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Hawthorn

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Specifically for High Cholesterol

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Why it works for High Cholesterol:

Researchers think hawthorn could influence several atherosclerosis- and lipid-related pathways:

  • Lipid-lowering actions (mostly preclinical): constituents (flavonoids like hyperoside/vitexin and triterpenes) have been reported to reduce total cholesterol and triglycerides, and to improve LDL/HDL handling via effects on lipid metabolism, anti-oxidative stress, and inflammation. These mechanisms are primarily shown in lab/animal models and summarized in peer-reviewed reviews. Frontiers
  • Endothelial function: standardized leaf/flower extracts (e.g., WS 1442) can modestly improve endothelial function in humans, which is relevant to cardiovascular risk, though not the same as proving lipid-lowering efficacy. PubMed

There are biologically plausible mechanisms, but the human evidence that hawthorn meaningfully lowers cholesterol is limited and mixed.

How to use for High Cholesterol:

There’s no established, guideline-endorsed dosing for cholesterol. If used adjunctively (not as a substitute for statins or lifestyle changes), clinicians typically reference regimens that have been studied for other cardiovascular endpoints or in small lipid studies:

  • Standardized leaf/flower extract (WS 1442): human trials for cardiovascular health have used 450–900 mg/day (often 450 mg twice daily) for ~12 weeks. This is not a lipid guideline, but reflects studied dosing of this specific extract. PubMed
  • Hawthorn fruit preparations: small RCTs have tested hawthorn fruit extract drinks in people with mild hypertension and/or hyperlipidaemia (8-week crossover design; beverage standardized to flavonoid content), showing modest lipid changes; exact consumer equivalents aren’t standardized. Europe PMC
  • A combo extract used in a 12-week RCT (Crataegus pinnatifida leaves + Citrus unshiu peels): 280–400 mg three times daily improved some lipid parameters in overweight adults; this was a combination product, not hawthorn alone. MDPI
  • Regulatory monographs (EU): the EMA HMPC monograph covers hawthorn leaf/flower for traditional cardiovascular uses and lists extract types/strengths; it does not provide a cholesterol-specific dose. Use only products that match a named extract and read the package leaflet. European Medicines Agency (EMA)

Practical tips

  • Choose a product that declares the plant part (fruit vs. leaf/flower), species, standardized extract, dose per capsule, and manufacturer.
  • Re-check your fasting lipid panel in ~8–12 weeks and stop if ineffective or if side effects occur. Coordinate with your GP/cardiologist—especially if you take heart or blood-pressure medicines. Authoritative fact sheet: NCCIH

Scientific Evidence for High Cholesterol:

  • Meta-analysis (2024, 14 RCTs of TCM formulas that include hawthorn): these combination formulas reduced total cholesterol and triglycerides and increased HDL, but were less effective than standard drugs for lowering LDL. Because they were multi-herb formulas, the effect can’t be attributed to hawthorn alone. Oxford Academic
  • Randomized pilot (2019, WS 1442 in overweight adults, 12 weeks): WS 1442 showed trends toward lower triglycerides and higher HDL; changes were modest and often within normal limits. Primary outcome was endothelial function, not lipids. PubMed
  • Randomized, double-blind, placebo-controlled crossover (2024): hawthorn fruit extract drink in mildly hypertensive and/or hyperlipidaemic adults reported lipid improvements across periods; more/larger trials are needed; formulation-specific. Europe PMC
  • Randomized, double-blind, placebo-controlled (2024): Crataegus+Citrus combination for 12 weeks improved several lipid measures in overweight adults; again, combination, not hawthorn alone. MDPI

Not cholesterol-specific but often cited:

  • WS 1442 has multiple RCTs in chronic heart failure and studies on vascular function; these inform safety/dosing of the extract but do not prove lipid-lowering efficacy. Nature

Summary: There is some human evidence (especially with combination products or small studies) suggesting modest lipid benefits, but hawthorn is not a proven or first-line therapy for high LDL. Use only as an adjunct under medical supervision.

Specific Warnings for High Cholesterol:

Quality & adulteration (critical): several “tejocote root” (marketed as Mexican hawthorn, Crataegus mexicana) supplements were found adulterated with toxic yellow oleander; the FDA warns these can cause severe or fatal cardiotoxicity. Avoid any “tejocote root” weight-loss products. U.S. Food and Drug Administration

Cardiac toxicity case report: Crataegus mexicana exposure caused bradycardia/heart block and a falsely elevated digoxin level on lab testing. PubMed

Interactions & precautions (general):

  • May potentiate blood-pressure or heart medicines (e.g., antihypertensives, antiarrhythmics); discuss with your prescriber and monitor closely. NCCIH
  • If you’re on evidence-based lipid therapy (statins, ezetimibe, PCSK9/Lp(a)-targeted drugs), don’t replace them with hawthorn. (General lipid guidance example resource: BHF overview on lowering cholesterol.) British Heart Foundation
  • Pregnancy/breastfeeding: safety is unknown—avoid unless specifically advised. NCCIH
  • Side effects: dizziness, GI upset, muscle pain have been reported; long-term safety beyond ~16 weeks is not established. NCCIH

Part matters: many standardized cardiovascular extracts are from leaf/flower (e.g., WS 1442), while several lipid studies use fruit; don’t assume effects (or doses) are interchangeable. NCCIH

General Information (All Ailments)

Note: You are viewing ailment-specific information above. This section shows the general remedy information for all conditions.

