Chi-Ju-Di-Huang-Wan
Specifically for Dry Eye Syndrome
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Why it works for Dry Eye Syndrome:
TCM rationale. Qi Ju Di Huang Wan is Liu-Wei-Di-Huang-Wan with two eye-focused additions—goji berry (Gou Qi Zi, Lycium) and chrysanthemum (Ju Hua)—to “nourish Liver & Kidney yin” and support the eyes. Formula overviews note its long-standing use for blurred/dry eyes. Nature
Mechanistic/biomedical clues.
- 2024 ARVO abstract (rat DED model): the formula reduced corneal inflammation and improved DED signs vs. controls. iovs.arvojournals.org
- 2024 systems-biology study (metabolomics + network pharmacology): proposes multi-target effects relevant to age-related dry eye, including anti-inflammatory and tear-film–related pathways. ScienceDirect
- Network-pharmacology/molecular docking (2022): maps >100 compounds in the pill to DED-related targets and pathways (e.g., NF-κB, cytokines). Mechanistic, not clinical. Wiley Online Library
How to use for Dry Eye Syndrome:
What’s in it (classical 8-herb pill): Shu Di Huang (Rehmannia), Shan Zhu Yu (Cornus), Shan Yao (Dioscorea), Mu Dan Pi (Moutan), Ze Xie (Alisma), Fu Ling (Poria), Gou Qi Zi (Lycium/goji), Ju Hua (Chrysanthemum). ajtcvm.org
Typical over-the-counter (patent) dosing (label references; exact pill size differs by maker):
- Teapills/tablets: commonly 8 teapills, 3×/day with warm water; some labels advise 8–12 teapills, 3×/day initially, then reduce to maintenance. Best Chinese Medicines
- Another common tablet instruction is 3–4 tablets, 2×/day (brand-specific). healthylicious.co.uk
How long until effects? In the human RCT (below), improvements appeared by 2–4 weeks; many clinicians trial 4–8 weeks, reassessing thereafter. Europe PMC
How it’s used clinically for DED
- Often combined with standard care (e.g., artificial tears). The RCT compared CJDHW + drops vs placebo + drops. Europe PMC
- Practitioners frequently modify the base formula to match TCM patterns (e.g., add Ophiopogon/Xuan Shen for marked mouth/tear dryness), so individualised prescriptions are common. Singapore Optometric Association
Quality matters. A university thesis that chemically profiled 11 marketplace products found ~4–29-fold variability in key analytes—so choose reputable manufacturers. Western Sydney University
Scientific Evidence for Dry Eye Syndrome:
Randomised, placebo-controlled trial (80 patients). Chang Y-H, Lin H-J, Li W-C. Phytotherapy Research, 2005.
CJDHW (added to standard drops) showed significant improvement in Rose-Bengal staining at 2 weeks and TBUT at 4 weeks vs placebo; Schirmer’s wasn’t different. (Abstracted on Europe PMC; also summarized by professional/association pages.) Europe PMC
Retrospective review (2021, Tzu Chi Med J).
Summarises clinical experience and literature; notes CJDHW can stabilise tear film and, when combined with Si Wu Tang, increase tear secretion over 3 months without reported adverse effects in that cohort (observational). tzuchi.com.tw
Mechanistic/Preclinical.
- ARVO 2024 rat study showing suppressed corneal inflammation with CJDHW. iovs.arvojournals.org
- Network-pharmacology papers mapping the pill’s compounds to DED pathways (supportive biology, not proof). Wiley Online Library
Specific Warnings for Dry Eye Syndrome:
Warfarin (and other anticoagulants): be very cautious.
Goji (Lycium barbarum), a core herb in this pill, has multiple human case reports of INR elevation/bleeding when combined with warfarin (tea/juice or supplements). If on warfarin, avoid or use only with prescriber approval and closer INR monitoring. oa.mg
Allergy/cross-reactivity.
Chrysanthemum (Asteraceae) can cause allergic reactions and photosensitivity; people allergic to ragweed/daisies/mums may react. WebMD
Digestive weakness / “cold–damp” tendencies.
Classical cautions for this yin-tonifying family (Liu-Wei-Di-Huang-Wan base): use caution with Spleen-qi deficiency, loose stools, dampness; avoid in frank Yang deficiency unless modified by a practitioner. shenclinic.com
Pregnancy & lactation.
Many retailers label the formula contraindicated in pregnancy/breastfeeding (conservative stance). Discuss with your obstetric provider before use. healthylicious.co.uk
Product variability & contaminants.
