Press to navigate, Enter to select, Esc to close
Recent Searches
Trending Now

Chasteberry (Vitex)

herb Verified

Specifically for PCOS

0% effective
0 votes
0 up0 down

Why it works for PCOS:

Dopaminergic action → lower prolactin. Vitex appears to act on dopamine D2 receptors in the pituitary, which can suppress prolactin. If menstrual irregularity is driven by elevated prolactin (which can mimic PCOS), lowering prolactin may regularize cycles. This is biologically plausible and supported by clinical data in hyperprolactinemia, not PCOS per se. Frontiers

General HPO-axis effects. Regulators in the EU (EMA) note vitex acts on the hypothalamic-pituitary axis; its approved indication there is premenstrual syndrome (PMS)—not PCOS. Benefits for PMS don’t automatically translate to PCOS. European Medicines Agency (EMA)

What major PCOS guidelines say. The 2023 International Evidence-based PCOS Guideline (Monash/ASRM/Endocrine Society) recommends lifestyle, the pill for irregular menses/hyperandrogenism, and metformin for metabolic features; it does not recommend chasteberry as a PCOS treatment. Monash University

How to use for PCOS:

If you and your clinician decide to trial vitex (typically for PMS or suspected prolactin-related cycle issues), the only well-defined, regulator-endorsed dosing comes from the EMA monograph:

  • Standardized extract: 20 mg dry extract (e.g., Ze 440, DER 6–12:1, 60% ethanol) once daily by mouth. European Medicines Agency (EMA)
  • Duration: Use daily for up to 3 months before judging benefit; if symptoms persist or worsen after ~3 months, see your clinician. European Medicines Agency (EMA)
  • Formulations: EMA also lists tinctures (1:5, 68–70% ethanol) and other dry extracts, but clinical trials most often used standardized tablets. Stick to products that state the extract type and dose (e.g., Ze 440 20 mg). European Medicines Agency (EMA)

PCOS-specific practicalities

  • Have your clinician check for elevated prolactin, thyroid disease, and nonclassic CAH—all recommended differentials in the PCOS guideline—before trying vitex “for irregular periods.” Treating unrecognized pituitary disease with vitex could mask symptoms. Monash University
  • Don’t expect weight loss or reliable improvement of acne/hirsutism from vitex; these are better addressed with guideline-supported therapies (lifestyle, COC, anti-androgens, metformin where appropriate). Monash University

Scientific Evidence for PCOS:

Best evidence (not PCOS):

  • PMS RCTs & meta-analyses. Multiple randomized, placebo-controlled trials using Ze 440 (often 20 mg/day) show benefit for PMS symptom clusters; a meta-analysis supports efficacy for PMS. This establishes dosing/safety but is indirect for PCOS. ScienceDirect
  • Hyperprolactinemia RCT. A double-blind, placebo-controlled trial in women with luteal phase defects due to latent hyperprolactinemia found vitex normalized prolactin and luteal function—relevant if high prolactin is your issue, but again not a PCOS trial. GlobinMed
  • Recent review on prolactin: Summarizes evidence of vitex’s dopaminergic/prolactin-lowering effects; helpful background for cycle issues related to prolactin. Frontiers

PCOS-specific evidence (limited/low quality):

  • Triple-blind RCT: COC ± vitex (Tabriz University). Adding vitex to a low-dose combined oral contraceptive improved some clinical/paraclinical PCOS parameters versus COC alone; however, combination design prevents attributing effects to vitex alone, and replication is lacking. Iranian Red Crescent Medical Journal
  • Small triple-blind RCT (infertile PCOS, vitex vs placebo). Reported ultrasound follicle changes with vitex vs placebo; methods and peer-review robustness are limited; outcomes are surrogate. Interpret cautiously. Directory of Open Access Journals
  • Narrative/systematic herbal reviews highlight theoretical benefits but conclude insufficient high-quality evidence to recommend vitex for PCOS core outcomes. BioMed Central
Specific Warnings for PCOS:
  • Pregnancy & breastfeeding: Not recommended—insufficient safety data; may affect lactation. Stop if you become pregnant. European Medicines Agency (EMA)
  • Pituitary disorders / prolactinomas: Because vitex acts on the pituitary-hypothalamic axis, consult a doctor first; vitex may mask symptoms of prolactin-secreting tumors. European Medicines Agency (EMA)
  • Drug interactions (theoretical but important): Use caution with dopamine agonists/antagonists, estrogens/anti-estrogens (e.g., antipsychotics, cabergoline, bromocriptine, hormone therapies). European Medicines Agency (EMA)
  • Hormone-sensitive conditions: Avoid or use only with medical advice in those with breast, uterine, or ovarian cancers (hormone-sensitive). NCCIH
  • Adverse effects: Usually mild—nausea, abdominal pain, headache, dizziness, rash/urticaria; acne and menstrual changes are reported. Stop and seek care if you have swelling, breathing trouble, or worsening symptoms. European Medicines Agency (EMA)
  • Adolescents: Safety/efficacy not established in those <18 years. European Medicines Agency (EMA)

General Information (All Ailments)

Note: You are viewing ailment-specific information above. This section shows the general remedy information for all conditions.

What It Is

Chasteberry, also known as Vitex or monk’s pepper, is a small, flowering shrub native to the Mediterranean region and parts of Asia. The plant produces dark purple berries that are dried and used for medicinal purposes. Traditionally, Chasteberry has been utilized for centuries—especially in women’s health—to address hormonal imbalances, menstrual irregularities, and symptoms of menopause or premenstrual syndrome (PMS).

