Hawthorn
Specifically for Arrhythmia
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Why it works for Arrhythmia:
- Plausible mechanisms (but not proven for rhythm control in humans): Standardized hawthorn leaf/flower extracts (especially WS 1442) contain oligomeric procyanidins and flavonoids that in lab and animal work show mild positive inotropy, vasodilation, antioxidant effects, and prolongation of myocardial refractory period—all of which could influence ectopy and rate. These mechanisms are summarized in pharmacology reviews and a benefit–risk review of WS 1442. Drugs.com
- What guidelines say: Major arrhythmia guidelines (e.g., 2022 ESC Ventricular Arrhythmias guideline) do not recommend hawthorn for treating arrhythmias; standard therapy remains antiarrhythmic drugs, catheter ablation, and risk-factor treatment. Oxford Academic
- NCCIH’s bottom line (updated Apr 2025): There isn’t enough evidence to know whether hawthorn helps abnormal heartbeat in people. NCCIH
How to use for Arrhythmia:
There is no guideline-endorsed regimen for arrhythmia. If hawthorn is used at all, it’s usually as an adjunct in chronic heart failure (CHF)—not to treat arrhythmias—and even there, evidence is mixed. Cochrane
Standardized extract & doses used in cardiac trials: Most rigorous studies used WS 1442, standardized to ~17–20% oligomeric procyanidins. Dosing in large CHF trials was 900 mg/day (often divided), for up to 24 months in research settings; smaller CHF studies used 160–900 mg/day for 8–16 weeks. These are research doses, not specific arrhythmia regimens. SpringerLink
Duration/safety window: NCCIH notes there’s no safety data beyond ~16 weeks for many supplements; longer durations in trials were monitored medically. NCCIH
Product quality matters: Use a reputable, standardized product if your clinician approves. Avoid “tejocote root” products—several were found to be adulterated with toxic yellow oleander. NCCIH
Scientific Evidence for Arrhythmia:
Human RCTs directly targeting arrhythmia:
- None demonstrating hawthorn as an effective treatment for arrhythmia. NCCIH explicitly states insufficient evidence for “abnormal heartbeat.” NCCIH
Signals related to rhythm (indirect or exploratory):
- Healthy-volunteer RCT (ECG study): Single 160 mg dose of hawthorn vs placebo in 20 healthy adults measured ECG intervals; this was not a therapeutic arrhythmia study and doesn’t establish benefit. AGRIS
- Real-world observational cohort (Germany, 2024): In >4,000 outpatients, prescription of WS 1442 was associated with lower cumulative incidence of atrial fibrillation/flutter, tachycardia, and other arrhythmias compared with magnesium/potassium (HR ~0.68). This is non-randomized and subject to confounding—useful as hypothesis-generating only. Nature
Cardiac failure trials (not arrhythmia treatment, but often cited):
- SPICE Trial (n=2,681, NYHA II–III CHF): 900 mg/day WS 1442 did not improve the primary composite endpoint vs placebo; exploratory analyses suggested reduced sudden cardiac death in a subgroup with LVEF > 25–35%. This does not prove antiarrhythmic efficacy, but it’s sometimes cited for potential antiarrhythmic properties. Wiley Online Library
- Cochrane review (CHF adjunct): Earlier RCTs showed modest symptom/exercise-tolerance benefits in CHF, but heterogeneity and methodological issues limit certainty; this review did not address arrhythmia treatment. Cochrane
Preclinical data: Multiple animal/isolated-tissue studies suggest antiarrhythmic effects, but translation to clinical arrhythmia care remains unproven. ScienceDirect
Specific Warnings for Arrhythmia:
Insufficient evidence for arrhythmias: “Not enough evidence” per NCCIH; avoid self-treating rhythm problems. NCCIH
Drug interactions (key concerns):
- Digoxin: A controlled study found no pharmacokinetic interaction, but pharmacodynamic interaction remains a concern; hawthorn may also interfere with digoxin immunoassays, causing spurious levels. Use only with clinician monitoring. Europe PMC+2Deep Blue Repositories+2
- Antihypertensives (β-blockers, calcium-channel blockers, ACE inhibitors), nitrates, PDE-5 inhibitors: Potential additive hypotension/vasodilation and heart-rate effects—monitor or avoid combinations without medical oversight. Hancock Health
Adulteration alert: Some “tejocote root” weight-loss products (C. mexicana) were actually yellow oleander, which can cause life-threatening cardiotoxicity—do not use these. NCCIH
Side effects: Dizziness, nausea, GI upset, myalgias reported; one study signaled early risk of heart-failure progression (mechanism unclear; possible drug interactions). NCCIH
Pregnancy/lactation: Insufficient safety data—avoid. NCCIH
Duration: Robust safety data beyond ~16 weeks are limited outside of monitored trials. NCCIH
General Information (All Ailments)
What It Is
Hawthorn is a medicinal plant derived from the berries, leaves, and flowers of shrubs in the Crataegus genus, part of the Rosaceae (rose) family. Native to Europe, North America, and Asia, it has been used for centuries in traditional medicine, especially in Europe and China, for supporting heart and circulatory health. The small red berries, sometimes called “haws,” are the most commonly used part of the plant, though the leaves and flowers also contain beneficial compounds.