Analytical work shows large variability between brands in active constituents; buy tested products and follow label dosing unless your clinician prescribes otherwise. Western Sydney University
General Information (All Ailments)
What It Is
Chi-Ju-Di-Huang-Wan (also spelled Qi Ju Di Huang Wan or Qi Ju Di Huang Pian) is a traditional Chinese herbal formula derived from the classical prescription Liu Wei Di Huang Wan (Six-Ingredient Rehmannia Pill). It was developed during the Song Dynasty and is commonly used in Traditional Chinese Medicine (TCM) to nourish Yin, particularly of the liver and kidneys, and to improve vision.
The formula typically includes:
- Rehmannia root (Shu Di Huang)
- Cornus fruit (Shan Zhu Yu)
- Chinese yam (Shan Yao)
- Poria mushroom (Fu Ling)
- Moutan bark (Mu Dan Pi)
- Alisma rhizome (Ze Xie)
- Chrysanthemum flower (Ju Hua)
- Lycium fruit (goji berry, Gou Qi Zi)
The last two ingredients—Ju Hua and Gou Qi Zi—distinguish this formula from Liu Wei Di Huang Wan, enhancing its effect on the eyes and vision.
How It Works
In TCM theory, Chi-Ju-Di-Huang-Wan works by tonifying the Yin of the liver and kidneys, which are considered the root of vitality and the foundation for eye health.
- Liver Yin nourishment: The liver stores blood and governs the eyes. By enriching liver Yin, the formula helps maintain proper vision, reduce eye dryness, and relieve fatigue.
- Kidney Yin support: The kidneys are believed to nourish the liver. Strengthening kidney Yin helps replenish vital essence (jing), combating symptoms such as dizziness, tinnitus, and lower back weakness.
- Heat clearing and balance: Herbs like Moutan bark and Alisma rhizome help clear deficient heat and promote fluid metabolism, preventing stagnation from excessive tonics.
- Eye-targeting herbs: Chrysanthemum and goji berries directly benefit the eyes by dispersing wind-heat, improving blood circulation to ocular tissues, and providing antioxidant effects in modern pharmacological terms.
Modern research supports that components of Chi-Ju-Di-Huang-Wan may help regulate oxidative stress, retinal function, and microcirculation, aligning with its traditional use for eye health.
Why It’s Important
Chi-Ju-Di-Huang-Wan holds a significant place in Chinese medicine because it bridges general Yin tonification with targeted eye and vision protection. It is widely prescribed for:
- Age-related eye conditions, such as dry eyes, blurry vision, or early cataract formation.
- Symptoms of Yin deficiency, including dizziness, tinnitus, night sweats, or irritability.
- Visual fatigue due to prolonged screen use or overwork, common in modern lifestyles.
Its importance lies in promoting systemic balance rather than only treating eye symptoms. By nourishing the body’s Yin aspect, it supports overall vitality, hormonal balance, and longevity, which are foundational in TCM preventive health philosophy.
Considerations
While Chi-Ju-Di-Huang-Wan is generally safe and well-tolerated, several considerations apply:
Not suitable for everyone:
- It should be avoided by individuals with Spleen Qi deficiency with dampness (symptoms such as bloating, loose stools, or fatigue after eating), since the formula is rich and tonifying, which can worsen digestive sluggishness.
Contraindicated during acute illness:
- Not recommended for use during colds, flu, or infections characterized by fever or excess heat, as its Yin-nourishing nature may trap pathogens inside.
Dosage and duration:
- Traditionally taken as pills or decoction, dosage should be guided by a licensed TCM practitioner to match the person’s constitution and condition. Long-term unsupervised use is discouraged.
Interactions and modern precautions:
- Individuals on medications for blood sugar, blood pressure, or diuretics should consult healthcare providers, as certain ingredients may influence these systems.
Pregnancy and breastfeeding:
- Use under medical supervision only, as the effects on these states have not been well-established in modern clinical contexts.
Helps with these conditions
Chi-Ju-Di-Huang-Wan is most effective for general wellness support with emerging research . The effectiveness varies by condition based on clinical evidence and user experiences.
Detailed Information by Condition
Dry Eye Syndrome
TCM rationale. Qi Ju Di Huang Wan is Liu-Wei-Di-Huang-Wan with two eye-focused additions—goji berry (Gou Qi Zi, Lycium) and chrysanthemum (Ju Hua)—to...
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