Hawthorn
Specifically for Atherosclerosis
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Why it works for Atherosclerosis:
Antioxidant + anti-inflammatory actions. Hawthorn extracts are rich in flavonoids and oligomeric procyanidins that can reduce LDL oxidation, scavenge reactive oxygen species, and down-regulate inflammatory signaling—key processes in atherogenesis. A 2020 pharmacology review summarizes four principal anti-atherosclerotic mechanisms: lipid-lowering, anti-oxidation, anti-inflammation, and endothelial protection. Frontiers
Endothelial function / nitric oxide (NO). In vitro and small human/animal studies suggest hawthorn can increase NO bioavailability and lower endothelin-1, improving vasodilation—an early target in atherosclerosis. Mechanistic data include eNOS activation leading to NO-mediated vasorelaxation (WS 1442 extract). Frontiers
Lipid effects (mostly preclinical, some small clinical). Animal models and small trials report decreases in total cholesterol and triglycerides; a 2024 meta-analysis of TCM formulas containing hawthorn found lipid-lowering effects versus conventional therapy, though formulas were multi-herb (so not hawthorn alone). Frontiers
How to use for Atherosclerosis:
Standardized extracts & dosing (adults):
• WS 1442 (leaf/flower extract, often standardized to ≈18.75–20% oligomeric procyanidins): total daily doses commonly 160–900 mg/day in divided doses.
• LI 132 (leaf/flower extract, standardized to ≈2.2% flavonoids): used at comparable daily amounts.
National regulators summarize ranges such as 160–900 mg/day for leaf/flower extracts (standardized to 18.75% OPC and/or 2.2% flavonoids). lekovitesirovine.rs
Whole herb alternatives: Dried flower/leaf 1.5–5 g/day or dried fruit 0.6–3.5 g/day are listed in monographs, but clinical trials primarily use standardized extracts. webprod.hc-sc.gc.ca
Duration to assess effect: Allow at least 2 months before judging benefit. webprod.hc-sc.gc.ca
Which condition is it best studied for? Most randomized trials are in chronic heart failure, where hawthorn is used in addition to conventional therapy—not as monotherapy. Evidence in atherosclerosis per se (plaque regression or clinical ASCVD events) is insufficient. Cochrane
General use tips: Take the product exactly per its label; stick to a single, reputable brand with a clearly listed extract (e.g., WS 1442) and standardization. Always review with your clinician/pharmacist, especially to screen drug interactions and duplicate therapies. (Regulatory monographs and NIH guidance discuss standardization and safe use.) lekovitesirovine.rs
Scientific Evidence for Atherosclerosis:
Atherosclerosis outcomes (plaque, ASCVD events):
- No high-quality human RCTs demonstrate that hawthorn reduces atherosclerotic plaque or prevents ASCVD events. NCCIH explicitly notes insufficient evidence for “the buildup of plaque in arteries.” NCCIH
Related cardiovascular domains (supportive but indirect):
- Endothelial function & risk markers (small trials): A randomized, partially blinded pilot trial in overweight adults studied WS 1442 ± Nordic walking for 12 weeks and reported feasibility and assessments of endothelial function and lipids (pilot scale; not powered for hard outcomes). PMU
- Lipid profile (small trials / beverages): An 8-week crossover RCT of a hawthorn fruit extract drink in mild hyperlipidemia assessed lipids and safety; results suggest modest effects but are not definitive for ASCVD outcomes. SAGE Journals
- Mechanistic/bench evidence: Reviews detail inhibition of LDL oxidation and modulation of lipid metabolism enzymes (e.g., ACAT, HMG-CoA reductase) and endothelial NO pathways; these support plausibility but aren’t clinical proof. Frontiers
Heart failure (adjacent indication, not atherosclerosis):
- A Cochrane review of 14 RCTs found hawthorn (often WS 1442) improved heart failure symptoms and some hemodynamic measures when added to standard therapy; however, trials were heterogeneous and not focused on atherosclerosis. Cochrane
- A benefit-risk review of WS 1442 summarizes these trials and mechanistic vascular effects (e.g., NO-mediated vasorelaxation). Again, this is adjacent to, but not evidence for, anti-atherosclerotic clinical outcomes. SpringerLink
Specific Warnings for Atherosclerosis:
Insufficient evidence for atherosclerosis: NIH/NCCIH: not enough evidence for angina, arrhythmia, or plaque buildup. Use only as an adjunct after discussing with your clinician. NCCIH
Drug interactions (most practical concerns):
• Cardiac glycosides / digoxin: Health Canada advises consult your clinician if taking digoxin (possible interaction and lab interference); case reports exist of falsely elevated digoxin levels with tejocote (C. mexicana) exposure. webprod.hc-sc.gc.ca
• Blood-pressure medicines: Health Canada advises caution if you’re on antihypertensives—blood pressure may drop more than expected. webprod.hc-sc.gc.ca
• Other CV drugs: Large authoritative monographs note few well-documented interactions, but prudence is warranted with beta-blockers, nitrates, and antiarrhythmics given overlapping effects; coordinate with your prescriber. Drugs.com
Adulteration alert (serious): The FDA (Jan 2024) warned of “tejocote root” supplements adulterated with yellow oleander, a cardiotoxic plant that can be fatal. Buy only from trusted sources; avoid products marketed as weight-loss “tejocote root.” (NCCIH summarizes this warning and links to FDA). NCCIH
Side effects: Usually mild—dizziness, nausea, GI upset, headache, palpitations—but discontinue and seek care if symptoms are concerning. Long-term safety beyond ~16 weeks isn’t well studied. NCCIH
Pregnancy & breastfeeding: Insufficient safety data—avoid unless your obstetric clinician specifically recommends otherwise. Drugs.com
Product quality & standardization: Choose products that clearly state species, plant part (leaf/flower vs fruit), extract type, drug-extract ratio, and standardization (e.g., 18.75–20% OPC). EU HMPC and national monographs outline acceptable preparations. European Medicines Agency (EMA)
General Information (All Ailments)
What It Is
Hawthorn is a medicinal plant derived from the berries, leaves, and flowers of shrubs in the Crataegus genus, part of the Rosaceae (rose) family. Native to Europe, North America, and Asia, it has been used for centuries in traditional medicine, especially in Europe and China, for supporting heart and circulatory health. The small red berries, sometimes called “haws,” are the most commonly used part of the plant, though the leaves and flowers also contain beneficial compounds.
