Overactive Bladder

Why it works: Bladder-afferent (C-fiber) dampening: In animal models of chemically induced bladder overactivity, GJG reduced expression of C-fiber–related transmitters (substance P, neurokinins)...

Instructions: Dose & schedule: The Japanese ethical-use package insert for TSUMURA Goshajinkigan (TJ-107) recommends 7.5 g/day of extract granules in 2–3 divided doses before or between meals (a...

Warnings: Pregnancy/lactation: Not recommended. Label warns Achyranthes and Moutan may induce uterine effects;...

Studies: Human studies (small, mostly uncontrolled):Women with OAB (J...

Why it works: Targets “cold/kidney-yang deficiency” patterns linked to urinary frequency/nocturia in Kampo/TCM. Modern Japanese prescribing info for Hachimijiogan lists urinary frequency/nocturi...

Instructions: Typical adult dose (ethical/prescription Kampo extract): 7.5 g/day of extract granules in 2–3 divided doses, before or between meals; adjust to age/weight/symptoms. (Tsumura TJ-7 o...

Warnings: Pregnancy: Not recommended in pregnancy or when pregnancy is possible. Rationale noted includes Mout...

Studies: Prospective add-on study (Japan, n=60, 12 weeks): Patients w...

Why it works: May relax bladder muscle via nitric-oxide pathways. Pumpkin seed preparations contain arginine (a nitric-oxide precursor). Urology reviewers note a leading hypothesis that increase...

Instructions: Oil (food-grade, not extract):. • 10 g/day (about 2 teaspoons) of pumpkin seed oil taken orally for 12 weeks was used in a human OAB study (Cucurbita maxima oil). Participants had...

Warnings: Overall tolerance: Clinical and reference sources report few adverse effects at studied doses; most...

Studies: Controlled trialsWomen with OAB (pumpkin seed extract + soy...

Why it works: Demulcent/soothing effect on urinary mucosa from corn-silk polysaccharides → may ease burning/irritation, which can feel like urgency. (Traditional use; mechanistic reviews.) MDPI....

Instructions: Tea / infusion (dried cornsilk):. • Pour 1 cup (≈240 mL) boiling water over ~2 tsp (≈2.5 g) dried cornsilk; cover, steep 10–15 min. Drink up to 3× daily. Encyclopedia.com. Fresh co...

Warnings: Insufficient safety data at medicinal doses; large amounts have caused electrolyte disturbances (↓po...

Studies: For OAB specifically:No randomized or observational human st...

Why it works: Traditional (TCM) rationale. • SPXS is classically used for urinary frequency, incontinence/enuresis and “bladder loss of restraint” due to Heart–Kidney deficiency; it “stabilizes...

Instructions: 1) Classical decoction (granules or raw herbs). • Typical composition (8 ingredients): Sang Piao Xiao (Mantidis Ootheca), Long Gu (fossil bone), Gui Ban (tortoise plastron, often v...

Warnings: 1) Not for every OAB presentation. • Contraindicated in damp-heat/active “bladder heat” patterns (e....

Studies: Systematic/overview sourcesA 2023–2024 review of natural pro...