: measure baseline labs — full blood count, serum folate (or RBC folate), serum B12, iron studies — because folate supplementation can correct blood indices while le...
Warnings:
Masking vitamin B12 deficiency: High folic-acid intake can correct anemia while neurologic injury fr...
Studies:
There are relatively few randomized drug trials specifically...
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Calcium
Verified Mineral
Why it works:
Calcium is not a cure for celiac disease. It is commonly used to treat or prevent the bone-related complications (osteopenia/osteoporosis) that result from celiac-related intestina...
Instructions:
A. Who typically needs calcium supplements. • People with newly diagnosed celiac disease (especially adults), those with documented osteopenia/osteoporosis, or those with low dieta...
Warnings:
A. Calcium-specific risks. • Hypercalcemia (rare with standard doses in people with normal renal fun...
Studies:
Important framing: most celiac-specific research shows that...
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Vitamin D3
Verified Vitamin
Why it works:
Vitamin D₃ (cholecalciferol) is not a cure for celiac disease (CD). What it is useful for in people with CD is (1) correcting very common vitamin-D deficiency caused by intestinal...
Instructions:
Key principle: test first (serum 25-hydroxyvitamin D), then treat deficiency according to established vitamin D guidelines, and re-check. Clinical societies/guidelines for CD recom...
Warnings:
Toxicity (hypervitaminosis D / hypercalcemia). Excessive vitamin D intake (especially long-term, ver...
Studies:
What we know from studies:Consistent finding: vitamin D defi...
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Vitamin B12
Verified Vitamin
Why it works:
People newly diagnosed with celiac disease often have micronutrient deficiencies, including vitamin B₁₂; guidelines therefore recommend screening for and correcting deficiencies at...
Instructions:
Testing / diagnosis. • Common tests: serum B₁₂ level as first line; if borderline, measure methylmalonic acid (MMA) and/or total homocysteine to confirm functional deficiency. Guid...
Warnings:
B₁₂ does NOT treat the underlying autoimmune small-bowel injury of celiac disease. It only corrects...
Studies:
Systematic reviews / guidelinesCochrane review: oral high-do...
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Zinc
Verified Mineral
Why it works:
Zinc deficiency is common in celiac disease. Intestinal damage (villous atrophy) and a restrictive gluten-free diet both reduce zinc intake/absorption, so many newly diagnosed or e...
Instructions:
Check first. Measure serum zinc (and consider other micronutrients) before starting supplements — many clinics only supplement when deficiency is documented. Re-check after therapy...
Warnings:
Do not exceed the tolerable upper intake level (UL) without medical supervision — for adults the UL...
Studies:
Systematic / review evidence on zinc in GI disease (includes...
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Magnesium
Verified Mineral
Why it works:
Magnesium does not treat or cure celiac disease — the only disease-directed therapy is a strict gluten-free diet. However, magnesium supplementation is often effective at correctin...
Instructions:
Test before treating (when possible).. • Serum magnesium is the common first test (simple but imperfect). If suspicion remains despite a “normal” serum level, clinicians may use er...
Warnings:
Magnesium is renally cleared. People with impaired kidney function can accumulate magnesium and deve...
Studies:
Narrative review of micronutrients in celiac disease (Medici...
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Fish oil
Verified Supplement
Why it works:
Fish-oil (marine omega-3 long-chain PUFAs — EPA and DHA) has plausible, biologic reasons to help with intestinal inflammation and barrier function that matters in celiac disease (C...
Instructions:
No formal, guideline-endorsed fish-oil dosing for treating celiac disease. There are no international celiac guidelines that recommend fish-oil as a treatment to replace a gluten-f...
Warnings:
Primary treatment remains gluten-free diet. Fish-oil is not a substitute for a gluten-free diet or r...
Studies:
VITAL randomized trial (large RCT; autoimmune outcomes): mar...
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