Qing Wei San
Specifically for Gingivitis
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Why it works for Gingivitis:
Classical indication matches gum signs. Qing Wei San is a classic TCM formula for “Stomach-Heat” rising to the mouth—characterised by sore, swollen or bleeding gums, toothache worse with heat, bad breath, red tongue with yellow coat. These are textbook gingivitis-like features. Authoritative formula monographs list gingivitis among treated conditions and detail the pattern rationale. tcmwiki.com
Pharmacology that fits periodontal inflammation. Modern network-pharmacology + lab work point to Qing Wei San components acting on inflammatory and microbial pathways relevant to periodontal disease (e.g., NF-κB, MAPK; anti-microbial berberine from Coptis). A 2025 open-access study decoded multi-target mechanisms for periodontitis, providing biological plausibility for gingival inflammation as well. BioMed Central
Animal/experimental data support anti-inflammatory effects. Legacy pharmacology shows Qing Wei San suppresses induced inflammation in rodents, aligning with observed symptom relief in gum disease patterns. globinmed.com
How to use for Gingivitis:
Classical decoction/powder (clinician-prepared)
- Ingredients & proportions (typical): Sheng Di Huang 12 g, Dang Gui 6 g, Mu Dan Pi 9 g, Huang Lian 4.5 g, Sheng Ma 6 g. tcmwiki.com
- Administration: traditionally taken as a powder, or decocted in water and taken twice daily. Many practitioners start with a 7–14-day course and reassess pattern/signs. (Exact course length is individualized.) tcmwiki.com
- Pattern-based tweaks for gum disease (examples used by TCM clinicians): add cooling/heat-clearing herbs (e.g., Shi Gao, Zhi Mu, Huang Qin) when swelling is pronounced, or combine with Yu Nu Jian for severe gum swelling/bleeding. These are common modification schemas rather than one-size-fits-all recipes. americandragon.com
Modern concentrated capsules/teapills (commercial)
- Example professional product directions: 3 capsules, twice daily (formulation equivalent to Qing Wei San; see exact ingredient listing on label). Always follow your product’s label and your practitioner’s guidance. eqilibrium.net
Essential adjuncts (don’t skip these):
- Gingivitis is plaque-driven. Keep twice-daily brushing + daily interdental cleaning; consider short-term antiseptic mouthrinses (e.g., chlorhexidine) if recommended. Professional cleaning is often required to reverse gingivitis. American Dental Association
Scientific Evidence for Gingivitis:
Clinical observations/RCT-like studies (mostly periodontitis):
• A Chinese randomized clinical observation (120 pts) found modified Qing Wei Tang + tinidazole + standard periodontal care improved plaque index, gingival crevicular bleeding, probing depth and symptoms versus tinidazole + care alone, with similar adverse-event rates over 7 days. (Chronic periodontitis, not isolated gingivitis.) med.wanfangdata.com.cn
• Practitioner literature and case-series report high “effective” rates for periodontitis and gum complaints using Qing Wei San, but these are lower-quality data and often lack modern endpoints or blinding. eqilibrium.net
Mechanistic/experimental:
• 2025 BMC paper (computational + experimental) maps Qing Wei San actives to periodontal-inflammation targets—supporting plausibility for gingival inflammation control. BioMed Central
• Network-pharmacology/molecular-docking analyses identify multi-component, multi-target interactions relevant to periodontitis. Europe PMC
• Older animal pharmacology shows anti-inflammatory activity of whole-formula extracts. globinmed.com
Specific Warnings for Gingivitis:
Not the right pattern: Avoid for tooth/gum pain from Wind-Cold patterns or kidney-deficiency-type gum problems—classical contraindications. Qing Wei San is for excess heat presentations. americandragon.com
Pregnancy & bleeding risks (herb-level cautions):
• Mu Dan Pi is generally contraindicated in pregnancy in TCM sources. sacredlotus.com
• Dang Gui (“dong quai”) may increase bleeding risk, especially with anticoagulants/antiplatelets; avoid if you have heavy menses or bleeding disorders unless supervised. Dr. Christopher Hobbs, Ph.D.
Drug interactions (notably via Coptis/berberine):
• Huang Lian contains berberine, which can interact with warfarin and potentially other drugs by affecting metabolism/protein binding—monitor or avoid with anticoagulants unless your prescriber approves. Frontiers
General safety notes: Use professional-grade products from reputable suppliers; monitor for GI upset/allergy; discontinue and seek care if bleeding worsens, fever develops, or pain becomes severe.
