Colorectal Cancer
Blood in stools, diarrhea or constipation, abdominal pain or cramping, unexplained weight loss, persistent fatigue
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About Colorectal Cancer
Colorectal cancer is cancer that forms in the colon or rectum, part of the large intestine. It begins as uncontrolled growth of abnormal cells, often developing from harmless growths called polyps. If left untreated, the cancer can invade deeper layers of the bowel and spread to other organs. Common symptoms can include changes in bowel habits, bleeding, abdominal pain, and weight loss. Early detection through screenings like colonoscopies is crucial for preventing cancer or treating it effectively, as symptoms may not appear in early stages.
Medical term: Colorectal carcinoma
Exercise (aerobic + resistance)
Verified Practice
Why it works:
Improves survival & lowers recurrence (now with RCT evidence): The phase-3 CHALLENGE trial (889 patients, 55 centres) found that a 3-year, coached exercise program reduced the risk...
Instructions:
Aerobic training. • Frequency/Time: Build to 150–300 min/week of moderate intensity (e.g., brisk walking, cycling) or 75–150 min/week vigorous, in ≥10–20 min bouts. Start lower if...
Warnings:
During/soon after treatment. • Severe anaemia, neutropenia or thrombocytopenia: Modify or pause high...
Studies:
Randomized, phase-3 outcome trialNEJM 2025 — CHALLENGE: Stru...
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PSK (Krestin)
Verified Supplement
Why it works:
Immune activation (TLR2-mediated): PSK is a selective Toll-like receptor-2 (TLR2) agonist that matures dendritic cells and boosts CD8⁺ T-cell and NK-cell activity—mechanisms that c...
Instructions:
Dose most often used: 3 g/day orally, typically 1 g three times daily as an adjuvant after curative surgery and with chemotherapy. Duration in trials ranged from months to multiple...
Warnings:
Do not self-substitute for guideline therapy: PSK has only been studied as an adjunct; skipping stan...
Studies:
Meta-analysis of 3 centrally randomised CRC trials (n=1,094)...
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Vitamin D3
Verified Vitamin
Why it works:
Biology: The active vitamin D hormone (calcitriol) binds the vitamin D receptor (VDR) in colon cells and can:. • Antagonise Wnt/β-catenin signalling (a key driver of CRC), promote...
Instructions:
There is no proven therapeutic dosing regimen of Vitamin D3 to treat CRC itself. Practical use today focuses on screening for and correcting deficiency, typically as part of suppor...
Warnings:
Not a standalone cancer therapy: Do not delay or replace evidence-based CRC treatments with Vitamin...
Studies:
Phase 3 (most definitive):SOLARIS (2024, phase-3, mCRC first...
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Probiotics
Verified Supplement
Why it works:
Microbiome modulation & barrier support. CRC is associated with dysbiosis; select probiotics can shift microbial composition, strengthen epithelial barrier, and reduce inflammation...
Instructions:
During chemo/radiotherapy to reduce diarrhea. • Multiple systematic reviews and meta-analyses (incl. an umbrella review) suggest certain probiotics reduce incidence and/or severity...
Warnings:
Infection risk in immunocompromised patients. Case reports and series document Lactobacillus bactere...
Studies:
Chemoradiotherapy-induced diarrhea (CRC): • 2025 meta-analys...
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Acupuncture
Practice
Why it works:
Nerve & brain circuits for pain: Needle stimulation activates A- and C-fiber afferents and engages central pain-modulating circuits; effects involve endogenous opioids and other ne...
Instructions:
During oxaliplatin chemotherapy (CIPN prevention/relief). • When: Start in the first cycle and continue weekly (or once every 1–2 weeks) through treatment, as studied in the CRC RC...
Warnings:
Adjunct only: Use acupuncture in addition to standard CRC treatments; it does not treat or cure canc...
Studies:
CIPN (oxaliplatin, CRC-specific): • The Oncologist 2023 RCT:...
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Huang Qin Tang (YIV-906 / PHY906)
Verified Medicine
Why it works:
Multi-target gut protection + immune modulation. In animal and early human studies, PHY906 reduced irinotecan-induced intestinal inflammation (down-regulating TNF-α, NF-κB, COX-2,...
Instructions:
With IFL chemotherapy (advanced CRC, phase I): Oral PHY906 given concomitantly with weekly bolus IFL. The trial tested escalating oral doses and found no PK interactions; details a...
Warnings:
Investigational status / product variability. YIV-906/PHY906 used in trials is a standardized, cGMP-...
Studies:
Randomized, placebo-controlled phase I in advanced CRC (IFL...
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