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Bu Yang Huan Wu Tang

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Specifically for Peripheral Neuropathy

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Why it works for Peripheral Neuropathy:

TCM rationale (pattern-based): BYHWT “supplements Qi and moves Blood, unblocking the channels.” Classically it’s used when PN presents with Qi deficiency + Blood stasis (numbness, paresthesia, weakness, worse with fatigue), the same pattern for which the formula was created. The original 7-herb composition (high-dose Huang Qi with Dang Gui, Chuan Xiong, Chi Shao, Tao Ren, Hong Hua, Di Long) reflects this principle. TCM Wiki

Biomedically plausible mechanisms (preclinical + translational):

  • Neurovascular support & microcirculation: BYHWT up-regulates angiogenic/neurotrophic factors (e.g., VEGF), improves neurovascular-unit function, and enhances microcirculation—relevant to ischemic and metabolic neuropathies. Frontiers
  • Neuroprotection & regeneration: Multiple studies show reduced ischemia–reperfusion injury, promotion of axonal regeneration and remyelination signals, and modulation of Wnt/Cav1 pathways. Semantic Scholar
  • Anti-inflammatory/antioxidant actions that down-regulate TNF-α/IL-1β and reduce ROS in neural models—mechanisms implicated in DPN. Clausius Press

Clinical signal specific to neuropathy:

  • Systematic reviews/meta-analyses (including RCTs) report improvement in nerve conduction velocities, symptom scores, and “total effective rate” for DPN and peripheral nerve injury when BYHWT is used (often adjunctive to standard care). journaltcm.cn

How to use for Peripheral Neuropathy:

1) Formula & forms

  • Classical composition (decoction): Huang Qi 120 g; Dang Gui 6 g; Chi Shao 6 g (often 4.5 g); Chuan Xiong 3 g; Tao Ren 3 g; Hong Hua 3 g; Di Long 3 g. TCM Wiki
  • Modern forms: water decoction, granules, or capsules from GMP suppliers. (Examples list identical herb set and indicate use for post-stroke/neuropathic patterns.) Golden Needle Online

2) Dosing (typical ranges used in clinic/trials)

  • Granules/capsules: Many dispensaries recommend roughly 3–6 g BYHWT extract, 2–3×/day (5:1 granules), adjusted to body size and tolerance. Crawford Wellness
  • Decoction: Based on the classical weights above (noting the unusually high Huang Qi), prepared once daily and split into 2–3 doses; modern practices often scale total herb weight down and standardize to extract equivalents. TCM Wiki

3) Course & combinations

  • Duration: Clinical studies of DPN commonly run 4–12 weeks; reassess every 4 weeks for symptom, sensory, and nerve-conduction changes. zgsyfjxzz.ijournals.cn
  • Adjuncts often studied: BYHWT + mecobalamin (B12) or standard WM care (glycaemic control ± ALA/pain meds) shows additive benefit in several RCTs/observational studies. zgsyfjxzz.ijournals.cn
  • Pattern modifications: Practitioners may add/remove herbs for significant pain, dampness, or heat; see evidence-based overviews of composition tailoring. ScienceDirect

4) Monitoring

  • Track neuropathic symptom scales, nerve conduction studies when available, and basic labs (CBC, LFTs) if using long-term or with polypharmacy. Meta-analyses in stroke populations suggest BYHWT did not increase adverse events vs control, but DPN-specific RCT quality is variable—monitor prudently. Frontiers

Scientific Evidence for Peripheral Neuropathy:

Peripheral neuropathy (diabetic PN & peripheral nerve injury):

  • DPN meta-analysis (2023, Journal of Traditional Chinese Medicine): Pooled RCTs found BYHWT (usually added to mecobalamin or standard care) improved nerve conduction velocity and symptom response vs control; authors call for higher-quality, larger RCTs. journaltcm.cn
  • Peripheral nerve injury meta-analysis (2023, Medicine): Across RCTs in traumatic PNI, BYHWT improved functional recovery vs control; protocol registered in PROSPERO. ResearchGate

Related neurovascular disorders (mechanistic/adjacent evidence):

  • Ischemic-stroke recovery meta-analysis (2022, Frontiers in Pharmacology): 39 RCTs (n=3,683) showed better neurological scores and ADLs with BYHWT without increased adverse events. These neurovascular and neurotrophic effects support plausibility for neuropathy. Frontiers
  • Reviews of mechanisms & composition: Summaries of multi-target actions (angiogenesis, anti-inflammation, oxidative stress, axonal repair). Frontiers
Specific Warnings for Peripheral Neuropathy:

1) Bleeding risk & drug interactions (important):

  • BYHWT contains blood-invigorating herbs (Dang Gui, Chuan Xiong, Tao Ren, Hong Hua) that may potentiate anticoagulants/antiplatelets (e.g., warfarin, DOACs, aspirin, clopidogrel). Case reports/reviews and herb monographs advise caution or avoidance, INR/bleeding monitoring, and coordination with the prescriber. Frontiers

2) Hemorrhagic conditions & pregnancy:

