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Nettle Leaf

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Specifically for Allergies (Hay Fever)

0% effective
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Why it works for Allergies (Hay Fever):

Blocks several allergy pathways (in vitro): Nettle extracts have shown activity at multiple points in the allergic cascade—antagonizing/negatively agonizing the histamine H1 receptor, inhibiting mast-cell tryptase (reducing degranulation), and inhibiting COX-1/COX-2 and prostaglandin D2 synthase—mechanisms that could translate to less sneezing, itching, and congestion. Academia

Anti-inflammatory polyphenols: Reviews summarize nettle’s broader anti-inflammatory effects (e.g., NF-κB modulation), providing a plausible biologic rationale for symptom relief. ScienceDirect

How to use for Allergies (Hay Fever):

There isn’t a universally accepted, standardized dosing protocol for allergic rhinitis; preparations vary. These are the best-documented ways it’s been used in trials or clinical references:

Freeze-dried nettle leaf capsules

  • Used in a randomized trial at 600 mg/day of freeze-dried leaf for 1 week during allergy season. Thieme+1
  • Some clinical references also list ~770 mg dried extract twice daily as a suggested adult dose, and tea made from ~4 g herb steeped ~10 min, 3–4×/day. (These are general nettle doses, not specific to one allergy trial.) Medscape

Root extract tablets (adjunctive use)

  • In a double-blind RCT, adults with allergic rhinitis used Urtica dioica root tablets 150 mg four times daily for 1 month, in addition to standard therapy; see “Clinical studies” below for outcomes and caveats. Semantic Scholar

Practical notes

  • Quality and standardization differ among products; match the form (freeze-dried leaf vs. root extract) and dose to what was studied. Drugs.com
  • If you try it, most clinicians advise a time-limited trial (e.g., 1–2 weeks for leaf capsules) to judge benefit, and to use it in season when symptoms occur. (This aligns with how the leaf trial was run.) Thieme

Scientific Evidence for Allergies (Hay Fever):

Freeze-dried leaf (Planta Medica, 1990 RCT): 98 participants with allergic rhinitis were randomized to freeze-dried nettle leaf vs. placebo for 1 week during peak season. Global assessments favored nettle over placebo after 1 week, but daily symptom diaries showed only slight advantage. This suggests a possible modest effect. Thieme

Root extract as add-on (Iranian J. Pharm. Res., 2017 RCT): 74 patients were randomized to Urtica dioica root 150 mg QID for 1 month vs. placebo, alongside loratadine and saline rinses. Both groups improved; nettle showed some favorable lab changes (e.g., nasal eosinophils) and a difference in IFN-γ, but placebo improvement was substantial and the authors concluded efficacy could not be determined given limitations (pilot size, attrition). Semantic Scholar

Mechanistic human-relevance (2009 Phytotherapy Research): In vitro work (not a clinical trial) demonstrated H1 receptor effects, tryptase inhibition, and eicosanoid pathway inhibition by nettle extract—supporting plausibility but not clinical efficacy by itself. Academia

Evidence summaries: Clinical monographs note a single RCT with 600 mg/day freeze-dried leaf for allergic rhinitis and emphasize lack of standardization across products and limited high-quality trials overall. Drugs.com

Specific Warnings for Allergies (Hay Fever):

Pregnancy & lactation: Most authorities recommend avoiding nettle during pregnancy and breastfeeding due to insufficient safety data and possible hormonal effects. Drugs.com

Allergy risk: Fresh nettle can cause contact urticaria; oral products rarely trigger allergy but it’s possible—avoid if you’re known to be sensitive to nettle. Drugs.com

Blood sugar & blood pressure: Nettle may have hypoglycemic or hypotensive/diuretic effects; use caution if you have diabetes, low blood pressure, or take related medications. WebMD

Drug interactions:

• Interaction listings are extensive (many theoretical/monitor-closely entries), particularly regarding effects on anticoagulation and interactions with numerous drugs/supplements; review if you take prescription meds. Medscape

• Comprehensive consumer monographs also flag the lack of well-documented interactions but err on the side of caution. Drugs.com

Children: Some monographs advise not using in children <12 years. Drugs.com

General adverse effects: Usually mild GI upset if any; again, avoid handling the fresh plant bare-handed due to stinging hairs. Drugs.com

General Information (All Ailments)

Note: You are viewing ailment-specific information above. This section shows the general remedy information for all conditions.

What It Is

Nettle leaf comes from the stinging nettle plant (Urtica dioica), a perennial herb native to Europe, Asia, North America, and parts of Africa. The plant is easily recognized by its serrated leaves and fine stinging hairs that cause a mild burning sensation upon contact with the skin. Despite this, when harvested and processed correctly—typically dried, cooked, or steeped into tea—nettle leaf becomes a highly nutritious herbal remedy. It has been used for centuries in traditional medicine systems for its wide range of health-promoting properties.

