Xiao Yin Pian
Specifically for Psoriasis
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Why it works for Psoriasis:
What it is. Xiao Yin Pian is a Chinese patent medicine tablet used in TCM for psoriasis patterns described as blood-heat / blood-deficiency with wind-dryness. Typical listed herbs include: Rehmannia (地黄), Moutan bark (牡丹皮), Red peony (赤芍), Angelica (当归), Sophora flavescens (苦参), Honeysuckle (金银花), Scrophularia (玄参), Arctium (牛蒡子), Cicada slough (蝉蜕), Dictamnus bark (白鲜皮), and Saposhnikovia (防风). These correspond to TCM actions of “clearing heat, cooling blood, nourishing blood and moistening dryness, dispelling wind and relieving itch.” 39药品通
Proposed biological mechanisms (preclinical/adjacent formulas):
- Anti-inflammatory & immunomodulation (Th17/IL-23 axis): An empiric formula “Xiao-Yin-Fang (XYF)” used clinically for psoriasis reduced disease severity in a mouse model and modulated T-cell–related pathways; RNA-seq showed down-regulation of inflammatory programs. (Note: XYF is not necessarily identical to every commercial “Xiao Yin” product but is compositionally similar in intent.) Frontiers
- Network-pharmacology/mechanistic analyses of related “Xiaoyin” mixtures suggest multi-target effects on cytokine and keratinocyte signaling relevant to psoriasis pathobiology (IL-17/IL-23, NF-κB, etc.). (Exploratory mechanistic work; not clinical proof.) Frontiers
How to use for Psoriasis:
Because Xiao Yin Pian is a patent medicine, dosing follows the package insert of the exact brand you buy. A representative Chinese label lists: oral, 5–7 tablets, 3 times daily; one month = one course. Indicated for psoriatic lesions with red base and silvery scale consistent with TCM patterns above. Pregnancy: use with caution / as directed by a physician. (Always check your product’s insert.) 39药品通
If you plan to integrate it with standard dermatology care (topical steroids, vitamin-D analogs, phototherapy, or systemic agents like acitretin, methotrexate, biologics), do so under clinician supervision because interactions and overlapping toxicities (especially liver) are possible (see “Warnings”). BNF
Scientific Evidence for Psoriasis:
Key point up front: High-quality, modern randomized trials specifically on Xiao Yin Pian tablets are scarce in the English literature. Most clinical evidence is for Xiaoyin granules (消银颗粒) or related “Xiao-Yin-Fang” formulas, often as an adjunct to standard drugs such as acitretin. Methodological quality is commonly low, and one widely cited meta-analysis has since been retracted.
- (Retracted) Meta-analysis on Xiaoyin granules + acitretin (2022): Initially reported added benefit on PASI vs either alone; this paper was formally retracted in 2023 (journal integrity concerns). Do not rely on its conclusions. Europe PMC
- Chinese-language systematic review/meta-analysis (to Jan 2022): Pooled 10 RCTs, n=1230 comparing Xiaoyin granules + conventional therapy vs conventional therapy alone in psoriasis vulgaris. Reported higher PASI90 response without increased adverse-event rates, but authors emphasized overall low study quality and the need for rigorous multicenter, double-blind RCTs. (This review is not about tablets per se and quality limitations apply.) ebmoftcm.whuznhmedj.com
- Single-center RCT (2020–2021) in comorbid impaired glucose tolerance: Xiaoyin granules (± another TCM) added to standard care improved PASI and inflammatory markers over 8 weeks vs control; small study, narrow population, and Chinese-language report. qikan.cqvip.com
- Preclinical (mouse) study of “Xiao-Yin-Fang”: Showed reduction of psoriasis-like dermatitis and modulation of T-cell subsets and gene expression; useful for mechanism, not clinical proof. Frontiers
Specific Warnings for Psoriasis:
Pregnancy & lactation: Many brand inserts advise pregnant people to avoid or use only under medical advice. If you might become pregnant, discuss any psoriasis plan with your clinician. 39药品通
Liver safety / drug combinations:
- Xiao Yin Pian often contains Sophora flavescens (苦参), rich in matrine/oxymatrine alkaloids that have documented hepatotoxic potential in experimental and clinical literature. Frontiers
- If you’re also on acitretin or other hepatotoxic drugs, combined liver burden is a concern; acitretin labeling includes hepatotoxicity warnings and requires liver-function monitoring. FDA Access Data
- Practical tip: If combining Xiao Yin Pian with systemic therapies, ask your clinician about baseline and periodic LFTs.