Hawthorn contains a variety of bioactive substances, including flavonoids (such as hyperoside, vitexin, and rutin) and oligomeric procyanidins, which are powerful antioxidants known to protect blood vessels and heart tissue.
How It Works
Hawthorn works primarily through its cardiovascular effects, acting on the heart muscle, blood vessels, and circulatory system. Its main mechanisms of action include:
- Improved Blood Flow and Circulation. Hawthorn dilates coronary arteries, which increases blood flow to the heart muscle. This helps deliver more oxygen and nutrients to the heart and may improve cardiac efficiency.
- Enhanced Cardiac Function. The plant’s compounds improve the contractility of the heart (its ability to pump blood effectively) without increasing oxygen demand — a unique property that distinguishes it from synthetic stimulants.
- Reduction of Blood Pressure and Vascular Resistance. Hawthorn has mild vasodilatory and diuretic effects, helping relax blood vessels and lower peripheral resistance, which can contribute to lower blood pressure.
- Antioxidant and Anti-inflammatory Effects. Flavonoids and procyanidins in hawthorn scavenge free radicals, reducing oxidative stress that can damage cardiovascular tissue. This helps protect against atherosclerosis (hardening of the arteries).
- Normalization of Heart Rhythm. Some studies suggest that hawthorn can help stabilize irregular heartbeats (arrhythmias) by modulating calcium and sodium channels in heart cells.
Why It’s Important
Hawthorn is important in health and herbal medicine primarily for its cardioprotective benefits. It is often referred to as a “heart tonic” and used for mild to moderate forms of heart failure, angina, and hypertension. Its value lies in the following:
- Supports Heart Health Naturally: Hawthorn provides gentle, long-term support for heart function, improving endurance and reducing fatigue associated with heart weakness.
- Complementary Use in Cardiovascular Care: It is frequently used alongside conventional medications (under medical supervision) for chronic heart conditions, as it can enhance cardiac efficiency without the side effects of stronger drugs.
- Stress and Anxiety Reduction: By improving blood flow and calming the nervous system, hawthorn may reduce heart palpitations and anxiety linked to stress or nervous tension.
- Preventive Health: Regular use may help maintain vascular elasticity, prevent plaque buildup, and support healthy blood lipid levels, which are key factors in preventing heart disease.
Considerations
While hawthorn is generally well-tolerated, there are important considerations when using it for health purposes:
- Possible Interactions: Hawthorn can interact with prescription medications, particularly those for heart disease such as digoxin, beta-blockers, nitrates, and antihypertensive drugs. It may enhance or alter their effects, so professional guidance is essential.
- Dosage and Form: Hawthorn is available as capsules, tinctures, teas, or extracts. Standardized extracts (often containing 2–3% flavonoids or 18–20% oligomeric procyanidins) are most studied. Effects develop gradually, often requiring 6–12 weeks of consistent use for full benefit.
- Side Effects: Mild side effects can include dizziness, nausea, headache, or gastrointestinal upset. These are usually temporary and dose-related.
- Medical Conditions and Safety: Individuals with severe heart disease, low blood pressure, or arrhythmias should not self-medicate with hawthorn without a doctor’s approval. Pregnant or breastfeeding women should also avoid it due to insufficient safety data.
- Long-term Use: Hawthorn is considered safe for long-term use in moderate doses, but because it influences cardiovascular function, ongoing monitoring is advised if used regularly.
Helps with these conditions
Hawthorn is most effective for general wellness support with emerging research . The effectiveness varies by condition based on clinical evidence and user experiences.
Detailed Information by Condition
High Blood Pressure
Hawthorn contains flavonoids and oligomeric procyanidins that can relax blood vessels (endothelium-dependent, nitric-oxide–mediated vasodilation) and...
High Cholesterol
Researchers think hawthorn could influence several atherosclerosis- and lipid-related pathways:Lipid-lowering actions (mostly preclinical): constituen...
Poor Circulation
Vasodilation & endothelial support. Hawthorn leaf/flower extracts are rich in oligomeric procyanidins and flavonoids that can stimulate nitric-oxi...
Atherosclerosis
Antioxidant + anti-inflammatory actions. Hawthorn extracts are rich in flavonoids and oligomeric procyanidins that can reduce LDL oxidation, scavenge...
Arrhythmia
Plausible mechanisms (but not proven for rhythm control in humans): Standardized hawthorn leaf/flower extracts (especially WS 1442) contain oligomeric...
Peripheral Artery Disease
Hawthorn extracts (especially standardized leaf-and-flower extracts like WS® 1442 and LI 132) have vasodilatory and endothelial effects (eNOS/NO), ant...
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Helps With These Conditions
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