Hawthorn contains a variety of bioactive substances, including flavonoids (such as hyperoside, vitexin, and rutin) and oligomeric procyanidins, which are powerful antioxidants known to protect blood vessels and heart tissue.
How It Works
Hawthorn works primarily through its cardiovascular effects, acting on the heart muscle, blood vessels, and circulatory system. Its main mechanisms of action include:
- Improved Blood Flow and Circulation. Hawthorn dilates coronary arteries, which increases blood flow to the heart muscle. This helps deliver more oxygen and nutrients to the heart and may improve cardiac efficiency.
- Enhanced Cardiac Function. The plant’s compounds improve the contractility of the heart (its ability to pump blood effectively) without increasing oxygen demand — a unique property that distinguishes it from synthetic stimulants.
- Reduction of Blood Pressure and Vascular Resistance. Hawthorn has mild vasodilatory and diuretic effects, helping relax blood vessels and lower peripheral resistance, which can contribute to lower blood pressure.
- Antioxidant and Anti-inflammatory Effects. Flavonoids and procyanidins in hawthorn scavenge free radicals, reducing oxidative stress that can damage cardiovascular tissue. This helps protect against atherosclerosis (hardening of the arteries).
- Normalization of Heart Rhythm. Some studies suggest that hawthorn can help stabilize irregular heartbeats (arrhythmias) by modulating calcium and sodium channels in heart cells.
Why It’s Important
Hawthorn is important in health and herbal medicine primarily for its cardioprotective benefits. It is often referred to as a “heart tonic” and used for mild to moderate forms of heart failure, angina, and hypertension. Its value lies in the following:
- Supports Heart Health Naturally: Hawthorn provides gentle, long-term support for heart function, improving endurance and reducing fatigue associated with heart weakness.
- Complementary Use in Cardiovascular Care: It is frequently used alongside conventional medications (under medical supervision) for chronic heart conditions, as it can enhance cardiac efficiency without the side effects of stronger drugs.
- Stress and Anxiety Reduction: By improving blood flow and calming the nervous system, hawthorn may reduce heart palpitations and anxiety linked to stress or nervous tension.
- Preventive Health: Regular use may help maintain vascular elasticity, prevent plaque buildup, and support healthy blood lipid levels, which are key factors in preventing heart disease.
Considerations
While hawthorn is generally well-tolerated, there are important considerations when using it for health purposes:
- Possible Interactions: Hawthorn can interact with prescription medications, particularly those for heart disease such as digoxin, beta-blockers, nitrates, and antihypertensive drugs. It may enhance or alter their effects, so professional guidance is essential.
- Dosage and Form: Hawthorn is available as capsules, tinctures, teas, or extracts. Standardized extracts (often containing 2–3% flavonoids or 18–20% oligomeric procyanidins) are most studied. Effects develop gradually, often requiring 6–12 weeks of consistent use for full benefit.
- Side Effects: Mild side effects can include dizziness, nausea, headache, or gastrointestinal upset. These are usually temporary and dose-related.
- Medical Conditions and Safety: Individuals with severe heart disease, low blood pressure, or arrhythmias should not self-medicate with hawthorn without a doctor’s approval. Pregnant or breastfeeding women should also avoid it due to insufficient safety data.
- Long-term Use: Hawthorn is considered safe for long-term use in moderate doses, but because it influences cardiovascular function, ongoing monitoring is advised if used regularly.
Helps with these conditions
Hawthorn is most effective for general wellness support with emerging research . The effectiveness varies by condition based on clinical evidence and user experiences.
Detailed Information by Condition
High Blood Pressure
Hawthorn contains flavonoids and oligomeric procyanidins that can relax blood vessels (endothelium-dependent, nitric-oxide–mediated vasodilation) and...
High Cholesterol
Researchers think hawthorn could influence several atherosclerosis- and lipid-related pathways:Lipid-lowering actions (mostly preclinical): constituen...
Poor Circulation
Vasodilation & endothelial support. Hawthorn leaf/flower extracts are rich in oligomeric procyanidins and flavonoids that can stimulate nitric-oxi...
Atherosclerosis
Antioxidant + anti-inflammatory actions. Hawthorn extracts are rich in flavonoids and oligomeric procyanidins that can reduce LDL oxidation, scavenge...
Arrhythmia
Plausible mechanisms (but not proven for rhythm control in humans): Standardized hawthorn leaf/flower extracts (especially WS 1442) contain oligomeric...
Peripheral Artery Disease
Hawthorn extracts (especially standardized leaf-and-flower extracts like WS® 1442 and LI 132) have vasodilatory and endothelial effects (eNOS/NO), ant...
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Helps With These Conditions
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