Ginkgo Biloba
Specifically for Erectile Dysfunction
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Why it works for Erectile Dysfunction:
Vasodilation / blood-flow effects. Standardized Ginkgo leaf extracts (e.g., EGb 761) can influence endothelial function and nitric oxide (NO) pathways in blood vessels—mechanisms central to penile erection. Cell/animal and vascular studies report increases in NO bioactivity and vasodilation, which in theory could support erectile function. SpringerLink
Antioxidant and microcirculatory actions. Ginkgo’s flavonoids/terpenes have antioxidant effects and can modulate endothelial enzymes; these are often cited as reasons it might aid vascular conditions that underlie many cases of ED. Frontiers
How to use for Erectile Dysfunction:
Typical studied ranges (for standardized leaf extract, usually 24% flavone glycosides/6% terpene lactones such as EGb 761): total 120–240 mg/day, often split into 2–3 doses with food. Sources note there’s no FDA-approved dosing for any indication; >240 mg/day isn’t advised. Drugs.com
Time to assess: Many supplement monographs suggest several weeks of consistent use are needed before judging benefit; again this is based on non-ED indications. GoodRx
Product quality: Choose standardized products; remember supplements are not prescreened by the FDA for efficacy or purity. NCCIH
Scientific Evidence for Erectile Dysfunction:
AISD randomized controlled trials (adults; mixed sexes):
• Kang et al., 2002—double-blind RCT (n≈37) found no significant benefit of Ginkgo over placebo for antidepressant-induced sexual dysfunction. Europe PMC
• Later reviews echo insufficient or negative findings for Ginkgo in AISD. SpringerLink
Men with ED: There are no robust RCTs showing Ginkgo alone improves erectile function. Some combination studies (Ginkgo plus other nutraceuticals ± PDE-5 inhibitors) report improvements, but combinations prevent attributing benefit to Ginkgo itself and quality varies. Example: a 2022 trial in men with type 2 diabetes tested a combo (alpha-lipoic acid + grape seed + Ginkgo) vs. placebo/avanafil; design doesn’t isolate Ginkgo’s effect. Frontiers
Systematic reviews of herbal ED products: Broad herbal reviews include Ginkgo but consistently conclude evidence is limited/heterogeneous and do not endorse Ginkgo as an effective monotherapy for ED. SpringerLink
Specific Warnings for Erectile Dysfunction:
Bleeding risk / drug interactions. Ginkgo may increase bleeding—especially with warfarin, antiplatelets (e.g., aspirin, clopidogrel), NSAIDs, or certain antidepressants/antiretrovirals. Recent observational and review data continue to flag bleeding-related interactions; national institutes warn accordingly. NCCIH
Surgery & dental procedures. Most medical centers advise stopping Ginkgo before surgery to reduce bleeding risk (typical guidance is about 7 days; some clinicians prefer longer). Follow your surgeon’s instructions. Stanford Medicine
Pregnancy & breastfeeding. Avoid—possible labor/bleeding risks and insufficient safety data. NCCIH
Seizure risk from seeds. Do not ingest raw or roasted Ginkgo seeds (ginkgotoxin is neurotoxic; seizures/coma reported). Stick to standardized leaf extract products only. NCCIH
Common side effects (leaf extract). Headache, GI upset, dizziness; rare allergic reactions. NCCIH
General Information (All Ailments)
What It Is
Ginkgo biloba is an herbal supplement derived from the leaves of the Ginkgo biloba tree, one of the oldest living tree species in the world. Native to China, it has been used in traditional medicine for thousands of years. Today, it is available in various forms such as capsules, tablets, extracts, and teas. The active components of ginkgo include flavonoids and terpenoids, which are known for their potent antioxidant and anti-inflammatory properties.
How It Works
Ginkgo biloba is believed to work primarily through three mechanisms:
- Improved Blood Flow: Ginkgo enhances circulation by dilating blood vessels and reducing blood viscosity, which can increase oxygen and nutrient delivery to tissues—especially in the brain, eyes, and extremities.
- Antioxidant Action: The flavonoids in ginkgo combat oxidative stress by neutralizing free radicals, which may help protect cells and slow age-related decline.
- Neuroprotective Effects: It may improve neuronal function and communication by influencing neurotransmitters such as dopamine and serotonin. Some studies suggest it can support cognitive function and memory, particularly in older adults or those with mild cognitive impairment.
Why It’s Important
Ginkgo biloba is valued for its potential benefits in several health areas:
- Cognitive Health: It is widely studied for supporting memory, focus, and mental clarity, with potential benefits for individuals experiencing cognitive decline or dementia.
- Circulatory Support: By improving blood flow, it may aid in conditions like peripheral artery disease or tinnitus (ringing in the ears) that are related to poor circulation.
