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Xiaosheng Powder

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Specifically for Dry Eye Syndrome

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Why it works for Dry Eye Syndrome:

TCM rationale & pattern

Xiaosheng Powder is used within a “soothe the Liver, nourish Yin” approach for DED that TCM ophthalmologists describe as liver depression with yin deficiency—a pattern they argue underlies many modern dry-eye cases. cccl-tcm.cacm.org.cn

Proposed biological actions (preclinical/clinical observations)

  • Tear film & goblet cells: Animal and small clinical studies report increased tear secretion, longer tear break-up time, improved corneal fluorescein staining, and higher conjunctival goblet-cell counts after Xiaosheng therapy. Goblet cells maintain the mucin layer of the tear film—so preserving them could stabilize tears and reduce symptoms. max.book118.com
  • Multi-component formula research: A pharmacology/chemistry study of the Xiaosheng prescription (XSP) used for over a decade at the Eye Hospital, China Academy of Chinese Medical Sciences, correlates identified constituents with anti-inflammatory/ocular-surface effects that could protect goblet cells and corneal epithelium. ScienceDirect

How to use for Dry Eye Syndrome:

Composition (typical modern granule form reported in clinics/articles)

Party ginseng (党参), Angelica sinensis/“Dang Gui” (当归), Rehmannia root/“Sheng Di” (生地), White peony/“Bai Shao” (白芍), Ophiopogon/“Mai Dong” (麦冬), Schisandra/“Wu Wei Zi” (五味子), Bupleurum/“Chai Hu” (柴胡), and Mint/“Bo He” (薄荷). This version is described as being built from Xiao Yao San + Sheng Mai Yin and adjusted for dry eye. Sohu

Form & route

Most reports use oral granules (颗粒剂) or a decoction taken by mouth; clinics individualize dosage and course based on pattern-differentiation. cccl-tcm.cacm.org.cn

Who it’s for (pattern guidance)

Indicated in TCM sources for DED with liver qi constraint + yin deficiency (symptoms can include dry/gritty eyes, light sensitivity, stress-related flares, poor sleep, dry mouth/skin). Pattern confirmation is typically done by a registered TCM practitioner. cccl-tcm.cacm.org.cn

Monitoring & outcomes used in studies

Symptom scores plus Schirmer test, tear break-up time (TBUT), corneal/ conjunctival staining, and impression cytology for goblet cells. max.book118.com

Scientific Evidence for Dry Eye Syndrome:

Animal study (mechanism & efficacy signals).

Journal of Beijing University of Traditional Chinese Medicine (2017): In a scopolamine-induced mouse DED model, Xiaosheng granules increased tear secretion, prolonged TBUT, improved corneal staining, and reduced goblet-cell loss vs. controls. max.book118.com

Clinical study (goblet cells) – small, single-center.

Reports from the same group describe Xiaosheng granules improving conjunctival goblet-cell density and tear-film indices in patients (clinical goblet-cell study, 2017; patient sample sizes modest). cccl-tcm.cacm.org.cn

Ingredient/effect correlation study.

A 2020 analysis links Xiaosheng prescription constituents to anti-inflammatory and ocular-surface protective actions, proposing this as the basis for benefits seen clinically. (Laboratory and network-analysis style work; not a therapeutic RCT.) ScienceDirect

Systematic review protocol + trial registration.

A peer-reviewed protocol planned a systematic review/meta-analysis of Xiaosheng Powder for DED (no pooled results were published in that protocol). Separately, a Chinese Clinical Trial Registry entry describes a multicenter clinical study of Xiaosheng San for DED (liver-depression/yin-deficiency subtype). Europe PMC

Specific Warnings for Dry Eye Syndrome:

General medical cautions

  • Do not self-treat sight-threatening or severe dry eye (e.g., persistent pain, photophobia, marked vision changes). Follow standard care pathways (lubricants, lid hygiene, anti-inflammatories, MGD management) per ophthalmology guidelines; use TCM only as adjunctive therapy under clinician supervision. cccl-tcm.cacm.org.cn

Herb-specific cautions (Xiaosheng combines multiple herbs, so combined interaction risk increases):

  • Dang Gui (Angelica sinensis) may increase bleeding risk with anticoagulant/antiplatelet drugs; avoid in pregnancy and bleeding disorders. Dr. Christopher Hobbs, Ph.D.
  • Ginseng has documented interactions with warfarin and potential interactions with several cardiovascular/psychiatric drugs; monitor INR/bleeding and discuss with your prescriber. Drugs.com+1
  • Schisandra (Wu Wei Zi) can modulate liver enzymes (notably CYP pathways), creating interaction potential with drugs metabolized by the liver (e.g., certain antihypertensives, immunosuppressants, antidepressants). ScienceDirect
  • White Peony (Bai Shao) has theoretical antiplatelet effects; caution with blood thinners. hellopharmacist.com
  • Bupleurum (Chai Hu) has liver-active saponins and is part of formulas known to affect hepatic metabolism; use caution if you have liver disease or take narrow-therapeutic-index drugs. WebMD
  • Mint (Bo He) is generally safe in food amounts; formal TCM sources list typical doses (3–6 g in formulas) and standard precautions; avoid high doses if you have reflux sensitivity and note that mint can reduce milk supply in some individuals. meandqi.com

