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Duhuo Jisheng Decoction

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Specifically for Nerve Pain (Neuropathy)

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Why it works for Nerve Pain (Neuropathy):

Neuroinflammation + glial modulation. Recent mechanistic work (network-pharmacology + validation) finds DHJSD targets pathways central to neuropathic pain—suppressing microglial M1 polarization and dampening pro-inflammatory signaling implicated in peripheral and central sensitization. This points to reduced TNF-α/IL-1β/NF-κB activity and pain behavior improvement in models. BioMed Central

Astrocyte/neuronal signaling. A 2025 preclinical study on Duhuo Jisheng Mixture (closely related formula) reported analgesia in a mouse chronic constriction injury model via the S1PR1/P2Y1R pathway, with downstream reductions in neuronal p-ERK/p-CREB/c-Fos—mechanisms highly relevant to neuropathic pain. ScienceDirect

Anti-inflammatory constituents. Individual herbs in DHJSD (e.g., Du Huo, Dang Gui, Qin Jiao, Sang Ji Sheng) have documented anti-inflammatory/analgesic effects; e.g., network analyses and experimental work highlight suppression of TLR/NF-κB and related axes in arthritic models, which overlap with neuropathic pain pathways. Syfjxzz

How to use for Nerve Pain (Neuropathy):

Important: Dosing and modifications are individualized in TCM. Work with a qualified practitioner—especially if you’re on medications or have comorbidities.

Classical composition (typical gram weights for 1 day’s decoction)

  • Common recipe (Sun Simiao’s Bei Ji Qian Jin Yao Fang) lists 15 herbs, e.g., Du Huo 9 g, Sang Ji Sheng 18 g, Du Zhong 9 g, Niu Xi 9 g, Xi Xin 3 g, Qin Jiao 9 g, Fu Ling 12 g, Rou Gui (small dose), Fang Feng 9 g, Chuan Xiong 6 g, Ren Shen ~10 g (often replaced by Dang Shen), Gan Cao 6 g, Dang Gui 12 g, Bai Shao 9 g, Sheng Di 15 g. Practitioners adjust for the patient’s pattern. TCM Wiki

Decoction prep (standard method)

  • Rinse herbs → add ~600–800 mL water → soak 20–30 min → simmer 30–45 min → strain → take warm in 2 doses/day. Many clinicians prepare 1–2 daily packs; powders/capsules or tinctures are alternatives (follow the product’s label or prescriber’s instructions). Sacred Lotus

Course / response window

  • For chronic neuropathic or radicular pain, formulas are typically tried for 4–8 weeks with reassessment; longer courses may be used if helping and well-tolerated (often alongside acupuncture/rehab). (General TCM practice guidance; exact duration individualized.) Sacred Lotus

Scientific Evidence for Nerve Pain (Neuropathy):

Direct neuropathic pain evidence

  • Mechanism-focused study (2023) using network pharmacology linked DHJSD to neuropathic pain targets and reported anti-neuroinflammatory effects consistent with analgesia. While not a clinical trial, it offers target-level plausibility. BioMed Central
  • Preclinical CCI model (2025, Phytomedicine): Duhuo Jisheng Mixture relieved neuropathic pain behaviors via S1PR1/P2Y1R modulation (astrocyte–neuron signaling). Preclinical but mechanistically strong. ScienceDirect

Related clinical pain conditions (share neuropathic/radicular features)

  • Lumbar disc herniation / sciatica (radicular pain): Multiple systematic reviews/meta-analyses (modified DHJSD; DHJSD + other care) show symptom improvements vs. controls, though overall trial quality is low–moderate and heterogeneity is high. Good news for pain/function, but better RCTs are needed. Europe PMC
  • Knee osteoarthritis: Meta-analysis suggests DJD reduces pain/stiffness vs. comparators; relevance is mainly analgesic/anti-inflammatory rather than neuropathic mechanisms. BMJ Open

Diabetic peripheral neuropathy (DPN)

  • An evidence mapping review of TCM in DPN cites a clinical report where Du Huo Ji Sheng Tang (oral or fumigation) improved oxidative stress indices (MDA, GSH-Px) in a DPN subgroup—but high-quality RCT evidence is limited; overall, more rigorous trials are needed. Frontiers

Summary: There is mechanistic and preclinical support for DHJSD in neuropathic pain and some clinical signals in radicular/low-back pain; robust, modern RCTs for neuropathy per se are sparse. Consider DHJSD as a complementary option under professional supervision.

Specific Warnings for Nerve Pain (Neuropathy):

Quality control (critical):

  • Ensure products are free of aristolochic acid (AA). Although DHJSD uses Asarum (Xi Xin) root (not Aristolochia), AA adulteration or use of aerial parts has caused serious renal/cancer risks. Buy from suppliers that test for AA and authenticate plant parts. FDA Access Data+2MedicineNet+2

Pregnancy / breastfeeding:

  • Traditional cautions apply—several DHJSD herbs (e.g., Dang Gui) are typically avoided in pregnancy unless specifically prescribed; safety in lactation is unclear. Darwyn Health

Blood thinners & bleeding risk:

  • Dang Gui (Angelica sinensis) may potentiate or alter warfarin effect (case reports and reviews—direction can vary). Ginseng in the formula can also interact with warfarin (mixed data; prudent to avoid or monitor INR closely). If you take warfarin or DOACs/antiplatelets, use only with prescriber oversight and monitoring. SAGE Journals

Blood pressure & electrolytes:

  • Licorice (Glycyrrhiza/Gan Cao) can raise blood pressure, lower potassium, and interact with diuretics and other drugs—even at modest doses. Consider risks in hypertension, CKD, heart failure. Verywell Health

Kidney disease:

  • Avoid any product with potential AA contamination; patients with existing renal issues should only use DHJSD under specialist guidance. FDA Access Data

Diabetes / hypoglycemics:

  • Ginseng-containing formulas can affect glucose and may interact with antidiabetic drugs—monitor if you’re on insulin/oral agents. AAFP

Herb–drug interactions (general):

  • Combining complex formulas with prescription meds requires caution; warfarin and other anticoagulants are particularly interaction-prone. AHA Journals

General Information (All Ailments)

Note: You are viewing ailment-specific information above. This section shows the general remedy information for all conditions.

