Gotu Kola
Specifically for Varicose Veins
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Why it works for Varicose Veins:
Improves microcirculation & reduces capillary leakage. Standardized triterpene extracts (TECA/TTFCA) have repeatedly been shown to lower abnormally high capillary filtration and ankle swelling in venous hypertension/CVI—key mechanisms behind varicose vein symptoms. SAGE Journals
Supports vein wall/connective tissue. Active triterpenes (asiaticoside, madecassic/asiatic acid) modulate fibroblasts and collagen remodeling in the venous wall, helping venous tone. SAGE Journals
Clinical guidance acknowledges venous use. Regulatory reviews summarize human data and traditional use for venous insufficiency (alongside wound healing). European Medicines Agency (EMA)
How to use for Varicose Veins:
When possible, use a standardized oral extract rather than non-standardized powders/teas. Typical regimens studied:
TTFCA/TECA oral dosing:
- 60 mg twice daily (TTFCA 60 mg b.i.d.) for 8 weeks in patients with severe venous hypertension reduced ankle swelling and capillary filtration vs placebo. Drugs.com
- 60–120 mg/day TECA for 2–3 months improved CVI signs/symptoms compared with placebo in a multicenter, double-blind RCT (n=94). Europe PMC
- Dose-response benefits reported up to 60 mg three times daily in dose-ranging trials. Europe PMC
Form to look for: products labeled “TTFCA,” “TECA,” or Centellase®” with standardized triterpenes (asiaticoside + madecassic/asiatic acids). SAGE Journals
Duration: Most trials ran 8–12 weeks. If helpful and well-tolerated, clinicians sometimes cycle or reassess periodically. (Discuss with your healthcare provider.)
Note: Topical centella is useful for skin/wound support, but the venous/CVI evidence is primarily for oral standardized extracts. European Medicines Agency (EMA)
Scientific Evidence for Varicose Veins:
Systematic review (RCTs) of Centella for CVI: Found improvements in objective microcirculatory measures and symptoms across randomized trials. (Evidence-Based Complementary and Alternative Medicine, 2013). Wiley Online Library
Double-blind RCT, TECA 60 or 120 mg/day vs placebo (n=94, 2 months): Improved CVI signs/symptoms vs placebo. Europe PMC
Randomized, dose-ranging, placebo-controlled trials (TTFCA): Reduced edema and capillary filtration in venous hypertension; effects were dose-related. (Angiology 2001; additional capillaroscopic studies from the same group). SAGE Journals
Monographs/regulatory reviews: European Medicines Agency (EMA) assessment consolidates human data, posology, and safety for Centella products. European Medicines Agency (EMA)
Clinical summary (independent monograph): Describes the 8-week TTFCA 60 mg b.i.d. trial and outcomes on edema and microcirculation. Drugs.com
Specific Warnings for Varicose Veins:
Liver safety: Although uncommon, rare cases of clinically apparent liver injury with jaundice have been reported after gotu kola ingestion; liver tests normalized after stopping and, in one case, injury recurred on re-challenge. Avoid if you have active liver disease; stop and seek care for symptoms of hepatitis (fatigue, dark urine, jaundice). Europe PMC
Drug interactions: Because of the liver signal, use caution with other hepatotoxic drugs (e.g., certain statins, TB meds, high-dose acetaminophen, etc.) and discuss with your clinician. Some references also flag theoretical additive sedation with CNS depressants. hellopharmacist.com
Pregnancy & breastfeeding: Insufficient safety data—most references advise avoiding systemic (oral) use during pregnancy/lactation. WebMD
Allergy/skin reactions: Contact dermatitis and hypersensitivity can occur (more often with topicals). Discontinue if rash or irritation develops. European Medicines Agency (EMA)
General supplement cautions: Choose reputable, third-party tested products; herbal mislabeling or contamination can occur. Regulatory reviews emphasize using authorized medicinal products where available. European Medicines Agency (EMA)
General Information (All Ailments)
What It Is
Gotu Kola, scientifically known as Centella asiatica, is a perennial herb native to Asia, particularly India, China, and Indonesia. It has been a cornerstone of traditional medicine systems such as Ayurveda, Traditional Chinese Medicine (TCM), and Indonesian jamu for centuries. Often referred to as the “herb of longevity,” Gotu Kola is part of the parsley family and is known for its small green leaves and delicate taste. It’s commonly consumed as a supplement, tea, extract, or topical preparation.
Gotu Kola is not to be confused with kola nut; unlike the latter, it contains no caffeine. Its primary active constituents are triterpenoids—notably asiaticoside, madecassoside, and asiatic acid—which are responsible for most of its therapeutic properties.
