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Gotu Kola

herb Verified

Specifically for Lichen Sclerosus

0% effective
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Why it works for Lichen Sclerosus:

LS involves chronic inflammation and fibrosis of vulvar/perineal skin; T-helper-1 cytokines and TGF-β–driven fibroblast activation are implicated in scarring. Frontiers

Gotu kola’s main triterpenes (asiaticoside, madecassoside, asiatic/madecassic acids) show wound-healing, anti-inflammatory and pro-/anti-fibrotic modulation in preclinical and dermatology contexts (e.g., keloid/hypertrophic-scar models; post-procedure healing). Proposed actions include modulating TGF-β/Smad signaling, influencing collagen balance, and antioxidant effects. MDPI

How to use for Lichen Sclerosus:

Crucial context: International LS guidelines still recommend ultra-potent topical corticosteroids (e.g., clobetasol 0.05%) as first-line therapy. Do not replace them with gotu kola; consider Centella only as a cosmetic/adjunct emollient for comfort or barrier support. Wiley Online Library+1

If you want to try an adjunctive Centella product:

Choose the right form

  • Look for fragrance-free creams/balms marketed for post-procedure or sensitive-skin care that list madecassoside or Centella asiatica extract. Evidence for skin recovery exists in post-laser and scar-care settings (not LS). Europe PMC

Where to apply

  • Apply externally to keratinised skin only (outer vulva/perineal skin). Avoid mucosal/internal application unless a healthcare professional confirms a product is safe for that area. (This aligns with general contact-dermatitis precautions and the lack of vulvar-mucosal data for Centella products.) DermNet®

When & how often

  • Use after your prescribed steroid has absorbed (e.g., 20–30 min later) to minimise dilution. Start once daily, increase to twice daily if well tolerated for moisturising/barrier support on non-steroid nights during maintenance. (This is a pragmatic regimen consistent with guideline-based steroid use and standard emollient layering.) Wiley Online Library

Patch-test first

  • Test a pea-sized amount on a less sensitive area for 24–48 h; discontinue if burning, worsening itch, or rash occurs (Centella can rarely cause allergic contact dermatitis). Core

Oral gotu kola

  • There is no clinical evidence that oral Centella helps LS. Because Centella has rare but documented hepatotoxicity, don’t start oral supplements for LS without clinician approval, especially if you have liver disease or take hepatically-metabolised drugs. Europe PMC

Scientific Evidence for Lichen Sclerosus:

Direct LS trials with gotu kola: None found. No randomized trials, cohorts, or even case reports demonstrating efficacy of Centella for LS specifically. (Comprehensive literature checks show LS is treated with steroids; Centella evidence is in other dermatologic contexts.) Wiley Online Library

Indirect dermatology evidence (not LS):

  • Post-laser wound care: Split-face randomized trial of a madecassoside + panthenol + mineral cream improved post-resurfacing healing vs control. Europe PMC
  • Scar modulation: Randomized/controlled studies and reviews suggest Centella-based creams may aid hypertrophic-scar quality and pigmentation after surgery/skin graft donor sites. Wiley Online Library
  • Mechanistic/bench data: Multiple studies show Centella compounds modulate collagen and TGF-β/Smad pathways relevant to fibrosis. SpringerLink
Specific Warnings for Lichen Sclerosus:

Do not replace guideline therapy. LS is managed long-term with ultra-potent topical corticosteroids, monitoring, and cancer-risk surveillance. Inadequate treatment risks scarring and architectural change. Wiley Online Library

Allergic/irritant reactions: Centella (and products containing it) can trigger allergic contact dermatitis—watch for new redness, burning, or rash; stop and seek care if this occurs. Core

Liver safety (oral forms): Rare but real hepatotoxicity has been reported; avoid oral Centella if you have liver disease, drink heavily, or take other hepatotoxic meds; discuss with your clinician first. Europe PMC

Pregnancy & breastfeeding: Safety data are limited—generally avoid oral use; topical use should still be discussed with your obstetric provider. European Medicines Agency (EMA)

Drug/supplement interactions: Use caution with medications that affect the liver, sedatives, diuretics, and others; consult a pharmacist/clinician. (General interaction cautions are noted in consumer-health monographs.) MedicineNet

General Information (All Ailments)

Note: You are viewing ailment-specific information above. This section shows the general remedy information for all conditions.

What It Is

Gotu Kola, scientifically known as Centella asiatica, is a perennial herb native to Asia, particularly India, China, and Indonesia. It has been a cornerstone of traditional medicine systems such as Ayurveda, Traditional Chinese Medicine (TCM), and Indonesian jamu for centuries. Often referred to as the “herb of longevity,” Gotu Kola is part of the parsley family and is known for its small green leaves and delicate taste. It’s commonly consumed as a supplement, tea, extract, or topical preparation.

Gotu Kola is not to be confused with kola nut; unlike the latter, it contains no caffeine. Its primary active constituents are triterpenoids—notably asiaticoside, madecassoside, and asiatic acid—which are responsible for most of its therapeutic properties.

