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Manuka Honey

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Specifically for Chronic Sinusitis

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Why it works for Chronic Sinusitis:

Manuka honey contains uniquely high levels of methylglyoxal (MGO), making it particularly effective against sinus infections. MGO has powerful anti-biofilm properties that are especially important in chronic sinusitis treatment. Biofilm-producing bacteria, particularly Staphylococcus aureus and Pseudomonas aeruginosa, are major contributors to chronic rhinosinusitis that persists after sinus surgery. Advancedsinusandallergy PubMed Central

The effectiveness stems from several mechanisms:

  1. Anti-biofilm Activity: MGO demonstrates significant antimicrobial and antibiofilm activity against methicillin-resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa biofilms, which are associated with poor chronic rhinosinusitis disease control following surgery. PubMed
  2. Broad Antimicrobial Spectrum: Manuka honey creates a barrier over infected areas, keeping in moisture while keeping out harmful bacteria, and stimulates cytokine production which regulates immune responses and promotes tissue formation with minimal scarring. Manuka Honey and Sinus Infections
  3. Antibiotic Enhancement: Manuka honey has been shown to increase the effectiveness of antibiotic drugs, specifically increasing the sensitivity of S. aureus to Linezolid. Is honey really good for your sinus infection?: Nadia Caballero, M.D.: Sinus Specialist

How to use for Chronic Sinusitis:

Concentration and Frequency

Clinical studies used 10% (vol/vol) Manuka honey (specifically MEDIHONEY® brand) mixed with saline solution, administered twice daily for 30 days. PubMed Central The University of Washington protocol specifies using 1 tablespoon of Comvita Manuka Honey UMF 15+ in 8 oz (240 mL) of appropriate water. Sinus Rinse with Manuka Honey - Health Online

Step-by-Step Instructions (from University of Washington Medical Center):

  1. Water Preparation: Use distilled water, filtered through 0.2 micron filter, reverse osmosis filtered, commercially bottled water, or tap water that was boiled and cooled. Sinus Rinse with Manuka Honey - Health Online
  2. Mixing: Fill clean bottle with 8 oz water, add NeilMed Sinus Rinse packet (or homemade saline), then add 1 tablespoon of Manuka Honey UMF 15+. Tighten cap and gently swirl to dissolve. Sinus Rinse with Manuka Honey - Health Online
  3. Application: Perform twice daily (morning and night), using half the bottle (120 mL or 4 oz) per nostril, standing over sink with head tilted forward. Sinus Rinse with Manuka Honey - Health Online
  4. Frequency Limitation: It's best not to use Manuka honey sinus irrigation more than once or twice daily, as beneficial immune cells in mucus need to remain to fight infection. Manuka Honey and Sinus Infections

Scientific Evidence for Chronic Sinusitis:

University of Washington RCT (2017): A randomized controlled trial of 42 patients with chronic rhinosinusitis and prior sinus surgery showed that both Manuka honey and saline achieved clinically significant improvement, but culture negativity was statistically better in the subset that received Manuka honey alone without oral antibiotics/steroids. PubMed Central PubMed

Cystic Fibrosis Study (2021): A pilot trial with cystic fibrosis patients showed Manuka honey achieved clinically important differences in quality-of-life scores and significantly better endoscopic outcomes compared to saline, with high tolerability and retention rates. PubMed Central PubMed

In Vivo Safety Study: Sheep sinus irrigation studies demonstrated that MGO concentrations between 0.9 and 1.8 mg/mL are both safe to mucosa and efficacious against S. aureus biofilm. Methylglyoxal-augmented manuka honey as a topical anti-Staphylococcus aureus biofilm agent: safety and efficacy in an in vivo model - PubMed

Phase 1 Clinical Trial: The first randomized, single-blinded, placebo-controlled phase 1 clinical trial investigated 16.5% Manuka honey with augmented MGO (1.3 mg/mL) in recalcitrant chronic rhinosinusitis patients. PubMed ResearchGate

Specific Warnings for Chronic Sinusitis:

Medical Contraindications:

Exclusion criteria in clinical studies included allergy to honey, terminal illness, significant immune dysfunction, severe complications from chronic rhinosinusitis, and presence of sinus tumors. PubMed Central

Specific Safety Warnings:

  1. Allergic Reactions: If you are allergic to bees or bee products, consult with your doctor before use. Signs of allergic reaction may include rashes, hives, itching, swelling, or breathing difficulties. ManukaGuard, Medical Grade Manuka Honey, Sinus Nasal Spray, 0.65 fl oz ( 20 ml)
  2. Temporary Side Effects: You may experience short temporary mild stinging - this is the effect of honey and saline. If stinging continues beyond 4-5 days, discontinue use and seek medical help. New Zealand Honey Co.™iHerb
  3. Blood Sugar Considerations: The sugar content in Manuka honey may raise blood glucose levels in those with diabetes. WebMDMemorial Sloan Kettering Cancer Center
  4. Professional Consultation: Always check with your medical professional before using anything as a topical treatment. Although Manuka honey has antibacterial effects, patients should not self-medicate with honey products - any infection should be examined by a physician. New Zealand Honey Co.™Memorial Sloan Kettering Cancer Center
  5. Product Quality: When purchasing Manuka honey, look for the Unique Manuka Factor (UMF) rating which categorizes MGO content. True Manuka honey comes from New Zealand and Australia, and there are fewer than 100 companies licensed to use the UMF rating system. Is honey really good for your sinus infection?: Nadia Caballero, M.D.: Sinus Specialist
  6. Usage Duration: Use only as needed when symptomatic, with recommended rest periods between extended use. ManukaGuard, Medical Grade Manuka Honey, Sinus Nasal Spray, 0.65 fl oz ( 20 ml)

General Information (All Ailments)

Note: You are viewing ailment-specific information above. This section shows the general remedy information for all conditions.

What It Is

Manuka honey is a specialized type of honey produced by bees that pollinate the Leptospermum scoparium plant, commonly known as the manuka bush, native to New Zealand and parts of Australia. Unlike regular honey, manuka honey possesses unique antibacterial, antiviral, and anti-inflammatory properties that are attributed to a compound called methylglyoxal (MGO).

The potency of manuka honey is measured using the UMF (Unique Manuka Factor) or MGO rating, which reflects its purity, quality, and antibacterial strength. The higher the UMF or MGO number, the stronger the honey’s therapeutic properties.

How It Works

Manuka honey works primarily through its bioactive compounds and natural enzymatic activity:

  • Antibacterial Action: The key compound, methylglyoxal (MGO), directly damages bacterial cell structures, hindering their growth and ability to reproduce. This gives manuka honey effectiveness even against some antibiotic-resistant bacteria such as Staphylococcus aureus (MRSA).
  • Osmotic Effect and pH: Like other honeys, manuka honey has a low water content and high sugar concentration, which draws moisture out of bacterial cells, dehydrating and killing them. Its acidic pH (around 3.5–4.5) further prevents microbial growth.
  • Hydrogen Peroxide Production: Enzymes naturally present in honey produce small amounts of hydrogen peroxide, adding another antibacterial layer, though manuka’s potency primarily stems from its MGO content rather than hydrogen peroxide.
  • Anti-inflammatory and Antioxidant Activity: It helps reduce inflammation and oxidative stress, which supports wound healing and tissue repair.
  • Wound Healing: When applied topically, manuka honey maintains a moist environment that promotes healing while forming a barrier to infection. It also helps remove dead tissue and stimulate new tissue growth.

Why It’s Important

Manuka honey is valued in both traditional and modern medicine for its broad health applications:

  • Wound and Burn Care: Medical-grade manuka honey is used in dressings for burns, ulcers, cuts, and surgical wounds. It accelerates healing, minimizes scarring, and protects against infection.
  • Digestive Health: Consumed orally, it may help soothe the gut lining, balance gut bacteria, and alleviate conditions like acid reflux, gastritis, or IBS.
  • Oral Health: Its antibacterial properties combat gingivitis, plaque, and sore throats while being gentler on teeth than refined sugars.
  • Immunity and Skin Health: Manuka honey is often taken as a natural immune booster, and when applied topically, it can support acne treatment and overall skin repair due to its anti-inflammatory and antimicrobial effects.
  • Antimicrobial Resistance Mitigation: Because it kills bacteria through multiple mechanisms, manuka honey is being studied as a potential aid in fighting antibiotic-resistant infections.

