Bu Zhong Yi Qi Tang
Specifically for Hypothyroidism
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Why it works for Hypothyroidism:
Traditional (TCM/Kampo) pattern rationale
- BZYQT “tonifies Spleen/Stomach qi and raises yang,” classically used for fatigue, poor appetite, weakness, and “qi sinking” (e.g., prolapse)—symptom clusters that often overlap with hypothyroid presentations in practice. Ingredient list and classical actions are documented in standard TCM references. TCM Wiki
Biologic/modern rationale (most data are indirect)
- Immunomodulation & anti-inflammatory effects: BZYQT and its Japanese/Korean equivalents (TJ-41/BJIKT) show anti-inflammatory and immune-modulating activity in preclinical and clinical contexts (e.g., cancer-related fatigue, COPD), providing a mechanistic basis for trials in autoimmune disease. MSK’s clinician monograph summarizes these effects and studies. Memorial Sloan Kettering Cancer Center
- Autoimmune thyroiditis (Hashimoto’s) relevance: A recent review on Hashimoto’s notes TCM formulations (including herbs contained in BZYQT) can reduce thyroid antibody levels and improve symptoms without harming thyroid function; it specifically cites a rat model where Buzhong Yiqi granules lowered antibodies and improved thyroid function in experimental autoimmune thyroiditis. (This supports use in Hashimoto’s more than in non-autoimmune hypothyroidism.) Frontiers
- Oxidative stress & immune pathways: Contemporary pharmacology papers attribute BZYQT’s effects to pathways relevant to autoimmunity—anti-oxidative, anti-inflammatory, and immune regulation; one review connects commonly used Hashimoto’s herbs (several appear in BZYQT) with regulation of efferocytosis (clearance of apoptotic cells), a mechanism implicated in autoimmunity. Frontiers
How to use for Hypothyroidism:
Formulations & typical adult dosing (standardized Kampo extracts)
- Tsumura TJ-41 (Hochuekkito): usual adult dose 7.5 g/day granules orally in 2–3 divided doses before or between meals; adjust by age/weight/symptoms. Tsumura
- Teikoku Hochuekkito: 2.5 g three times daily before meals (total 7.5 g/day). 帝國製薬株式会社
Classical decoction (traditional recipe)
- Classical composition (e.g., Huang Qi/Astragalus 15 g; Bai Zhu/Atractylodes 10 g; Dang Gui 9 g; Ren Shen/Ginseng 6 g; Chen Pi 6 g; Zhi Gan Cao 6 g; Chai Hu 3 g; Sheng Ma 3 g) decocted in water, taken twice daily; patent pills/bolus 10–15 g per dose 2–3×/day are also documented. Use only if the TCM pattern fits. TCM Wiki
Pattern-directed modifications (for Hashimoto’s subtypes)
- Practitioner resources describe additions/subtractions for presentations like “blood stasis,” “qi & blood deficiency,” “phlegm nodules,” etc., when BZYQT is used for Hashimoto’s thyroiditis. (This requires qualified TCM/Kampo assessment rather than self-design.) americandragon.com
Practical clinical guidance
- BZYQT is not a replacement for levothyroxine when indicated. It may be trialed adjunctively for patients with Hashimoto’s symptoms/antibodies under clinician supervision, with periodic monitoring of TSH, FT4, FT3, and thyroid antibodies. (General safety/immunology summaries) Memorial Sloan Kettering Cancer Center
Scientific Evidence for Hypothyroidism:
Autoimmune thyroiditis / thyroid-related
- Rat AIT model: Buzhong Yiqi granules reduced thyroid autoantibodies and improved thyroid function vs. controls. (Cited within Frontiers review; original in Journal of Traditional Chinese Medicine, 2024.) Frontiers
- Review (2025) on obesity-associated Hashimoto’s: summarizes evidence that TCM can reduce antibodies and improve symptoms; highlights mechanisms (efferocytosis, antioxidant/immune regulation) and notes Buzhong Yiqi decoction contains herbs analyzed. Frontiers