  • Do not use when hemorrhagic stroke has not been excluded, with active bleeding disorders, or in pregnancy, given the moving-blood components. kamwo.com

3) Allergies/intolerances:

  • Contains earthworm (Di Long; Lumbricus)—avoid if you have known hypersensitivity to annelid extracts. (Allergic reactions to worm proteins are documented in other contexts.) BioMed Central

4) Quality & sourcing:

  • Use GMP-grade products to reduce contamination/adulteration risk; many clinical papers use hospital-compounded decoctions or standardized granules. andrewflower.info

5) General cautions:

  • BYHWT is not a substitute for glucose control or neuropathy standard care; use adjunctively and reassess. Adverse events in meta-analyses were not increased vs control, but reporting quality varies. Frontiers

General Information (All Ailments)

Note: You are viewing ailment-specific information above. This section shows the general remedy information for all conditions.

What It Is

Bu Yang Huan Wu Tang, translated as “Tonify the Yang to Restore the Five (tentatively referring to the five kinds of paralysis or five organs)”, is a traditional Chinese medicinal formula developed by the Qing dynasty physician Wang Qing-Ren, and first recorded in his book Yi Lin Gai Cuo (Correction of Errors Among Physicians).

It is composed of seven primary herbs, typically:

  • Huang Qi (Astragalus membranaceus) – chief herb
  • Dang Gui Wei (Angelica sinensis tail)
  • Chi Shao (Paeonia rubra)
  • Chuan Xiong (Ligusticum chuanxiong)
  • Tao Ren (Prunus persica seed)
  • Hong Hua (Carthamus tinctorius)
  • Di Long (Pheretima aspergillum, Earthworm)

The formula is primarily used to reinvigorate Qi (vital energy) and promote blood circulation, especially in conditions resulting from Qi deficiency leading to blood stasis, such as post-stroke hemiplegia or numbness.

How It Works

In TCM theory, Qi is the driving force of blood movement. When Qi is weak, blood circulation becomes sluggish, leading to blood stasis, which manifests as paralysis, numbness, or weakness—particularly following stroke or traumatic injury.

  • Huang Qi (Astragalus) serves as the chief herb, powerfully tonifying Qi, strengthening the body’s energy, and supporting the functions of other herbs.
  • Dang Gui Wei, Chuan Xiong, Chi Shao, Tao Ren, and Hong Hua work together to activate and nourish blood, dissolve stasis, and open obstructed channels.
  • Di Long (Earthworm) is added to unblock the channels and collaterals, improving movement and neurological recovery.

From a modern pharmacological perspective, Bu Yang Huan Wu Tang has been found to:

  • Improve cerebral blood flow and neuronal repair after ischemic injury.
  • Exhibit anti-inflammatory, antioxidant, and neuroprotective effects.
  • Promote angiogenesis (formation of new blood vessels) and neurogenesis (generation of new nerve cells).

This makes it a powerful restorative formula for post-stroke rehabilitation, targeting both Qi and blood components.

Why It’s Important

Bu Yang Huan Wu Tang is significant in both traditional and modern integrative medicine because it bridges classical herbal theory with modern neurovascular science.

  • In TCM practice, it represents a balanced approach: strengthening the body’s vital energy (Qi) while dispersing stagnation (Blood stasis).
  • Clinically, it has been widely applied in the rehabilitation phase of cerebrovascular diseases, including ischemic stroke, hemiplegia, facial paralysis, and peripheral neuropathies.
  • Modern research supports its potential in promoting functional recovery and reducing neurological deficits after brain injury.

Its importance lies in its dual action: restorative (tonification) and circulatory (mobilization)—a combination that addresses both the root (Qi deficiency) and the manifestation (Blood stasis) of disease.

Considerations

While Bu Yang Huan Wu Tang is potent, it must be used carefully under professional supervision. Key considerations include:

Individual Constitution

  • It is suited for patients with Qi deficiency (fatigue, pale complexion, weak pulse) and blood stasis (numbness, paralysis, purple tongue). It should not be used in cases of strong excess syndromes or active inflammation without deficiency signs.

Contraindications

  • Not recommended during acute stroke phase with high fever or hypertension.
  • Avoid in cases of bleeding disorders, pregnancy, or blood-heat syndromes.
  • May interact with anticoagulants or antiplatelet drugs, increasing bleeding risk.

Dosage and Duration

  • Typically prescribed as a decoction or granule extract, dosage and duration depend on the severity of Qi and blood stagnation, age, and constitution. Long-term use should be monitored by a TCM practitioner.

Integration with Western Medicine

  • Bu Yang Huan Wu Tang is often used alongside physiotherapy and Western medical treatments in post-stroke recovery programs. Coordination between healthcare providers ensures safety and efficacy.

Helps with these conditions

Bu Yang Huan Wu Tang is most effective for general wellness support with emerging research . The effectiveness varies by condition based on clinical evidence and user experiences.

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Detailed Information by Condition

TCM rationale (pattern-based): BYHWT “supplements Qi and moves Blood, unblocking the channels.” Classically it’s used when PN presents with Qi deficie...

0 votes Updated 1 month ago 4 studies cited

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