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Bugleweed

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Specifically for Hyperthyroidism

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Why it works for Hyperthyroidism:

TSH-receptor/Graves’ antibody interference (in vitro): Extracts of Lycopus spp. (and related Lamiaceae) reduced TSH binding to its receptor and blunted TSH-stimulated adenylate cyclase activity; they also inhibited the bioactivity of Graves’ immunoglobulins. Oxford Academic

Possible inhibition of peripheral T4→T3 deiodination (preclinical): Aqueous Lycopus extracts inhibited rat liver iodothyronine deiodinase, which could reduce active hormone levels. Restorative Medicine

Cardiac symptom benefit in a hyperthyroid animal model (in vivo): L. europaeus extract reduced tachycardia and other cardiac signs in T4-induced hyperthyroid rats. ScienceDirect

Observed symptomatic improvements in people with mild hyperthyroidism: Small human studies (see below) report improvement in vegetative/cardiac symptoms (e.g., palpitations). ScienceDirect

How to use for Hyperthyroidism:

Standardized extract (as used in studies):

  • German product Thyreogutt® mono (dry extract of L. europaeus) was used in open post-marketing cohorts for mild symptomatic hyperthyroidism in primary care. (Exact commercial specs vary and may not be available in all countries.) SpringerLink

General dosing ranges cited in professional monographs:

  • 100–400 mg per dose, 2–3×/day of a bugleweed extract; higher daily totals (≈2 g/day) have been reported as tolerated in clinical experience. (These are not disease-specific posology standards.) Restorative Medicine

Monitoring/administration tips (from clinical guidance and monographs):

  • Restrict use to mild cases or as an adjunct, with medical oversight. Track TSH, free T4, free T3 every 4–6 weeks initially; adjust/stop if hypothyroid. Drugs.com
  • Avoid combining with antithyroid drugs or thyroid hormone unless a clinician is explicitly coordinating care (risk of over-suppression or lab interference). Drugs.com
  • If a radiolabeled thyroid uptake/scan is planned, disclose bugleweed use; it may interfere with diagnostic testing. Drugs.com

Scientific Evidence for Hyperthyroidism:

Mechanistic & preclinical

  • Endocrinology (1985): Freeze-dried extracts of Lycopus spp. and related plants inhibited TSH receptor binding and TSH-stimulated signaling; also reduced bioactivity of Graves’ IgG. Oxford Academic
  • Hormone & Metabolic Research (1984): Plant extracts (including Lycopus) inhibited iodothyronine deiodinase in rat liver. (Mechanistic support for reduced T3 formation.) Restorative Medicine
  • Life Sciences (2006): In T4-induced hyperthyroid rats, L. europaeus extract reduced cardiac signs (tachycardia/arrhythmia). ScienceDirect

Human (mostly small, open-label/observational; no robust RCTs)

  • Phytomedicine (2008): Prospective open study of L. europaeus in patients with low TSH and hyperthyroid-associated symptoms: reported reduced morning heart rate and changes in thyroidal parameters (including increased urinary T4 excretion). Symptom-focused improvement; limited design. ScienceDirect
  • Wiener Medizinische Wochenschrift (2013): Open post-marketing surveillance (three cohorts; primary care) of Thyreogutt® mono (dry L. europaeus extract) in mild hyperthyroidism; clinically relevant symptom improvement vs. untreated control cohort; good tolerability. (Observational; not randomized.) SpringerLink
Specific Warnings for Hyperthyroidism:

Do NOT use in pregnancy or breastfeeding. Safety data are lacking; some sources flag theoretical hormonal effects. Restorative Medicine

Avoid if you have hypothyroidism, subclinical hypothyroidism, or Hashimoto’s (bugleweed may further suppress thyroid activity). Verywell Health

Drug interactions & lab interference: May potentiate effects of antithyroid medications (risk of overtreatment), counteract thyroid hormone replacement, and interfere with thyroid function tests or uptake scans—coordinate with your clinician and lab. Drugs.com

Adverse effects: Generally well-tolerated in small studies; isolated reports include palpitations/arrhythmia sensations. Abrupt cessation at high intakes is theoretically linked to thyroid enlargement; evidence is limited. Drugs.com

Children: Insufficient evidence—avoid unless a specialist directs use. Drugs.com

Quality & standardization: Supplements vary widely and are not regulated like medicines; choose third-party tested products and verify exact species (L. europaeus or L. virginicus). Verywell Health

General Information (All Ailments)

Note: You are viewing ailment-specific information above. This section shows the general remedy information for all conditions.