What It Is

Hawthorn is a medicinal plant derived from the berries, leaves, and flowers of shrubs in the Crataegus genus, part of the Rosaceae (rose) family. Native to Europe, North America, and Asia, it has been used for centuries in traditional medicine, especially in Europe and China, for supporting heart and circulatory health. The small red berries, sometimes called “haws,” are the most commonly used part of the plant, though the leaves and flowers also contain beneficial compounds.

Hawthorn contains a variety of bioactive substances, including flavonoids (such as hyperoside, vitexin, and rutin) and oligomeric procyanidins, which are powerful antioxidants known to protect blood vessels and heart tissue.

How It Works

Hawthorn works primarily through its cardiovascular effects, acting on the heart muscle, blood vessels, and circulatory system. Its main mechanisms of action include:

  1. Improved Blood Flow and Circulation. Hawthorn dilates coronary arteries, which increases blood flow to the heart muscle. This helps deliver more oxygen and nutrients to the heart and may improve cardiac efficiency.
  2. Enhanced Cardiac Function. The plant’s compounds improve the contractility of the heart (its ability to pump blood effectively) without increasing oxygen demand — a unique property that distinguishes it from synthetic stimulants.
  3. Reduction of Blood Pressure and Vascular Resistance. Hawthorn has mild vasodilatory and diuretic effects, helping relax blood vessels and lower peripheral resistance, which can contribute to lower blood pressure.
  4. Antioxidant and Anti-inflammatory Effects. Flavonoids and procyanidins in hawthorn scavenge free radicals, reducing oxidative stress that can damage cardiovascular tissue. This helps protect against atherosclerosis (hardening of the arteries).
  5. Normalization of Heart Rhythm. Some studies suggest that hawthorn can help stabilize irregular heartbeats (arrhythmias) by modulating calcium and sodium channels in heart cells.

Why It’s Important

Hawthorn is important in health and herbal medicine primarily for its cardioprotective benefits. It is often referred to as a “heart tonic” and used for mild to moderate forms of heart failure, angina, and hypertension. Its value lies in the following:

  • Supports Heart Health Naturally: Hawthorn provides gentle, long-term support for heart function, improving endurance and reducing fatigue associated with heart weakness.
  • Complementary Use in Cardiovascular Care: It is frequently used alongside conventional medications (under medical supervision) for chronic heart conditions, as it can enhance cardiac efficiency without the side effects of stronger drugs.
  • Stress and Anxiety Reduction: By improving blood flow and calming the nervous system, hawthorn may reduce heart palpitations and anxiety linked to stress or nervous tension.
  • Preventive Health: Regular use may help maintain vascular elasticity, prevent plaque buildup, and support healthy blood lipid levels, which are key factors in preventing heart disease.

Considerations

While hawthorn is generally well-tolerated, there are important considerations when using it for health purposes:

  1. Possible Interactions: Hawthorn can interact with prescription medications, particularly those for heart disease such as digoxin, beta-blockers, nitrates, and antihypertensive drugs. It may enhance or alter their effects, so professional guidance is essential.
  2. Dosage and Form: Hawthorn is available as capsules, tinctures, teas, or extracts. Standardized extracts (often containing 2–3% flavonoids or 18–20% oligomeric procyanidins) are most studied. Effects develop gradually, often requiring 6–12 weeks of consistent use for full benefit.
  3. Side Effects: Mild side effects can include dizziness, nausea, headache, or gastrointestinal upset. These are usually temporary and dose-related.
  4. Medical Conditions and Safety: Individuals with severe heart disease, low blood pressure, or arrhythmias should not self-medicate with hawthorn without a doctor’s approval. Pregnant or breastfeeding women should also avoid it due to insufficient safety data.
  5. Long-term Use: Hawthorn is considered safe for long-term use in moderate doses, but because it influences cardiovascular function, ongoing monitoring is advised if used regularly.

Helps with these conditions

Hawthorn is most effective for general wellness support with emerging research . The effectiveness varies by condition based on clinical evidence and user experiences.

High Blood Pressure 0% effective
High Cholesterol 0% effective
Poor Circulation 0% effective
Atherosclerosis 0% effective
Arrhythmia 0% effective
Peripheral Artery Disease 0% effective
6
Conditions
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Total Votes
32
Studies
0%
Avg. Effectiveness

Detailed Information by Condition

Hawthorn contains flavonoids and oligomeric procyanidins that can relax blood vessels (endothelium-dependent, nitric-oxide–mediated vasodilation) and...

0 votes Updated 2 months ago 6 studies cited

High Cholesterol

0% effective

Researchers think hawthorn could influence several atherosclerosis- and lipid-related pathways:Lipid-lowering actions (mostly preclinical): constituen...

0 votes Updated 1 month ago 5 studies cited

Poor Circulation

0% effective

Vasodilation & endothelial support. Hawthorn leaf/flower extracts are rich in oligomeric procyanidins and flavonoids that can stimulate nitric-oxi...

0 votes Updated 1 month ago 6 studies cited

Atherosclerosis

0% effective

Antioxidant + anti-inflammatory actions. Hawthorn extracts are rich in flavonoids and oligomeric procyanidins that can reduce LDL oxidation, scavenge...

0 votes Updated 1 month ago 6 studies cited

Arrhythmia

0% effective

Plausible mechanisms (but not proven for rhythm control in humans): Standardized hawthorn leaf/flower extracts (especially WS 1442) contain oligomeric...

0 votes Updated 1 month ago 6 studies cited

Hawthorn extracts (especially standardized leaf-and-flower extracts like WS® 1442 and LI 132) have vasodilatory and endothelial effects (eNOS/NO), ant...

0 votes Updated 1 month ago 3 studies cited

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