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Lemon Balm

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Specifically for Insomnia

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Why it works for Insomnia:

Anxiolytic / GABAergic effects. Several lab and animal studies — and reviews of human data — indicate lemon balm’s constituents can modulate the GABAergic system (GABA is a principal calming neurotransmitter). By enhancing GABA activity or reducing GABA breakdown, lemon balm may reduce anxiety and promote relaxation, which helps people fall asleep and sleep better. graphyonline.com

Active phytochemicals (rosmarinic acid, polyphenols). Rosmarinic acid and related polyphenols in lemon balm have antioxidant, anti-inflammatory and neuromodulatory activity; rosmarinic acid has also been identified as a contributor to acetylcholinesterase inhibition in fractionation studies — actions that can alter central nervous system signalling in ways that favour calm and sleep. ScienceDirect

Indirect route — reduces daytime anxiety / stress. Because anxiety and stress commonly underlie chronic insomnia, lemon-balm’s anxiolytic effects (documented in human trials) likely translate into improved sleep as a downstream effect. graphyonline.com

How to use for Insomnia:

Forms used clinically: herbal tea (infusion), tincture, capsule/extract (standardized extracts or “phytosome” formulations are common in trials).

Common clinical doses used in trials: roughly 300–600 mg daily of lemon balm extract (many studies used 300–500 mg; some used specialized phytosome extracts standardized for rosmarinic acid). When combined formulations are used (e.g., lemon balm + valerian), doses vary. ScienceDirect

Practical, evidence-based guidance:

  • Capsule / standardized extract: many randomized, placebo-controlled studies used ~300–500 mg once daily at bedtime (or divided doses totalling that amount). If using a phytosomal extract (improved bioavailability), studies commonly gave it nightly. Check the product label for standardization (eg. % rosmarinic acid). MDPI
  • Tea (infusion): widely used traditionally. Tea dose is less standardized (harder to quantify active mg). A practical approach used by clinicians: 1 cup (herbal infusion) 30–60 minutes before bed — start with a single cup and observe effects. Note: herbal tea will generally deliver lower and variable amounts of active compounds than a standardized extract. WebMD
  • Tincture: follow manufacturer dosing; tinctures are concentrated and should be dosed conservatively (and avoided if pregnant/breastfeeding unless advised by a clinician). WebMD

Timing: take ~30–60 minutes before bedtime (this matches typical trial timing and the expected onset of sedative/anxiolytic effects). MDPI

Note on combinations: lemon balm is often combined with other calming herbs (valerian, hops, passionflower). Some clinical trials use combinations — that can be effective but makes it harder to know the contribution of lemon balm alone. If you want to test lemon balm specifically, use a single-ingredient standardized extract. ScienceDirect

Scientific Evidence for Insomnia:

Nutrients (2024) — phytosome extract, double-blind, placebo-controlled cross-over: a recent randomized, double-blind, placebo-controlled, cross-over study found that a phytosomal Melissa officinalis extract improved sleep quality in people with mild insomnia symptoms (used nightly; improved objective/subjective sleep measures). This is one of the most recent high-quality human studies. MDPI

Placebo-controlled RCTs in clinical settings: Several trials (including a trial in post-operative patients with capsules containing 500 mg dried leaf) have reported improvements in sleep quality and reductions in anxiety when compared with placebo. (Example trial reporting sleep quality improvement after repeated dosing.) ScienceDirect

Clinical trial registrations / ongoing trials: There are registered randomized controlled trials examining lemon balm supplementation for sleep, stress and mood (trial registry entries are available), indicating active research and interest. ICHGCP

Reviews & mechanistic papers: Reviews of lemon balm and valerian summarize human clinical evidence and mechanisms (GABA modulation, rosmarinic acid activity) supporting anxiolytic and sleep-promoting effects. These reviews synthesize the preclinical and clinical literature and conclude there is suggestive evidence supporting use for mild anxiety/insomnia, though they note heterogeneity of preparations and doses. graphyonline.com

