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Qi Ju Di Huang Wan

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Specifically for Glaucoma

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Why it works for Glaucoma:

TCM pattern match: QJDH is used to “nourish Liver & Kidney yin” and “benefit the eyes.” Glaucoma in TCM is sometimes mapped to yin-deficiency patterns; hence the formula is often suggested in that context. Me and Qi

Pre-clinical neuroprotection in ischemic retina: In rats with high-IOP retinal ischemia, CJDHW reduced retinal damage via down-regulating MMP-9 and inhibiting p38 MAPK—pathways plausibly relevant to glaucomatous retinal ganglion cell (RGC) loss. This supports a biological plausibility, not clinical efficacy. BioMed Central

Component-level signals:

  • Lycium barbarum (goji) shows antioxidant/neuroprotective retinal effects in various models (not glaucoma-specific in humans). Memorial Sloan Kettering Cancer Center
  • Chrysanthemum morifolium has anti-inflammatory/antioxidant activities that could be relevant to optic nerve stress. ScienceDirect

Network pharmacology/dry-eye data: Recent multi-omics papers explore QJDH pathways in ocular surface disease (dry eye); they don’t prove glaucoma benefit but outline anti-inflammatory/oxidative-stress targets also discussed in glaucoma. ScienceDirect

How to use for Glaucoma:

There is no glaucoma-specific, evidence-based dosing. Use only under a TCM practitioner alongside your ophthalmologist.

  • Common patent-pill label dosing (example): 8 teapills, 3×/day; sometimes 8–12 teapills 3×/day initially, then taper. Take 30 min before or 1 h after food. Follow your specific product label/practitioner—products vary. barefootdoctorherbs.com
  • Pattern-based use: In TCM, QJDH is chosen when signs suggest Liver/Kidney yin deficiency (dry eyes, blurred vision, etc.). Selection should be individualized after consultation. Me and Qi
  • Do not stop standard care: Proven glaucoma treatments (e.g., latanoprost; SLT) preserve vision; herbs are, at most, adjuncts. The Lancet

Scientific Evidence for Glaucoma:

Supports plausibility (non-clinical):

  • Rat model: CJDHW reduced retinal ischemic injury via MMP-9 and p38-MAPK modulation. (Animal model related to glaucoma pathophysiology.) BioMed Central
  • Reviews: Broad TCM-for-glaucoma reviews summarize herbs/formulas with antioxidant/anti-apoptotic hypotheses; they highlight a lack of robust RCTs. ScienceDirect
  • Systems pharmacology: In-silico/network studies map QJDH constituents to inflammatory/oxidative pathways; these are hypothesis-generating only. Europe PMC
Specific Warnings for Glaucoma:

Do not rely on QJDH for acute symptoms. Sudden painful red eye, halos, nausea, or rapid vision loss can signal acute angle-closure—a medical emergency. Herbs are inappropriate in this setting; seek urgent care. (General glaucoma standard of care sources above.) The Lancet+1

Drug interactions—most important:

  • Warfarin/anticoagulants: Lycium (goji) in QJDH has case reports of markedly elevated INR and bleeding with warfarin; avoid or monitor closely with your physician. indigo.uic.edu
  • Antiplatelets/anticoagulants (general): Paeonia (moutan cortex) constituents exhibit antiplatelet/anticoagulant effects in vitro; additive bleeding risk is possible. MDPI
  • Hypoglycemics: Cornus officinalis (shan zhu yu) shows antidiabetic activity; monitor if on diabetes meds (risk of low glucose). Frontiers
  • Diuretics/electrolytes: QJDH contains Alisma (ze xie), a diuretic herb; use caution if you take diuretics or lithium (diuretics can shift lithium levels). Discuss with your prescriber. nhs.uk

Adverse effects: Generally mild GI upset or allergy have been reported with components like rehmannia; stop and seek care if rash, swelling, or severe symptoms occur. WebMD

Pregnancy: Many commercial labels list pregnancy as a contraindication; avoid unless specifically cleared by a qualified clinician. (Example vendor & label cautions.) healthylicious.co.uk

Quality control: Potency and contaminants vary across manufacturers; buy from reputable suppliers and prefer products tested for heavy metals/adulterants. (General herb-safety resources.) Memorial Sloan Kettering Cancer Center

General Information (All Ailments)

Note: You are viewing ailment-specific information above. This section shows the general remedy information for all conditions.

