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Black seed oil

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Specifically for H. Pylori Infection

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Why it works for H. Pylori Infection:

Black seed oil's effectiveness against H. pylori stems from several mechanisms of action. The mechanism of action of N. sativa is not clear. N. sativa seeds contain a number of essential oils, including thymoquinone, dihydrothymoquinone and terpenes. Essential oils obtained from many herbs are considered to possess antimicrobial activity, which is ascribed to their ability to disrupt the lipid structure of cell membrane. Comparative Study of Nigella sativa and Triple Therapy in Eradication of Helicobacter pylori in Patients with Non-Ulcer Dyspepsia - PMC More specifically, the anti-H. pylori action of N. sativa is probably due to its urease inhibitory effect. H. pylori uses ammonia, the urease enzyme product, to protect itself from the stomach acidic condition. Combination of Nigella sativa and Honey in Eradication of Gastric Helicobacter pylori Infection - PMC

The seeds of N. Sativa, generally recognized as black cumin or black seed, are the source of biologically active components such as thymol, dithymoquinone, thymoquinone, nigellicine, nigellidine, etc. which are synergistically responsible for beneficial health effects. Nigella sativa powder for helicobacter pylori infected patients: a randomized, double-blinded, placebo-controlled clinical trial - PMC The primary active compound, thymoquinone, has gastroprotective mechanisms and anti-ulcer activity via an inhibiting proton pump, acid secretion and neutrophil infiltration, while enhancing mucin secretion and nitric oxide production. Combination of Nigella sativa and Honey in Eradication of Gastric Helicobacter pylori Infection - PMC

How to use for H. Pylori Infection:

The clinical studies have tested various dosages and forms of black seed oil for H. pylori treatment:

Dosage Guidelines:

Treatment Duration: Most studies used treatment periods of 4-8 weeks, with one teaspoon of the mixture of Dosin (6 g/day of N. sativa as ground seeds and 12 g/day of honey) three times a day after meals for two weeks Combination of Nigella sativa and Honey in Eradication of Gastric Helicobacter pylori Infection - PMC showing a 57.1% eradication rate.

Combined Therapy: The most effective approach appears to be using black seed oil as an adjunct to conventional therapy rather than alone. supplementation with 2 gr/day N. Sativa powder with quadruple therapy for 8 weeks could significantly rise the eradication of H. pylori infection The beneficial health effects of Nigella sativa on Helicobacter pylori eradication, dyspepsia symptoms, and quality of life in infected patients: A pilot study

Scientific Evidence for H. Pylori Infection:

Several well-designed clinical trials have demonstrated black seed oil's efficacy:

Key Clinical Trials:

  1. The study was conducted on 88 adult patients attending King Fahd Hospital of the University, Al-Khobar, Saudi Arabia, from 2007 to 2008, with dyspeptic symptoms and found positive for H. pylori infection by histopathology and urease test. Comparative Study of Nigella sativa and Triple Therapy in Eradication of Helicobacter pylori in Patients with Non-Ulcer Dyspepsia - PMC This study found optimal results at 2g daily dosage.
  2. In the present study, 51 H. pylori-positive patients were randomly allocated to treatment (n = 26) or placebo (n = 25) groups. Nigella sativa powder for helicobacter pylori infected patients: a randomized, double-blinded, placebo-controlled clinical trial - PMC This double-blind, placebo-controlled trial showed significant improvements in H. pylori eradication when combined with standard therapy.
  3. Seventy patients diagnosed with functional dyspepsia according to ROME III criteria and confirmed by upper gastrointestinal endoscopy were selected to receive a traditional honey based formulation of N. sativa (5 ml N. sativa oil orally daily) or placebo for 8 weeks in a double-blind randomized placebo-controlled clinical trial Efficacy and safety of honey based formulation of Nigella sativa seed oil in functional dyspepsia: A double blind randomized controlled clinical trial - ScienceDirect

In Vitro Evidence: the anti-H. pylori activity of N. sativa was presented by O'Mahony et al. who found that the aqueous extract of N. sativa had 100% bactericidal activity against H. pylori Combination of Nigella sativa and Honey in Eradication of Gastric Helicobacter pylori Infection - PMC

Specific Warnings for H. Pylori Infection:

While generally considered safe, black seed oil has important safety warnings:

Serious Adverse Effects: It is important to keep in mind that rhabdomyolysis, acute renal damage, and hepatotoxicity might occur following the use of black seed oil. Black seed oil ingestion should be considered when making a differential diagnosis for these conditions in patients suspected of taking herbal products. Rhabdomyolysis and acute kidney injury after consumption of black seed oil - ScienceDirect

Dosage-Related Toxicity: One 2021 study on the safe levels of the component of thymoquinone shows that adults should limit usage to a maximum of 900 milligrams (mg) of the oil or 48.6 mg of thymoquinone daily in order to reduce the risk of side effects. Black seed oil benefits: Health, skin, and side effects

Drug Interactions: One potential concern is that black seed oil may interact with medications that are processed through the cytochrome P450 pathway. Common medications that could be affected include warfarin (Coumadin) and beta-blockers like metoprolol (Lopressor) Black Seed Oil: Benefits, Dosage, and Side Effects