Its use dates back to ancient Greek and Roman times, when it was associated with promoting chastity—hence the name—due to its supposed ability to reduce sexual desire. Today, it’s widely used as an herbal supplement, often found in capsules, tinctures, or teas.

How It Works

Chasteberry primarily influences the pituitary gland, the central regulator of hormone production in the body. Rather than directly containing hormones, it acts indirectly to balance levels of estrogen and progesterone by affecting the secretion of prolactin—a hormone involved in menstruation and lactation.

Here’s how it’s believed to function:

  • Dopaminergic effects: Chasteberry compounds, particularly agnuside and aucubin, bind to dopamine receptors in the brain, reducing the release of prolactin. Elevated prolactin can disrupt menstrual cycles and cause breast tenderness; thus, lowering it helps restore normal hormonal rhythms.
  • Progesterone balance: By moderating prolactin levels, Vitex can support the luteal phase of the menstrual cycle, improving progesterone production. This helps regulate cycles, ease PMS, and support fertility.
  • Menopausal and PMS symptom relief: Through its hormone-modulating properties, Chasteberry can alleviate symptoms like mood swings, bloating, irritability, and breast pain.

Its effects are subtle and cumulative—it typically requires consistent use for several weeks to months to notice significant changes.

Why It’s Important

Chasteberry holds importance because it offers a natural, non-synthetic approach to managing a variety of hormone-related conditions that affect women’s quality of life. Some of the key reasons for its significance include:

  • PMS and PMDD management: Research suggests it reduces common premenstrual symptoms such as irritability, depression, and breast pain by balancing hormone fluctuations.
  • Cycle regulation: For women with irregular or absent periods (often due to hormonal imbalances), Vitex can help restore rhythm by supporting natural hormone feedback mechanisms.
  • Fertility support: In cases where low progesterone or luteal phase defects affect conception, Chasteberry can promote healthier ovulation and luteal function.
  • Menopausal symptom relief: It can ease mild menopausal symptoms such as mood changes and hot flashes by supporting endocrine balance.
  • Alternative to hormonal drugs: Many women prefer Chasteberry as a gentler option compared to synthetic hormones or birth control pills for menstrual regulation.

In essence, Chasteberry’s importance lies in its adaptogenic hormonal support, bridging traditional herbal wisdom and modern endocrinological understanding.

Considerations

While Chasteberry is generally well-tolerated, there are several important considerations to keep in mind:

  • Time and consistency: Results typically take 2–3 menstrual cycles to appear. Patience and consistent use are key.
  • Possible side effects: Some individuals may experience mild nausea, headache, dizziness, skin rash, or menstrual changes at the beginning of use.
  • Hormonal interactions: Because Vitex acts on hormone pathways, it may interfere with birth control pills, hormone replacement therapy (HRT), or dopamine-related medications (e.g., for Parkinson’s disease).
  • Pregnancy and lactation: It’s generally not recommended during pregnancy or while breastfeeding unless directed by a healthcare professional, as it can alter prolactin and progesterone levels.
  • Individual variability: The effects can differ widely depending on a person’s hormonal baseline and health condition; medical guidance is advised before use.
  • Quality and formulation: The effectiveness of Chasteberry supplements depends heavily on standardized extract quality and dosage. Reputable, third-party-tested brands are preferable.

Helps with these conditions

Chasteberry (Vitex) is most effective for general wellness support with emerging research . The effectiveness varies by condition based on clinical evidence and user experiences.

PMS 0% effective
PCOS 0% effective
Endometriosis 0% effective
Fertility Support (Female) 0% effective
Fibroids 0% effective
Ovarian Cysts 0% effective
6
Conditions
0
Total Votes
30
Studies
0%
Avg. Effectiveness

Detailed Information by Condition

PMS

0% effective

Dopamine-like action → lowers prolactin: Extracts of Vitex contain diterpenes (e.g., clerodadienols) that bind to dopamine D2 receptors and suppress p...

0 votes Updated 1 month ago 5 studies cited

PCOS

0% effective

Dopaminergic action → lower prolactin. Vitex appears to act on dopamine D2 receptors in the pituitary, which can suppress prolactin. If menstrual irre...

0 votes Updated 1 month ago 6 studies cited

Endometriosis

0% effective

Mechanistic rationale (indirect): Standardized vitex extracts act (primarily) on the pituitary—dopaminergic (D2) activity lowers prolactin; downstream...

0 votes Updated 1 month ago 5 studies cited

1) Prolactin modulation (pituitary level).Elevated or “latent” (mild) hyperprolactinaemia can shorten the luteal phase and impair progesterone product...

0 votes Updated 1 month ago 5 studies cited

Fibroids

0% effective

Mechanistic rationale (indirect): Standardized Vitex extracts show dopamine-D2 agonist activity that lowers prolactin in vitro/in vivo; several diterp...

0 votes Updated 1 month ago 5 studies cited

Ovarian Cysts

0% effective

Mechanism: Extracts of Vitex act (at least partly) as dopamine D₂-receptor agonists, which can lower prolactin. Lower prolactin can normalize luteal-p...

0 votes Updated 1 month ago 4 studies cited

Community Discussion

Share results, tips, and questions about Chasteberry (Vitex).

0 comments 0 participants
Only registered members can join the discussion.
Please log in or create an account to share your thoughts.

Loading discussion...

No comments yet. Be the first to start the conversation!

Discussion for PCOS

Talk specifically about using Chasteberry (Vitex) for PCOS.

0 comments 0 participants
Only registered members can join the discussion.
Please log in or create an account to share your thoughts.

Loading discussion...

No comments yet. Be the first to start the conversation!

Remedy Statistics

Effectiveness
Not yet rated
Safety Rating 8/10

Recommended Products

No recommended products added yet.