What It Is

Qi Ju Di Huang Wan is a classical Chinese herbal formula that originated from traditional medicine texts dating back to the Song Dynasty. It is a modified version of Liu Wei Di Huang Wan (Six-Ingredient Rehmannia Pill), a foundational tonic for nourishing the yin (the body’s cooling, moistening, and restorative aspect).

The modification includes two additional herbsGou Qi Zi (Lycium fruit, or goji berry) and Ju Hua (Chrysanthemum flower) — which focus the formula’s action on the eyes and the liver system.

It is commonly used in TCM to nourish liver and kidney yin, improve eye function, and support overall vitality, especially as people age or experience yin deficiency symptoms.

How It Works

In Traditional Chinese Medicine terms, Qi Ju Di Huang Wan works by replenishing yin in the liver and kidneys — organ systems believed to govern vision, growth, aging, and the body’s essential fluids.

Here’s how its key ingredients function synergistically:

  • Shu Di Huang (Rehmannia root, prepared): Deeply nourishes kidney and liver yin, replenishing essence and blood.
  • Shan Zhu Yu (Cornus fruit): Stabilizes the essence and prevents fluid loss.
  • Shan Yao (Chinese yam): Strengthens the spleen and supports kidney function.
  • Fu Ling (Poria mushroom): Promotes water metabolism and prevents damp accumulation.
  • Ze Xie (Alisma): Clears excess heat from the kidneys.
  • Mu Dan Pi (Tree peony bark): Cools blood and removes stagnant heat.
  • Gou Qi Zi (Goji berries): Nourish liver blood and improve eyesight.
  • Ju Hua (Chrysanthemum): Clears wind and heat from the eyes and liver, improving visual clarity.

Physiologically, this combination supports endocrine balance, eye health, and antioxidant protection, while promoting fluid regulation and cellular repair.

Why It’s Important

Qi Ju Di Huang Wan plays an important role in maintaining healthy aging and vision. It’s often prescribed when there are signs of liver and kidney yin deficiency, which in TCM may manifest as:

  • Blurred vision or dry, tired eyes
  • Dizziness or tinnitus (ringing in the ears)
  • Lower back weakness
  • Night sweats
  • Thirst with a dry mouth or throat
  • Restlessness in the evening

It is considered particularly valuable for people who strain their eyes regularly (e.g., from long hours of reading or screen use), and for older adults who experience declining vision or vitality.

From a modern health perspective, many of its herbs — especially goji berries and chrysanthemum — are recognized for antioxidant, anti-inflammatory, and hepatoprotective properties, which may help protect eye tissues and liver cells from oxidative damage.

Considerations

While Qi Ju Di Huang Wan is generally regarded as safe and gentle, certain considerations should be kept in mind:

  1. Constitutional Fit: It is most suitable for those with yin deficiency patterns — meaning people who feel warm, dry, or restless. It is not appropriate for those with coldness, digestive weakness, or phlegm-damp accumulation (e.g., bloating, loose stools, fatigue).
  2. Possible Reactions: Overuse may cause digestive discomfort, loose stools, or loss of appetite, especially in people with weaker digestion.
  3. Medical Interactions: People on prescription medications — especially diuretics, hypoglycemics, or antihypertensives — should consult a healthcare provider, as some herbs may enhance or interfere with drug effects.
  4. Pregnancy & Special Conditions: Should be used cautiously during pregnancy or in individuals with severe liver disease without professional supervision.
  5. Quality & Authenticity: As with all Chinese patent medicines, it’s essential to purchase from reputable sources, as formulations can vary widely in potency and purity.

Helps with these conditions

Qi Ju Di Huang Wan is most effective for general wellness support with emerging research . The effectiveness varies by condition based on clinical evidence and user experiences.

Glaucoma 0% effective
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Detailed Information by Condition

Glaucoma

0% effective

TCM pattern match: QJDH is used to “nourish Liver & Kidney yin” and “benefit the eyes.” Glaucoma in TCM is sometimes mapped to yin-deficiency patt...

0 votes Updated 1 month ago 3 studies cited

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