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Gui Pi Tang

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Specifically for Brain Fog

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Why it works for Brain Fog:

TCM pattern logic. Brain fog often overlaps with poor concentration, forgetfulness, fatigue, insomnia, and anxiety. In TCM this commonly maps to Spleen-Qi + Heart-Blood deficiency, a classic indication for Gui Pi Tang. The formula’s traditional actions are to tonify Qi and Blood, strengthen the Spleen, and nourish/calm the Heart/Spirit (shen)—which aligns with symptoms people describe as “brain fog.” meandqi.com

What’s in it (and why). Core ingredients include Panax ginseng (Ren Shen), Astragalus (Huang Qi), Atractylodes (Bai Zhu), and Licorice (Gan Cao) to build Qi; Longan (Long Yan Rou) and Angelica sinensis (Dang Gui) to nourish Blood; and Ziziphus seed (Suan Zao Ren), Poria (Fu Shen), and Polygala (Yuan Zhi) to calm the spirit and support memory/sleep. These choices reflect the aim of improving energy, sleep quality, and cognitive clarity. meandqi.com

How to use for Brain Fog:

Confirm the pattern. A TCM consultation should verify Spleen-Qi and Heart-Blood deficiency (tongue/pulse & symptom cluster). Using formulae without pattern fit reduces effectiveness. meandqi.com

Choose a form & a starting dose.

  • Granules/extracts (common in clinics): For the closely related Japanese/Korean modification Kamikihito / Kami-Guibi-Tang (adds a few herbs to classic Gui Pi Tang), the standard adult dose is 7.5 g extract granules per day in 2–3 divided doses, before/between meals, adjusted for body size and response. This is a regulated, labeled dosing reference you can use to calibrate granule equivalents. tsumura.co.jp
  • Classical decoction/teapill equivalents: Practitioners typically match the classical composition and scale to modern grams; the AJTCVM and TCM references list the canonical ingredients and proportions used to compound the formula. ajtcvm.org

Timing & trial length. Take before or between meals. Reassess after 6–12 weeks for changes in fatigue, sleep, and cognitive clarity; discontinue if no improvement. (This timing mirrors clinical trials of the modified formula and the package-insert guidance to avoid prolonged use without benefit.) tsumura.co.jp

Quality matters. Use GMP-grade herbal products and avoid duplicating overlapping formulas (many contain the same herbs, e.g., licorice). tsumura.co.jp

Monitor. Because Gui Pi Tang contains licorice (Gan Cao) and ginseng, monitor blood pressure and, when indicated, potassium and INR if you take interacting meds (see Warnings). tsumura.co.jp

Scientific Evidence for Brain Fog:

There are no large RCTs specifically on “brain fog” per se. However, related outcomes—memory, global cognition, insomnia, fatigue/anxiety—have been studied with Kami-Guibi-Tang/Kamikihito (a modern modification that contains the Gui Pi Tang core):

Mild Cognitive Impairment (MCI):

  • Pilot randomized, double-blind, placebo-controlled trial in amnestic MCI (24 weeks) found signals suggesting cognitive benefit; a larger phase-III RCT protocol is published. BioMed Central
  • Phase-III protocol (84 patients; 24 weeks + 12-week follow-up) details outcomes on neuropsychological testing—useful for understanding dosing and endpoints. BioMed Central

Alzheimer’s disease (adjunct):

  • Pilot clinical study adding Kami-Guibi-Tang to acetylcholinesterase inhibitors in mild AD reported improvements on cognitive measures vs. control (pilot scale). Home

Retrospective clinical data:

  • Chart review (Heliyon 2024) of patients with cognitive impairment treated ≥90 days showed within-group MMSE improvements (uncontrolled; hypothesis-generating). Cell+1

Insomnia (closely linked to “brain fog”):

  • Systematic review of CHM for insomnia identified Gui Pi Tang as one of the most commonly used standardized formulas; authors call for higher-quality trials. ScienceDirect
  • RCT protocol: elderly with insomnia + subjective cognitive decline testing Kami-Guibi-Tang vs placebo for 12 weeks. BioMed Central

