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Jin Gui Shen Qi Wan

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Specifically for Low Testosterone

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Why it works for Low Testosterone:

Traditional (TCM/Kampo) rationale.

Jin Gui Shen Qi Wan is a classic “warm Yang & tonify Kidney” formula. In TCM theory, symptoms that often travel with clinically low testosterone—fatigue, reduced libido/erections, cold limbs, low back/knee soreness, frequent/night urination—map to Kidney-Yang deficiency. This is why practitioners may select Jin Gui Shen Qi Wan for such presentations rather than to “treat a lab value.” Yin Yang House

Modern mechanistic hints (preclinical).

Research on Ba-Wei-Di-Huang-Wan/Hachimijiogan (the same formula family) suggests potential endocrine actions:

  • In hydrocortisone-induced “Kidney-Yang deficiency” rats, Jinkui Shenqi Wan mitigated the drop in serum testosterone and restored androgen-receptor (AR) mRNA/protein expression in testis/kidney—effects comparable to methyltestosterone in that model. (Animal data; not humans.) ScienceDirect
  • Hachimijiogan has been reported to stimulate testicular testosterone production in rats and shows nuclear-receptor activity (e.g., PPAR-α) in cell assays, which could relate to metabolic/endocrine effects. (Again: preclinical.) Europe PMC

What this means in practice.

From a biomedical standpoint, these findings do not prove Jin Gui Shen Qi Wan raises testosterone in men. They do explain why practitioners might consider it when a patient’s pattern fits Kidney-Yang deficiency and when goals include symptom relief alongside lifestyle care or medically supervised therapy. Mainstream guidelines still regard testosterone replacement therapy as the evidence-based treatment for confirmed organic hypogonadism. The Lancet

How to use for Low Testosterone:

Professional diagnosis first.

Because this is a warming Yang formula containing stimulating herbs (traditionally including processed aconite), it should only be used after a TCM/Kampo diagnosis confirms a Yang-deficiency pattern and rules out Yin-deficiency/“internal heat.” Practitioner references emphasize evaluation and pattern-matched prescribing. Yin Yang House

Typical dosing references (for standardized Kampo extract TJ-7 = Hachimijiogan).

  • Usual adult dose: 7.5 g/day of extract granules, taken orally in 2–3 divided doses before/between meals; adjust by age/weight/symptoms. (This is the official package insert used in Japan.) Tsumura
  • Japanese labeling also lists common adverse effects and cautions (see “Warnings” below) and is a good model for safe, standardized use. Rad AR

Traditional pill/decoction forms.

Commercial “wan” pills or practitioner-made decoctions vary in strength; reputable TCM formularies stress that a single formula may be combined or staged and is not a one-size-fits-all fix. Work with a licensed practitioner for product quality and dose. Yin Yang House

Scientific Evidence for Low Testosterone:

Animal model (hydrocortisone-suppressed testosterone): Jinkui Shenqi Wan reversed declines in testosterone and AR expression in rats. ScienceDirect

Rat data / in vitro: Hachimijiogan increased testicular testosterone in rats; showed receptor/PPAR activity in cell assays (mechanistic interest, not proof in humans). Europe PMC

Related areas: Hachimijiogan has preclinical/adjunctive data in bone and reproductive models, but these are not hypogonadism RCTs. ScienceDirect

Specific Warnings for Low Testosterone:

1) Product quality & aconite (Fu Zi) risk.

Some classical versions include processed aconite (Zhi Fu Zi), a potentially cardiotoxic herb if not properly processed/formulated. Regulators in Australia have found excess aconitum alkaloids in certain Jin Gui Shen Qi Wan products and issued safety notices/market actions. Choose reputable, tested products only. Therapeutic Goods Administration

  • Aconite poisoning can cause life-threatening arrhythmias, hypotension, GI and neurologic symptoms; case reports exist even with herbal products. Wiley Online Library

2) Pattern-mismatch (heat/Yin deficiency).

Authoritative formularies caution: avoid Jin Gui Shen Qi Wan in Yin-deficiency with heat/dryness (red tongue with little coat, thirst, flushing), and use with care in GI weakness. Using a warming formula in a “hot” pattern can aggravate symptoms (palpitations, flushing, insomnia, acne). sacredlotus.com

3) Adverse effects & precautions from standardized labeling (TJ-7).

Reported reactions include rash/itching, loss of appetite/abdominal discomfort, nausea/vomiting/diarrhea/constipation, palpitations, “rush of blood” (flushing), and numb tongue. Use with care in heat-sensitive/robust constitutions (over-stimulation). Stop and seek care if reactions occur. Tsumura

4) Children, pregnancy, comorbidities, drug interactions.

Because of warming/stimulating ingredients and aconite risk, do not give to children or use in pregnancy unless specifically prescribed by a qualified clinician. Patients with cardiac disease, arrhythmia risk, uncontrolled hypertension, or taking antiarrhythmics/diuretics should avoid unsupervised use. (These cautions follow from known aconite/toxicity profiles and Kampo labeling.) Wiley Online Library

General Information (All Ailments)

Note: You are viewing ailment-specific information above. This section shows the general remedy information for all conditions.

