Gotu Kola
Specifically for Brain Fog
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Why it works for Brain Fog:
Antioxidant & mitochondrial support. In animals, water extracts of Centella activate the Nrf2 antioxidant pathway, improve mitochondrial function, and enhance cognition; blocking Nrf2 prevents these benefits, implying a mechanistic link. Frontiers
Synaptic plasticity & neurotrophins. Preclinical work reports increases in synaptic proteins and BDNF and improved hippocampal plasticity, which are plausibly relevant to attention and working memory. Taylor & Francis Online
Human “target-engagement” signals. A Phase I program in older adults (MCI/very mild Alzheimer’s) is testing a standardized water extract for effects on oxidative stress and brain mitochondrial activity—aimed at the biological mechanisms above. ctv.veeva.com
How to use for Brain Fog:
Standardized triterpene extracts (TECA/TTFCA)
- Typical oral dose: 60–120 mg/day of a titrated extract standardized to asiaticoside/asiatic acid/madecassic acid (often split BID). Drugs.com
Aqueous (water) extracts used in cognition studies
- Small RCTs in healthy older adults used 750 mg/day of Centella extract for 2 months, with acute (1-hour) effects on working memory/attention also reported. Europe PMC
- Phase I PK trials in older adults tested 2 g and 4 g single doses of a standardized water extract to establish bioavailability and plasma levels of key compounds (not efficacy-dosed guidance, but helpful for context). MDPI
How to take & for how long
- Take with food to minimize GI upset. Start at the low end of the applicable range for your product type (e.g., 60 mg/day standardized triterpenes, or ~500–750 mg/day of a water extract), and assess after 2–8 weeks. Stop if no benefit. (Human cognition studies ran ≈8 weeks.) Europe PMC
- Choose third-party–tested products; labels should specify the extract type and standardization (e.g., “titrated extract 40% triterpenes” or a named extract such as ECa 233). Regulatory monographs and drug references emphasize variable product quality. European Medicines Agency (EMA)
Scientific Evidence for Brain Fog:
Randomized, placebo-controlled trial (healthy elderly).
Wattanathorn et al., 2008—28 participants received 250, 500, or 750 mg/day for 2 months. The highest dose improved working memory and event-related potentials; acute (1-hour) improvements in attention/working memory were also reported. (Small sample; exploratory.) Europe PMC
Systematic review & meta-analysis (11 RCTs; mixed populations).
Puttarak et al., 2017, Sci Rep. Centella showed signals for working memory/alertness, but overall cognitive benefits remained inconclusive because of small/heterogeneous trials and combo products. ResearchGate
Phase I clinical pharmacology (older adults with cognitive impairment).
Wright et al., 2022, Antioxidants. Randomized crossover PK/PD trial of a standardized water extract (2 g vs 4 g single doses) documented oral bioavailability of key compounds and explored antioxidant/mitochondrial markers (not powered for clinical efficacy). MDPI
Ongoing/related target-engagement RCTs (older adults with MCI/very mild AD).
Registered, double-blind studies testing whether Centella modulates brain biomarkers of neuronal/mitochondrial function and oxidative stress. Results pending. ctv.veeva.com
Specific Warnings for Brain Fog:
Liver risk (rare but real). Case reports of hepatotoxicity have been published; authoritative drug/tox databases advise caution/avoidance in liver disease and recommend monitoring if used. Europe PMC
Pregnancy/breastfeeding: Avoid oral use (insufficient safety data). Drugs.com
Sedation & surgery: May have sedative effects—stop at least 2 weeks before surgery to avoid additive CNS depression with anesthetics. WebMD
Dermatologic reactions: Contact dermatitis and itch/redness reported with topical use. Drugs.com
Drug interactions: Caution with hepatotoxic drugs, sedatives/CNS depressants, and diuretics (the herb may have mild diuretic effects). WebMD
Regulatory guidance: The EMA herbal monograph lists contraindications, precautions, and adverse effects for Centella herbal products; heed product-specific posology and warnings. European Medicines Agency (EMA)
General Information (All Ailments)
What It Is
Gotu Kola, scientifically known as Centella asiatica, is a perennial herb native to Asia, particularly India, China, and Indonesia. It has been a cornerstone of traditional medicine systems such as Ayurveda, Traditional Chinese Medicine (TCM), and Indonesian jamu for centuries. Often referred to as the “herb of longevity,” Gotu Kola is part of the parsley family and is known for its small green leaves and delicate taste. It’s commonly consumed as a supplement, tea, extract, or topical preparation.