What It Is

Duhuo Jisheng Decoction is a classical herbal formula used in traditional Chinese medicine, first recorded in the ancient text Bei Ji Qian Jin Yao Fang (Essential Prescriptions Worth a Thousand Gold Pieces) by Sun Simiao during the Tang Dynasty. It is primarily designed to dispel wind and dampness, relieve pain, and tonify the liver and kidneys, which in TCM are believed to govern the health of bones, joints, and tendons.

The formula is typically composed of multiple herbs working synergistically, including:

  • Duhuo (Radix Angelicae Pubescentis) – dispels wind-dampness and alleviates pain.
  • Sangjisheng (Taxillus chinensis) – nourishes liver and kidneys, strengthens sinews and bones.
  • Qin Jiao (Gentiana macrophylla) – relieves pain and relaxes the tendons.
  • Fangfeng (Saposhnikovia divaricata) and Xixin (Asarum sieboldii) – help dispel external wind and cold.
  • Danggui (Angelica sinensis), Chuanxiong (Ligusticum wallichii), Shudihuang (Rehmannia glutinosa), and Baishao (Paeonia lactiflora) – nourish blood and promote circulation.
  • Renshen (Panax ginseng), Fuling (Poria cocos), and Gancao (Glycyrrhiza uralensis) – support qi and harmonize the formula.

It is traditionally prepared as a decoction (boiled herbal tea) and consumed warm.

How It Works

From a TCM perspective, Duhuo Jisheng Decoction acts on two main fronts:

  1. Expelling Pathogenic Factors – It eliminates “wind-damp” and “cold” from the meridians and joints, which are believed to obstruct qi and blood flow, leading to pain, stiffness, and limited movement.
  2. Nourishing and Strengthening the Body – It simultaneously replenishes qi, blood, and the essence of the liver and kidneys, promoting long-term healing and strengthening the musculoskeletal system.

From a modern biomedical viewpoint, studies suggest that the decoction has anti-inflammatory, analgesic, and immunomodulatory effects. Research indicates it can:

  • Inhibit inflammatory mediators such as prostaglandins and cytokines.
  • Improve microcirculation and oxygen supply to joint tissues.
  • Enhance bone density and collagen synthesis in degenerative conditions.

This dual approach makes it particularly effective for chronic musculoskeletal disorders such as osteoarthritis, rheumatoid arthritis, and lumbar spondylosis.

Why It’s Important

Duhuo Jisheng Decoction is significant because it represents the integrative philosophy of TCM—addressing both symptoms (pain, stiffness) and root causes (organ deficiency and internal imbalance). Its importance lies in:

  • Chronic Joint and Back Conditions: It is one of the most trusted herbal treatments for chronic, cold-type arthritis and lower back pain due to kidney and liver deficiency.
  • Elderly Health: Often prescribed for older adults, it helps strengthen bones and tendons while alleviating pain and promoting mobility.
  • Holistic Healing: Unlike many painkillers, it seeks to restore balance and vitality rather than merely suppress discomfort.

In clinical practice, it remains a cornerstone formula for conditions involving joint degeneration, weakness, and chronic pain with cold, heavy sensations.

Considerations

While generally regarded as safe when prescribed correctly, several considerations should be kept in mind:

  1. Diagnosis-Specific Use: Duhuo Jisheng Decoction is intended for patterns of wind-damp-cold with liver and kidney deficiency. It is not suitable for “heat-type” pain or acute inflammation, as its warming nature could worsen such conditions.
  2. Professional Supervision: The dosage and composition often require adjustment by a qualified TCM practitioner to fit the individual’s constitution and condition. Self-prescription is discouraged.
  3. Potential Interactions: Since the formula contains multiple bioactive herbs, it may interact with pharmaceuticals such as anticoagulants, antihypertensives, or immunosuppressants. Medical consultation is advised for individuals taking such drugs.
  4. Side Effects: Mild digestive discomfort or drowsiness may occur in sensitive individuals. Rarely, allergic reactions to certain ingredients are possible.
  5. Pregnancy and Lactation: Use is typically not recommended during pregnancy or breastfeeding unless under strict professional guidance.
  6. Quality of Ingredients: The efficacy depends on the quality and authenticity of the herbal materials used. Reputable sources and standardized formulations are essential to ensure safety and potency.

Helps with these conditions

Duhuo Jisheng Decoction is most effective for general wellness support with emerging research . The effectiveness varies by condition based on clinical evidence and user experiences.

Nerve Pain (Neuropathy) 0% effective
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Detailed Information by Condition

Neuroinflammation + glial modulation. Recent mechanistic work (network-pharmacology + validation) finds DHJSD targets pathways central to neuropathic...

0 votes Updated 2 months ago 5 studies cited

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