Yin Xie Ling
Specifically for Psoriasis
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Why it works for Psoriasis:
Multi-herb formula targeting inflammation & keratinocyte overgrowth. Yinxieling traditionally combines 10 herbs (e.g., Angelica sinensis, Paeonia rubra, Lithospermum “Zi Cao”, Curcuma zedoaria, Smilax glabra, etc.). In vitro/animal and translational work on the original formula and its optimized descendant PSORI-CM01 (developed from Yinxieling) show suppression of inflammatory cytokines and reduced keratinocyte proliferation/hyperplasia—mechanisms central to psoriasis. Annals of Palliative Medicine
• Composition listed in a clinical pilot paper; mechanistic lines of evidence include down-regulation of Cyclin B2 and other pathways in PSORI-CM01 (derived from Yinxieling). Annals of Palliative Medicine
Clinical tradition + hospital preparation. Yinxieling has been used for >20 years at Guangdong Provincial Hospital of Chinese Medicine (GPHCM) and registered as a hospital-made preparation (approval No. Z20080123). Annals of Palliative Medicine
Optimization lineage (context). Because the 10-herb Yinxieling is complex, researchers created PSORI-CM01 by simplifying/optimizing Yinxieling; many modern studies reference PSORI-CM01 but this still informs why the parent formula is used. BMJ Open
How to use for Psoriasis:
Yinxieling tablets (original formula) – In a multicentre, double-blind pilot RCT, participants randomized to the Yinxieling arm took five Yinxieling tablets, three times daily after meals for 12 weeks. Annals of Palliative Medicine
Dietary/topical co-therapies – Trials commonly combined herbal therapy with standard topical regimens or followed patients for relapse after stopping; exact co-therapies and follow-up differ by study. (See individual protocols below.) BioMed Central
Scientific Evidence for Psoriasis:
Human studies
- Pilot RCT (2021) – PSORI-CM01 granules vs Yinxieling tablets for chronic plaque psoriasis, 12 weeks + 3-month follow-up (n=63 randomized; n=39 completed). Both groups improved; PSORI-CM01 showed a larger mean PASI reduction (2.03 vs 0.89) and better itch VAS; no major safety concerns. Yinxieling dose in this trial was 5 tablets TID after meals. Annals of Palliative Medicine
- Protocol (BMJ Open, 2017) – Multicentre RCT designed to compare PSORI-CM01 granules with Yinxieling tablets (details on the derivation of PSORI-CM01 from Yinxieling and rationale). Useful for understanding endpoints and planned analyses. BMJ Open
- Pilot RCT (2016) – PSORI-CM01 plus standard topical “sequential therapy” vs placebo + topical therapy; designed to assess relapse and feasibility; supports the development path from Yinxieling to PSORI-CM01. BioMed Central
- Randomized, single-blind trial (2011/2012) – Optimized Yinxieling formula ± auricular therapy, 8 weeks, n=84 outpatients; reported clinical improvement (older study; methods reflect era). SpringerLink
- Observational/earlier clinical reports – Decreases in PASI and inflammatory cytokines (e.g., TNF-α, IL-8) reported after Yinxieling treatment; cited within later pilot RCTs. (Primary papers include Dai et al., 2014; Wang et al., 2009—see references within the APM trial.) Annals of Palliative Medicine
Mechanistic/preclinical (relevance to parent formula)
- PSORI-CM01 inhibits keratinocyte proliferation (HaCaT), reduces epidermal hyperplasia in an imiquimod mouse model; Cyclin-B2–linked mechanism. BioMed Central
- Systems-pharmacology and network analyses (and small human biomarker work) suggest regulation of miRNAs (e.g., miR-20a-3p, miR-3184-3p) and inflammatory pathways. Dove Medical Press
Specific Warnings for Psoriasis:
Formulation/quality control: Yinxieling is a hospital preparation in China rather than a globally standardized OTC product; potency and ingredient quality can vary by manufacturer. Work with a qualified clinician and verified source. Annals of Palliative Medicine
Drug interactions—anticoagulants/antiplatelets:
• Components like Curcuma spp. (curcumin-like constituents) can have antiplatelet effects and have been implicated in raising INR with warfarin; use caution and monitor if on blood thinners. Medsafe
• Angelica (Dang Gui) has case-level and theoretical interactions with warfarin—seek medical supervision. SAGE Journals
