Leaky Gut Syndrome
Bloating, food sensitivities, fatigue
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9 remedies
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About Leaky Gut Syndrome
Leaky gut syndrome isn't a recognized medical diagnosis, but it is a popular theory. The concept behind it is that increased intestinal permeability, or a "leaky gut," allows toxins and bacteria to enter the bloodstream, potentially leading to various diseases throughout the body.
While the medical community acknowledges that increased intestinal permeability is a real condition, they don't agree that it's a standalone cause of other health problems. The symptoms often associated with this theory, such as bloating and diarrhoea, are common to many other digestive issues. A major challenge with the "syndrome" is that there are no scientifically validated tests for it, and the proposed treatments lack strong evidence to support their effectiveness.
Digestive Enzymes
Verified Supplement
Why it works:
Reduce antigenic load. If food proteins are poorly digested, larger peptides can reach the intestinal lining and stimulate immune responses that contribute to inflammation and barr...
Instructions:
General rules (OTC enzyme supplements and digestive enzyme blends). • Timing: take with the first bite or at the start of the meal so the enzymes mix with food. If the meal lasts >...
Warnings:
Drug interactions — bleeding risk. Proteolytic plant enzymes (bromelain, papain) may increase bleedi...
Studies:
Strong evidence — for enzyme replacement in pancreatic insuf...
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Betaine HCl
Verified Supplement
Why it works:
Restores/temporarily increases gastric acidity (HCl) — BHCl is an oral source of hydrochloric acid. Raising stomach acidity improves protein breakdown (pepsin activation) and reduc...
Instructions:
Confirm indication first: ideally test for hypochlorhydria/achlorhydria or consult a clinician (some practitioners use symptom assessment or gastric pH testing). Many clinicians ca...
Warnings:
Do NOT use BHCl if you have a history of gastric or duodenal ulcers, esophagitis, Barrett’s esophagu...
Studies:
Direct human trials of BHCl for “leaky gut”: none or very li...
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Diatomaceous Earth (Food Grade)
Verified Mineral
Why it works:
Physical adsorption / dehydration of microbes & parasites. DE is a very fine, abrasive silica powder whose microscopic particles can damage/inactivate small invertebrates and bind...
Instructions:
Important caveat: these are community/folk protocols commonly found online, not evidence-based medical dosing. Because there are no standardized clinical trials, there’s no validat...
Warnings:
Inhalation hazard — serious and well documented for crystalline silica. The main documented health r...
Studies:
Science-Based Medicine review — reviews the literature and c...
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Collagen
Verified Supplement
Why it works:
Amino-acid building blocks for mucosal repair. Collagen is rich in glycine, proline and hydroxyproline — amino acids important for connective tissue and extracellular matrix (ECM)...
Instructions:
Formulation: use hydrolysed collagen peptides (powder or capsules). Hydrolysed forms are easier to digest/absorb than gelatin or whole-protein forms. Health. Common clinical/practi...
Warnings:
Allergies / source-specific reactions: collagen supplements are derived from bovine, porcine, chicke...
Studies:
Key human / clinical evidence (limited but notable):JMIR For...
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Slippery Elm
Verified Herb
Why it works:
Mucilage / demulcent effect: the inner bark contains mucilage — a sticky, gel-like soluble fiber — that forms a protective coating over irritated mucous membranes (throat, stomach,...
Instructions:
Forms commonly used and typical practical instructions found in herbal and clinical guidance:. • Powder/porridge (inner bark powder): mix 1–2 teaspoons (≈2–6 g) of slippery elm pow...
Warnings:
May interfere with absorption of oral medications. Because it forms a viscous coating, take slippery...
Studies:
Clinical trials specifically for “leaky gut” (increased inte...
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Turmeric (Curcumin)
Verified Herb
Why it works:
Curcumin's efficacy in addressing leaky gut stems from its potent anti-inflammatory and antioxidant properties. Research indicates that curcumin can modulate gut inflammation, a ke...
Instructions:
Determining the appropriate dosage of curcumin for leaky gut syndrome requires careful consideration of individual health status and response. While specific dosing guidelines for...
Warnings:
While curcumin is generally considered safe, it may cause side effects in some individuals:. • Gastr...
Studies:
Several clinical studies have explored curcumin's role in ga...
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Probiotics
Verified Supplement
Why it works:
They can strengthen the intestinal barrier. Multiple mechanistic reviews show specific probiotic strains up-regulate tight-junction proteins (e.g., occludin, claudins), increase mu...
Instructions:
Choose products by strain and indication (not just by brand).. • Look for the full name: Genus species strain (e.g., Lactobacillus rhamnosus GG).. • Use clinician guides/checklists...
Warnings:
Immunocompromised, critically ill, or central-line (CVC) patients: Live probiotics can (rarely) tran...
Studies:
Syntheses (helpful starting points):Systematic review/meta-a...
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L-Glutamine
Verified Supplement
Why it works:
Primary fuel for enterocytes (intestinal lining cells). Enterocytes use glutamine as a preferred energy source; supplying extra glutamine helps epithelial cells repair and maintain...
Instructions:
Dose used in the best-known randomized trial (post-infectious IBS with increased permeability): 5 g three times daily (5 g t.i.d.) — total 15 g/day — for 8 weeks. That trial report...
Warnings:
General safety profile: Glutamine is generally well tolerated in short-term use for most healthy adu...
Studies:
Randomized, double-blind, placebo-controlled trial (IBS-D af...
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Zinc
Verified Mineral
Why it works:
Tight-junction support. Zinc increases expression and/or prevents loss of tight-junction proteins (e.g., occludin, ZO-1) that control paracellular permeability — this reduces leaki...
Instructions:
Which form is best-studied for intestinal mucosa?. • Zinc-L-carnosine (ZnC / PepZin GI / polaprezinc) is by far the best-studied zinc formulation for mucosal protection and intesti...
Warnings:
Main safety points. • Elemental zinc upper limits. US guidance commonly cites 40 mg/day as the adult...
Studies:
Key human trial (gut permeability / healthy volunteers)Mahmo...
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