Contraindications: Consider limiting your intake of black seed oil if you have functional dyspepsia, liver disease, or kidney disease. As with all supplements, speak with a healthcare professional before taking black seed oil, especially if you're pregnant. Black Seed Oil: Health Benefits, Uses, and Side Effects

Common Side Effects: Side effects can include abdominal discomfort, bloating, dysgeusia, diarrhea, and headache, but these effects are generally transient and mild. Black Cumin Seed - LiverTox - NCBI Bookshelf

Pregnancy and Surgery Warnings: Because black seed oil might slow blood clotting and reduce blood sugar, it may interfere with medications used during and after surgical procedures, causing severe side effects. Black seed oil has been shown to slow down or stop uterus contractions, making it inadvisable to take during pregnancy. Is Black Seed Oil Good for Rheumatoid Arthritis?

General Information (All Ailments)

Note: You are viewing ailment-specific information above. This section shows the general remedy information for all conditions.

What It Is

Black seed oil is a natural oil extracted from the seeds of Nigella sativa, a flowering plant native to Southwest Asia, the Middle East, and parts of Eastern Europe. The oil has been used for thousands of years in traditional medicine — particularly in Ayurvedic and Middle Eastern practices — and is sometimes referred to as black cumin seed oil or kalonji oil.

The primary active compound in black seed oil is thymoquinone, which is largely responsible for many of its purported health benefits. The oil also contains antioxidants, essential fatty acids (like linoleic and oleic acid), vitamins (such as vitamin E), and amino acids.

How It Works

Black seed oil exerts its effects through several biological mechanisms:

Anti-inflammatory action:

  • Thymoquinone and other components inhibit inflammatory enzymes and cytokines in the body, which can reduce swelling, pain, and tissue damage. This makes it potentially helpful for conditions like arthritis or asthma.

Antioxidant activity:

  • The oil neutralizes harmful free radicals that cause oxidative stress, helping to protect cells from damage and slow the aging process.

Antimicrobial effects:

  • Studies have shown that black seed oil possesses antibacterial, antiviral, antifungal, and antiparasitic properties. This helps support immune function and protect against infections.

Immune modulation:

  • It is believed to balance and strengthen immune responses — stimulating defense when needed while preventing overactivation (which can cause autoimmune issues).

Metabolic regulation:

  • Some evidence suggests black seed oil can help regulate blood sugar levels, improve cholesterol profiles, and support liver and digestive health.

Respiratory and skin benefits:

  • Its anti-inflammatory and antimicrobial properties make it useful for managing asthma, allergies, eczema, and acne when used topically or taken orally.

Why It’s Important

Black seed oil is valued for its wide-ranging health benefits, supported both by traditional use and modern research:

  • General health maintenance: Supports immune system balance, detoxification, and overall vitality.
  • Chronic disease prevention: Antioxidant properties help reduce risks associated with conditions like heart disease, diabetes, and certain cancers.
  • Skin and hair care: Moisturizes, soothes irritation, and may promote hair growth.
  • Respiratory and digestive support: Can ease asthma symptoms, congestion, and indigestion.
  • Complementary therapy: Used alongside modern treatments for its anti-inflammatory and immune-modulating effects.

While not a cure-all, black seed oil serves as a nutritional and therapeutic supplement that complements healthy living and disease prevention strategies.

Considerations

Before using black seed oil, several key considerations should be kept in mind:

Dosage:

  • Typical oral doses range from 500 mg to 2 g per day, but it’s important to follow product-specific guidelines or consult a healthcare professional, especially if used for medical purposes.

Quality:

  • Look for cold-pressed, 100% pure black seed oil to preserve active compounds and avoid additives or oxidation.

Possible side effects:

  • When taken in moderation, black seed oil is generally safe. However, large doses may cause:
  • Gastrointestinal upset (nausea, bloating)
  • Allergic skin reactions (when applied topically)
  • Lowered blood pressure or blood sugar (caution for those on related medications)

Drug interactions:

  • It may interact with medications such as anticoagulants, antihypertensives, or diabetes medications due to its physiological effects.

Pregnancy and breastfeeding:

  • Insufficient data exists on safety during these periods; it’s best avoided or used under professional supervision.

Form of use:

  • Available as capsules, raw oil, or topical formulations. Oral use targets systemic benefits, while topical use focuses on skin or hair health.

Helps with these conditions

Black seed oil is most effective for general wellness support with emerging research . The effectiveness varies by condition based on clinical evidence and user experiences.

Asthma 0% effective
H. Pylori Infection 0% effective
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Detailed Information by Condition

Asthma

0% effective

Anti-inflammatory & immunomodulatory actions. The main bioactive, thymoquinone, down-regulates pro-inflammatory cytokines and oxidative stress pat...

0 votes Updated 1 month ago 4 studies cited

Black seed oil's effectiveness against H. pylori stems from several mechanisms of action. The mechanism of action of N. sativa is not clear. N. sativa...

0 votes Updated 2 months ago 4 studies cited

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