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Exercise (aerobic + resistance)

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Specifically for Colorectal Cancer

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Why it works for Colorectal Cancer:

Improves survival & lowers recurrence (now with RCT evidence): The phase-3 CHALLENGE trial (889 patients, 55 centres) found that a 3-year, coached exercise program reduced the risk of new/recurrent cancer or death by ~28% and all-cause mortality by ~37% after resection and adjuvant chemotherapy for stage III/high-risk II colon cancer. Results were presented at ASCO and published in the New England Journal of Medicine in 2025. New England Journal of Medicine

Backed by earlier cohort data in CRC: Prospective studies in stage II–III colon cancer linked ≥~18 MET-h/wk (e.g., brisk walking ~6 hrs/wk) with lower recurrence and death. ASCO Publications

Biological mechanisms: Exercise favourably modulates insulin/IGF signalling, chronic inflammation, immune surveillance (e.g., NK/T-cell activity), myokine release (e.g., SPARC, IL-6), and epigenetic pathways; these changes have been observed in CRC-specific reviews and trials measuring biomarkers. erc.bioscientifica.com

Symptom control & function: Consensus guidelines show exercise reduces cancer-related fatigue and improves physical function and quality of life across cancers, including CRC.

How to use for Colorectal Cancer:

Aerobic training

  • Frequency/Time: Build to 150–300 min/week of moderate intensity (e.g., brisk walking, cycling) or 75–150 min/week vigorous, in ≥10–20 min bouts. Start lower if deconditioned and progress by ~10–20%/week. Aim Clinic
  • Intensity: Aim for RPE 12–14/20 or talk test (you can speak in phrases, not sing). If you use heart-rate: ~64–76% HRmax (moderate) as tolerated. (Ranges per ACSM oncology guidance.) Aim Clinic

Resistance training

  • Frequency: 2–3 non-consecutive days/week. Aim Clinic
  • Sets/Reps/Loads: 1–3 sets of 8–15 reps for major muscle groups (legs, push, pull, core). Begin with bodyweight/bands or ~40–60% 1RM; progress toward 60–70% 1RM for 8–12 reps as tolerated. Aim Clinic

Weekly example (post-treatment or on “good weeks” during therapy)

  • Mon: 30–40 min brisk walk + beginner circuit (squat to chair, wall push-ups, row with band; 2 sets × 10–12).
  • Wed: 30–40 min cycle/elliptical + core bracing and hip hinge drills (protect ostomy if applicable).
  • Fri: 30–40 min brisk walk/jog + resistance (3 sets × 8–10 for leg press or goblet squat, lat pull-down/band row, chest press, dead bug/pallof press).
  • Optional: Short easy walks on other days to manage fatigue.

Behavioural support matters: In CHALLENGE, coaching + personalized plans (initial weekly then tapered) drove adherence and outcomes—try to emulate this with an accredited exercise physiologist/physiotherapist. qub.ac.uk

Trusted, patient-friendly guides (with programs & adaptations):

  • ACSM Roundtable prescriptions & safety notes (core oncology guideline). Aim Clinic
  • Cancer Council Australia booklet on exercising before/during/after treatment. cancer.org.au
  • NCCN Survivorship (patients) healthy living guide including activity targets. nccn.org

Scientific Evidence for Colorectal Cancer:

Randomized, phase-3 outcome trial

  • NEJM 2025 — CHALLENGE: Structured, 3-year behaviourally supported exercise vs health education after adjuvant chemo for resected colon cancer; improved disease-free survival and overall survival over long-term follow-up. (First definitive survival-endpoint RCT for exercise in any solid cancer.) New England Journal of Medicine

Mechanistic & dose-finding RCTs in CRC survivors

  • Aerobic-dose trials: Randomized 150 vs 300 min/wk lowered fasting insulin and inflammatory markers (plausible antitumour pathways). erc.bioscientifica.com

Prospective cohorts (CRC)

  • Stage III colon (CALGB 89803) & others: Higher post-diagnosis activity associated with lower recurrence and mortality; effects seen around ≥~18 MET-h/wk. ASCO Publications

