Endometriosis

Why it works: They shift inflammatory signaling. EPA/DHA compete with omega-6 arachidonic acid for COX/LOX enzymes, yielding less-pro-inflammatory prostaglandins/leukotrienes and more “pro-resol...

Instructions: Dietary approach. • Aim for 2–3 seafood meals/week with low-mercury, high-omega-3 fish (e.g., salmon, sardines, mackerel). For pregnancy or if trying to conceive, follow local merc...

Warnings: Atrial fibrillation & stroke signal (supplements): A large UK Biobank cohort (~415k adults; median 1...

Studies: Endometriosis-specific human trials**SAGE randomized, double...

Why it works: Mechanistic rationale (indirect): Standardized vitex extracts act (primarily) on the pituitary—dopaminergic (D2) activity lowers prolactin; downstream, this may normalize luteal ph...

Instructions: If, after discussing with your clinician, you still want to try vitex alongside standard endometriosis care, use regimens validated for PMS, because that’s where dosing is standard...

Warnings: Pregnancy & breastfeeding: Not recommended during pregnancy or lactation due to uncertain safety and...

Studies: Evidence in other conditions (why vitex is often discussed):...

Why it works: Targets the biology that drives endo pain. Endometriosis is an estrogen-dependent, inflammatory disease in which lesions recruit new blood vessels (angiogenesis). Therapies that re...

Instructions: There is no endometriosis-specific dosing guideline for ginger. What follows reflects how ginger has been used in human trials for primary dysmenorrhea (period pain) and in officia...

Warnings: Bleeding risk / drug interactions: Ginger can inhibit platelet aggregation and may potentiate antico...

Studies: Human trials (period cramps—indirect evidence for endometrio...

Why it works: Anti-inflammatory & immunomodulatory effects (down-regulating cytokines, COX-2/PGE2 pathways) and angiogenesis inhibition (VEGF), which could reduce lesion viability and pain. Netw...

Instructions: Because GZFLW is a classical formula made from five herbs (Cinnamon twig, Poria, Moutan bark, Peach kernel, Peony root), dosing depends on the product form and local pharmacopeia.....

Warnings: Use only under supervision of a clinician who can monitor liver tests, interactions, pregnancy statu...

Studies: Meta-analysis of RCTs (Medicine, 2019): Adding Guizhi Fuling...

Why it works: Pathophysiologic fit (TCM → biomed bridge): In TCM, Shao Fu Zhu Yu Tang (SFZYT) “warms the channels,” invigorates blood, and relieves lower-abdominal pain—a pattern often seen in e...

Instructions: Core composition (10 herbs):. Xiao Hui Xiang (Foeniculi), Gan Jiang (Zingiberis), Yan Hu Suo (Corydalis), Mo Yao (Myrrh), Dang Gui (Angelica sinensis), Chuan Xiong (Ligusticum chua...

Warnings: Because SFZYT “moves blood,” several safety points apply—especially in people seeking pregnancy or t...

Studies: Systematic review & meta-analysis (2025): 11 randomized...

Why it works: TCM rationale (pattern-based):. Jia Wei Xiao Yao San is a classic modification of Xiao Yao San that adds Moutan cortex (牡丹皮) and Gardenia fruit (梔子) to “soothe Liver qi,” move...

Instructions: Important: Correct use in TCM is pattern-driven—the formula is appropriate only if your presentation matches its indication. A registered TCM practitioner should confirm the fit an...

Warnings: Follow the product label and practitioner guidance. Key cautions from the Japanese OTC monograph (TJ...

Studies: Evidence specific to endometriosis + CHM overall (not one fo...

Why it works: Endometriosis is driven by chronic inflammation, estrogen-dependent growth, cell adhesion/invasion, and new blood-vessel formation. Curcumin (the main active in turmeric) has lab a...

Instructions: 1) Choose an evidence-based form. Curcumin’s absorption is notoriously poor. Approaches that raise absorption include formulations (e.g., phytosome/“Meriva,” micelles/nanomicelles)...

Warnings: Liver injury (rare but real): National and international safety bodies report idiosyncratic hepatiti...

Studies: Randomized trials (endometriosis):Curcumin + dienogest vs. d...

Why it works: Shifts estrogen metabolism toward “less proliferative” metabolites. DIM induces CYP1A enzymes and is consistently associated with a higher urinary 2-hydroxyestrone:16-hydroxyestron...

Instructions: Typical supplemental dosing seen in studies & practice. • Human trials outside endometriosis suggest 100–300 mg/day oral DIM (often BR-DIM® microencapsulated for absorption) is gen...

Warnings: Pregnancy & breastfeeding: Insufficient safety data—avoid supplement-level dosing (stick to food sou...

Studies: Small randomized pilot (DIM + dienogest vs dienogest alone):...

Why it works: Smooth-muscle relaxation & prostaglandins: Magnesium can reduce uterine smooth-muscle excitability and may lower prostaglandin synthesis—both relevant to cramping and dysmenorrhea,...

Instructions: Form & dose. • Typical supplemental dose used for cramps: ~300–400 mg elemental magnesium/day, often as magnesium glycinate or magnesium citrate (better tolerated/absorbed than oxi...

Warnings: Kidney disease: Avoid unsupervised supplementation; impaired clearance can lead to hypermagnesemia (...

Studies: Endometriosis-specific painAdjunctive IV magnesium sulfate:...