Dang Gui Liu Huang Tang
Specifically for Psoriasis
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Why it works for Psoriasis:
Anti-inflammatory/immune modulation relevant to psoriasis biology. In a mouse model of psoriasiform dermatitis (imiquimod-induced), Dang Gui Liu Huang Tang (DGLHT) reduced skin inflammation by inhibiting IL-22 (a Th17/IL-23 axis cytokine implicated in human psoriasis) and attenuated related pathways. دانشیاری | دانستنیهای جذاب برای زندگی
TCM rationale. Classical indications of DGLHT are “yin deficiency with heat/fire,” with symptoms such as dry mouth, irritability, constipation, red tongue, rapid pulse. Psoriasis cases fitting this pattern (e.g., dryness, burning/heat, night sweats, thirst) are sometimes treated by “nourishing yin and clearing deficiency-heat.” TCM Wiki
Broader CHM context. Contemporary reviews of Chinese medicine for psoriasis describe anti-psoriatic effects through down-regulation of Th1/Th17 cytokines, barrier support, and anti-angiogenic actions; DGLHT is specifically cited among formulas with preclinical benefit in IMQ models. (These are supportive for the approach, but not proof for DGLHT in humans.) BioMed Central
How to use for Psoriasis:
Classical composition & typical decoction amounts (per day):
- Dang Gui 9 g
- Sheng Di Huang 9 g
- Shu Di Huang 9 g
- Huang Qin 9 g
- Huang Bai 9 g
- Huang Lian 6 g
- Huang Qi 18 g
- Administration: traditionally decocted in water and taken twice daily (originally used as powder). TCM Wiki
Modern practice notes (common, but practitioner-dependent):
- Granules/extracts are often substituted for raw decoctions; dose is adjusted to the manufacturer’s extract ratio and the patient’s presentation.
- Course/duration often reassessed every 2–4 weeks, with formula modified as signs shift (e.g., adding moistening/itch-relief herbs for severe dryness/pruritus, or cooling/blood-moving herbs if “blood-heat” predominates), consistent with TCM reviews of psoriasis care. BioMed Central
Scientific Evidence for Psoriasis:
Preclinical (animal/mechanistic) evidence specific to DGLHT:
- Phytomedicine 2018: DGLHT ameliorated IMQ-induced psoriasis-like skin inflammation in mice by inhibiting IL-22 production and related signaling. (No human participants.) دانشیاری | دانستنیهای جذاب برای زندگی
Human clinical evidence for DGLHT specifically in psoriasis:
- None located (as of now). There are no randomized controlled trials (RCTs) directly testing DGLHT in people with psoriasis that we could find.
Human clinical evidence for CHM (various formulas) in psoriasis (not DGLHT-specific):
- Frontiers in Pharmacology 2020 meta-analysis of 11 high-quality RCTs found Chinese herbal medicine (varied internal/topical formulas) improved PASI and global responses versus controls, with acceptable safety; this synthesizes CHM broadly, not DGLHT alone. Frontiers
- Additional reviews summarize supporting roles of Chinese medicine in psoriasis, mechanisms, and clinical experience (again, not specific to DGLHT). BioMed Central
Specific Warnings for Psoriasis:
Because DGLHT combines multiple herbs, consider both formula-level risks (quality/adulteration) and herb-level interactions/contraindications:
1) Quality/adulteration concerns
- Some Chinese herbal products have been found contaminated with steroids or heavy metals; ensure sourcing from reputable, tested suppliers. NCCIH
- Heavy-metal toxicity has been reported in psoriasis patients using folk remedies; lab-tested products are essential. Nature
2) Drug–herb interactions (not exhaustive)
- Coptis (Huang Lian), Phellodendron (Huang Bai) contain berberine, which can inhibit CYP3A4 and P-glycoprotein. This may raise blood levels of drugs metabolized or transported by these systems. Clinically relevant concern: cyclosporine (used for severe psoriasis)—berberine increased cyclosporine concentrations in transplant patients/interaction trials. Avoid combining without specialist oversight and therapeutic drug monitoring. ScienceDirect
- Astragalus (Huang Qi) is immunostimulatory; avoid in autoimmune disease flares or when taking immunosuppressants unless your clinician approves. (Important if you’re on biologics or cyclosporine/methotrexate.) NCCIH
3) Patient-specific cautions (key constituents)
- Dang Gui (Angelica sinensis): avoid in pregnancy and use caution with bleeding disorders or anticoagulants/antiplatelets due to potential bleeding/photosensitivity risks. WebMD
- Scutellaria (Huang Qin): rare liver injury cases reported with Skullcap supplements; monitor liver enzymes if used long-term or with hepatotoxic drugs. WJGnet
4) General
- If you’re on biologics, methotrexate, cyclosporine, retinoids, or phototherapy, speak with your dermatologist/pharmacist before adding DGLHT.