Specific Warnings for Insomnia:

May potentiate sedatives / CNS depressants. Because lemon balm has sedative/anxiolytic effects, it can increase drowsiness if taken with benzodiazepines, sedative antihistamines, alcohol, opioids, certain sleep medications, or other CNS depressants. Use caution and consult a clinician if you take those medicines. WebMD

Thyroid effects — caution with thyroid disease or thyroid medications. Lemon balm contains rosmarinic acid and other constituents that in vitro/in vivo can inhibit thyroid activity (used historically to help hyperthyroidism). People with hypothyroidism, Hashimoto’s, or who take thyroid replacement (levothyroxine etc.) should consult their physician before regular use — lemon balm might alter thyroid function or interfere with therapy. Paloma Health

Pregnancy and breastfeeding. Limited safety data. Many sources advise avoidance of concentrated lemon balm supplements during pregnancy and breastfeeding or only use under specialist advice. Breastfeeding guidance resources recommend caution. Drugs.com

Allergic/contact dermatitis. Rarely, topical or dermal exposure can cause contact dermatitis in sensitive people. MedicineNet

Pediatric use. Children: insufficient high-quality safety data for concentrated extracts — use only with pediatrician advice. WebMD

Quality/standardization risk. Herbal supplements are not uniformly regulated; product potency and purity vary. Look for third-party testing (USP, NSF, ConsumerLab) and products that list standardization (e.g., rosmarinic acid content) if you’re using extracts. Health

Side effects reported (rare / usually mild): nausea, dizziness, sedation (daytime drowsiness), increased appetite, and very rarely hypersensitivity reactions. If you experience excessive sedation or adverse effects, stop and contact a clinician. MedicineNet

General Information (All Ailments)

Note: You are viewing ailment-specific information above. This section shows the general remedy information for all conditions.

What It Is

Lemon balm is a perennial herb belonging to the mint family (Lamiaceae). Native to the Mediterranean region, it has a mild lemon scent and flavor, which is due to its natural essential oils. In the health context, lemon balm is used both as a herbal remedy and a natural supplement. Its medicinal components—found in the leaves—include rosmarinic acid, citral, citronellal, and eugenol, which give it potent antioxidant, antiviral, antispasmodic, and calming properties. It can be consumed as a tea, tincture, capsule, or essential oil, and is also used in topical preparations for skin and nerve-related conditions.

How It Works

Lemon balm influences both the nervous system and digestive system, acting through multiple biological pathways:

  1. Neurochemical Effects: Lemon balm enhances the activity of gamma-aminobutyric acid (GABA)—a neurotransmitter that calms brain activity. Its rosmarinic acid content inhibits the enzyme that breaks down GABA, thereby prolonging its calming effect. This mechanism underlies lemon balm’s reputation for reducing anxiety, promoting relaxation, and improving sleep quality.
  2. Antioxidant and Anti-inflammatory Actions: The phenolic compounds in lemon balm neutralize free radicals and reduce inflammation in body tissues. This helps protect cells from oxidative stress, which contributes to aging and chronic diseases.
  3. Antiviral and Antibacterial Effects: Lemon balm essential oil has been found to inhibit viral replication, particularly in cases of herpes simplex virus (HSV-1 and HSV-2). Topical applications can shorten the duration of cold sores and reduce recurrence rates. Its antimicrobial activity also helps balance gut flora and reduce digestive discomfort.
  4. Digestive System Support: Lemon balm relaxes smooth muscles in the digestive tract, alleviating bloating, cramping, and indigestion. It is commonly used to relieve mild gastrointestinal distress linked to stress or nervous tension.

