Tianma Gouteng Yin
Specifically for Oxidative Stress
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Why it works for Oxidative Stress:
Targets redox pathways: Studies on the full formula (or close variants) show reductions in ROS and oxidative-stress markers, often via Nrf2/HO-1 and related antioxidant pathways, alongside anti-inflammatory effects. Examples include protection in ischemia models and Parkinson’s models, and AngII-hypertensive mice where Tianma Gouteng Decoction (TGD) regulated oxidative stress and endothelial inflammation to lower blood pressure. BioMed Central
Key herbs have antioxidant actions:
- Gastrodia elata (Tianma) bioactives like gastrodin modulate Nrf2/HO-1, reduce ROS, and dampen NF-κB-mediated inflammation in neurodegenerative and ischemic settings (mechanisms directly tied to oxidative stress). Frontiers
- Uncaria rhynchophylla (Gouteng) alkaloids (e.g., rhynchophylline) are anti-hypertensive and neuroprotective; they also show antioxidant/anti-inflammatory effects and calcium-channel–blocking vasodilation that can improve endothelial redox balance. Frontiers
Neuroprotection under oxidative load: A water extract of Gastrodia+Uncaria (a simplified TG-type extract) protected neuronal cells and rats against ischemic insult, a context heavily driven by oxidative injury. BioMed Central
How to use for Oxidative Stress:
Typical composition (classical form): Tianma (Gastrodia), Gou Teng (Uncaria), Shi Jue Ming (Haliotis shell), Zhi Zi (Gardenia), Huang Qin (Scutellaria), Du Zhong (Eucommia), Sang Ji Sheng (Taxillus), Chuan Niu Xi (Cyathula), Yi Mu Cao (Leonurus), Ye Jiao Teng (Polygonum multiflorum vine), and Fu Shen (Poria). Commercial professional products reflect similar ingredient lists per daily serving. TCMzone
Forms & dosing seen in practice/monographs (examples—follow your clinician’s plan):
- Decoction (traditional): 1 “dose” per day split 2–3 times; boil the prescribed raw herbs in water as directed. globinmed.com
- 5:1 concentrated extract (granules): ~9 g/day total extract powder is a commonly cited professional dose (adjust per pattern, age, weight). globinmed.com
- Capsules/tablets: Professional products titrate to an equivalent of the above daily raw-herb amounts; follow label or practitioner dosing. (Example ingredient totals provided by a professional supplier.) TCMzone
Duration: For redox-linked conditions (e.g., vascular or neuro symptoms), courses are often 4–8+ weeks with reassessment; duration should be individualized by a TCM clinician. (General practice guidance from formula monographs and clinical reviews.) sacredlotus.com
Scientific Evidence for Oxidative Stress:
Whole-formula or close-variant studies involving oxidative stress:
- Ischemic brain injury: Tianma Gouteng Yin/TMG reduced brain injury in MCAO stroke models and explored oxidative-stress mechanisms (e.g., AGE/RAGE pathway). techscience.com
- Neuroprotection/PD models: TG-Yin showed neuroprotective effects in cellular and animal Parkinson’s models—mechanisms include anti-oxidative and anti-apoptotic actions. (Scientific Reports; open-access PDF.) Nature
- Cerebral ischemia (simplified GU extract): Gastrodia+Uncaria water extract protected PC12 neurons (OGD) and rats (MCAO), with antioxidant and anti-inflammatory readouts. BioMed Central
- Hypertension/vascular oxidative stress: In AngII-hypertensive mice, TGD regulated oxidative stress and inflammation (via TFEB), improving blood pressure and endothelial function. Europe PMC
- Placental oxidative stress (preeclampsia model cells): TGD modulated oxidative stress and NO production in human trophoblast cells. (Mechanistic, not a clinical trial; relevant for redox biology.) Frontiers
Clinical blood-pressure data (indirect to oxidative stress):
- A systematic review of RCTs found TG-Yin as an adjunct to antihypertensives may improve BP and symptoms, but trial quality was generally low; stronger RCTs are needed. (Open PDF of review.) Wiley Online Library
- A Cochrane review concluded evidence is insufficient—no high-quality placebo-controlled trials of TG-Yin alone; more rigorous studies required. Cochrane
Constituent-level evidence relevant to oxidative stress:
- Gastrodia elata (gastrodin, p-hydroxybenzyl alcohol, etc.) repeatedly shown to activate antioxidant defenses (Nrf2/HO-1) and reduce neuroinflammation/ROS in modern reviews. Frontiers
- Uncaria rhynchophylla (rhynchophylline and related alkaloids) exhibits antioxidant and vasodilatory actions (e.g., L-type Ca²⁺-channel blockade in human artery), potentially easing oxidative endothelial stress. Frontiers
Specific Warnings for Oxidative Stress:
Pregnancy: Avoid the classic formula during pregnancy—Yi Mu Cao (Leonurus) in TG-Yin is contraindicated due to its blood-moving/uterotonic properties. kamwo.com
Low blood pressure / on antihypertensives: Uncaria alkaloids (e.g., rhynchophylline) have hypotensive and calcium-channel–blocking effects; combining TG-Yin with BP meds may additively lower BP—monitor BP and discuss with your prescriber. SpringerLink
Sedation/dizziness: Uncaria can be calming; caution if you take sedatives or feel light-headed at baseline. (Pharmacology reviews on rhynchophylline.) MDPI
Pattern mismatch: In TCM terms, avoid using TG-Yin when there is yin/blood deficiency without internal wind, or if the presentation doesn’t fit the formula’s indications—work with a practitioner. sacredlotus.com
Quality & composition vary: Use professional-grade products; ingredient lists and daily raw-herb equivalents differ by brand and should mirror classical compositions. TCMzone
General Information (All Ailments)
What It Is
Tianma Gouteng Yin is a classical Chinese herbal formula traditionally used to address patterns associated—within TCM theory—with Liver Yang rising and internal wind. It is composed of herbal substances such as Gastrodia elata (天麻) and Uncaria rhynchophylla (钩藤), typically combined with herbs that nourish the Liver and Kidney yin, invigorate blood circulation, and calm what TCM calls “wind.”
Common modern indications within TCM include presentations like dizziness, headache, hypertension-type symptoms, tremor, tinnitus, or irritability—but crucially, always within the framework of a specific TCM pattern, not as a generic supplement.
How It Works (within TCM logic and modern hypotheses)
Within TCM physiology, the formula is understood to:
– Pacify internal wind to reduce spasmodic or tremor-like phenomena
– Settle hyperactive Yang to ease headache and dizziness
– Nourish yin and blood to treat the root not just the branch
– Support circulation to clear what TCM regards as “stagnation”
Biomedical hypotheses often proposed by researchers include:
– Neuroprotective and anti-excitotoxic / anti-convulsant effects of gastrodin (from Tianma)
– Mild hypotensive and vasodilatory effects suggested for Gouteng and adjuncts
– Antioxidant / anti-inflammatory actions of multiple constituents
Evidence base is mixed and varies in quality (many small, heterogeneous studies); mechanisms described above remain hypothesis or preclinical insights, not proof.
Why It’s Considered Important (in TCM clinical logic)
Practitioners regard this formula as valuable because it targets both roots and branches of a pattern that often expresses as vascular or neurologic-type symptoms. Instead of merely lowering blood pressure or merely easing headache, it simultaneously cools rising Yang, nourishes deficits, and calms internal wind, making it “multi-mechanistic” in TCM thinking.
Clinically it is used when pattern matches — not universally for all headaches, dizziness or tremors. Its importance is less about the formula itself than about its fit to a validated TCM diagnostic pattern, which is central to individualized care.
Considerations (risks, constraints, practice caveats)
– Pattern-dependence: It is inappropriate if there is not Liver-Yang-rising / wind pattern; in cold or deficiency-only patterns it may aggravate.
– Medical safety: Headache, dizziness, tremor, hypertension or tinnitus may reflect dangerous biomedical conditions (stroke, aneurysm, arrhythmia, temporal arteritis, etc.) that require immediate medical evaluation. Do not self-treat.
– Drug-herb interactions: Possible potentiation with antihypertensives, sedatives, antiepileptics, or anticoagulants. Medical and pharmacy review is prudent.
– Pregnancy/lactation: Use only with professional supervision.
– Duration and monitoring: Classical formulas are not intended for indefinite casual daily use; response and burden must be monitored by a qualified clinician.
– Quality control: Source purity, adulteration, pesticide/metal residue, and batch variability matter materially to safety.
Helps with these conditions
Tianma Gouteng Yin is most effective for general wellness support with emerging research . The effectiveness varies by condition based on clinical evidence and user experiences.
Detailed Information by Condition
Oxidative Stress
Targets redox pathways: Studies on the full formula (or close variants) show reductions in ROS and oxidative-stress markers, often via Nrf2/HO-1 and r...
Epilepsy
TCM rationaleTianma Gouteng Yin was created to calm Liver yang, extinguish internal wind, clear heat, invigorate blood, and nourish Liver–Kidney—a pat...
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