Gotu Kola is not to be confused with kola nut; unlike the latter, it contains no caffeine. Its primary active constituents are triterpenoids—notably asiaticoside, madecassoside, and asiatic acid—which are responsible for most of its therapeutic properties.
How It Works
Gotu Kola works primarily through its influence on circulation, collagen synthesis, and the nervous system.
- Cellular and Vascular Repair: The triterpenoids in Gotu Kola help stimulate fibroblast proliferation and collagen production, aiding in the repair of connective tissues and blood vessels. This action enhances wound healing and strengthens veins and capillaries, making it beneficial for conditions such as varicose veins and venous insufficiency.
- Anti-inflammatory and Antioxidant Effects: Gotu Kola’s compounds exhibit strong antioxidant properties, scavenging free radicals and reducing oxidative stress. This anti-inflammatory action helps protect the brain, skin, and vascular tissues from chronic inflammation-related damage.
- Neurological and Cognitive Support: The herb promotes dendritic and axonal growth, improving neural connectivity and potentially enhancing memory, learning, and mental clarity. Studies suggest it may increase levels of brain-derived neurotrophic factor (BDNF), which supports neuroplasticity and mood balance.
- Anxiolytic and Adaptogenic Properties: Gotu Kola influences the GABAergic system in the brain, which can help reduce anxiety and promote relaxation. Its adaptogenic nature supports the body’s response to physical and emotional stress.
- Skin Health: When used topically or orally, Gotu Kola improves skin elasticity, moisture retention, and wound closure. This makes it popular in dermatology for scars, burns, psoriasis, and anti-aging formulations.
Why It’s Important
Gotu Kola holds significance for both preventive and restorative health due to its wide-ranging physiological benefits:
- Cognitive Function and Mental Health: It has been studied for its ability to improve memory, reduce anxiety, and alleviate symptoms of depression—making it potentially useful in managing cognitive decline, ADHD, and mild mood disorders.
- Circulatory and Cardiovascular Health: By improving blood flow and strengthening veins, Gotu Kola is valuable for individuals with chronic venous insufficiency, varicose veins, and peripheral edema. Enhanced microcirculation can also support tissue regeneration and skin repair.
- Longevity and Vitality: Traditional systems revere it as a rasayana (rejuvenative tonic) that promotes longevity, vitality, and clarity of mind. Modern science supports its role in maintaining healthy cell regeneration and combating oxidative aging.
- Skin Repair and Aesthetic Applications: It has gained popularity in modern skincare for its ability to improve collagen synthesis, support wound healing, and reduce the appearance of scars and stretch marks.
Considerations
While Gotu Kola is generally considered safe, certain factors should be kept in mind:
Dosage and Form:
- Typical oral doses range from 300–600 mg of standardized extract per day. However, the concentration of active triterpenoids can vary across brands, so medical guidance is recommended before long-term use.
Side Effects:
- In high doses or with prolonged use, Gotu Kola may cause headache, dizziness, nausea, or skin sensitivity. Topical use can occasionally lead to allergic reactions.
Precautions:
- Pregnancy and Breastfeeding: Not enough evidence exists for safety; it’s best avoided.
- Liver Health: Rare cases of hepatotoxicity have been reported, particularly with excessive use.
- Medication Interactions: It may potentiate the effects of sedatives, anxiolytics, or diuretics, and theoretically interact with liver-metabolized drugs.
- Sun Sensitivity: Some users experience increased photosensitivity; sunscreen use is advisable when taking Gotu Kola regularly.
Quality and Source:
- Since herbal supplements vary in purity and potency, it’s important to choose products standardized to known levels of asiaticoside or madecassoside, preferably from reputable brands that undergo third-party testing.
Helps with these conditions
Gotu Kola is most effective for general wellness support with emerging research . The effectiveness varies by condition based on clinical evidence and user experiences.
Detailed Information by Condition
Poor Circulation
Microcirculation & edema: Standardized Centella extracts (TECA/TTFCA) have repeatedly been shown to improve objective microcirculatory markers in...
Varicose Veins
Improves microcirculation & reduces capillary leakage. Standardized triterpene extracts (TECA/TTFCA) have repeatedly been shown to lower abnormall...
Minor Burns
Speeds tissue repair: The plant’s triterpenes—asiaticoside and madecassoside (and their acids)—stimulate fibroblasts, collagen synthesis (type I), ang...
Brain Fog
Antioxidant & mitochondrial support. In animals, water extracts of Centella activate the Nrf2 antioxidant pathway, improve mitochondrial function,...
Lichen Sclerosus
LS involves chronic inflammation and fibrosis of vulvar/perineal skin; T-helper-1 cytokines and TGF-β–driven fibroblast activation are implicated in s...
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Helps With These Conditions
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