Gui Zhi Fu Ling Wan
Specifically for Endometriosis
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Why it works for Endometriosis:
Anti-inflammatory & immunomodulatory effects (down-regulating cytokines, COX-2/PGE2 pathways) and angiogenesis inhibition (VEGF), which could reduce lesion viability and pain. Network-pharmacology and docking analyses for GZFLW highlight multi-target actions across inflammatory and angiogenic signaling relevant to endometriosis. PeerJ
Effects on fibrosis/ECM remodeling and apoptosis suggested by preclinical work and quality-marker studies of GZFLW prepared for endometriosis indications. Frontiers
Component importance: recent pharmacology indicates Gui Zhi (cinnamon twig) and Fu Ling (poria) are key contributors to GZFLW’s anti-endometriosis effect in model systems. ScienceDirect
Metabolomic/animal studies show lowered TGF-β1 and altered VEGF/GLUT-4 expression in rat endometriosis models treated with Gui-Zhi-Fu-Ling capsules.
How to use for Endometriosis:
Because GZFLW is a classical formula made from five herbs (Cinnamon twig, Poria, Moutan bark, Peach kernel, Peony root), dosing depends on the product form and local pharmacopeia.
- Kampo (Japan) standardized extract (TJ-25: Keishibukuryogan): the official package insert lists
- 7.5 g/day of extract granules in 2–3 divided doses before or between meals, with dose adjustments by age/weight/symptoms. This insert also states its traditional indication pattern and monitoring advice. tsumura.co.jp
- Traditional/OTC pills or concentrated pills/capsules: commercial TCM sources describe typical adult ranges around 6–12 g/day of concentrated pills in divided doses, but products differ widely; clinical supervision is recommended to tailor dose and duration. Tcmly
Treatment context & duration: In published clinical studies for endometriosis, GZFLW (often as capsules) is commonly used in combination with hormonal agents (e.g., mifepristone) for several menstrual cycles (roughly 8–12 weeks in many trials), rather than as a sole therapy—see evidence section below. BioMed Central
Professional use tip: Kampo/TCM formulas are prescribed based on a patient’s pattern (“Sho”); the TJ-25 insert emphasizes confirming suitability and discontinuing if no benefit is observed. tsumura.co.jp
Scientific Evidence for Endometriosis:
Meta-analysis of RCTs (Medicine, 2019): Adding Guizhi Fuling capsules to mifepristone for women with endometriosis (n≈1052 across included trials) improved outcomes (e.g., symptom control, recurrence) versus mifepristone alone. (Note: trials were largely Chinese; risk-of-bias and heterogeneity should be considered.) Europe PMC
Earlier/related evidence syntheses: A broader meta-analysis (BMC Complementary Medicine, 2014) found Guizhi Fuling + mifepristone showed fewer adverse events than mifepristone alone in gynecologic indications, with endometriosis included among target conditions. BioMed Central
Ongoing/modern RCT design in Australia: A placebo-controlled, double-blind RCT evaluating a modified GZFLW (Gynoclear™) for endometriosis-related pelvic pain has been conducted/registered; the published paper is a study protocol (results not reported in that article). BioMed Central
Mechanistic reviews: Recent reviews in the ethnopharmacology literature summarize 5 preclinical and 13 clinical studies on GZFLW for endometriosis and outline likely multi-target mechanisms. (These reviews are supportive but are not substitutes for large, high-quality RCTs.) ScienceDirect
Specific Warnings for Endometriosis:
Use only under supervision of a clinician who can monitor liver tests, interactions, pregnancy status, and symptom response.
- Pregnancy & trying to conceive: Do not use in pregnancy or if you might be pregnant. The TJ-25 insert explicitly warns that Peach kernel (Tao Ren) and Moutan bark in this formula may cause premature birth or abortion. Avoid during lactation unless a clinician advises otherwise. tsumura.co.jp
- Liver safety: The TJ-25 insert lists hepatic dysfunction/jaundice (elevated AST/ALT, etc.) as clinically significant adverse reactions; stop and evaluate if abnormalities occur. tsumura.co.jp
- Bleeding/anticoagulants: Because Peach kernel is a blood-invigorating herb with antiplatelet/anticoagulant potential, use caution (or avoid) if you’re on warfarin, DOACs, or antiplatelet drugs due to additive bleeding risk. (Multiple materia-medica and pharmacology sources note this precaution; discuss with your prescriber.) sacredlotus.com
- Elderly & frail patients: The Kampo insert recommends careful supervision and possible dose reduction in older adults or those with weakened constitution. tsumura.co.jp
- Product variability: Evidence applies to specific preparations (e.g., capsules used in Chinese trials, Kampo TJ-25, or the Gynoclear™ formulation under study). Quality, extraction ratio, and dose vary by brand, so efficacy/safety may not generalize across all OTC products. Protocols and inserts emphasize matching to the correct pattern/Sho and stopping if ineffective. BioMed Central
- Guideline status: Major Western guidelines (e.g., NICE) don’t include GZFLW among recommended treatments; consider it an adjunct if you and your clinician decide it fits your case. BMJ
General Information (All Ailments)
What It Is
Gui Zhi Fu Ling Wan (桂枝茯苓丸) is a classical Chinese herbal formula that originated from the ancient medical text Jin Gui Yao Lue (Essentials from the Golden Cabinet) by Zhang Zhongjing. It consists of five main herbs:
- Gui Zhi (Cinnamon Twig) – Warms and unblocks the channels, promotes circulation of Qi and blood.
