Lemon Balm
Specifically for Hyperthyroidism
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Why it works for Hyperthyroidism:
TSH/TSH-receptor inhibition (lab data): Classic in-vitro studies showed Melissa officinalis extracts can bind to/complex with TSH, preventing it from binding its receptor and blunting cAMP signaling in human thyroid membranes. These extracts also reduced the activity of Graves’ disease autoantibodies at the TSH receptor. Oxford Academic
Regulatory assessment echoes the lab finding: The European Medicines Agency monograph notes that water extract of Melissa leaf may inhibit TSH activity in vitro, while stressing that clinical relevance is unknown. European Medicines Agency (EMA)
Anti-inflammatory/antioxidant effects (indirect): In a 2024 animal model of induced hyperthyroidism, Melissa extract reduced oxidative stress and inflammatory markers while moderating thyroid overactivity—supportive but not definitive for humans. BioMed Central
How to use for Hyperthyroidism:
Common forms & reference doses (adults) from EMA monograph:
- Tea/infusion: 1.5–4.5 g dried, comminuted leaf in ~150 mL boiling water, 1–3× daily. European Medicines Agency (EMA)
- Liquid extract (1:1 in 45–53% ethanol): 2–4 mL, 1–3× daily. European Medicines Agency (EMA)
- Tincture (1:5 in 45–53% ethanol): 2–6 mL, 1–3× daily. European Medicines Agency (EMA)
- Standardized dried extracts/capsules: Use products whose dose equates to the above (labels often specify DER). The EMA lists these preparations but doesn’t endorse a hyperthyroid indication. European Medicines Agency (EMA)
Symptom-focused pairing: Because hyperthyroidism often causes anxiety/insomnia, some clinicians leverage lemon balm’s calming data (separate from thyroid effects) when selecting timing (e.g., afternoon/evening). Evidence for acute calming exists, though not specific to thyroid disease. ClinicalTrials
Monitoring (important):
- If you try lemon balm, check TSH, free T4/T3 within 2–4 weeks of starting or changing dose and coordinate with your endocrinologist so antithyroid drugs can be adjusted if needed. (Rationale: possible antithyroid effect plus sedation potential.) European Medicines Agency (EMA)
Scientific Evidence for Hyperthyroidism:
Mechanistic & preclinical (supportive):
- Endocrinology 1984: Melissa extracts inhibited TSH binding and TSH-stimulated adenylate cyclase in human thyroid membranes. Oxford Academic
- Endocrinology 1985: Plant extracts/oxidized phenolics (related to Melissa/bugleweed) inhibited both receptor binding and biologic activity of Graves’ immunoglobulins. Oxford Academic
- EMA HMPC monograph (2013): notes in-vitro TSH inhibition; clinical relevance unknown. European Medicines Agency (EMA)
- BMC Complementary Medicine & Therapies 2024 (rat model): Melissa extract mitigated hyperthyroid changes and oxidative stress in an induced model. (Animal data; dosage/formulations don’t translate directly to humans.) BioMed Central
Human evidence specific to hyperthyroidism:
- No randomized controlled trials demonstrating that lemon balm treats hyperthyroidism. A recent endocrine meeting abstract discussed folk use and in-vitro data alongside case experiences, but this is not proof of efficacy. Oxford Academic
- Major thyroid organizations do not list lemon balm as an evidence-based therapy; standard care remains antithyroid medications, radioiodine, or surgery.
Specific Warnings for Hyperthyroidism:
Not a substitute for standard care: Uncontrolled hyperthyroidism can cause arrhythmias, bone loss, and thyroid storm. Always continue prescribed therapy unless your physician changes it. (Consensus guidance; see BTF for context.) BTF Thyroid
Thyroid medication interactions (theoretical but plausible): Because Melissa may inhibit TSH signaling and thyroid secretion (lab/animal data), it could potentiate antithyroid drugs or counteract thyroid hormone replacement (e.g., levothyroxine). Space dosing and monitor labs closely if your clinician okays use. Hello Pharmacist
Sedation/CNS depressants: Melissa can be sedating; use caution with other sedatives and avoid driving if drowsy. (Regulatory monograph warning about impairment.) European Medicines Agency (EMA)
Pregnancy & lactation: Safety not established; avoid unless your obstetric provider specifically approves. European Medicines Agency (EMA)
Children <12 y: Not recommended due to lack of data. European Medicines Agency (EMA)
Hypothyroidism: People with underactive thyroid (or those who become euthyroid/hypothyroid during treatment) should generally avoid Melissa unless supervised, because it may further suppress thyroid activity. (Patient-facing guidance reflects this caution.) Paloma Health
General side effects: Usually mild (GI upset, drowsiness), but discontinue and seek care if unusual symptoms occur. Reputable consumer monographs also warn those with thyroid disease to use only with medical advice. WebMD
General Information (All Ailments)
What It Is
Lemon balm is a perennial herb belonging to the mint family (Lamiaceae). Native to the Mediterranean region, it has a mild lemon scent and flavor, which is due to its natural essential oils. In the health context, lemon balm is used both as a herbal remedy and a natural supplement. Its medicinal components—found in the leaves—include rosmarinic acid, citral, citronellal, and eugenol, which give it potent antioxidant, antiviral, antispasmodic, and calming properties. It can be consumed as a tea, tincture, capsule, or essential oil, and is also used in topical preparations for skin and nerve-related conditions.