Evidence summaries:

  • Alzheimer’s Drug Discovery Foundation – Cognitive Vitality review concludes Kamikihito/Kami-Guibi-Tang may improve function or cognition in MCI/dementia, but larger, placebo-controlled studies are needed (summarizes human/animal data and safety). alzdiscovery.org
Specific Warnings for Brain Fog:

Because Gui Pi Tang (and its common modifications) contain licorice (Glycyrrhiza) and ginseng, pay special attention to the following:

  • Blood pressure & potassium (licorice). Licorice can cause pseudo-aldosteronismhypertension, edema, hypokalemia, arrhythmia. Package inserts for Kamikihito specifically warn to monitor BP and potassium and to stop if abnormalities occur; long-term use of gardenia-containing formulas has been associated with mesenteric phlebosclerosis (very rare; monitor with prolonged use). tsumura.co.jp
  • Independent clinical literature also documents licorice-induced hypertension/hypokalemia and explains the mechanism (11β-HSD2 inhibition). CMAJ
  • Drug interactions—anticoagulants. Ginseng may reduce warfarin’s anticoagulant effect in some patients; case reports and controlled studies show INR reductions. If you take warfarin, avoid ginseng-containing formulas or monitor INR closely with your prescriber. internationaljournalofcardiology.com
  • GI & other adverse effects. Labeling lists GI upset, rash/urticaria as possible reactions. Stop and seek care if significant symptoms occur. tsumura.co.jp
  • Pregnancy & lactation. Safety in pregnancy/lactation has not been established; use only if benefits clearly outweigh risks under clinician supervision. tsumura.co.jp
  • Elderly & comorbidity. Start low and monitor closely (package insert advises dose caution in older adults). Those with cardiovascular, renal, or electrolyte disorders should discuss risks first. tsumura.co.jp
  • General herb-safety resources. MSK’s About Herbs monographs provide neutral, clinician-vetted interaction and safety summaries for licorice and ginseng. Memorial Sloan Kettering Cancer Center

General Information (All Ailments)

Note: You are viewing ailment-specific information above. This section shows the general remedy information for all conditions.

What It Is

Gui Pi Tang, which translates as Restore the Spleen Decoction, is a classical herbal formula from traditional Chinese medicine. It was first recorded in the Ji Sheng Fang (Formulas to Aid the Living) during the Song Dynasty. The formula combines herbs that tonify both Qi (vital energy) and Blood, strengthen the Spleen and Heart, and calm the Shen (spirit).

The standard composition typically includes herbs such as:

  • Ren Shen (Ginseng) or Dang Shen (Codonopsis) – tonifies Qi
  • Huang Qi (Astragalus) – strengthens Spleen and raises Yang
  • Bai Zhu (Atractylodes) – supports digestion and Spleen function
  • Fu Ling (Poria) – drains dampness and supports the Spleen
  • Suan Zao Ren (Ziziphus seed) and Long Yan Rou (Longan fruit) – nourish Heart Blood and calm the spirit
  • Dang Gui (Angelica sinensis) – nourishes Blood
  • Mu Xiang (Aucklandia) – promotes Qi movement to prevent stagnation from tonics
  • Zhi Gan Cao (Honey-fried Licorice) – harmonizes the formula
  • Sometimes Yuan Zhi (Polygala) is added to enhance calming of the mind

It is commonly prescribed for people experiencing fatigue, poor memory, insomnia, palpitations, anxiety, or menstrual irregularities — symptoms that arise from Spleen Qi deficiency and Heart Blood deficiency.

How It Works

In the TCM framework, the Spleen governs transformation of food into Qi and Blood, while the Heart governs Blood circulation and mental activity. When the Spleen is weak, it cannot generate sufficient Blood; when the Heart is under-nourished, emotional and cognitive symptoms arise.