- Fu Ling (Poria Mushroom) – Promotes urination, reduces dampness, and strengthens the spleen.
- Mu Dan Pi (Moutan Cortex / Tree Peony Bark) – Cools the blood and promotes circulation.
- Chi Shao (Red Peony Root) – Invigorates blood and removes stasis, also cools the blood.
- Tao Ren (Peach Kernel) – Breaks up blood stasis and moistens the intestines.
This formula is traditionally made into small pills or capsules and is used in TCM to address blood stasis with cold and stagnation, particularly in the lower abdomen or uterus.
How It Works
Gui Zhi Fu Ling Wan works primarily by promoting blood circulation, resolving stasis, and regulating menstruation. In TCM theory, many gynecological and reproductive disorders arise from blood stasis—a condition where blood flow is sluggish or obstructed, leading to pain, clots, or palpable masses.
- Warming and moving (Gui Zhi): Warms the meridians and assists in dispersing cold-induced stagnation.
- Circulating and breaking stasis (Tao Ren, Chi Shao, Mu Dan Pi): These herbs help remove congealed blood, reduce swelling or masses, and restore normal flow of Qi and blood.
- Draining dampness and supporting fluid metabolism (Fu Ling): Balances fluid movement, helping the body to clear excess moisture that might contribute to stagnation.
In modern pharmacological studies, the formula is thought to improve uterine blood flow, modulate hormonal balance, and reduce inflammation. It has been used to support conditions such as uterine fibroids, ovarian cysts, endometriosis, dysmenorrhea (painful periods), and infertility related to blood stasis.
Why It’s Important
Gui Zhi Fu Ling Wan holds great importance in both classical and modern Chinese medicine for women’s health. It is one of the few traditional formulas that effectively addresses both cold and heat patterns simultaneously, because it includes warming (Gui Zhi) and cooling (Mu Dan Pi, Chi Shao) ingredients in balance.
Its significance lies in several areas:
- Women’s reproductive health: It is widely used to promote healthy menstruation and fertility by ensuring smooth blood flow and resolving stagnation.
- Postpartum recovery: Helps the body eliminate retained blood and restore uterine tone after childbirth.
- Chronic gynecological conditions: Provides non-invasive support for fibroids or cysts when surgery or hormonal therapy is not preferred.
- Circulatory health: Although primarily used for gynecological purposes, it can also be applied in some cases of blood stasis elsewhere in the body, such as bruising or pelvic congestion.
In essence, Gui Zhi Fu Ling Wan embodies the TCM principle of harmonizing contradictions—balancing warm and cool, moving and nourishing—to restore the natural rhythm of the body.
Considerations
While Gui Zhi Fu Ling Wan is a gentle yet potent herbal formula, several important considerations should be noted:
- Individual diagnosis: It should be prescribed based on a proper TCM assessment of blood stasis. Using it without stasis symptoms (e.g., in people with deficiency or bleeding tendencies) may worsen the condition.
- Pregnancy: The formula contains Tao Ren (Peach Kernel), which has blood-moving and stasis-breaking properties. These can potentially stimulate uterine contractions and are not recommended during pregnancy, except under close supervision by a qualified practitioner.
- Dosage and duration: Overuse can deplete the body’s energy or Yin. The formula is typically taken in moderate doses over a defined period, with reassessment every few weeks.
- Potential interactions: Herbal medicines can interact with anticoagulant or antiplatelet drugs (e.g., warfarin, aspirin). Individuals on such medications should use this formula only with professional guidance.
- Symptoms indicating caution: Avoid during active bleeding, heavy menstrual flow, or if signs of Yin deficiency (dry mouth, hot flashes, night sweats) are present.
- Quality and sourcing: Use products from reputable manufacturers to avoid contamination or adulteration, as purity and accurate formulation affect both safety and efficacy.
Helps with these conditions
Gui Zhi Fu Ling Wan is most effective for general wellness support with emerging research . The effectiveness varies by condition based on clinical evidence and user experiences.
Detailed Information by Condition
PCOS
Improves ovulation & pregnancy outcomes (as add-on therapy). A 2022/2023 systematic review and meta-analysis of 16 RCTs (1,385 women) found that G...
Endometriosis
Anti-inflammatory & immunomodulatory effects (down-regulating cytokines, COX-2/PGE2 pathways) and angiogenesis inhibition (VEGF), which could redu...
Fibroids
Traditional (TCM) rationale. GZFLW is a five-herb formula (Cinnamomi Ramulus, Poria, Paeoniae Radix Alba, Moutan Cortex, Persicae Semen) used to invig...
Ovarian Cysts
TCM pattern: The classic indication is gynecologic “masses from Blood stasis” (fixed lower-abdominal masses/pain, dysmenorrhea). The five-herb formula...
Menstrual cramps
Traditional rationale & composition. GZFLW is a 5-herb formula (Gui Zhi/Cinnamomi ramulus, Fu Ling/Poria, Bai Shao/Paeonia, Mu Dan Pi/Moutan corte...
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Helps With These Conditions
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