- Pharmacology paper (2025, J Ethnopharmacol) indicates BZYQ improves inflammation/oxidative damage in autoimmune thyroiditis (preclinical/experimental focus). ScienceDirect
Mechanism & composition
- Screening studies and monographs outline constituents and quality markers for BZYQT, supporting reproducible preparation and mechanistic exploration. ScienceDirect
Related clinical outcomes (indirect but relevant to fatigue/immune tone)
- MSK clinician summary aggregates small clinical studies showing improvements in fatigue, immune function, and QOL (cancer/other chronic conditions) with BZYQT/TJ-41; also COPD and wound-healing data. Memorial Sloan Kettering Cancer Center
- RCTs and reviews on cancer-related fatigue with BZYQT/BJIKT (pilot RCT; scoping/systematic reviews) demonstrate safety and symptom benefit, backing immunomodulatory/anti-inflammatory actions relevant to autoimmune disease contexts. SAGE Journals
Perinatal/subclinical thyroid context (preclinical)
- Animal work in subclinical hypothyroidism of pregnancy has explored BZYQT’s effects on mitochondrial dysfunction/offspring neurodevelopment, underscoring oxidative-stress mechanisms; this is not direct therapy evidence for adult hypothyroidism. syfjxzz.com
Specific Warnings for Hypothyroidism:
General safety (authoritative monograph)
- MSK monograph lists nausea/bloating and emphasizes discussing all supplements with clinicians; it summarizes immune and anti-inflammatory actions and calls for larger trials. Memorial Sloan Kettering Cancer Center
Glycyrrhiza (licorice root)–related risks (present in BZYQT)
- Pseudoaldosteronism / hypokalemia / hypertension / edema / myopathy risk due to glycyrrhizin—monitor blood pressure & potassium; discontinue if abnormalities occur. This is explicitly warned in official package inserts for standardized Hochuekkito (TJ-41). Tsumura
Serious but rare reactions in Kampo labeling
- Interstitial pneumonia (fever, cough, dyspnea) has been reported with some Kampo formulas; stop immediately and evaluate if symptoms arise (listed in TJ-41 inserts). Tsumura
Drug–herb duplication / interactions
- Avoid combining with other licorice-containing products (including some cough syrups/herbal formulas) to reduce hypokalemia risk. Package inserts instruct caution when co-administered with preparations containing Glycyrrhiza/glycyrrhizin(ates). Tsumura
Pattern/diagnosis caveat
- Kampo/TCM labeling requires the patient’s pattern (“Sho”) to fit; avoid prolonged use if no response. Tsumura
Do not use as monotherapy for overt hypothyroidism
- For frank hypothyroidism, levothyroxine remains standard of care; BZYQT should be adjunctive if used at all, with thyroid labs monitored and prescribing clinicians informed. (Clinical practice notes and reviews on Hashimoto’s management referenced within Frontiers review.) Frontiers
General Information (All Ailments)
What It Is
Bu Zhong Yi Qi Tang (literally “Tonify the Middle and Augment the Qi Decoction”) is a classical Chinese herbal formula originally created by the physician Li Dong-yuan during the Jin–Yuan dynasty (13th century). It is one of the most renowned Qi-tonifying formulas in Traditional Chinese Medicine (TCM).
The formula’s primary purpose is to strengthen the Spleen and Stomach, replenish Qi (vital energy), and raise Yang Qi that has sunken due to deficiency.
The traditional composition includes:
- Huang Qi (Astragalus membranaceus) – chief herb that powerfully tonifies Qi and raises Yang.
- Ren Shen (Ginseng) or Dang Shen (Codonopsis) – strengthens Spleen Qi.
- Bai Zhu (Atractylodes macrocephala) – supports digestion and strengthens the Spleen.
- Zhi Gan Cao (Honey-fried Licorice Root) – harmonizes and strengthens Qi.
- Chen Pi (Aged Tangerine Peel) – regulates Qi and supports digestion.
- Dang Gui (Angelica sinensis) – nourishes and invigorates the blood.