General Information (All Ailments)
What It Is
Qing Wei San, translated as “Clear the Stomach Powder,” is a classical herbal formula in Traditional Chinese Medicine (TCM). It was first recorded in the Lan Shi Mi Cang (Orchid Chamber Secret Treasury) during the Song Dynasty. The formula is primarily used to clear stomach heat and cool blood, especially when excessive internal heat rises to the face and gums.
The traditional composition usually includes:
- Huang Lian (Coptidis Rhizoma) – clears fire and damp-heat, especially from the stomach.
- Sheng Ma (Cimicifugae Rhizoma) – raises clear yang and disperses heat.
- Mu Dan Pi (Moutan Cortex) – cools the blood and reduces inflammation.
- Sheng Di Huang (Rehmanniae Radix) – nourishes yin and clears heat.
- Dang Gui (Angelicae Sinensis Radix) – nourishes and invigorates the blood.
This combination creates a synergistic effect that balances clearing heat with nourishing and protecting body fluids.
How It Works
In TCM theory, stomach fire or heat accumulation in the stomach channel can manifest as symptoms such as:
- Swollen, bleeding, or painful gums
- Mouth ulcers
- Facial swelling or acne (particularly around the mouth)
- Bad breath
- Toothache aggravated by heat or spicy foods
Qing Wei San works by:
- Clearing Stomach Fire: Herbs like Huang Lian directly purge heat and reduce inflammation.
- Cooling the Blood: Mu Dan Pi and Sheng Di Huang calm excessive heat that has entered the blood level, reducing redness and swelling.
- Nourishing and Protecting Fluids: Sheng Di Huang and Dang Gui prevent dryness and tissue damage that can result from prolonged heat.
- Guiding Heat Outward: Sheng Ma disperses pathogenic heat upwards and outwards, helping relieve facial symptoms and gum issues.
Physiologically, modern interpretations suggest Qing Wei San may have anti-inflammatory, antibacterial, and immunomodulatory effects. It helps normalize oral and digestive health by reducing inflammatory cytokines and oxidative stress associated with gastrointestinal and oral mucosal inflammation.
Why It’s Important
Qing Wei San plays an essential role in TCM for balancing digestive fire and addressing disorders linked to excess heat in the stomach meridian.
Its importance lies in:
- Holistic oral health: It provides a natural alternative for treating gingivitis, stomatitis, and recurrent mouth ulcers.
- Digestive harmony: By regulating stomach heat, it can alleviate symptoms of acid reflux, bad breath, and excessive appetite related to internal heat.
- Skin and systemic balance: Because the stomach meridian connects to the face, this formula can improve complexion issues like acne caused by internal heat.
- Preventive care: Regular use (under supervision) helps maintain balance between digestive fire and body fluids, supporting long-term oral and digestive health.
Considerations
While Qing Wei San is a well-established and safe formula when prescribed correctly, several important considerations apply:
- Pattern Differentiation: It should only be used for true stomach heat syndromes. Using it for conditions caused by cold deficiency or lack of stomach fire could worsen symptoms such as fatigue, cold limbs, or poor appetite.
- Contraindications: Avoid in individuals with yin deficiency without excess heat, or those with weak digestion and cold stomach.
- Pregnancy and Nursing: Use only under professional supervision, as some ingredients like Mu Dan Pi can affect blood circulation.
- Drug Interactions: Because it contains Huang Lian (which affects the CYP450 enzyme system), it may interact with certain medications such as anticoagulants or antibiotics.
- Duration of Use: Prolonged or unsupervised use can deplete stomach qi and fluids; it’s meant for short-term treatment of acute heat symptoms.
- Professional Guidance: Always consult a qualified TCM practitioner to ensure proper diagnosis and formulation matching, as herbal combinations and dosages are adjusted based on individual constitution and symptom patterns.
Helps with these conditions
Qing Wei San is most effective for general wellness support with emerging research . The effectiveness varies by condition based on clinical evidence and user experiences.
Detailed Information by Condition
Gingivitis
Classical indication matches gum signs. Qing Wei San is a classic TCM formula for “Stomach-Heat” rising to the mouth—characterised by sore, swollen or...
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