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Shi Hu Ye Guang Wan

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Specifically for Macular Degeneration

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Why it works for Macular Degeneration:

TCM rationale (pattern-based): Shi Hu Ye Guang Wan is a classic formula used to “nourish Liver–Kidney yin, clear Liver fire, and brighten the eyes.” It’s traditionally given for eye symptoms like blurred vision, photophobia, tearing, dizziness—patterns TCM attributes to Liver–Kidney yin deficiency with heat/wind. tcmwiki.com

Modern/preclinical signals (not AMD trials): In a light-damage mouse model, Shihu Yeguang Pill (SYP) reduced photoreceptor apoptosis and protected outer retinal structure/function—mechanistic actions (anti-oxidative/anti-apoptotic) that could be relevant to degenerative retinal diseases such as AMD, but this is animal data, not proof of clinical benefit in people with AMD. ScienceDirect

How to use for Macular Degeneration:

Common indications on Chinese labels: “Nourish yin and Kidney, clear Liver and brighten the eyes” for blurred vision, ‘internal eye obstruction,’ etc. (often marketed more for early cataract than AMD). ypk.39.net

Typical adult dosing from an official Chinese OTC label (Tong Ren Tang brand):

• Water-honey pills: 6 g, orally, twice daily

• Small honey pills: 9 g, orally, twice daily

• Large honey pill: 1 pill, twice daily

Labels also advise medical review if no improvement in ~7 days. ypk.39.net

Representative (pharmacopoeial) formula ingredients: Dendrobium, Ginseng, Dioscorea, Poria, Licorice, Cistanche, Lycium (goji), Cuscuta, Rehmannia (raw & prepared), Schisandra, Asparagus root, Ophiopogon, Bitter almond, Saposhnikovia, Chuanxiong, fried Aurantium (Zhi Ke), Coptis, Achyranthes (wine-processed), Chrysanthemum, Tribulus (salt-processed), Celosia seed, Cassia seed, water-buffalo horn extract and goat horn (animal products appear in some pharmacopoeial versions). Exact composition varies by manufacturer. db.ouryao.com

Scientific Evidence for Macular Degeneration:

No high-quality randomized clinical trials demonstrate that Shi Hu Ye Guang Wan improves visual acuity or slows AMD progression in humans. A 2021 review of TCM approaches to AMD discusses various formulas/approaches but does not provide definitive clinical proof for Shi Hu Ye Guang Wan. ScienceDirect

The mouse light-damage study above shows retinal protection in animals, not people with AMD. ScienceDirect

Current ophthalmology guidelines (AAO Preferred Practice Pattern; NICE) do not list this formula as a treatment for AMD; evidence-based care remains anti-VEGF agents for wet AMD, and emerging options (e.g., complement inhibitors) for geographic atrophy, plus AREDS2 supplementation when indicated. AAO

Specific Warnings for Macular Degeneration:

Not a substitute for guideline-based AMD care. Delaying proven treatments (e.g., anti-VEGF injections for wet AMD) risks irreversible vision loss; coordinate any herbal use with your retinal specialist. AAO

Labelled contraindications/cautions (example Tong Ren Tang label):

Contraindicated in diabetes (honey-based pills).

Pregnancy: use only under medical supervision.

Caution with loose stools/weak digestion.

Stop and seek care if symptoms don’t improve in 7 days.

Avoid alcohol, tobacco, spicy/greasy/seafood while taking.

Allergy: avoid if allergic; keep away from children; don’t use if product characteristics change.

Interactions (per TCM incompatibilities): preparations containing ginseng shouldn’t be combined with Veratrum (Li Lu); formulas with licorice should not be used with seaweed/Kansui/Daphne (Hai Zao, Da Ji, Gan Sui, Yuan Hua). Discuss all meds/supplements with your clinician/pharmacist. ypk.39.net

Animal-derived components: Some pharmacopoeial versions include water-buffalo horn extract and goat horn—relevant for dietary, ethical, or allergy considerations. Check your brand’s ingredient list. db.ouryao.com

Product variability & quality: Formulas and doses vary by manufacturer; look for products that conform to the Chinese Pharmacopoeia (latest English edition released 2023) and purchase from reputable sources. Cisema

General Information (All Ailments)

Note: You are viewing ailment-specific information above. This section shows the general remedy information for all conditions.

What It Is

Shi Hu Ye Guang Wan (literally “Dendrobium (Shi Hu) Night-Light Pill”) is a classical Chinese patent formula (pill form) used in TCM.

