You Gui Wan
Specifically for Fertility Support (Female)
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Why it works for Fertility Support (Female):
Pattern it targets: In TCM, You Gui Wan warms and tonifies Kidney yang and replenishes Essence (jing)—patterns often implicated in anovulation, luteal insufficiency, cold uterus, low libido, fatigue, and low back/knee soreness. These are classic indications for infertility of the “Kidney-yang deficiency / cold” type. yinyanghouse.com
Classical composition & actions: Core ingredients typically include Shu Di Huang (Rehmannia), Rou Gui (Cinnamon bark), Fu Zi (prepared Aconite), Lu Jiao Jiao (deer antler gelatin), Du Zhong (Eucommia), Tu Si Zi (Cuscuta), Shan Yao (Dioscorea), Shan Zhu Yu (Cornus), Gou Qi Zi (Lycium), Dang Gui (Angelica). The formula is recorded (with ratios) in the Jingyue Quanshu and appears in the Chinese Pharmacopoeia (2020). TCM Wiki
Mechanistic clues (modern): Network/multi-omics pharmacology papers suggest You Gui Wan may modulate HPO-axis hormones, ovarian function, mitochondrial/oxidative stress pathways, endometrial receptivity and microcirculation—biological themes congruent with its TCM indications for cold/yang-deficient infertility. (These are mechanistic and not themselves clinical proof.) RSC Publications
How to use for Fertility Support (Female):
Typical forms & label directions (examples):
Pharmacopoeia-standard honey pills (“small” vs “big” pills):
- Small pills: 9 g per dose, 3×/day by mouth.
- Big pill: 1 pill (≈9 g) per dose, 3×/day by mouth.
- These directions come from China’s official drug standard entries for You Gui Wan. db.ouryao.com
Commercial big honey pill (Zhongjing brand) example: “1 pill, 3×/day by mouth.” (Same composition/indications; shows how OTC labels align with pharmacopeia.) ypk.39.net
- Classical prep as pills or decoction: Traditional instruction (for hand-made pills) is 9–15 g per dose, 2–3×/day; decoction quantities are adjusted per practitioner. (This is historical preparation guidance, not a substitute for your product’s label.) Sacred Lotus
- Granules/capsules (modern extracts): Follow the exact manufacturer’s label; strengths differ by maker (e.g., Sun Ten, Treasure of the East). Your clinician will convert classical doses to extract grams. Sun Ten
Timing & course (typical clinician practice):
- Often taken through follicular and/or luteal phases depending on pattern; many clinicians reassess after 1–3 cycles and adjust formulas (e.g., pair with Yin-tonics in follicular phase if needed). This cycle-based tailoring is standard TCM practice rather than a one-size label rule. yinyanghouse.com
Scientific Evidence for Fertility Support (Female):
Human studies (condition-specific):
- PCOS-associated infertility (randomized, China): 92 patients randomized to standard western care ± You Gui Wan + Er Chen Tang for PCOS showed improvements in ovarian ultrasound indices and cervical mucus scores vs control; adverse events were monitored. (Herbal combo; Chinese journal). jcmp.yzu.edu.cn
- Ovarian reserve/infertility (observational, China): Women with diminished ovarian reserve received You Gui Wan for 6 months with pre/post comparison of hormones (FSH/LH/AMH), antral follicle counts, and symptoms; improvements were reported. (Single-arm clinical observation; not randomized.) doc88.com
Related human evidence (not infertility endpoints but relevant physiology):
- Bone/Endocrine health (randomized): A randomized, controlled trial in osteoporotic patients found You Gui Wan or Zuo Gui Wan improved bone mineral density and quality of life vs control—supporting systemic yang/essence-tonifying effects, though not fertility outcomes per se. ScienceDirect
Preclinical & mechanistic studies (supporting plausibility, not proof):
- Multi-omics/network-pharmacology papers and animal models suggest You Gui Wan influences oxidative stress, apoptosis pathways, and ovarian folliculogenesis; e.g., in a DOR rat model it improved AMH and follicle counts and modulated Keap1/Nrf2 signaling. X-MOL
- Additional systems-biology analyses identify potential targets and pathways tied to Kidney-yang deficiency states. RSC Publications
- Broader systematic reviews of Chinese herbal RCTs for female infertility note potential benefits for certain herbal strategies but still call for better-designed, well-reported trials—i.e., the overall evidence base is evolving. ScienceDirect
Specific Warnings for Fertility Support (Female):
Pattern mismatch: Do not use if your presentation is yin-deficient with heat or damp-heat (e.g., heat signs, red tongue with yellow coat). This is a traditional contraindication and a key reason to be evaluated by a TCM professional. Yaozi
Contains prepared aconite (Fu Zi):
• Aconite is inherently toxic; only properly processed (zhi fu zi) is used in TCM formulas and only under professional supervision. Accidental exposure/overdose can cause serious cardiotoxicity/arrhythmias, hypotension, and death. Do not self-dose or exceed labels. Drugs.com
• Pregnancy & breastfeeding: Aconite is unsafe; avoid during pregnancy/breastfeeding unless your obstetrics and herbal teams specifically direct otherwise (uncommon). WebMD
• Drug interactions: Aconite may affect clotting and interact with anticoagulants/antiplatelets; many cardiac drugs also pose theoretical risks—coordinate with your prescriber. WebMD
Deer antler (Lu Jiao/lu jiao jiao): Animal product—avoid if you have related allergies or ethical/dietary restrictions; sourcing varies by brand/region. Sun Ten
Quality control matters: Choose reputable brands that follow pharmacopeial limits for aconitine and identity testing; the Chinese Pharmacopoeia specifies aconitine limit tests for You Gui Wan products. db.ouryao.com
When to stop/seek care: Discontinue and seek medical attention for palpitations, numbness/tingling around mouth or limbs, severe dizziness, chest pain, unusual bleeding, rash, or GI distress—possible signs of aconite toxicity or reaction. (General safety guidance aligned with aconite toxicity literature.) ConsumerLab.com
General Information (All Ailments)
What it is
You Gui Wan is a classical Chinese herbal formula from the school of tonification. It is traditionally used for patterns described as Kidney Yang Deficiency with Jing/Fertility depletion — often when a person appears cold, fatigued, depleted, and weak at the constitutional level. It is a “warming and restoring” formula, not a quick symptom reliever.
