Hand, Foot & Mouth Disease

Why it works: Antiviral + immunomodulatory actions. Propolis is rich in polyphenols (flavonoids, phenolic acids). In vitro and review data show broad antiviral effects (including against enterov...

Instructions: The first randomized clinical study in children with HFMD used a standardized Anatolian propolis extract (30% hydro-ethanolic oral drops) as add-on to usual care:. • Dose: 10 drops...

Warnings: Allergy risk (especially in bee-product–allergic patients). Propolis can cause contact allergy and m...

Studies: Clinical (children with HFMD):2025 multicenter randomized cl...

Why it works: Mechanistic/plausibility data (lab only):. • Extracts of H. cordata have shown in-vitro antiviral activity against enterovirus A71 (EV-A71)—one of the main HFMD viruses—by neutrali...

Instructions: Because there are no validated paediatric dosing regimens or formulations of H. cordata proven to help HFMD, there are no evidence-based “instructions” that can safely be recommend...

Warnings: Avoid injectable preparations. China’s regulator suspended Houttuynia injection years ago after seri...

Studies: The best-supported items are preclinical:EV-A71 cell-culture...

Why it works: Antiviral + anti-inflammatory pharmacology. Xiyanping is a water-soluble sulfonated derivative of andrographolide (from Andrographis paniculata). Sulfonation improves solubility wh...

Instructions: Route: Intravenous infusion is the recommended method for children (not mixed in the same container with other drugs). Dayi. Typical paediatric dose: 5–10 mg/kg/day (andrographolid...

Warnings: Allergic / pseudo-allergic reactions (including serious). Large database and pharmacovigilance studi...

Studies: Randomised controlled trial (mild HFMD). A 329-child RCT rep...

Why it works: Targets both the virus and inflammation (multi-component action). Reduning is extracted from Artemisia annua, Lonicera japonica and Gardenia jasminoides. Systems-pharmacology and b...

Instructions: Note: The following instructions reflect dosing exactly as used in a multicentre randomized, double-blind trial in children with mild HFMD—and not a substitute for local product la...

Warnings: Hypersensitivity/anaphylaxis risk (class effect of TCM injections, including Reduning).. • Post-mark...

Studies: Randomized, double-blind, multicentre clinical trial (n≈360,...

Why it works: Anti-inflammatory & antiviral mechanisms (preclinical/chemistry): Network-pharmacology and lab studies suggest constituents may inhibit inflammatory signaling (e.g., TLR4/NF-κB), r...

Instructions: Product form: Pudilan Xiaoyan Oral Liquid. Package inserts list the four herbs above; indicated broadly for inflammatory throat/mumps/tonsillitis conditions. ypk.39.net. Administra...

Warnings: Not standard of care for HFMD: Authoritative guidelines (NICE/CDC/WHO) recommend supportive care (an...

Studies: Randomized comparison (children with HFMD): “Effect of Pudil...