- Sheng Ma (Cimicifuga) and Chai Hu (Bupleurum) – help raise clear Yang Qi and lift prolapsed organs.
This formula is commonly used in decoction, pill, or granule form.
How It Works
From a TCM perspective, Bu Zhong Yi Qi Tang works by addressing Spleen and Stomach Qi deficiency and Yang Qi sinking.
- Tonifying Spleen Qi: The Spleen governs digestion and transformation of food into Qi and Blood. When it is weak, fatigue, poor appetite, and loose stools result. Herbs like Huang Qi, Ren Shen, and Bai Zhu strengthen this function, restoring the body’s ability to generate energy.
- Raising Yang Qi: When Qi is weak, Yang (the active, uplifting energy) tends to sink. This leads to symptoms such as organ prolapse, chronic fatigue, or low mood. Chai Hu and Sheng Ma help raise Yang Qi, lifting both physical and emotional states.
- Supporting Qi and Blood: Dang Gui nourishes Blood while Huang Qi and Ren Shen boost Qi — the combination ensures that Qi and Blood are balanced and mutually supportive, improving vitality and resilience.
- Regulating Qi Flow and Digestion: Chen Pi helps prevent stagnation caused by tonifying herbs, promoting smoother digestion and better assimilation of nutrients.
In modern biomedical terms, the formula is thought to enhance immune function, improve gastrointestinal absorption, and increase energy metabolism. It has been studied for use in chronic fatigue, hypotension, digestive disorders, and post-illness recovery.
Why It’s Important
Bu Zhong Yi Qi Tang holds a central place in TCM because it treats one of the most fundamental patterns — Qi deficiency — which underlies many chronic and constitutional conditions.
Its importance lies in:
- Restoring vitality: Often prescribed for those who feel persistently tired, weak, or depleted, especially after illness, childbirth, or surgery.
- Enhancing digestion and metabolism: Supports nutrient absorption and the body’s ability to transform food into energy.
- Promoting recovery and resilience: Used to strengthen the immune system and aid in long-term recuperation.
- Preventing organ prolapse and chronic fatigue syndromes: Its Yang-raising effect makes it useful for uterine, gastric, or anal prolapse, and for low-grade fever or exhaustion worsened by exertion.
- Supporting mental clarity and mood: By lifting Yang Qi and nourishing Qi and Blood, it can improve concentration, alertness, and emotional stability.
This formula exemplifies how TCM emphasizes root treatment — strengthening the body’s foundation rather than just addressing symptoms.
Considerations
While generally safe under professional guidance, several important considerations apply:
Pattern differentiation:
- Bu Zhong Yi Qi Tang is suitable only for Qi deficiency and sinking Yang patterns (e.g., fatigue, weak limbs, prolapse, spontaneous sweating). It is not appropriate for conditions of excess heat, Yin deficiency, or strong internal dampness without clear Qi deficiency.
Contraindications:
- Avoid during acute infections with high fever or inflammation, as tonifying Qi can trap pathogens.
- Use caution in those with hypertension or excessive irritability, since the Yang-raising effect could aggravate heat or restlessness.
- Not ideal for very Yin-deficient individuals (dryness, night sweats) unless modified.
Dosage and duration:
- Overuse can cause bloating, dryness, or heat sensations. Usually prescribed for short to moderate-term use (weeks to months) depending on recovery needs.
Interactions:
- Because it strengthens Qi, it may potentiate the effects of other tonics or stimulants (like caffeine or adaptogenic herbs).
Professional guidance:
- Always used under the supervision of a qualified TCM practitioner, who can modify the formula (e.g., adding herbs for dampness, heat, or blood deficiency) according to individual patterns.
Helps with these conditions
Bu Zhong Yi Qi Tang is most effective for general wellness support with emerging research . The effectiveness varies by condition based on clinical evidence and user experiences.
Detailed Information by Condition
Hypothyroidism
Traditional (TCM/Kampo) pattern rationaleBZYQT “tonifies Spleen/Stomach qi and raises yang,” classically used for fatigue, poor appetite, weakness, an...
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