The core actions are to warm Kidney Yang, replenish Essence (Jing), strengthen the lower back and reproductive axis, and support constitutional vitality.
How it works (TCM mechanisms)
You Gui Wan works by:
• Warming the Mingmen fire
— helps reverse coldness, slowed metabolism, low libido, cold limbs, fatigue
• Rebuilding Jing (essence)
— addresses depletion from chronic illness, overwork, aging, or reproductive loss
• Supporting marrow and reproduction
— classically linked to memory, bones, fertility, hormonal vigor
• Anchoring long-term recovery instead of just stimulating
— it builds the “bank account” rather than just spending what’s left
From a Western physiology framing, clinicians often correlate its effects with modulating HPA axis tone, improving microcirculation, and influencing metabolic and reproductive endocrine function in deficient presentations (not hyper/hot ones).
Why it’s important (clinical relevance)
You Gui Wan is important because it is used in conditions where the person is not just symptomatic, but constitutionally depleted. In TCM, this depletion is seen as upstream of many chronic, recurring, or never-fully-resolved health problems. It becomes relevant when patterns include some combination of:
• persistent low vitality despite rest
• cold intolerance, low libido, impotence, infertility
• spinal/low back weakness, bone weakness with aging
• loose stools with cold, clear urine, fatigue on waking
• post-illness or post-birth depletion
• signs of aging with cold-type decline (not heat-type)
It is used when the goal is rebuilding capacity and reserve, not merely patching symptoms.
Considerations
1) Pattern-specific — not for everyone
This is a hot/warming formula. It can aggravate people with heat signs, inflammation, or thick/yellow tongue coat. Wrong pattern = worse outcome.
2) Time horizon is slow and cumulative
Effects are tonifying; meaningful changes are evaluated over weeks to months, not days.
3) Pregnancy, IVF, and hormone-related cases require supervision
Because it influences reproductive and metabolic axis, dosing and timing with cycles or ART should be guided.
4) May interact with Western conditions
Use caution or active MD coordination in people with hyperthyroidism, hypertension with heat/agitation, active infections, autoimmune flares, or severe inflammatory states — You Gui Wan is generally not given during febrile/acute inflammatory phases.
5) Formula variations matter
There are related formulas (You Gui Yin; Jin Gui Shen Qi Wan; Zuo Gui Wan) chosen based on degree of cold vs deficiency vs fluids, not interchangeably.
6) Quality and sourcing
Because this is a classic “slow repletion” formula, adulteration or low potency materially changes outcomes; professional-grade sourcing is not a trivial detail.
Helps with these conditions
You Gui Wan is most effective for general wellness support with emerging research . The effectiveness varies by condition based on clinical evidence and user experiences.
Detailed Information by Condition
Erectile Dysfunction
TCM rationale. In traditional theory, many cases of ED map to Kidney Yang deficiency (low libido, cold limbs, low back/knee soreness, fatigue). You Gu...
Hypothyroidism
TCM rationale (pattern-based): In traditional Chinese medicine (TCM), many hypothyroid presentations map to Kidney Yang deficiency (sometimes Spleen-K...
Fertility Support (Female)
Pattern it targets: In TCM, You Gui Wan warms and tonifies Kidney yang and replenishes Essence (jing)—patterns often implicated in anovulation, luteal...
Low Testosterone
TCM rationale (Kidney-Yang deficiency): In traditional Chinese medicine (TCM), many symptoms that overlap with hypogonadism—fatigue, cold intolerance,...
Low Sperm Count
TCM rationale (pattern-based): You Gui Wan warms and tonifies Kidney Yang and replenishes essence (jing)—the classic TCM pattern linked to male subfer...
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