Photosensitivity & herb-specific cautions: Some Angelica species contain furanocoumarins that can increase photosensitivity (sun sensitivity); although specific to A. archangelica in many summaries, caution is reasonable with A. sinensis–containing formulas. Verywell Health
Liver & general tolerability: Naphthoquinones in Lithospermum (Zi Cao) (e.g., shikonin) are bioactive; comprehensive human safety data are incomplete—monitor for GI or hepatic symptoms if using concentrated preparations or multiple hepatically-metabolized drugs. Frontiers
Pregnancy/breastfeeding: Many included herbs (e.g., Angelica, Curcuma) have insufficient safety data or are traditionally avoided—do not use without specialist guidance. (General safety notes and regulatory advisories apply.) Verywell Health
What trials reported: In the 2021 pilot RCT comparing PSORI-CM01 and Yinxieling, no major safety/tolerability concerns were observed over 12 weeks; nonetheless, the sample was small and cannot rule out rarer events. Annals of Palliative Medicine
General Information (All Ailments)
What It Is
Yin Xie Ling is a multi-herb traditional Chinese medicine formula used primarily to clear toxic heat and dampness, reduce inflammation and discharge, and protect or nourish Yin when pathogenic heat threatens to consume fluids. The exact composition may differ depending on manufacturer or practitioner, but the formulation typically includes heat-clearing, detoxifying, damp-resolving, and Yin-protective herbs.
How It Works (Mechanism in TCM logic)
The formula is built on two strategic axes:
- Clear “Xie” — the pathogen: The herbs reduce internal fire-toxin and damp-heat, which in TCM are understood to drive eruptions, purulence, red/swollen lesions, foul discharge, bitter taste, irritability, or systemic inflammatory signs.
- Preserve Yin while clearing: Many “heat-clearing” regimens dry out fluids; this formula is designed to moderate the dryness so that the process of clearing does not deplete Yin. Yin preservation prevents post-treatment dryness, worsening of itch/cracking, and rebounds from underlying deficiency.
From a biomedical analogue, one could map this to reducing inflammatory mediators, modulating immune activation, assisting exudate clearance, and preventing overt dehydration or barrier compromise through more gentle heat management rather than aggressive purging.
Why It’s Important
- Balanced clearing — Some formulas purge heat aggressively; Yin Xie Ling approaches inflammation in a measured, protective way, reducing the risk of over-drying.
- Chronic inflammation suitability — In chronic, smoldering inflammatory states (skin or mucosal) that coexist with subtle Yin deficiency (night-warmth, mild dryness, low-grade irritation), a purely “cold and drying” formula may worsen the terrain. Yin Xie Ling fills that gap.
- Barrier and rebound prevention — By protecting Yin, the body’s moist-cool nutritive substrate remains intact, reducing the risk of post-treatment relapse, insomnia from heat, or dryness-induced itch cycles.
Considerations (Clinical prudence)
- Pattern-specific, not symptom-specific — It is not appropriate for all rashes, infections, or heat signs. If the underlying pattern is cold, Qi-deficient with damp without heat, or pure Yin deficiency without active heat-toxin, the formula can worsen symptoms.
- Course and intensity must be individualized — Some patterns need stronger detoxification or stronger Yin support; Yin Xie Ling is a balanced middle solution, not always the end state prescription.
- Interactions and comorbidities — Patients with cold digestion, pregnancy, immunosuppressive regimens, or heavy anticoagulation require careful review before use.
- Professional supervision advised — Because the formula presumes a specific TCM pattern diagnosis, self-use without pattern confirmation can mislead the clinical course and delay appropriate care.
- Not a substitute for antibiotics or urgent care — In cases of rapidly progressive infection, systemic fever with instability, or necrosis, biomedical care is priority; TCM support may be adjunctive, not primary.
Helps with these conditions
Yin Xie Ling is most effective for general wellness support with emerging research . The effectiveness varies by condition based on clinical evidence and user experiences.
Detailed Information by Condition
Psoriasis
Multi-herb formula targeting inflammation & keratinocyte overgrowth. Yinxieling traditionally combines 10 herbs (e.g., Angelica sinensis, Paeonia...
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