Sjogren’s Syndrome

Why it works: Anti-inflammatory + pro-resolving actions. Long-chain omega-3s (EPA, DHA) can dampen inflammatory eicosanoids/cytokines and give rise to specialized pro-resolving mediators (SPMs)...

Instructions: There is no SS-specific, guideline-endorsed dose of omega-3s. What’s used in practice (and in trials of dry eye more broadly) looks like this:. Diet first: Eat oily fish (e.g., sal...

Warnings: Atrial fibrillation (AF) signal at higher intakes/long-term use: Large cohort data (UK Biobank; BMJ...

Studies: Sjögren’s-specific studiesRandomized, double-blind, placebo-...

Why it works: It’s a powerful humectant + viscoelastic lubricant. HA binds water, clings (mucoadheres) to the ocular and mucosal surface, and increases tear-film stability—reducing friction and...

Instructions: Eyes (dry eye disease). What to buy: Preservative-free artificial tears whose active is sodium hyaluronate 0.1–0.4% (gels/ointments at night if needed). Look for single-use vials i...

Warnings: Symptom relief only: HA treats dryness symptoms; it does not treat the underlying autoimmune disease...

Studies: Eyes (including Sjögren-specific)Sjögren-specific RCT (isoto...

Why it works: 1) Mucolytic action (helps with stringy mucus and filaments on the eye).. NAC’s free sulfhydryl (-SH) group breaks disulfide bonds in mucin glycoproteins, thinning sticky secretion...

Instructions: A) Topical (eye drops) for mucus-stringy dry eye / filamentary keratitis. When considered: After standard dry-eye care fails (preservative-free lubricants, lid hygiene, environment...

Warnings: Topical (eye drops):. • Common: transient stinging/irritation, redness, itchiness, blurred vision af...

Studies: Topical (eye):Filamentary keratitis/dry-eye contexts: Multip...

Why it works: pSS is driven by dysregulated innate/adaptive immunity (e.g., activated dendritic cells; polarized Th1/Th17 responses) that damages exocrine glands. TGP is a standardized extract (...

Instructions: The most rigorous dosing information comes from a multicentre, double-blind RCT in pSS:. • Dose: 600 mg three times daily (TID) oral TGP (total 1,800 mg/day).. • Duration: 24 weeks...

Warnings: 1) Regulatory status & availability. • TGP is approved in China (since 1998) as a disease-modifying...

Studies: Phase III-style RCT (China): 320 adults with pSS randomized...

Why it works: Autonomic + neuropeptide effects on salivary glands. Sensory stimulation from needling can activate autonomic pathways and trigger release of neuropeptides that influence salivary...

Instructions: If you decide to trial acupuncture, align with studied protocols and work with a qualified practitioner:. • Session frequency/duration. A large sham-controlled RCT in primary SjS d...

Warnings: Work with a properly trained, registered practitioner who follows infection-control and anatomic saf...

Studies: Primary SjS trials2025 Clinical Rheumatology RCT (double-bli...

Why it works: Targets immune pathways implicated in SS. In a randomized, double-blind, placebo-controlled crossover trial (57 patients; 28 weeks), SS-1 reduced markers linked to B-cell activity...

Instructions: Dose & schedule used in the RCT: 6 grams, three times daily (oral powder) as an add-on to stable hydroxychloroquine, in a 12-weeks on → 4-weeks washout → 12-weeks crossover design....

Warnings: Because SS-1 contains multiple herbs (e.g., Glycyrrhiza glabra [licorice] via SJY; Chrysanthemum spe...

Studies: Human clinical trialFrontiers in Pharmacology (2021): Herbal...

Why it works: Moisture-restoring, anti-inflammatory rationale (TCM + modern signals). Zengye Tang’s three classic herbs—Xuán Shēn (Scrophularia ningpoensis root), Mài Dōng (Ophiopogon japonicus...

Instructions: 1) Classic Zengye Tang (3-herb base) — traditional decoction. Typical ingredients (classical proportions):. • Xuán Shēn (Scrophulariae Radix) 30 g. • Mài Dōng (Ophiopogonis Radix)...

Warnings: Work with your rheumatologist and a registered Chinese medicine practitioner. Zengye Tang is a patte...

Studies: Human data specifically on Zengye Tang in pSSProspective, un...

Why it works: Bioactives in colostrum (immunoglobulins, lactoferrin, growth factors) can have antimicrobial and immunomodulatory effects that could theoretically aid mucosal surfaces (mouth/eyes...

Instructions: Because dosing/formulations are unstandardized and data are sparse, there are no official instructions for using BC to treat SS. If you’re considering it (ideally with your rheumat...

Warnings: Milk allergy / lactose intolerance: Avoid BC/Lf if you have a cow’s-milk protein allergy; lactose in...

Studies: For Sjögren’s specificallyOral-care BC products (pSS): 20 pS...