Parkinson's

Why it works: Mechanistically, curcumin (a key compound in turmeric) has several actions that are relevant to Parkinson’s biology:. • Anti-inflammatory & antioxidant effects (NF-κB, NLRP3, Nrf2...

Instructions: There is no approved curcumin regimen for Parkinson’s, and major Parkinson’s organizations don’t recommend it as a treatment. If you still want to consider it as a complementary (n...

Warnings: Most culinary turmeric use is safe. Supplement-level dosing has real cautions:. • Liver injury (rare...

Studies: Human data in Parkinson’s are limited and mixed, with small...

Why it works: Mechanistic rationale (theory): PD involves oxidative stress and lipid peroxidation in dopaminergic neurons. Vitamin E is a lipid-phase antioxidant that can interrupt lipid peroxid...

Instructions: There’s no established, guideline-supported dosing of vitamin E to treat PD. If someone still wants to explore it (e.g., for general nutrition or as part of a diet), clinicians typ...

Warnings: If you’re thinking about vitamin E supplements, the safety profile matters more than usual in PD due...

Studies: No proven efficacy for vitamin E alone:DATATOP (NIH/Parkinso...

Why it works: It’s a natural source of levodopa (L-DOPA), the gold-standard symptomatic therapy for PD. MP seeds contain appreciable L-DOPA; lab studies show seed L-DOPA typically in the ~0.6–6%...

Instructions: Forms used in studies. • Roasted seed powder prepared locally (often mixed with liquid), given as single or repeated daily doses. American Academy of Neurology. • Standardized seed...

Warnings: Variable and sometimes excessive L-DOPA content in commercial MP supplements. Independent testing of...

Studies: Randomized, double-blind crossover trials (acute dosing)Katz...

Why it works: Antioxidant & anti-inflammatory effects. Ginkgo flavonoids and terpene lactones scavenge free radicals and dampen neuroinflammation—mechanisms relevant to dopaminergic neuron stres...

Instructions: There’s no established, PD-specific dosing regimen. In other conditions (e.g., age-related cognitive symptoms), standardized EGb 761® is typically used at 120–240 mg/day, often spl...

Warnings: Bleeding risk & surgery: Ginkgo can increase bleeding risk, especially with warfarin, antiplatelets...

Studies: Human PD trials: There are no high-quality randomized contro...

Why it works: Mitochondrial + antioxidant rationale. PD biology involves mitochondrial dysfunction and oxidative stress in dopaminergic neurons. CoQ10 shuttles electrons in the mitochondrial ele...

Instructions: Major organizations do not recommend CoQ10 to treat PD. NIH’s NCCIH says no dietary supplements (including CoQ10) have shown benefit for PD symptoms; Mayo Clinic states that even h...

Warnings: Drug interactions. • Warfarin (Coumadin): CoQ10 may reduce anticoagulant effect—INR can drop. Patien...

Studies: The highest-quality trials do not support efficacy.QE3 Phase...

Why it works: TCM mechanism (pattern-based): This classical formula “sedates the Liver, extinguishes internal Wind, nourishes Yin, and anchors Yang.” In TCM, parkinsonian tremor/rigidity can map...

Instructions: Classical composition & typical decoction method. • Typical herbs & ranges (decoction): Huái Niú Xī (Achyranthes), Dài Zhe Shí (Hematite), Lóng Gǔ (Fossil bone), Mǔ Lì (Oyster shel...

Warnings: Do not replace levodopa/dopaminergic therapy. All major PD guidance positions levodopa or other dopa...

Studies: Most evidence is from Chinese RCTs and small trials; quality...

Why it works: Neuroprotective, anti-oxidative mechanisms (preclinical): In rodent/cell PD models, LWDHW protected dopaminergic neurons, likely via anti-oxidant and anti-inflammatory pathways. Sc...

Instructions: Kampo (Japan) pharmaceutical insert for Rokumigan (LWDHW): Adults typically 7.5 g/day extract granules in 2–3 divided doses before/between meals; adjust per age/weight/symptoms. (E...

Warnings: Pattern mismatch / GI sensitivity: Because LWDHW is “cloying,” avoid/caution in Spleen/Stomach defic...

Studies: Animal/in vitro studies: Show dopaminergic neuron protection...

Why it works: Neuroprotection in lab/animal PD models. A water extract of TMGTY protected dopaminergic neurons, improved locomotion, and reduced α-synuclein burden in fly and rodent PD models. M...

Instructions: Classical composition & decoction order. • A typical classical recipe uses (approximate adult quantities): Tian Ma (9 g), Gou Teng (12–15 g), Shi Jue Ming (18–24 g), Zhi Zi (9 g),...

Warnings: Because TMGTY is a multi-herb formula, think across its components:. • Blood pressure lowering → ort...

Studies: Human studiesSpecific to TMGTY in PD: Peer-reviewed preclini...