Guideline-level syntheses

  • ACSM 2019 Roundtable (multi-organization consensus) and NCCN Survivorship endorse exercise for cancer-related outcomes and overall wellness; NCCN 2025 update reinforces integrating PA in survivorship. Aim Clinic
Specific Warnings for Colorectal Cancer:

During/soon after treatment

  • Severe anaemia, neutropenia or thrombocytopenia: Modify or pause higher-intensity/impact work and favour light activity; use institutional thresholds and symptoms to guide what’s safe the day of treatment/infusions. (Clinician handouts and ASCO guidance discuss tailoring to blood counts and symptoms.) healthonline.washington.edu
  • Peripheral neuropathy, balance issues, ostomy, incisions, catheter/port: Prefer stable footwear, machine-based resistance, and supervised form; avoid falls and heavy Valsalva bracing. Aim Clinic

After colorectal surgery / with an ostomy

  • Early phase (first 6–8+ weeks): Prioritize walking and gentle core activation; avoid heavy lifting to lower parastomal hernia risk; gradually progress loads; consider support garments/belts for abdominal work or lifting. (Follow your surgeon’s time frame.) publicdocuments.sth.nhs.uk
  • Long term: Core strengthening is encouraged, but progress thoughtfully and monitor for bulging/discomfort around the stoma. Colorectal Cancer Alliance

General red flags (stop and seek medical advice)

  • New/worsening abdominal pain, rectal bleeding, unexplained weight loss, fever, chest pain, severe breathlessness, or sudden swelling/pain in a limb.

General Information (All Ailments)

Note: You are viewing ailment-specific information above. This section shows the general remedy information for all conditions.

What It Is

Exercise refers to structured, purposeful physical activity performed to improve or maintain physical fitness and overall health. It generally encompasses two main types:

  • Aerobic Exercise (Cardio): Continuous, rhythmic activities that use large muscle groups and elevate heart rate and breathing for an extended period. Examples include walking, running, swimming, or cycling. Aerobic exercise primarily targets the cardiovascular and respiratory systems.
  • Resistance Exercise (Strength Training): Activities designed to improve muscle strength, endurance, and power by working against a force or resistance—such as weights, resistance bands, or body weight. Examples include weightlifting, push-ups, or squats.

When combined, aerobic and resistance exercise form a comprehensive fitness approach that enhances cardiovascular health, muscular strength, endurance, flexibility, and body composition.

How It Works

Aerobic exercise works by increasing the efficiency of the heart, lungs, and circulatory system. During sustained movement, the body requires more oxygen to produce energy, leading to improved oxygen uptake (VO₂ max), stronger heart muscles, and enhanced capillary density in tissues. This, in turn, reduces the workload on the heart and improves endurance over time.

Resistance training works through a process known as muscle adaptation. When muscles are exposed to resistance, small microscopic tears occur in the muscle fibers. The body repairs these fibers by fusing them, resulting in stronger and larger muscles (hypertrophy). Additionally, resistance training enhances neuromuscular coordination, increases bone density, and boosts resting metabolism, as muscle tissue consumes more energy even at rest.

When both exercise types are integrated, the result is a synergistic effect—improving both cardiovascular efficiency and muscular strength, supporting overall physical performance, and optimizing body composition (more lean muscle, less fat).

Why It’s Important

Regular aerobic and resistance exercise provide a wide range of health benefits:

  1. Cardiovascular Health: Aerobic exercise reduces the risk of heart disease, lowers blood pressure, improves cholesterol balance, and enhances circulation.
  2. Metabolic Health: Combined training improves insulin sensitivity, helps regulate blood glucose, and supports healthy weight management.
  3. Musculoskeletal Strength: Resistance training prevents muscle loss with age (sarcopenia), enhances bone density (reducing osteoporosis risk), and improves joint stability.
  4. Mental Well-being: Both exercise types release endorphins and neurotransmitters (like serotonin and dopamine) that reduce stress, anxiety, and depression, while improving mood and sleep.
  5. Functional Fitness: The combination enhances balance, coordination, and mobility—key factors in maintaining independence, especially in older adults.
  6. Longevity: Regular exercise is associated with reduced risk of chronic diseases such as cardiovascular disease, type 2 diabetes, obesity, and certain cancers, contributing to longer, healthier lives.