- Start low, monitor LFTs and renal function when appropriate, and stop if you develop rash, jaundice, dark urine, or other concerning symptoms.
General Information (All Ailments)
What It Is
Dang Gui Liu Huang Tang — literally translated as “Tangkuei and Six-Yellow Decoction” — is a classic traditional Chinese herbal formula first recorded in Wen Bing Tiao Bian (Treatise on Epidemic Febrile Diseases) during the Qing Dynasty.
It contains seven key herbs, with “six yellow” referring to the inclusion of several herbs that have a yellow hue and a cooling nature. The standard formulation includes:
- Dang Gui (Angelica sinensis) – Nourishes and invigorates the blood.
- Sheng Di Huang (Rehmannia glutinosa, raw) – Cools the blood and nourishes yin.
- Shu Di Huang (Rehmannia glutinosa, prepared) – Deeply nourishes yin and blood.
- Huang Qin (Scutellaria baicalensis) – Clears heat from the upper burner.
- Huang Lian (Coptis chinensis) – Clears heat from the middle burner and heart fire.
- Huang Bai (Phellodendron amurense) – Drains damp-heat from the lower burner.
- Huang Qi (Astragalus membranaceus) – Tonifies qi and strengthens the body’s surface to stop sweating.
The combination of these herbs balances the yin and yang, nourishes the blood and fluids, and clears internal heat.
How It Works
From a Traditional Chinese Medicine (TCM) perspective, Dang Gui Liu Huang Tang acts by addressing two main pathological conditions:
- Yin Deficiency with Excess Fire. The formula nourishes the yin (particularly the blood and kidney yin) to replenish body fluids and restore balance. Herbs such as Sheng Di Huang and Shu Di Huang deeply nourish yin, while Dang Gui supports blood enrichment.
- Fire or Heat Rising from Deficiency. The “six yellows” (Huang Qin, Huang Lian, Huang Bai, etc.) have strong heat-clearing and fire-draining actions, especially targeting the heart, liver, and kidneys. This helps to reduce symptoms such as irritability, night sweats, and a sensation of heat.
- Qi Consolidation to Prevent Fluid Loss. Huang Qi is particularly important for reinforcing the defensive qi (wei qi) to stabilize the exterior. This helps control spontaneous or night sweating by sealing the pores and reducing yin leakage.
In biomedical terms, modern research suggests that the formula may:
- Regulate endocrine and immune function.
- Exhibit anti-inflammatory and antioxidant effects.
- Support autonomic nervous balance, reducing stress-related sweating.
- Improve microcirculation and hormonal homeostasis in yin-deficient conditions.
Why It’s Important
Dang Gui Liu Huang Tang holds an important place in Chinese herbal medicine because it is one of the most effective formulas for addressing yin-deficient internal heat with night sweats — a hallmark sign of imbalance between yin and yang.
It is particularly valuable for:
- Perimenopausal and menopausal women experiencing hot flashes, night sweats, and irritability.
- Post-illness recovery, where body fluids and yin have been depleted.
- Chronic low-grade fevers, insomnia, and restlessness from yin deficiency.
- Hyperthyroidism-like symptoms (in a TCM framework).
- Diabetic internal heat patterns and certain skin conditions with dryness and heat.
Its balanced nature — nourishing while cooling — makes it suitable for long-term use under supervision, offering a harmonizing effect rather than a purely suppressive one.
Considerations
While Dang Gui Liu Huang Tang is powerful, it must be used thoughtfully:
Pattern Differentiation
- It is suitable only when the root cause is yin deficiency with fire or heat symptoms. If used in people with cold deficiency or damp stagnation, it can worsen symptoms such as fatigue, bloating, or diarrhea.
Contraindications
- Should be avoided in cases of cold-type sweating, spleen qi deficiency with dampness, or yang deficiency.
- Not ideal for those with digestive weakness, as the heavy, cloying herbs can burden the stomach.
Dosage and Administration
- Traditionally taken as a decoction, but modern versions exist as granules or pills. Dosage and proportions should be adjusted based on individual constitution and presenting symptoms by a qualified TCM practitioner.
Possible Side Effects
- Mild gastrointestinal discomfort, reduced appetite, or loose stools may occur in those with weak digestion. Overuse may lead to overcooling or digestive stagnation.
Medical Supervision
- It’s best prescribed by a licensed practitioner after proper pattern diagnosis. Those taking Western medications, especially hormone regulators or antihypertensives, should consult both practitioners to avoid interactions.
Helps with these conditions
Dang Gui Liu Huang Tang is most effective for general wellness support with emerging research . The effectiveness varies by condition based on clinical evidence and user experiences.
Detailed Information by Condition
Psoriasis
Anti-inflammatory/immune modulation relevant to psoriasis biology. In a mouse model of psoriasiform dermatitis (imiquimod-induced), Dang Gui Liu Huang...
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