How It Works

Gotu Kola works primarily through its influence on circulation, collagen synthesis, and the nervous system.

  • Cellular and Vascular Repair: The triterpenoids in Gotu Kola help stimulate fibroblast proliferation and collagen production, aiding in the repair of connective tissues and blood vessels. This action enhances wound healing and strengthens veins and capillaries, making it beneficial for conditions such as varicose veins and venous insufficiency.
  • Anti-inflammatory and Antioxidant Effects: Gotu Kola’s compounds exhibit strong antioxidant properties, scavenging free radicals and reducing oxidative stress. This anti-inflammatory action helps protect the brain, skin, and vascular tissues from chronic inflammation-related damage.
  • Neurological and Cognitive Support: The herb promotes dendritic and axonal growth, improving neural connectivity and potentially enhancing memory, learning, and mental clarity. Studies suggest it may increase levels of brain-derived neurotrophic factor (BDNF), which supports neuroplasticity and mood balance.
  • Anxiolytic and Adaptogenic Properties: Gotu Kola influences the GABAergic system in the brain, which can help reduce anxiety and promote relaxation. Its adaptogenic nature supports the body’s response to physical and emotional stress.
  • Skin Health: When used topically or orally, Gotu Kola improves skin elasticity, moisture retention, and wound closure. This makes it popular in dermatology for scars, burns, psoriasis, and anti-aging formulations.

Why It’s Important

Gotu Kola holds significance for both preventive and restorative health due to its wide-ranging physiological benefits:

  • Cognitive Function and Mental Health: It has been studied for its ability to improve memory, reduce anxiety, and alleviate symptoms of depression—making it potentially useful in managing cognitive decline, ADHD, and mild mood disorders.
  • Circulatory and Cardiovascular Health: By improving blood flow and strengthening veins, Gotu Kola is valuable for individuals with chronic venous insufficiency, varicose veins, and peripheral edema. Enhanced microcirculation can also support tissue regeneration and skin repair.
  • Longevity and Vitality: Traditional systems revere it as a rasayana (rejuvenative tonic) that promotes longevity, vitality, and clarity of mind. Modern science supports its role in maintaining healthy cell regeneration and combating oxidative aging.
  • Skin Repair and Aesthetic Applications: It has gained popularity in modern skincare for its ability to improve collagen synthesis, support wound healing, and reduce the appearance of scars and stretch marks.

Considerations

While Gotu Kola is generally considered safe, certain factors should be kept in mind:

Dosage and Form:

  • Typical oral doses range from 300–600 mg of standardized extract per day. However, the concentration of active triterpenoids can vary across brands, so medical guidance is recommended before long-term use.

Side Effects:

  • In high doses or with prolonged use, Gotu Kola may cause headache, dizziness, nausea, or skin sensitivity. Topical use can occasionally lead to allergic reactions.

Precautions:

  • Pregnancy and Breastfeeding: Not enough evidence exists for safety; it’s best avoided.
  • Liver Health: Rare cases of hepatotoxicity have been reported, particularly with excessive use.
  • Medication Interactions: It may potentiate the effects of sedatives, anxiolytics, or diuretics, and theoretically interact with liver-metabolized drugs.
  • Sun Sensitivity: Some users experience increased photosensitivity; sunscreen use is advisable when taking Gotu Kola regularly.

Quality and Source:

  • Since herbal supplements vary in purity and potency, it’s important to choose products standardized to known levels of asiaticoside or madecassoside, preferably from reputable brands that undergo third-party testing.

Helps with these conditions

Gotu Kola is most effective for general wellness support with emerging research . The effectiveness varies by condition based on clinical evidence and user experiences.

Poor Circulation 0% effective
Varicose Veins 0% effective
Minor Burns 0% effective
Brain Fog 0% effective
Lichen Sclerosus 0% effective
5
Conditions
0
Total Votes
24
Studies
0%
Avg. Effectiveness

Detailed Information by Condition

Poor Circulation

0% effective

Microcirculation & edema: Standardized Centella extracts (TECA/TTFCA) have repeatedly been shown to improve objective microcirculatory markers in...

0 votes Updated 1 month ago 5 studies cited

Varicose Veins

0% effective

Improves microcirculation & reduces capillary leakage. Standardized triterpene extracts (TECA/TTFCA) have repeatedly been shown to lower abnormall...

0 votes Updated 1 month ago 5 studies cited

Minor Burns

0% effective

Speeds tissue repair: The plant’s triterpenes—asiaticoside and madecassoside (and their acids)—stimulate fibroblasts, collagen synthesis (type I), ang...

0 votes Updated 1 month ago 6 studies cited

Brain Fog

0% effective

Antioxidant & mitochondrial support. In animals, water extracts of Centella activate the Nrf2 antioxidant pathway, improve mitochondrial function,...

0 votes Updated 1 month ago 4 studies cited

Lichen Sclerosus

0% effective

LS involves chronic inflammation and fibrosis of vulvar/perineal skin; T-helper-1 cytokines and TGF-β–driven fibroblast activation are implicated in s...

0 votes Updated 1 month ago 4 studies cited

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