Gui Pi Tang works through multiple synergistic actions:

  • Tonifying Spleen Qi: Ginseng, Astragalus, and Atractylodes enhance digestive function and energy production, helping to rebuild Qi and support nutrient assimilation.
  • Nourishing Heart Blood: Angelica sinensis, Longan fruit, and Ziziphus seed replenish Blood and moisten dryness that may disturb the Heart.
  • Calming the Shen: The combined action of nourishing Blood and using tranquilizing herbs like Suan Zao Ren settles the mind, reducing anxiety and improving sleep.
  • Harmonizing and Circulating Qi: Mu Xiang ensures that the rich tonic herbs do not cause stagnation or digestive heaviness, maintaining smooth Qi flow.
  • Supporting overall vitality: The interaction of Qi and Blood tonics restores balance, leading to improved focus, emotional stability, and resilience to stress.

From a modern biomedical view, research suggests Gui Pi Tang may influence the nervous system, endocrine regulation, and immune modulation, possibly explaining its calming, adaptogenic, and restorative effects.

Why It’s Important

Gui Pi Tang is important because it addresses a common TCM pattern known as Spleen-Heart deficiency, which manifests in physical exhaustion and emotional fragility. It has been widely used for:

  • Chronic fatigue and weakness from overwork or stress
  • Insomnia, poor memory, and anxiety due to mental strain
  • Palpitations or irregular menstruation from Blood deficiency
  • Recovery support after illness, childbirth, or prolonged mental exertion

By strengthening both Qi and Blood, the formula nourishes the foundation of vitality and supports the integration of body and mind. It remains a cornerstone prescription for individuals who feel “drained,” “forgetful,” or “on edge” from both physical and emotional overuse.

Considerations

While Gui Pi Tang is gentle and restorative, several considerations apply:

  1. Pattern Differentiation: It should be used only when signs clearly indicate Spleen Qi and Heart Blood deficiency (e.g., fatigue, pale complexion, poor appetite, weak pulse). It is not suitable for conditions involving excess heat, dampness accumulation, or acute infections.
  2. Individualization: Dosage and specific herb substitutions (e.g., Ginseng vs. Codonopsis) should be tailored by a licensed practitioner to the person’s constitution and current symptoms.
  3. Duration of Use: The formula is designed for gradual, tonic support, not rapid symptom relief. It may be used for several weeks or months under supervision.
  4. Possible Side Effects: Rarely, if taken in excess or in individuals with sluggish digestion, it may cause bloating or fullness due to its tonifying nature.
  5. Modern Interactions: As it may affect energy metabolism and stress response, it should be used cautiously alongside stimulants, antidepressants, or immune-modulating drugs; consultation with a qualified healthcare provider is advised.
  6. Lifestyle Integration: For best results, users are encouraged to combine it with rest, proper diet (warm, easily digestible foods), and balanced emotional habits — all of which reinforce the Spleen’s role in TCM physiology.

Helps with these conditions

Gui Pi Tang is most effective for general wellness support with emerging research . The effectiveness varies by condition based on clinical evidence and user experiences.

Alzheimer's 0% effective
Anemia (Iron-Deficiency) 0% effective
Brain Fog 0% effective
3
Conditions
0
Total Votes
14
Studies
0%
Avg. Effectiveness

Detailed Information by Condition

Alzheimer's

0% effective

TCM rationale. Gui Pi Tang (GPT) “tonifies Spleen-Qi and Heart-Blood” and “calms the Shen,” traditionally used for poor memory, insomnia, anxiety, fat...

0 votes Updated 1 month ago 4 studies cited

TCM rationale: Gui Pi Tang “augments Qi, nourishes Blood, strengthens the Spleen, and nourishes the Heart,” patterns that often co-present with fatigu...

0 votes Updated 1 month ago 3 studies cited

Brain Fog

0% effective

TCM pattern logic. Brain fog often overlaps with poor concentration, forgetfulness, fatigue, insomnia, and anxiety. In TCM this commonly maps to Splee...

0 votes Updated 1 month ago 7 studies cited

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