What It Is

Bugleweed, scientifically known as Ajuga reptans, is a perennial herb in the mint family (Lamiaceae). It is native to Europe and parts of Asia but has become naturalized in North America and other regions. The plant typically grows low to the ground, forming dense mats of glossy, dark green to purplish leaves and producing spikes of blue to violet flowers in spring.

In herbal medicine, bugleweed refers to several Ajuga species, primarily Ajuga reptans and Ajuga genevensis, that have been used traditionally for their medicinal properties. Extracts from the plant—made from its leaves and flowering tops—are commonly used in teas, tinctures, and supplements.

How It Works

Bugleweed contains several bioactive compounds, including lithospermic acid, flavonoids, tannins, and phenolic acids. These constituents are thought to contribute to its thyroid-suppressing, astringent, and mild sedative effects.

The primary mechanism of action appears to involve the inhibition of thyroid-stimulating hormone (TSH) and the reduction of thyroxine (T4) production. This makes bugleweed particularly interesting for people with mild hyperthyroidism (overactive thyroid) or related symptoms such as palpitations, anxiety, or rapid heartbeat.

Additionally, bugleweed may have antioxidant and anti-inflammatory properties, helping to reduce oxidative stress and calm tissues. It is also thought to have diuretic effects, supporting the removal of excess fluid from the body, and mild cardiac sedative properties, helping regulate heart rhythm and blood pressure.

Why It’s Important

Bugleweed holds importance mainly for its role as a natural thyroid modulator and calming herb. In traditional and modern herbalism, it is valued for several reasons:

  1. Thyroid Health: Bugleweed is often used as a natural alternative for mild cases of hyperthyroidism or Graves’ disease, helping to regulate hormone levels without synthetic medication—though it should never replace medical treatment without supervision.
  2. Cardiovascular Benefits: Its mild calming and heart-slowing effects can help reduce symptoms such as rapid heartbeat or nervous agitation that sometimes accompany thyroid imbalance or anxiety.
  3. Hormonal and Metabolic Balance: Because of its influence on thyroid hormones, bugleweed can indirectly affect metabolism, energy levels, and hormonal balance.
  4. Traditional Uses: Historically, it was used for wound healing, respiratory conditions (like coughs and bleeding from the lungs), and as a tonic for calming the nervous system.

Considerations

While bugleweed has valuable uses, it must be approached with care. Key considerations include:

  • Thyroid Conditions: Bugleweed is contraindicated for individuals with hypothyroidism (underactive thyroid) or those taking thyroid hormone replacement therapy, as it can further suppress thyroid activity.
  • Pregnancy and Breastfeeding: It is not recommended during pregnancy or lactation due to possible hormonal effects and lack of sufficient safety data.
  • Drug Interactions: Bugleweed may interact with medications such as thyroid drugs, hormone therapies, or sedatives. Consultation with a healthcare provider is important before use.
  • Dosage and Form: The herb is typically consumed as a tea, tincture, or capsule, but dosing should be guided by an herbalist or healthcare professional. Overuse can lead to fatigue, hormonal imbalance, or slowed metabolism.
  • Medical Supervision: Because of its effect on endocrine and cardiovascular systems, bugleweed should only be used under the guidance of a qualified practitioner—especially for those with thyroid disorders or heart conditions.

Helps with these conditions

Bugleweed is most effective for general wellness support with emerging research . The effectiveness varies by condition based on clinical evidence and user experiences.

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Detailed Information by Condition

Hyperthyroidism

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TSH-receptor/Graves’ antibody interference (in vitro): Extracts of Lycopus spp. (and related Lamiaceae) reduced TSH binding to its receptor and blunte...

0 votes Updated 1 month ago 5 studies cited

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