How It Works
Lemon balm influences both the nervous system and digestive system, acting through multiple biological pathways:
- Neurochemical Effects: Lemon balm enhances the activity of gamma-aminobutyric acid (GABA)—a neurotransmitter that calms brain activity. Its rosmarinic acid content inhibits the enzyme that breaks down GABA, thereby prolonging its calming effect. This mechanism underlies lemon balm’s reputation for reducing anxiety, promoting relaxation, and improving sleep quality.
- Antioxidant and Anti-inflammatory Actions: The phenolic compounds in lemon balm neutralize free radicals and reduce inflammation in body tissues. This helps protect cells from oxidative stress, which contributes to aging and chronic diseases.
- Antiviral and Antibacterial Effects: Lemon balm essential oil has been found to inhibit viral replication, particularly in cases of herpes simplex virus (HSV-1 and HSV-2). Topical applications can shorten the duration of cold sores and reduce recurrence rates. Its antimicrobial activity also helps balance gut flora and reduce digestive discomfort.
- Digestive System Support: Lemon balm relaxes smooth muscles in the digestive tract, alleviating bloating, cramping, and indigestion. It is commonly used to relieve mild gastrointestinal distress linked to stress or nervous tension.
Why It’s Important
Lemon balm holds significance in holistic health for its broad range of gentle yet effective therapeutic benefits:
- Stress and Anxiety Relief: By calming the nervous system and supporting emotional balance, lemon balm helps manage stress, anxiety, and nervous exhaustion without the sedative side effects of stronger medications.
- Sleep Support: Its natural sedative qualities make it effective for treating mild insomnia or restlessness, especially when combined with herbs like valerian root or chamomile.
- Cognitive and Mood Enhancement: Research suggests lemon balm can improve memory, concentration, and mental clarity while simultaneously elevating mood. It’s often used to support cognitive function in older adults.
- Digestive Health: Lemon balm’s carminative (gas-relieving) and antispasmodic properties soothe the stomach and intestines, making it beneficial for conditions like irritable bowel syndrome (IBS) and functional dyspepsia.
- Immune and Skin Health: Due to its antiviral activity, lemon balm is helpful for treating cold sores and supporting immune defense. It can also reduce inflammation and redness in sensitive or irritated skin.
Considerations
While lemon balm is generally considered safe and well-tolerated, there are important precautions and considerations to keep in mind:
- Dosage Awareness: Excessive intake, especially in concentrated supplement form, can cause drowsiness, nausea, or abdominal discomfort. Standardized extracts or teas should be used according to recommended guidelines.
- Thyroid Function: Lemon balm may mildly inhibit thyroid-stimulating hormone (TSH) activity. People with hypothyroidism or those taking thyroid medication should consult a healthcare provider before use.
- Sedative Interaction: Because lemon balm enhances relaxation, it may amplify the effects of sedatives, sleep aids, or alcohol, leading to excessive drowsiness or reduced alertness.
- Pregnancy and Breastfeeding: There is limited evidence on its safety during pregnancy or lactation; therefore, use should be cautious and under medical supervision.
- Allergic Reactions: Rarely, individuals may experience skin irritation from topical applications of lemon balm essential oil or hypersensitivity to its compounds.
Helps with these conditions
Lemon Balm is most effective for general wellness support with emerging research . The effectiveness varies by condition based on clinical evidence and user experiences.
Detailed Information by Condition
Anxiety
GABA system modulation. Lemon balm extracts (especially rosmarinic acid and triterpenes such as ursolic and oleanolic acid) inhibit GABA-transaminase...
Insomnia
Anxiolytic / GABAergic effects. Several lab and animal studies — and reviews of human data — indicate lemon balm’s constituents can modulate the GABAe...
Bipolar Disorder
There is no strong evidence that lemon balm (Melissa officinalis) is an established treatment for bipolar disorder. Clinical research shows lemon balm...
Hyperthyroidism
TSH/TSH-receptor inhibition (lab data): Classic in-vitro studies showed Melissa officinalis extracts can bind to/complex with TSH, preventing it from...
Seasonal Affective Disorder
Lemon balm (Melissa officinalis) has plausible, well-studied anxiolytic, sleep-improving and mild antidepressant actions (mechanisms: GABAergic, choli...
Colic
Antispasmodic on gut smooth muscle. Laboratory work shows lemon-balm preparations relax intestinal smooth muscle (reduced ileal contractility), a plau...
Chickenpox
Lemon balm contains polyphenols (notably rosmarinic acid) and an essential oil with antiviral activity in vitro. It has randomized, placebo-controlled...
Morning Sickness
Calming/anxiolytic effects via GABA: Lemon balm contains rosmarinic, ursolic, and oleanolic acids that can inhibit GABA-transaminase (GABA-T) in vitro...
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Remedy Statistics
Helps With These Conditions
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