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SS-1 Formula

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Specifically for Sjogren’s Syndrome

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Why it works for Sjogren’s Syndrome:

Targets immune pathways implicated in SS. In a randomized, double-blind, placebo-controlled crossover trial (57 patients; 28 weeks), SS-1 reduced markers linked to B-cell activity (BAFF and BCMA), and patients had significant increases in Schirmer tear test readings and reduced artificial-tear use versus placebo—consistent with improved lacrimal gland function. The same paper’s BioMAP profiling suggested anti-proliferative effects on B cells and anti-inflammatory/immunomodulatory activity. Frontiers

Down-regulates pathogenic T-cell responses. Experimental and translational work shows SS-1 inhibits T-cell activation and reduces Th1/Th2/Th17 polarization (in mice and in PBMCs from SS patients), aligning with the autoimmune pathophysiology of SS. Europe PMC

Improves salivary function in animal models. In a salivary-gland protein–induced SS mouse model, SS-1 increased saliva flow, lowered IFN-γ/IL-6/IL-17A in glands, and reduced anti-M3R autoantibodies—mechanistic signals that map to exocrine dysfunction in human SS. MDPI

What it’s made of (and why that matters). SS-1 combines three classic TCM prescriptions in a 2:1:1 ratio—Gan-Lu-Yin (GLY), Sang-Ju-Yin (SJY), and Xue-Fu-Zhu-Yu decoction (XZD)—selected for antioxidant/anti-inflammatory, immunomodulatory, and antifibrotic properties respectively. MDPI

How to use for Sjogren’s Syndrome:

Dose & schedule used in the RCT: 6 grams, three times daily (oral powder) as an add-on to stable hydroxychloroquine, in a 12-weeks on → 4-weeks washout → 12-weeks crossover design. Pilocarpine/cevimeline were not allowed during the trial. Frontiers

Formula & manufacturer in trials: The study product was standardized and manufactured by Kaiser Pharmaceutical Co., Ltd. (Taiwan); quality was verified by HPLC “fingerprinting.” Frontiers

Animal-model dose context (not for patient use): 1,500 mg/kg in mice improved saliva flow and inflammation; this is mechanistic context only and not a human dose guide. MDPI

Scientific Evidence for Sjogren’s Syndrome:

Human clinical trial

  • Frontiers in Pharmacology (2021): Herbal Formula SS-1 Increases Tear Secretion for Sjögren’s Syndrome — RCT showed increases in Schirmer’s test (~+3.4 mm per eye vs smaller placebo gains), reduced artificial-tear use, and dampened BAFF/BCMA signals; no serious SS-1–related AEs. Frontiers

Trial registration

  • NCT02110446: Randomized, double-blind, placebo-controlled, crossover study evaluating SS-1 in SS (Taiwan; phase listed as “Unknown” on registry mirror). ctv.veeva.com
  • NCT02855658: Mechanistic study on oxidative stress, cytokines, and gene expression under SS-1 treatment. ClinicalTrials

Mechanistic/translational

  • Journal of Ethnopharmacology (2020): Chinese herbal medicine SS-1 inhibits T-cell activation and abrogates TH responses in Sjögren’s syndrome—reductions in activation markers and Th1/Th2/IL-17+IFNγ+ responses in murine cells and decreased IFN-γ/IL-4/IL-13 in patient PBMCs after SS-1. (Open access summaries & repositories linked.) Europe PMC

Preclinical (mouse)

  • Life (MDPI, 2021): Effect of the Chinese Herbal Medicine SS-1 on a Sjögren’s Syndrome-Like Disease in Mice—improved saliva flow, reduced lymphocytic infiltration and pro-inflammatory cytokines, and lower anti-M3R autoantibodies. MDPI

Related context

  • Contemporary SS pathogenesis reviews (T/B-cell activation, cytokines, ectopic germinal centers) provide biological plausibility for targeting these pathways. Cell
Specific Warnings for Sjogren’s Syndrome:

Because SS-1 contains multiple herbs (e.g., Glycyrrhiza glabra [licorice] via SJY; Chrysanthemum species via GLY/SJY; Angelica sinensis [dong quai] via XZD), standard herb-safety considerations apply:

  • Blood-pressure & potassium effects (licorice/glycyrrhizin): Can raise blood pressure and cause hypokalemia (low potassium), sometimes severe—risk higher in older adults, people with cardiovascular/kidney disease, or on diuretics/corticosteroids. Monitor BP and electrolytes; avoid in uncontrolled hypertension and during pregnancy. PubMed
  • Anticoagulation/bleeding risk (dong quai in XZD): Documented interaction potential with warfarin and other antiplatelet/anticoagulant drugs; case reports note elevated INR. If on anticoagulants or with bleeding risk, consult your prescriber and monitor closely. Drugs.com
  • Allergy/cross-reactivity (Asteraceae/Compositae): Chrysanthemum (present in GLY/SJY) can trigger contact or respiratory allergy; individuals sensitized to ragweed/Asteraceae may be at higher risk of reactions. DermNet®
  • Possible antithrombotic activity (XZD): Pharmacology studies suggest thrombin-inhibitory/antithrombotic components; be cautious when combined with anticoagulants/antiplatelets. RSC Publishing
  • Liver tests & general tolerability: In the RCT, adverse events were mostly mild; some cases of elevated transaminases occurred (only one possibly related to SS-1). Periodic LFT monitoring is prudent. Frontiers
  • Product quality matters: The trial used a GMP-manufactured, HPLC-fingerprinted product; over-the-counter versions may differ in composition and glycyrrhizin content (which drives licorice-related side effects). Discuss brands/quality control with a clinician trained in TCM pharmacognosy. Frontiers

General Information (All Ailments)

Note: You are viewing ailment-specific information above. This section shows the general remedy information for all conditions.