Its traditional indications are for deficiencies of liver-yin and kidney-yin, accompanied by internal “fire” rising, leading to vision problems, especially in low light or nighttime vision.

In more “health supplement” marketing contexts, it is often described (more broadly) as a formula for supporting eye health, improving night vision, reducing blurred vision, or supporting the liver and kidneys.

Its herbal composition is complex, containing many ingredients (herbs) that, in TCM theory, nourish yin, quench internal heat, calm internal wind, and brighten the eyes.

In some modern commercial versions, it is packaged as pills (e.g. 200 pills per bottle, or 60 concentrated pills) with suggested dosages (e.g. 5–8 pills two or three times daily) noted. Max Nature

How It Works (From the TCM Perspective, and Caveats)

TCM Theory / Mechanisms (Traditional Framework)

Within TCM theory, the formula works via several mechanisms:

Nourishing Yin of Liver and Kidney

  • The liver and kidney in TCM are said to share in nourishing (moistening) functions, especially for the eyes, tendons, bone, and internal fluids.
  • When the yin of liver and kidney is deficient, “fire” (a hyperactive, drying, heat-like influence) may rise, causing damage or disturbance (e.g. to the eyes).
  • Many of the herbs in Shi Hu Ye Guang Wan are classified as “nourish yin” or “enrich kidney yin / liver yin” herbs (for example, Shu Di Huang, Mai Men Dong, Tian Men Dong). en.wikibooks.org

Clearing or Subduing Excess Fire / Heat / Wind

  • Because yin deficiency allows “fire” to flare up, this internal heat needs to be cooled or quelled. Some herbs in the formula are intended to clear heat, remove pathogenic fire from the blood, calm internal wind, or suppress hyperactivity of the liver. tcmwiki.com
  • Ling Yang Jiao and other cooling / heat-clearing components are classically included for such purposes. tcmwiki.com

Brightening / Improving Vision / Clearing the Eyes

  • The formula is said to “brighten the eyes,” “clear vision,” “quench liver fire,” and “subdue wind” to prevent or ameliorate symptoms such as blurred vision, sensitivity to light, or impaired night vision. tcmwiki.com
  • In TCM language, the eyes are closely linked to the liver meridian; if liver function is disturbed or yin is lacking, the eyes may show signs of distress.

Harmonizing / Supporting Qi, Blood, and Organ Interaction

  • Because the formula is multi-herbal and “balanced,” some of its herbs are thought to moderate or harmonize Qi, promote fluid balance, or assist in the absorption/transport of the more active components.
  • In classical formulations, many formulas have “jun (chief), chen (deputy), zuo (assistant), shi (messenger)” roles. In Shi Hu Ye Guang Wan, certain herbs act as the core (chief) and others support or moderate effects, or direct the formula toward the eyes/liver/kidney. (TCM prescription theory)

What We Do Not Know / Scientific Evidence

  • There is scarce (if any) robust, high-quality clinical trial evidence (e.g. randomized double-blind controlled human trials) proving that Shi Hu Ye Guang Wan is effective for particular eye diseases (e.g. cataracts, glaucoma) in a modern biomedical sense.
  • Mechanisms in conventional biomedical terms (e.g. how active compounds interact with oxidative stress, vascular supply to the retina, inflammation, free radical damage, etc.) are not well established. Some individual herbs (e.g. Chrysanthemum, Lycium / goji, Dendrobium) have been studied for antioxidant or anti-inflammatory effects, but using them in a multi-herb formula complicates attribution.
  • Herb-herb interactions, pharmacokinetics, absorption, and safety in different populations are underexplored from rigorous modern research.

Thus, the “how it works” is primarily framed in the TCM conceptual model (yin, fire, meridians, liver/kidney relationships) rather than a validated biochemical or pharmacological pathway.

Why It’s (or Might Be) Important / Value Proposition

From the TCM / integrative medicine viewpoint, Shi Hu Ye Guang Wan is considered valuable for several reasons:

Addressing a pattern (yin deficiency + internal fire) that is common in eye disorders

  • In TCM diagnosis, many chronic eye complaints (blurriness, night vision decline, photophobia, cataract onset, etc.) are attributed to a deficiency-heat or yin deficiency pattern. This formula is tailored specifically for that pattern.
  • In that sense, it offers a targeted approach rather than a generic tonic.