What It Is

Jin Gui Shen Qi Wan (金匮肾气丸), often translated as Kidney Qi Pill from the Golden Cabinet, is a classical Traditional Chinese Medicine (TCM) formula originating from the ancient medical text Jin Gui Yao Lue (“Essential Prescriptions from the Golden Cabinet”), written by Zhang Zhongjing during the Han Dynasty.

It is primarily used to tonify the Kidney Yang—the warming, activating, and energy-producing aspect of the kidneys in TCM theory. The formula consists of eight main herbs, including Fu Zi (Aconite) and Gui Zhi (Cinnamon Twig) for warming Yang, combined with Shu Di Huang (Rehmannia Root), Shan Zhu Yu (Cornus Fruit), Shan Yao (Chinese Yam), Ze Xie (Alisma), Fu Ling (Poria), and Mu Dan Pi (Moutan Bark) to nourish Yin and regulate water metabolism.

It is available as pills, granules, or decoctions and is commonly prescribed for conditions associated with Kidney Yang Deficiency, such as fatigue, cold limbs, lower back weakness, frequent urination, and edema.

How It Works

In TCM theory, Kidney Yang represents the body’s “fire” or life energy that drives warmth, metabolism, and activity. Jin Gui Shen Qi Wan works by replenishing and activating this Yang energy and restoring balance between Yin (cooling, nourishing energy) and Yang (warming, active energy).

  • Warming and Tonifying the Kidneys:
  • Herbs like Fu Zi and Gui Zhi stimulate the Yang energy, enhance warmth, and support adrenal and metabolic functions in modern physiological terms.
  • Regulating Water Metabolism:
  • By strengthening Kidney Yang, the formula helps control fluid distribution and excretion. Herbs such as Ze Xie and Fu Ling promote urination and reduce water retention, balancing the body’s internal moisture.
  • Supporting Energy and Circulation:
  • The improved Yang function enhances blood circulation and energy levels, helping alleviate fatigue, low libido, and cold extremities.
  • Modern Biomedical Interpretation:
  • Some research suggests that Jin Gui Shen Qi Wan may influence the hypothalamic-pituitary-adrenal (HPA) axis, support mitochondrial energy production, and modulate endocrine and renal function, providing a physiological foundation for its traditional use.

Why It’s Important

Jin Gui Shen Qi Wan holds an essential place in Chinese herbal medicine because it addresses one of the most fundamental energy deficiencies: Kidney Yang Deficiency.

In TCM, the kidneys are seen as the root of vitality, growth, and aging. Therefore, maintaining kidney health is considered crucial for longevity, fertility, and general vitality.

The formula is important because it:

  • Supports Vital Energy (Qi) and Longevity: It helps restore core energy reserves that decline with age or chronic illness.
  • Balances Yin and Yang: By restoring warmth and metabolism, it helps balance internal dynamics that influence overall systemic health.
  • Addresses Common Age-Related Disorders: It is often used for chronic fatigue, hypothyroidism-like symptoms, low libido, urinary incontinence, edema, and certain forms of arthritis or cold-type pain.
  • Serves as a Foundation Formula: Many later TCM prescriptions are derived from or based on Jin Gui Shen Qi Wan, highlighting its foundational role in herbal medicine.

Considerations

While Jin Gui Shen Qi Wan is widely regarded as safe when used appropriately, several important considerations should be kept in mind:

  • Individual Diagnosis Is Essential: The formula should only be used under the guidance of a qualified TCM practitioner. It is suitable for Kidney Yang Deficiency, but may worsen conditions caused by excess heat or Yin deficiency without cold.
  • Possible Side Effects: Because it contains warming herbs like Fu Zi (which can be toxic in raw form if not properly prepared), improper use can cause symptoms such as dry mouth, irritability, or overheating sensations.
  • Contraindications: It should not be used by individuals with fever, inflammation, or excessive internal heat conditions. Pregnant women should use it with caution and professional guidance.
  • Medication Interactions: Caution is advised when combining it with other stimulants, thyroid medications, or blood pressure drugs, as the warming and activating properties may enhance certain physiological effects.
  • Long-Term Use: Chronic administration should be periodically reviewed by a practitioner to ensure balance and prevent overstimulation of Yang energy.

Helps with these conditions

Jin Gui Shen Qi Wan is most effective for general wellness support with emerging research . The effectiveness varies by condition based on clinical evidence and user experiences.

Erectile Dysfunction 0% effective
Prostate Enlargement 0% effective
Low Testosterone 0% effective
Adrenal Insufficiency 0% effective
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Detailed Information by Condition

TCM rationale (pattern-based):Jin Gui Shen Qi Wan is a classic formula that “warms and tonifies Kidney-Yang.” In TCM, a subset of erectile dysfunction...

0 votes Updated 1 month ago 3 studies cited

Classical indication: JGSQW is a yang-warming, water-metabolism formula. In TCM it “warms Kidney yang, assists Qi transformation, and promotes urinati...

0 votes Updated 1 month ago 4 studies cited

Low Testosterone

0% effective

Traditional (TCM/Kampo) rationale.Jin Gui Shen Qi Wan is a classic “warm Yang & tonify Kidney” formula. In TCM theory, symptoms that often travel...

0 votes Updated 1 month ago 3 studies cited

TCM rationale. In Traditional Chinese Medicine, adrenal insufficiency symptoms map loosely onto “Kidney Yang deficiency.” Jin Gui Shen Qi Wan is a cla...

0 votes Updated 1 month ago 4 studies cited

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