- Antioxidant Protection: Its antioxidant capacity can help combat cellular damage associated with aging and environmental stressors.
- Mood and Anxiety Relief: Some evidence indicates that ginkgo may have mild anxiolytic (anti-anxiety) effects by modulating stress-related hormones and neurotransmitters.
Considerations
While ginkgo biloba is generally considered safe when taken at recommended doses, there are important precautions:
- Interactions: Ginkgo may interact with blood thinners (like warfarin or aspirin), increasing the risk of bleeding. It can also interact with antidepressants and certain diabetes medications.
- Side Effects: Possible side effects include headaches, dizziness, upset stomach, or allergic reactions. Rarely, it may cause heart palpitations or gastrointestinal discomfort.
- Dosage and Quality: Standardized extracts (often 24% flavone glycosides and 6% terpene lactones) are typically recommended for consistency and safety. The quality of supplements can vary widely, so reputable brands should be chosen.
- Special Populations: Pregnant or breastfeeding individuals, and those with seizure disorders or bleeding conditions, should avoid ginkgo unless directed by a healthcare professional.
Helps with these conditions
Ginkgo Biloba is most effective for general wellness support with emerging research . The effectiveness varies by condition based on clinical evidence and user experiences.
Detailed Information by Condition
PTSD
Ginkgo’s plausibility for PTSD comes from several biological actions that map onto processes believed to underlie PTSD (neuroinflammation, oxidative s...
Fibromyalgia
Antioxidant / anti-inflammatory effects. Standardized ginkgo extracts (e.g., EGb 761) contain flavone glycosides and terpene lactones that can reduce...
Erectile Dysfunction
Vasodilation / blood-flow effects. Standardized Ginkgo leaf extracts (e.g., EGb 761) can influence endothelial function and nitric oxide (NO) pathways...
Alzheimer's
Proposed mechanisms (based largely on pharmacology and preclinical data) include:Antioxidant & anti-inflammatory effects (flavone glycosides; terp...
Parkinson's
Antioxidant & anti-inflammatory effects. Ginkgo flavonoids and terpene lactones scavenge free radicals and dampen neuroinflammation—mechanisms rel...
Macular Degeneration
Researchers have hypothesized that standardized ginkgo leaf extracts (especially EGb 761) could support retinal health via:Antioxidant/neuroprotective...
Cataracts
Antioxidant & anti-fibrotic actions. Standardized ginkgo extracts (e.g., EGb 761 or LI 1370) contain flavone glycosides and terpene lactones that...
Tinnitus
Blood flow & anti-platelet effects. Ginkgo’s terpene lactones (especially the ginkgolides) antagonize the platelet-activating-factor (PAF) recepto...
Poor Circulation
Vasomodulatory & antioxidant actions. Standardized Ginkgo leaf extracts (e.g., EGb 761) contain ~24% flavone glycosides and ~6% terpene lactones....
Brain Fog
Neurovascular & antioxidant actions. Standardized ginkgo leaf extracts contain ~24% flavone glycosides and ~6% terpene lactones (ginkgolides/bilob...
Vertigo
Improved vestibular compensation & neuroplasticity. Animal and human data suggest EGb 761® can speed the brain’s adaptation after vestibular injur...
Atherosclerosis
Antioxidant & anti-inflammatory actions: Standardized leaf extracts (e.g., EGb 761®) contain flavone glycosides and terpene lactones that can scav...
Vitiligo
Targets mechanisms implicated in vitiligo: Oxidative stress and immune dysregulation contribute to melanocyte loss in vitiligo. Standardized Ginkgo ex...
Glaucoma
Neuroprotection & mitochondrial support. Standardized Ginkgo biloba extract (often EGb 761) contains flavonoids/terpenoids that scavenge free radi...
Meniere’s Disease
Proposed mechanisms: standardized Ginkgo extracts (e.g., EGb 761) have antioxidant, microcirculatory and anti-platelet-activating-factor effects that...
Multiple Sclerosis
Anti-inflammatory / antioxidant actions. Standardized extracts (e.g., EGb 761) reduce pro-inflammatory cytokines in preclinical work and have antioxid...
Peripheral Artery Disease
Antiplatelet/hemorheologic effects. Ginkgo’s terpene lactones (especially ginkgolides A/B) antagonize the platelet-activating factor (PAF) receptor an...
Raynaud’s Disease
Raynaud’s attacks are caused by excessive vasospasm and impaired microcirculation in the digits. Standardized Ginkgo leaf extracts contain flavonoids...
Schizophrenia
Ginkgo biloba (usually as a standardized extract such as EGb-761) has been studied as an adjunct (add-on) therapy to antipsychotics in schizophrenia....
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Helps With These Conditions
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