Photosensitivity risk (especially with light therapy):
- Dictamnus (白鲜皮) in some formulations contains furanocoumarins (psoralens) which are phototoxic under UVA; this class is well known to cause phytophotodermatitis. (This is ingredient-class information; the exact furanocoumarin content of a given tablet can vary.) If you’re receiving NB-UVB/PUVA, use extra caution and follow your dermatologist’s advice. Academic Oxford
Allergy & GI upset: Herbal combinations can cause rash, pruritus, GI symptoms in some users; product inserts and consumer-health write-ups note such possibilities. Stop and seek care if you develop allergic symptoms. 39药品通
Quality & variability: “Xiao Yin Pian” is a category name sold by multiple manufacturers. Ingredient lists, strengths, and quality controls differ by brand and batch. Always read your product’s official insert and source from reputable pharmacies. 39药品通
General Information (All Ailments)
What it is
Xiao Yin Pian (消银片) is a traditional Chinese herbal formula most commonly used in China for chronic inflammatory skin disorders, especially psoriasis (银屑病, literally “silver-scale disease”) and conditions with similar features such as thick plaques, scaling, recurrent flare-ups, and itch. It is sold in OTC tablet form and typically contains a combination of anti-inflammatory, detoxifying, and “blood-cooling” herbs such as Smilax (土茯苓), Rehmannia (生地, 玄参), Paeonia, Forsythia, and others depending on manufacturer.
Even though it is “OTC” in China, it is still a traditional prescription-style, multi-herb intervention, not a simple nutraceutical.
How it works (mechanistic logic in TCM & modern terms)
From the perspective of traditional theory, psoriasis and related dermatoses arise from heat and toxin lodged in the blood level, sometimes complicated by dryness, wind, and stasis. Xiao Yin Pian is designed to cool the blood, clear heat, resolve toxins, and soften or disperse thickened lesions.
From a modern biomedical lens, component herbs are associated in studies with down-regulation of inflammatory mediators, inhibition of keratinocyte hyperproliferation, improvement of microcirculation, and immune modulation in chronic dermatitis and psoriasis. It is not a steroid; it aims at tempering dysregulated immune and inflammatory cycles, which is why effects typically accumulate over weeks rather than delivering instant suppression like topical steroids.
Why it’s important (clinical role & rationale)
Chronic plaque-type conditions such as psoriasis are relapsing inflammatory diseases, often worsened by stress, infection, metabolic syndrome, and immune triggers. Conventional therapies — topical steroids, vitamin D analogues, immunosuppressants, biologics — can be effective but may bring cost, side-effects, or taper-withdrawal problems. Xiao Yin Pian represents a non-steroid, integrative option aiming for longer-horizon regulation rather than short-term suppression.
Its clinical importance lies especially in scenarios where patients:
- Cannot tolerate or wish to reduce reliance on steroids or systemic immunosuppressants
- Experience recurrent flares despite topical control
- Benefit from a combined internal + topical strategy rather than topical-only care
- Need a gentler long-course approach to dampen inflammatory drive without abrupt rebound
Considerations (caveats, safety, appropriate use)
- Diagnosis matters: Xiao Yin Pian is suitable for heat/toxin-dominant patterns; not all plaques are from that mechanism. “Cold-type,” dry, thin, or blood-deficient presentations may worsen with cold/bitter formulas.
- Course and expectations: Effects are typically gradual. Expectation of steroid-like rapid clearing leads to disappointment or premature discontinuation.
- Drug–herb interactions & comorbidities: Patients on immunosuppressants, with autoimmune complexity, or with renal/hepatic compromise should use under clinician supervision. Bitter-cold prescriptions can impair digestion in weak GI systems.
- Pregnancy / lactation: Most TCM dermatology formulas, including heat-clearing complexes, are not automatically pregnancy-safe; individual herb safety must be reviewed.
- Quality and source variability: Xiao Yin Pian is a category name, not a single monograph formula. Composition may differ by brand (hospital-prep vs factory). Standardization and safety depend on manufacturer.
- Not a standalone cure: Good response often requires coordinated care — trigger control, sleep, stress, barrier repair, weight/metabolic management, infection control, and sometimes combination with topicals or phototherapy.
Helps with these conditions
Xiao Yin Pian is most effective for general wellness support with emerging research . The effectiveness varies by condition based on clinical evidence and user experiences.
Detailed Information by Condition
Psoriasis
What it is. Xiao Yin Pian is a Chinese patent medicine tablet used in TCM for psoriasis patterns described as blood-heat / blood-deficiency with wind-...
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