Medication classes to flag with your clinician

Anticoagulants/antiplatelets, immunosuppressants, many cardio-metabolic agents, and other CYP-metabolized drugs (because several ingredients may influence CYP activity). Review your full medication list with a pharmacist/physician before starting. U.S. Food and Drug Administration

Quality & standardization

Herbal products vary widely in composition, assay, and contaminants; use products with lot testing and professional sourcing. (This is a general risk highlighted in herb–drug interaction literature.) ScienceDirect

General Information (All Ailments)

Note: You are viewing ailment-specific information above. This section shows the general remedy information for all conditions.

What It Is

Xiaosheng Powder (sometimes transliterated as “Xiao Sheng San” or described under similar names in various regional materia medica) is a traditional Chinese herbal formula typically composed of a blend of plant-based ingredients used historically to reduce inflammatory and accumulative patterns in the body. Exact composition can vary by tradition and lineage, but its core intent is to support the body’s ability to resolve conditions associated with stagnation, swelling, heat, residual toxin, or chronic non-healing states. It is not a “vitamin” or “nutritional supplement” in the Western sense; it is used within the pattern-based logic of Chinese medicine, not simply symptom-matching.

How It Works

From a traditional Chinese medicine (TCM) perspective, Xiaosheng Powder is used to clear heat, move stasis, and soften or disperse accumulations when the body has entered a state where tissue repair is obstructed by inflammatory viscosity, congealed blood, or residual toxin-like stagnation. In practice, this means two things are happening in parallel:

  1. Internal terrain regulation — herbs that “cool” or “resolve toxin” counter what TCM considers pathological heat and fire that drive swelling, redness, pain, or refractory inflammation.
  2. Mechanical relief via circulation — herbs that “move blood” and “soften hardness” improve microcirculatory and drainage dynamics, helping the body re-enter a state in which repair and resolution can proceed.

When viewed through a biomedical lens, one can loosely imagine this as a combination of anti-inflammatory modulation, micro-circulation support, and support for tissue turnover and detoxification, though the TCM logic for prescribing is not based on Western biomarkers.

Why It’s Important

Xiaosheng Powder sits in a cluster of classical formulas aimed at breaking chronic cycles: conditions that don’t spontaneously resolve because the body has entered a locked inflammatory or stagnation loop. Instead of suppressing a symptom, it is used to change the underlying milieu such that healing becomes possible again.

Its importance in practice is less about the formula itself and more about the niche it fills: an interventional step between passive waiting and invasive correction when the presenting pattern is dominated by heat + stasis + fixed or recurring swelling. In settings where integrative or conservative management is preferred, Xiaosheng Powder can serve as a non-surgical, non-pharmaceutical option within skilled hands to push the body out of a stuck state.

Considerations

  • Pattern-correctness is mandatory — The formula is not “for anyone with inflammation.” If the patient does not have the heat-stasis pattern, using the formula can worsen fatigue, chilliness, or deficiency states.
  • Individual modification is the norm — Skilled clinicians rarely use the textbook formula unchanged; they add, subtract, or swap herbs based on tongue, pulse, constitution, timeline, and trajectory.
  • Contraindications exist — Caution or avoidance is typical in pregnancy, in bleeding disorders, when the target tissue is already fragile or ischemic, or when cold-deficiency predominates.
  • Not a substitute for urgent care — If an accumulation is rapidly progressive, infectious, or suggests malignancy or vascular compromise, formula use without concurrent medical work-up is unsafe.
  • Interaction risk — Herbs that move blood or resolve stasis may interact with anticoagulants, antiplatelets, or post-operative conditions.
  • Quality and sourcing matter — Potency and safety differ drastically by manufacturer, batch, and storage; adulteration and substitution are non-rare in unregulated supply chains.
  • Monitoring is part of therapy — Re-examination of tongue, pulse, and trajectory is not optional; a formula that is correct at week one may be inappropriate once the terrain shifts.

Helps with these conditions

Xiaosheng Powder is most effective for general wellness support with emerging research . The effectiveness varies by condition based on clinical evidence and user experiences.

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Detailed Information by Condition

Dry Eye Syndrome

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TCM rationale & patternXiaosheng Powder is used within a “soothe the Liver, nourish Yin” approach for DED that TCM ophthalmologists describe as li...

0 votes Updated 1 month ago 4 studies cited

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