What it is

“SS-1 Formula” is a composite traditional Chinese medicine (TCM) prescription consisting of three classical formulas blended together:

  • Gan Lu Yin (Sweet Dew Drink) — clears heat & generates fluids
  • Sang Ju Yin (Mulberry Leaf & Chrysanthemum Drink) — vents early wind-heat from Lung surface, soothes cough
  • Xue Fu Zhu Yu Tang (Drive Out Stasis from the Mansion of Blood) — promotes circulation and resolves blood stagnation in the chest-Heart network

Taken as decoction or granules in the rough range of 6–12 g/day of concentrated granules (equivalent crude-herb decoction is higher).

In TCM pattern language it is designed to clear heat, nourish yin, and invigorate blood — i.e. to discharge residual “smoldering” inflammatory heat, repair fluid-yin deficits, and normalize impaired microcirculation.

How it works (mechanistic logic in mixed TCM / biomedical terms)

Clears latent heat & reduces low-grade inflammatory tone

  • Sang Ju Yin + Gan Lu Yin are archetypal “light clear” heat drinks that reduce heat in the upper burner / respiratory tract and protect mucosa. In biomedical analogies: these formulas tend to have antipyretic, anti-inflammatory, anti-oxidative, and epithelial-barrier-support phytochemistry.

Nourishes yin & restores fluid homeostasis

  • The Gan-Lu component emphasizes fluid generation and moistening, which in biomedical parallels maps to support of epithelial repair, mucus barrier recovery, and reduction of dryness-injury–induced inflammation.

Invigorates blood & resolves micro-stasis

  • Xue Fu Zhu Yu Tang is a central formula for microcirculatory dysfunction in the chest and vasculature, with repeatedly documented effects on hemorheology, endothelial signaling, and inflammatory cytokine modulation. Removing stasis reduces “fuel” for chronic post-inflammatory loops.
  • Tri-vector synergy

Chronic post-inflammatory states often co-cluster heat, dryness/yin-depletion, and local circulatory rigidity. SS-1 addresses all three axes at once — discharging, replenishing, and mobilizing — which is why it’s often chosen for sub-acute / chronic, not acute crisis phases.

Why it’s important

Targets the post-acute plateau

  • Many patients stall in a “not acutely sick but not well” band, where dryness + micro-stasis sustain low-grade inflammatory tone. There are few Western levers for this niche; TCM formulas like SS-1 are built exactly for this zone.

Prevents scar-inflammation loops

  • If micro-stasis and dryness persist, tissues remodel unfavorably. By restoring perfusion and fluid milieu, you mitigate long-horizon risk of fibrosis, recurring flares, vascular stiffening, and neuro-immune sensitization.

Improves functional domains with low toxicity

  • Properly matched to pattern, these formulas tend to improve sleep, throat/airway comfort, chest ease, fatigue, circulation-feel, and irritability/heat signs while being comparatively gentle relative to many chronic-phase drugs.

Considerations (safety, fit, and prudent use)

Pattern specificity is non-negotiable

  • Best when there is residual heat + yin insufficiency + signs of blood stasis (e.g. dryness, red tip/tongue cracks, wiry/choppy pulse, chest tightness/pain, fixed dull pain, insomnia with heat signs, low-grade throat irritation). Poorly matched use yields mediocre or paradoxical results.

Caution if constitution is cold / depleted without heat

  • In cold yang-deficiency bodies this can further cool / suppress, worsening fatigue or loose stools.

Bleeding / anticoagulation

  • The blood-moving component is not trivial: caution with warfarin/DOACs, thrombocytopenia, peri-surgical windows, or active heavy menses.

Pregnancy

  • Contra-indicated or tightly supervised because of the blood-invigorating portion.

Immune suppression & acute biotech timing

  • With active chemotherapy, transplant immunosuppression, or soon after live vaccines, use only with specialist oversight — herb–drug immunologic crosstalk is non-zero.

Dosing and duration are dynamic

  • These are course-based, not chronic forever medicines. Typical use is weeks → a few months, then reevaluation/step-down or formula pivot as the internal terrain changes.

Quality & supervision

  • Require verified source granules and a clinician trained in pathway-level TCM reasoning, not over-the-counter improvisation.

Helps with these conditions

SS-1 Formula is most effective for general wellness support with emerging research . The effectiveness varies by condition based on clinical evidence and user experiences.

Sjogren’s Syndrome 0% effective
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Targets immune pathways implicated in SS. In a randomized, double-blind, placebo-controlled crossover trial (57 patients; 28 weeks), SS-1 reduced mark...

0 votes Updated 1 month ago 6 studies cited

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