Non-invasive / supportive therapy

  • For individuals who want to use herbal / complementary approaches in addition to conventional eye care (e.g. in early stages or as adjunct), this formula offers a relatively traditional, system-oriented option.

Holistic organ support

  • Because it is designed to support liver and kidney yin (in TCM theory), proponents believe it may have broader benefits beyond just the eyes—improving overall balance, reducing “heat,” preserving vitality, etc.

Historical and traditional usage

  • Shi Hu Ye Guang Wan is part of the corpus of classical Chinese formulas. Its continued use indicates it holds a place in traditional herbal therapeutics for ocular health.

Potential for delaying progression or alleviating symptoms

  • In conditions like early cataract, mild blurred vision, or early retinal changes (in TCM theory), it may be used with the hope of slowing down progression or mitigating symptom severity (though clinical validation is lacking).

However, it’s important to emphasize: the importance is theoretical/traditional, not definitively proven in modern biomedical terms.

Considerations, Risks, and Cautions

Because herbal formulas can interact with health conditions, medications, individual constitution, etc., several important considerations apply:

Pattern Matching / Correct Indication

  • TCM formulas are not "one size fits all." Shi Hu Ye Guang Wan is intended for a specific TCM pattern (liver/kidney yin deficiency with internal fire). If an individual’s condition is due to a different pattern (e.g. Qi stagnation, phlegm obstruction, wind invasion, dampness, etc.), this formula may be inappropriate or even harmful.
  • A qualified TCM practitioner should diagnose the syndrome pattern before recommending use.

Interactions & Contraindications

  • Some product labels warn not to use Shi Hu Ye Guang Wan in certain conditions: e.g. pregnancy or breastfeeding, diabetes, hypertension, hypotension, liver disorders, severe kidney insufficiency, hypokalemia, gastrointestinal obstruction or inflammation, abdominal pain of unknown cause, diarrhea, or excessive menstruation.
  • Because it contains multiple active herbs, there is potential for herb–drug interactions (e.g. with medications for diabetes, hypertension, anticoagulants, immunosuppressants, etc.).
  • There is a risk of adulteration, heavy metals, contamination, or inconsistent dosing in herbal products, particularly those not tightly regulated.

Quality, Purity, Standardization

  • The herbal industry (especially traditional / import markets) has variability in herb sourcing, processing, quality control, and standardization of active components.
  • Users should prefer reputable manufacturers, transparent ingredient lists, third-party testing, and good manufacturing practices.

Dosing, Duration, and Monitoring

  • Overuse or prolonged use without supervision may lead to imbalances or side effects (especially if internal fire is suppressed too much, or if body fluids / yin become dampened).
  • Some commercial sources suggest limiting continuous use to 8–10 days or to cycles (though this is likely cautious practitioner guidance) Chinese Herbs Direct
  • Monitoring of eye function, vision changes, other organ function (liver, kidney) is advisable if one uses such formulas over time.

Not a Substitute for Conventional Eye Care

  • Especially in serious ocular diseases (advanced glaucoma, cataract requiring surgery, retinal detachment, macular degeneration, diabetic retinopathy, etc.), this formula cannot replace medical or surgical interventions.
  • It may at best serve as adjunctive/supportive therapy; delaying proper treatment in favor of relying solely on herbal therapy could be harmful.

Lack of Strong Clinical Evidence

  • Because rigorous clinical evidence is lacking, any claimed benefits should be treated with cautious skepticism. Users and practitioners should monitor effects closely and reassess use.

Individual Variation, Sensitivities, Allergies

  • People may respond differently (some may find the herbs too “cooling,” others may get digestive upset, allergic reactions, or other side effects).
  • Persons with gastrointestinal sensitivities, weak digestion, or certain chronic conditions may require modifications or avoidance.

Regulatory & Safety Oversight Differences by Country

  • In many places, herbal formulas are regulated as supplements rather than drugs, thus not held to the same standards as pharmaceuticals.
  • Some countries may restrict or ban certain herbal ingredients (especially if endangered, or if safety concerns arise) — always check local regulations.

Helps with these conditions

Shi Hu Ye Guang Wan is most effective for general wellness support with emerging research . The effectiveness varies by condition based on clinical evidence and user experiences.

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Detailed Information by Condition

TCM rationale (pattern-based): Shi Hu Ye Guang Wan is a classic formula used to “nourish Liver–Kidney yin, clear Liver fire, and brighten the eyes.” I...

0 votes Updated 1 month ago 3 studies cited

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