Juan Bi Tang
Specifically for Rheumatoid Osteoarthritis
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Why it works for Rheumatoid Osteoarthritis:
TCM pattern & actions. JBT is classically used for wind-cold-damp “Bi” pain with joint stiffness and heaviness; it “dispels wind-damp, warms the channels, moves qi & blood, and relieves pain.” Ingredient lists and indications are detailed in standard materia medica references. American Dragon
Preclinical anti-RA effects. In collagen-induced arthritis and TNF-transgenic mouse models, JBT reduced synovial inflammation and bone destruction (lower arthritis scores, less pannus). Proposed pathways include suppression of pro-inflammatory cytokines and matrix metalloproteinases. Frontiers
Systems-pharmacology work. Integrated metabolomics/network pharmacology links absorbed JBT compounds to MAPK/FoxO/Rap1 and immune/metabolic pathways relevant to RA; these studies help explain multi-target anti-inflammatory effects. Read by QxMD
How to use for Rheumatoid Osteoarthritis:
1) Make sure the pattern fits (key TCM step). JBT is for cold-damp Bi with stiffness that improves with warmth/movement; it’s contraindicated in damp-heat presentations (hot, red, swollen, worse with heat). Work with a licensed TCM practitioner for pattern confirmation and modifications. American Dragon
2) Typical compositions & dosing used in studies
- A commonly used modern granule composition includes (per batch, raw-herb equivalents): Angelica sinensis, Paeonia rubra, Astragalus, Curcuma longa, Notopterygium (Qiang Huo), Saposhnikovia (Fang Feng), fresh ginger, jujube, prepared licorice, etc. Frontiers
- Study dosing examples (for reference, not individualized advice):
- Granules: 3 g three times daily for 4 weeks (randomized crossover protocol in dialysis-related myofascial pain; gives a reasonable benchmark for granule use). Frontiers
- Juan Bi Pill (patent form) + methotrexate for active RA: 4 g twice daily for 12 weeks (with follow-ups to 48 weeks) in a multicentre double-blind RCT. SpringerLink
3) How it’s taken. Most modern products are GMP granules or pills taken orally with warm water; decoctions can be prescribed and adjusted by a practitioner. (Formula actions/ingredients and clinical manifestations listed here for clinician reference.) American Dragon
4) Do not replace RA standard of care. If you have RA, JBT—when used—should be adjunctive to DMARDs (e.g., methotrexate) under rheumatology care; do not stop prescribed RA medicines without your doctor’s guidance. The highest-quality trial to date tested JBP added to methotrexate, not as monotherapy. SpringerLink
Scientific Evidence for Rheumatoid Osteoarthritis:
Rheumatoid arthritis (human data)
- 48-week multicentre RCT (double-blind, placebo-controlled) – Juan Bi Pill + methotrexate vs. placebo + methotrexate in active RA (n≈115). Dosing: 4 g BID for 12 weeks with assessments to week 48. Results: greater improvements in DAS28 (ESR/CRP), higher ACR20/50 response, and no between-group difference in adverse events. Trial registered NCT02885597. SpringerLink
Mechanistic/animal data
- Mouse/rat RA models: JBT reduced synovial inflammation and bone damage in CIA and TNF-Tg mice. Frontiers
- Absorption-target mapping: Identified absorbed JBT compounds and predicted anti-RA targets/pathways (MAPK/FoxO/Rap1). Read by QxMD
Osteoarthritis (OA)
- Evidence is preclinical or network-pharmacology (e.g., modified Juan Bi–type formulas in knee OA models). No large, high-quality RCTs of classic JBT for OA were identified. Treat any OA use as experimental and focused on symptom relief. Cell
Specific Warnings for Rheumatoid Osteoarthritis:
Because JBT is a multi-herb formula, screen for interactions from individual ingredients—especially if you use anticoagulants, have hypertension, are pregnant, or have liver/kidney disease.