Considerations

While manuka honey offers significant health benefits, there are several important considerations to keep in mind:

  • Quality and Authenticity: Only honey produced from the Leptospermum scoparium plant qualifies as genuine manuka honey. Look for certified UMF or MGO labeling from reputable sources. Counterfeit products are common.
  • Dosage and Use: For general wellness, 1–2 teaspoons per day may suffice. For wound care, medical-grade manuka honey (sterilized and approved for topical use) should be used, not raw or store-bought varieties.
  • Allergies and Side Effects: People allergic to bees or honey should avoid it. Overconsumption can cause digestive discomfort or contribute to high sugar intake.
  • Not Suitable for Infants: Like all honeys, it should never be given to infants under 12 months due to the risk of infant botulism.
  • Cost and Labeling Confusion: Manuka honey tends to be expensive. Verify authenticity through UMF/MGO certification rather than relying on vague “manuka” labeling.
  • Medical Conditions: Diabetics should monitor blood glucose levels when consuming manuka honey, as it still contains natural sugars.

Helps with these conditions

Manuka Honey is most effective for general wellness support with emerging research . The effectiveness varies by condition based on clinical evidence and user experiences.

Stomach Ulcers 0% effective
COVID-19 0% effective
Sleep Apnea 0% effective
Minor Burns 0% effective
Cuts & Scrapes 0% effective
Insect Bites & Stings 0% effective
12
Conditions
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Total Votes
55
Studies
0%
Avg. Effectiveness

Detailed Information by Condition

Stomach Ulcers

0% effective

Manuka honey's efficacy in treating stomach ulcers is attributed to several bioactive compounds:Methylglyoxal (MGO): A potent antibacterial agent that...

0 votes Updated 2 months ago 3 studies cited

COVID-19

0% effective

There are laboratory (in-vitro) studies and mechanistic reasons why Manuka (and honey in general) might have antiviral, anti-inflammatory and symptoma...

0 votes Updated 2 months ago 10 studies cited

Sleep Apnea

0% effective

Manuka honey contains bioactive compounds (notably high methylglyoxal — MGO — plus polyphenols) with antibacterial, anti-inflammatory, antioxidant and...

0 votes Updated 2 months ago 4 studies cited

Minor Burns

0% effective

Antimicrobial action (incl. against some resistant bacteria). Mānuka honey has multiple antibacterial mechanisms: high sugar/osmolarity (draws water o...

0 votes Updated 1 month ago 4 studies cited

Cuts & Scrapes

0% effective

Broad antimicrobial action: Honey’s low pH, high sugar/osmotic effect and enzymatic hydrogen peroxide inhibit microbes; mānuka adds methylglyoxal (MGO...

0 votes Updated 1 month ago 4 studies cited

Antibacterial activity (esp. against skin pathogens). Mānuka’s non-peroxide activity is largely due to methylglyoxal (MGO), plus acidity and high suga...

0 votes Updated 1 month ago 2 studies cited

Chronic Sinusitis

0% effective

Manuka honey contains uniquely high levels of methylglyoxal (MGO), making it particularly effective against sinus infections. MGO has powerful anti-bi...

0 votes Updated 2 months ago 7 studies cited

Laryngitis

0% effective

Soothing/coating + anti-inflammatory effects. Thick, viscous honeys coat irritated mucosa and may dampen throat inflammation and cough reflex, providi...

0 votes Updated 1 month ago 4 studies cited

Whooping Cough

0% effective

Manuka (and other) honey can help soothe and reduce cough symptoms, but there’s no reliable evidence that honey cures whooping cough (pertussis) or re...

0 votes Updated 2 months ago 6 studies cited

Croup

0% effective

Honey can soothe coughs. Multiple RCTs show a bedtime dose of honey reduces cough frequency/severity in children with viral URIs compared with placebo...

0 votes Updated 1 month ago 5 studies cited

Chickenpox

0% effective

Antibacterial & anti-inflammatory effects: Medical-grade honey (including mānuka) lowers wound pH, draws fluid (osmotic effect), and inhibits bact...

0 votes Updated 1 month ago 3 studies cited

Mumps

0% effective

Mumps is a viral illness (a paramyxovirus) with no specific antiviral treatment; care is supportive. CDC and other clinical references emphasize isola...

0 votes Updated 1 month ago 3 studies cited

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