Nettle leaf is rich in vitamins A, C, K, and several B vitamins, as well as minerals such as iron, calcium, magnesium, potassium, and silica. It also contains chlorophyll, flavonoids, and polyphenols, which contribute to its antioxidant and anti-inflammatory effects.

How It Works

The bioactive compounds in nettle leaf exert multiple physiological effects in the body. The plant’s anti-inflammatory action is largely attributed to compounds such as quercetin and kaempferol, which inhibit pro-inflammatory pathways and cytokines. This makes it particularly beneficial for conditions like arthritis, allergies, and eczema.

Nettle also acts as a natural diuretic, helping to support kidney function and promote detoxification by increasing urine output and the elimination of metabolic waste. Additionally, it influences circulatory health by supporting blood purification and may help lower blood pressure through mild vasodilatory effects.

In terms of immune support, nettle leaf’s antioxidant capacity helps neutralize free radicals and strengthen cellular defenses. Some research suggests it may also modulate histamine responses, which is why it’s often used for seasonal allergies and hay fever.

For metabolic and endocrine support, nettle has been studied for its role in stabilizing blood sugar levels and supporting hormonal balance—particularly in men, where it may assist in maintaining healthy testosterone levels and prostate function.

Why It’s Important

Nettle leaf’s importance in health comes from its combination of nutritional density and medicinal versatility. It offers a natural, plant-based source of essential nutrients that contribute to bone strength, red blood cell production, and overall vitality. Its ability to reduce inflammation and oxidative stress makes it a valuable ally in preventing chronic diseases related to aging and lifestyle.

For individuals suffering from joint pain or autoimmune inflammation, nettle provides a gentle yet effective herbal option that complements medical treatment. Likewise, its detoxifying and diuretic actions support the liver and kidneys, which are central to metabolic health.

Furthermore, in traditional herbalism, nettle is often considered a “tonic herb” — one that nourishes and strengthens multiple systems over time rather than providing short-term symptom relief. Its regular use in tea or capsule form can contribute to sustained wellness and resilience.

Considerations

Although generally safe when used appropriately, there are several important considerations for using nettle leaf:

  • Allergic Reactions and Skin Contact: Fresh nettle can cause stinging, redness, or itching due to its formic acid and histamine content. Processed nettle (dried or cooked) eliminates this effect.
  • Medication Interactions: Because nettle has diuretic properties, it may enhance the effects of prescription diuretics or medications for high blood pressure, increasing the risk of dehydration or low blood pressure. It may also interact with diabetes medications or lithium.
  • Pregnancy and Lactation: While nettle tea is sometimes used to support lactation and iron levels, it should be used cautiously and under professional supervision during pregnancy due to potential uterine-stimulating effects.
  • Dosage and Quality: The potency of nettle preparations varies by brand and preparation method (tea, tincture, capsule). High-quality, organically sourced nettle products are recommended to avoid contamination with heavy metals or pesticides.
  • Underlying Conditions: Individuals with kidney disease, heart conditions, or on chronic medication should consult a healthcare provider before using nettle, as its diuretic and mineral-altering properties could influence electrolyte balance.

Helps with these conditions

Nettle Leaf is most effective for general wellness support with emerging research . The effectiveness varies by condition based on clinical evidence and user experiences.

Gout 0% effective
Allergies (Hay Fever) 0% effective
Chronic Sinusitis 0% effective
Hives 0% effective
Food Allergies 0% effective
5
Conditions
0
Total Votes
22
Studies
0%
Avg. Effectiveness

Detailed Information by Condition

Gout

0% effective

Anti-inflammatory activity. Nettle leaf contains polyphenols (e.g., quercetin) and other constituents that can down-regulate inflammatory pathways imp...

0 votes Updated 2 months ago 4 studies cited

Blocks several allergy pathways (in vitro): Nettle extracts have shown activity at multiple points in the allergic cascade—antagonizing/negatively ago...

0 votes Updated 1 month ago 4 studies cited

Chronic Sinusitis

0% effective

Stinging nettle is thought to be beneficial due to its antihistamine effects (helping reduce histamine-mediated inflammation), combined with anti-infl...

0 votes Updated 2 months ago 6 studies cited

Hives

0% effective

Antihistamine &amp; mast-cell effects (in vitro): Extracts of nettle leaf can antagonize the histamine-H1 receptor and inhibit mast-cell tryptase, whi...

0 votes Updated 1 month ago 4 studies cited

Food Allergies

0% effective

There is some biological plausibility and clinical evidence that stinging nettle (Urtica dioica) can reduce histamine-mediated symptoms (mostly allerg...

0 votes Updated 2 months ago 4 studies cited

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