Considerations

While exercise offers extensive benefits, several considerations are important for safety and effectiveness:

  • Individualization: Exercise programs should be tailored to personal fitness levels, goals, and health conditions. Beginners should start gradually to avoid injury.
  • Medical Clearance: Individuals with chronic diseases (e.g., heart conditions, diabetes, arthritis) or those over 40 who have been inactive should consult a healthcare provider before starting an exercise regimen.
  • Balance and Progression: It’s important to balance aerobic and resistance sessions to prevent overtraining or burnout. Gradual increases in intensity, duration, and resistance yield better long-term results.
  • Technique and Recovery: Proper form in resistance exercises prevents injury, while rest days are essential for muscle repair and adaptation.
  • Nutrition and Hydration: Adequate protein supports muscle recovery, and hydration maintains performance and thermoregulation.
  • Consistency: Sustainable results come from regular participation—ideally, most days of the week for aerobic activity and 2–3 times weekly for resistance training.

Helps with these conditions

Exercise (aerobic + resistance) is most effective for general wellness support with emerging research . The effectiveness varies by condition based on clinical evidence and user experiences.

Rheumatoid Arthritis 0% effective
Poor Circulation 0% effective
Varicose Veins 0% effective
Lupus 0% effective
Oxidative Stress 0% effective
Cellular Aging 0% effective
11
Conditions
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Total Votes
81
Studies
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Avg. Effectiveness

Detailed Information by Condition

Reduces pain and improves function. Multiple systematic reviews and guidelines conclude that both aerobic and strengthening programs produce small–mod...

0 votes Updated 1 month ago 6 studies cited

Poor Circulation

0% effective

Arterial side (PAD / claudication)Repeated walking bouts increase shear stress on vessel walls → improves endothelial nitric-oxide–mediated vasodilati...

0 votes Updated 1 month ago 9 studies cited

Varicose Veins

0% effective

It powers the “calf-muscle pump.” Every step contracts your calf and foot muscles, squeezing deep veins and pushing blood upward; this reduces venous...

0 votes Updated 1 month ago 6 studies cited

Lupus

0% effective

Fatigue, fitness & mood: Randomised trials show graded or supervised aerobic programs reduce fatigue and improve perceived global change, compared...

0 votes Updated 1 month ago 9 studies cited

Oxidative Stress

0% effective

Redox hormesis: Repeated, moderate exercise produces a small ROS signal that up-regulates your body’s own antioxidant defenses (SOD, catalase, GPx), i...

0 votes Updated 1 month ago 6 studies cited

Cellular Aging

0% effective

Mitochondrial rejuvenation & proteostasis. Endurance and interval training up-regulate AMPK/PGC-1α pathways, boosting mitochondrial biogenesis and...

0 votes Updated 1 month ago 7 studies cited

Stimulates mitochondrial biogenesis and function. Endurance and resistance training up-regulate PGC-1α signaling and downstream nuclear-encoded mitoch...

0 votes Updated 1 month ago 5 studies cited

Improves core MS symptoms and function. Well-designed trials and guidelines show that structured aerobic and resistance training can reduce fatigue, i...

0 votes Updated 1 month ago 9 studies cited

Breast Cancer

0% effective

Symptom control & function. Large guideline panels reviewing dozens of randomized trials conclude that exercise reduces cancer-related fatigue and...

0 votes Updated 1 month ago 11 studies cited

Lung Cancer

0% effective

Counters deconditioning & breathlessness. Exercise (especially supervised pulmonary-rehab style programs) improves cardiorespiratory fitness and f...

0 votes Updated 1 month ago 9 studies cited

Colorectal Cancer

0% effective

Improves survival & lowers recurrence (now with RCT evidence): The phase-3 CHALLENGE trial (889 patients, 55 centres) found that a 3-year, coached...

0 votes Updated 1 month ago 4 studies cited

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