Why It’s Important

Lemon balm holds significance in holistic health for its broad range of gentle yet effective therapeutic benefits:

  • Stress and Anxiety Relief: By calming the nervous system and supporting emotional balance, lemon balm helps manage stress, anxiety, and nervous exhaustion without the sedative side effects of stronger medications.
  • Sleep Support: Its natural sedative qualities make it effective for treating mild insomnia or restlessness, especially when combined with herbs like valerian root or chamomile.
  • Cognitive and Mood Enhancement: Research suggests lemon balm can improve memory, concentration, and mental clarity while simultaneously elevating mood. It’s often used to support cognitive function in older adults.
  • Digestive Health: Lemon balm’s carminative (gas-relieving) and antispasmodic properties soothe the stomach and intestines, making it beneficial for conditions like irritable bowel syndrome (IBS) and functional dyspepsia.
  • Immune and Skin Health: Due to its antiviral activity, lemon balm is helpful for treating cold sores and supporting immune defense. It can also reduce inflammation and redness in sensitive or irritated skin.

Considerations

While lemon balm is generally considered safe and well-tolerated, there are important precautions and considerations to keep in mind:

  • Dosage Awareness: Excessive intake, especially in concentrated supplement form, can cause drowsiness, nausea, or abdominal discomfort. Standardized extracts or teas should be used according to recommended guidelines.
  • Thyroid Function: Lemon balm may mildly inhibit thyroid-stimulating hormone (TSH) activity. People with hypothyroidism or those taking thyroid medication should consult a healthcare provider before use.
  • Sedative Interaction: Because lemon balm enhances relaxation, it may amplify the effects of sedatives, sleep aids, or alcohol, leading to excessive drowsiness or reduced alertness.
  • Pregnancy and Breastfeeding: There is limited evidence on its safety during pregnancy or lactation; therefore, use should be cautious and under medical supervision.
  • Allergic Reactions: Rarely, individuals may experience skin irritation from topical applications of lemon balm essential oil or hypersensitivity to its compounds.

Helps with these conditions

Lemon Balm is most effective for general wellness support with emerging research . The effectiveness varies by condition based on clinical evidence and user experiences.

Anxiety 0% effective
Insomnia 0% effective
Bipolar Disorder 0% effective
Hyperthyroidism 0% effective
Seasonal Affective Disorder 0% effective
Colic 0% effective
8
Conditions
0
Total Votes
35
Studies
0%
Avg. Effectiveness

Detailed Information by Condition

Anxiety

0% effective

GABA system modulation. Lemon balm extracts (especially rosmarinic acid and triterpenes such as ursolic and oleanolic acid) inhibit GABA-transaminase...

0 votes Updated 2 months ago 4 studies cited

Insomnia

0% effective

Anxiolytic / GABAergic effects. Several lab and animal studies — and reviews of human data — indicate lemon balm’s constituents can modulate the GABAe...

0 votes Updated 2 months ago 4 studies cited

Bipolar Disorder

0% effective

There is no strong evidence that lemon balm (Melissa officinalis) is an established treatment for bipolar disorder. Clinical research shows lemon balm...

0 votes Updated 2 months ago 6 studies cited

Hyperthyroidism

0% effective

TSH/TSH-receptor inhibition (lab data): Classic in-vitro studies showed Melissa officinalis extracts can bind to/complex with TSH, preventing it from...

0 votes Updated 1 month ago 5 studies cited

Lemon balm (Melissa officinalis) has plausible, well-studied anxiolytic, sleep-improving and mild antidepressant actions (mechanisms: GABAergic, choli...

0 votes Updated 2 months ago 7 studies cited

Colic

0% effective

Antispasmodic on gut smooth muscle. Laboratory work shows lemon-balm preparations relax intestinal smooth muscle (reduced ileal contractility), a plau...

0 votes Updated 1 month ago 3 studies cited

Chickenpox

0% effective

Lemon balm contains polyphenols (notably rosmarinic acid) and an essential oil with antiviral activity in vitro. It has randomized, placebo-controlled...

0 votes Updated 1 month ago 3 studies cited

Morning Sickness

0% effective

Calming/anxiolytic effects via GABA: Lemon balm contains rosmarinic, ursolic, and oleanolic acids that can inhibit GABA-transaminase (GABA-T) in vitro...

0 votes Updated 1 month ago 3 studies cited

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