- Angelica sinensis (dong quai) – case reports and interaction checkers note increased warfarin effect/bleeding risk; use caution with any blood thinner (warfarin, DOACs, antiplatelets). Hello Pharmacist
- Curcuma longa (turmeric/curcumin) – may have antiplatelet effects; multiple clinical resources flag bleeding risk with anticoagulants/antiplatelets and potential warfarin interaction. Drugs.com
- Glycyrrhiza (licorice, Zhi Gan Cao) – can cause hypertension, hypokalemia, and arrhythmias (pseudo-aldosteronism) with chronic or high-dose use; avoid if you have cardiovascular/kidney issues. NCCIH
- Pregnancy – Dong quai is generally not recommended in pregnancy due to theoretical uterine/bleeding effects. Discuss any herb use with your obstetric team. WebMD
- Pattern mismatch – Traditional sources list damp-heat joint patterns as a contraindication to JBT; wrong-pattern use can aggravate symptoms. American Dragon
- Quality & dosing – Use GMP products; dosing varies by extract strength and brand. Follow the product label or your clinician’s prescription and monitor for side effects (BP changes, edema, bruising/bleeding, LFT abnormalities). (Study-grade granules/pills and dosing shown above.) Frontiers
General Information (All Ailments)
What It Is
- The name Juan Bi Tang translates roughly as “Remove Painful Obstruction Decoction.”
- It is a classical TCM herbal formula originating in the Song dynasty, included in Yang Shi Jia Cang Fang (杨氏家藏方).
- The purpose of the formula is to treat a pattern called “Bi” (痹), particularly Wind-Bi or Wind-Cold-Damp Bi, in which pathogenic wind, cold, or dampness invade the channels/joints and obstruct Qi and Blood flow, causing pain, stiffness, heaviness, numbness, or limited mobility.
- The classic formula consists of a set of herbs (often about 8–11 components, depending on variant) including Qiang Huo (Notopterygium root), Fang Feng (Saposhnikovia root), Dang Gui (Chinese angelica), Bai Shao (white peony root), Huang Qi (Astragalus), Zhi Gan Cao (prepared licorice root), Jiang Huang (turmeric), Sheng Jiang (fresh ginger), etc.
- There is also mention in sources that there are two classical versions of Juan Bi Tang: one (1178) more balanced toward tonification (i.e. replenishing Qi and Blood while dispelling pathogenic factors), and another (1732) more aggressive in dispersing wind/damp in more acute presentations (less focus on tonics).
How It Works (Mechanisms & Actions in TCM Framework and Possible Biomedical Insights)
From a TCM (theoretical) perspective:
- Expel Wind & Dispel Dampness: The formula’s “king” herbs (Qiang Huo, Fang Feng) are considered strong in clearing external wind and damp pathogens from the superficial or joint channels. They help to release the obstruction of pernicious influences.
- Tonify / Support Qi & Blood: Because obstruction of Qi and Blood is central to the Bi pattern, herbs like Huang Qi (Astragalus), Dang Gui, Bai Shao nourish Qi and Blood, allowing the body’s proper (upright) energy to resist and push out the pathogens.
- Promote Circulation, Relieve Pain, Harmonize Ying & Wei: Some herbs (e.g. Jiang Huang, Sheng Jiang, Gan Cao) assist by moving Qi, facilitating blood flow in the channels, harmonizing conflict between nutritive and protective levels, and moderating harsh actions of more dispersing herbs.
- Warm & Disperse Cold (if present): Some ingredients have warming or aromatic properties (e.g. Sheng Jiang, the nature of Qiang Huo) to counteract cold dampness that may be present in the Bi syndrome.
From a more biomedical / integrative (speculative) viewpoint:
- Some of the herbs in the formula have known anti-inflammatory, analgesic, antioxidant, or modulatory properties in modern pharmacology studies (e.g. components of Dang Gui, turmeric, licorice). (However, rigorous clinical trials on Juan Bi Tang as a whole are limited in Western literature.) wellbeing-clinic.uk
- By supporting microcirculation, reducing oxidative stress or local inflammation, theoretically the formula may help to improve tissue perfusion, reduce pain mediators, and assist repair in joint or connective tissues (though evidence is sparse). Some sources mention its use in arthritis, musculoskeletal disorders, chronic pain. wellbeing-clinic.uk
- It is also thought, in some integrative TCM-to-biomedicine interpretations, that “dispersing stagnation” of Qi/Blood correlates to reducing local congestion, improving lymphatic flow, or anti-inflammatory signaling pathways — but these are more speculative connections made by TCM practitioners rather than rigorously proven mechanisms across all contexts.