How It Works
Gotu Kola works primarily through its influence on circulation, collagen synthesis, and the nervous system.
- Cellular and Vascular Repair: The triterpenoids in Gotu Kola help stimulate fibroblast proliferation and collagen production, aiding in the repair of connective tissues and blood vessels. This action enhances wound healing and strengthens veins and capillaries, making it beneficial for conditions such as varicose veins and venous insufficiency.
- Anti-inflammatory and Antioxidant Effects: Gotu Kola’s compounds exhibit strong antioxidant properties, scavenging free radicals and reducing oxidative stress. This anti-inflammatory action helps protect the brain, skin, and vascular tissues from chronic inflammation-related damage.
- Neurological and Cognitive Support: The herb promotes dendritic and axonal growth, improving neural connectivity and potentially enhancing memory, learning, and mental clarity. Studies suggest it may increase levels of brain-derived neurotrophic factor (BDNF), which supports neuroplasticity and mood balance.
- Anxiolytic and Adaptogenic Properties: Gotu Kola influences the GABAergic system in the brain, which can help reduce anxiety and promote relaxation. Its adaptogenic nature supports the body’s response to physical and emotional stress.
- Skin Health: When used topically or orally, Gotu Kola improves skin elasticity, moisture retention, and wound closure. This makes it popular in dermatology for scars, burns, psoriasis, and anti-aging formulations.
Why It’s Important
Gotu Kola holds significance for both preventive and restorative health due to its wide-ranging physiological benefits:
- Cognitive Function and Mental Health: It has been studied for its ability to improve memory, reduce anxiety, and alleviate symptoms of depression—making it potentially useful in managing cognitive decline, ADHD, and mild mood disorders.
- Circulatory and Cardiovascular Health: By improving blood flow and strengthening veins, Gotu Kola is valuable for individuals with chronic venous insufficiency, varicose veins, and peripheral edema. Enhanced microcirculation can also support tissue regeneration and skin repair.
- Longevity and Vitality: Traditional systems revere it as a rasayana (rejuvenative tonic) that promotes longevity, vitality, and clarity of mind. Modern science supports its role in maintaining healthy cell regeneration and combating oxidative aging.
- Skin Repair and Aesthetic Applications: It has gained popularity in modern skincare for its ability to improve collagen synthesis, support wound healing, and reduce the appearance of scars and stretch marks.
Considerations
While Gotu Kola is generally considered safe, certain factors should be kept in mind:
Dosage and Form:
- Typical oral doses range from 300–600 mg of standardized extract per day. However, the concentration of active triterpenoids can vary across brands, so medical guidance is recommended before long-term use.
Side Effects:
- In high doses or with prolonged use, Gotu Kola may cause headache, dizziness, nausea, or skin sensitivity. Topical use can occasionally lead to allergic reactions.
Precautions:
- Pregnancy and Breastfeeding: Not enough evidence exists for safety; it’s best avoided.
- Liver Health: Rare cases of hepatotoxicity have been reported, particularly with excessive use.
- Medication Interactions: It may potentiate the effects of sedatives, anxiolytics, or diuretics, and theoretically interact with liver-metabolized drugs.
- Sun Sensitivity: Some users experience increased photosensitivity; sunscreen use is advisable when taking Gotu Kola regularly.
Quality and Source:
- Since herbal supplements vary in purity and potency, it’s important to choose products standardized to known levels of asiaticoside or madecassoside, preferably from reputable brands that undergo third-party testing.
Helps with these conditions
Gotu Kola is most effective for general wellness support with emerging research . The effectiveness varies by condition based on clinical evidence and user experiences.
Detailed Information by Condition
Poor Circulation
Microcirculation & edema: Standardized Centella extracts (TECA/TTFCA) have repeatedly been shown to improve objective microcirculatory markers in...
Varicose Veins
Improves microcirculation & reduces capillary leakage. Standardized triterpene extracts (TECA/TTFCA) have repeatedly been shown to lower abnormall...
Minor Burns
Speeds tissue repair: The plant’s triterpenes—asiaticoside and madecassoside (and their acids)—stimulate fibroblasts, collagen synthesis (type I), ang...
Brain Fog
Antioxidant & mitochondrial support. In animals, water extracts of Centella activate the Nrf2 antioxidant pathway, improve mitochondrial function,...
Lichen Sclerosus
LS involves chronic inflammation and fibrosis of vulvar/perineal skin; T-helper-1 cytokines and TGF-β–driven fibroblast activation are implicated in s...
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Helps With These Conditions
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