Why It’s Important (Clinical / Health Significance)
- Addressing Chronic Joint / Musculoskeletal Complaints: In TCM practice, Bi syndromes (joint pain, arthralgia, stiffness) are common, especially in older adults or in climates with cold/damp conditions. Juan Bi Tang is considered a classic go-to formula for chronic joint pain patterns when there is also underlying deficiency (Qi/Blood weakness) involved. acupuncturetoday.com
- Holistic / Balanced Approach: Because Juan Bi Tang not only expels pathogens but also supports the body’s internal strength (Qi and Blood), it is seen as gentler and more sustainable than formulas that only forcefully expel pathogens without tonification. This may reduce the risk of weakening the patient or causing depletion. acupuncturetoday.com
- Complementary to Other Modalities: In integrative settings, it is often used in combination with modalities like acupuncture, cupping, tuina, physical therapy, or exercise to improve outcomes in chronic pain or joint stiffness. Springbank Wellness Clinic
- Versatile Indications: Some sources list its use in conditions such as rheumatoid arthritis, frozen shoulder, sciatica, gout-related joint pain, general body aches associated with “wind-damp” patterns, and other “bi” conditions where pain is worse with damp or cold exposure. Healthlab
- Cultural / Historical Value: As a long-standing TCM formula (dating back to at least the 12th century), it represents centuries of empirical use and tradition, which many TCM practitioners regard as a tested foundation in the craft. meandqi.com
Considerations (Safety, Contraindications, Practical Notes)
Pattern Matching Is Essential: In TCM theory, selecting Juan Bi Tang requires diagnosing the correct pattern. It is not a “one-size-fits-all” joint pain remedy. If the underlying pattern is different (e.g. Wind-Heat Bi, Damp-Heat Bi, Blood stagnation without deficiency, or cold deficiency), another formula may be more appropriate. meandqi.com
Contraindications / Cautions
- Because the formula tonifies Qi and may warm the body, one should use caution if there is internal heat, Yin deficiency, or damp-heat conditions. Some sources warn about using Juan Bi Tang cautiously in cases of Damp-Heat in the channels.
- During pregnancy, nursing, or postpartum periods, care is needed; some sources suggest avoiding or using under supervision.
- In people with liver disease or other chronic organ impairments, herbal therapy always demands more careful oversight and monitoring. Some vendors note (in their disclaimers) that people with liver disease use Juan Bi Tang with caution.
- Herbal-drug interactions: Because some herbs may influence metabolism (e.g. cytochrome P450 systems), coagulation, or immune function, concomitant use of pharmaceuticals (anti-inflammatories, anticoagulants, immunosuppressants) requires caution. I did not find a robust, well-established list of interactions specific to Juan Bi Tang, but standard herb–drug vigilance applies.
Quality, Purity, Source Matters: As with many herbal formulas, the efficacy and safety depend heavily on correct species identification, proper processing, absence of contaminants (heavy metals, pesticides, adulterants). Always use high-quality, standardized herbal products from reputable suppliers, ideally under TCM practitioner guidance. Treasure of the East
Dosage & Duration: The dosage can vary depending on the formulation (decoction, granules, capsules). For example, one source states that in capsule form the usual dose is 4 capsules, 2–3 times daily; or 4.5 g in decocted granule form, 2–3 times per day. Treasure of the East
- It is rarely intended for indefinite use; often treatments are given in courses (several weeks to months), with periodic reassessment of symptoms and underlying pattern shifts.
Monitoring & Adjustment: Because the body’s condition changes, a formula may require modification (adding/subtracting herbs) to respond to evolving symptoms (e.g. heat signs appearing, worsening deficiency, etc.). A TCM practitioner often tailors Juan Bi Tang per individual case.
Not a Substitute for Conventional Care (When Needed): In cases of severe joint destruction, infections, autoimmune flares, or when biomedical interventions are indicated (e.g. surgery, immunosuppressants), Juan Bi Tang is an adjunct rather than a standalone replacement.
Possible Side Effects: Although generally regarded as safe when properly used, some individuals might experience digestive upset, allergic reactions, or herb-related idiosyncratic responses. Monitoring is prudent, particularly when starting the formula.
Helps with these conditions
Juan Bi Tang is most effective for general wellness support with emerging research . The effectiveness varies by condition based on clinical evidence and user experiences.
Detailed Information by Condition
Tendonitis
Juan Bi Tang (蠲痺湯, “Remove Painful Obstruction Decoction”) is a classic Chinese herbal formula used in TCM for “wind-cold-damp bi” patterns—aching/...
Carpal Tunnel Syndrome
Pattern fit: In Traditional Chinese Medicine, many wrist/hand pain presentations that resemble CTS are classified as “Bi” (painful obstruction) with W...
Rheumatoid Osteoarthritis
TCM pattern & actions. JBT is classically used for wind-cold-damp “Bi” pain with joint stiffness and heaviness; it “dispels wind-damp, warms the c...
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