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Hawthorn

herb Verified

Specifically for Peripheral Artery Disease

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Why it works for Peripheral Artery Disease:

Hawthorn extracts (especially standardized leaf-and-flower extracts like WS® 1442 and LI 132) have vasodilatory and endothelial effects (eNOS/NO), antioxidant, anti-inflammatory, and anti-platelet actions in preclinical and small human mechanistic studies. These properties are theoretically relevant to PAD’s atherosclerosis and impaired micro/macro-circulation. ScienceDirect

Examples: WS 1442 activates nitric-oxide pathways and improves red-blood-cell NO formation (vasodilatory potential), and hawthorn leaf constituents show antithrombotic/antiplatelet activity in vitro/animal models. ScienceDirect

How to use for Peripheral Artery Disease:

There are no PAD-specific dosing instructions supported by clinical trials. If it’s used at all, clinicians typically borrow doses from heart-failure/vascular studies with standardized extracts:

  • Formulations: standardized leaf-and-flower extracts WS® 1442 (≈18.75% oligomeric procyanidins) or LI 132 (≈2.2% flavonoids). jpp.krakow.pl
  • Typical studied daily doses (non-PAD indications): ~160–900 mg/day of standardized extract in 2–3 divided doses; most RCTs ran 6–16 weeks before maximal effect. Drugs.com
  • What to look for: products that state the exact extract (e.g., “WS 1442” or “LI 132”) and standardization on the label; quality varies widely between non-standardized supplements. SpringerLink
  • Do not replace guideline-directed PAD therapy with hawthorn; use only as an adjunct after discussing drug interactions (see warnings below). Nice

Scientific Evidence for Peripheral Artery Disease:

I could not find high-quality randomized trials showing hawthorn improves claudication distance, ABI, or PAD outcomes. Reviews and monographs emphasize evidence in chronic heart failure and hypertension, not PAD; PAD guidelines do not include hawthorn. AAFP

For context only (non-PAD): WS 1442 and LI 132 have RCT evidence for NYHA II heart failure symptom/exercise endpoints, and small trials/meta-analyses suggest modest blood-pressure-lowering—but these do not establish benefit in PAD. AAFP

By contrast, herbal ginkgo has older meta-analysis data showing only modest increases in pain-free walking distance in intermittent claudication—highlighting how hard it’s been for botanicals to show clinically meaningful PAD gains. Hawthorn lacks even this level of PAD-specific evidence. SpringerLink

Specific Warnings for Peripheral Artery Disease:

Drug interactions (major concern):

  • Digoxin (Lanoxin): hawthorn may potentiate effects; avoid/comanage with clinician. WebMD
  • Beta-blockers & calcium-channel blockers: additive hypotension/bradycardia possible. WebMD
  • Nitrates and PDE-5 inhibitors (e.g., sildenafil): additive vasodilation/hypotension. Hello Pharmacist
  • Antiplatelets/anticoagulants (e.g., aspirin, clopidogrel, warfarin): hawthorn has antiplatelet activity; bleeding risk may rise, including reports around cardiac surgery. Thrombosis Research

Perioperative bleeding: a study in cardiac-surgery patients linked pre-op hawthorn use with higher postoperative bleeding and mortality—stop well before procedures (discuss timing with your surgeon). Frontiers

General adverse effects: usually mild—dizziness, GI upset, headache, palpitations—but scoping safety reviews catalogue assorted adverse reactions; supplements vary in composition and purity. NCCIH

Pregnancy/lactation: avoid (insufficient safety data). NCCIH

General Information (All Ailments)

Note: You are viewing ailment-specific information above. This section shows the general remedy information for all conditions.

What It Is

Hawthorn is a medicinal plant derived from the berries, leaves, and flowers of shrubs in the Crataegus genus, part of the Rosaceae (rose) family. Native to Europe, North America, and Asia, it has been used for centuries in traditional medicine, especially in Europe and China, for supporting heart and circulatory health. The small red berries, sometimes called “haws,” are the most commonly used part of the plant, though the leaves and flowers also contain beneficial compounds.

Hawthorn contains a variety of bioactive substances, including flavonoids (such as hyperoside, vitexin, and rutin) and oligomeric procyanidins, which are powerful antioxidants known to protect blood vessels and heart tissue.

How It Works

Hawthorn works primarily through its cardiovascular effects, acting on the heart muscle, blood vessels, and circulatory system. Its main mechanisms of action include:

  1. Improved Blood Flow and Circulation. Hawthorn dilates coronary arteries, which increases blood flow to the heart muscle. This helps deliver more oxygen and nutrients to the heart and may improve cardiac efficiency.
  2. Enhanced Cardiac Function. The plant’s compounds improve the contractility of the heart (its ability to pump blood effectively) without increasing oxygen demand — a unique property that distinguishes it from synthetic stimulants.
  3. Reduction of Blood Pressure and Vascular Resistance. Hawthorn has mild vasodilatory and diuretic effects, helping relax blood vessels and lower peripheral resistance, which can contribute to lower blood pressure.
  4. Antioxidant and Anti-inflammatory Effects. Flavonoids and procyanidins in hawthorn scavenge free radicals, reducing oxidative stress that can damage cardiovascular tissue. This helps protect against atherosclerosis (hardening of the arteries).
  5. Normalization of Heart Rhythm. Some studies suggest that hawthorn can help stabilize irregular heartbeats (arrhythmias) by modulating calcium and sodium channels in heart cells.

Why It’s Important

Hawthorn is important in health and herbal medicine primarily for its cardioprotective benefits. It is often referred to as a “heart tonic” and used for mild to moderate forms of heart failure, angina, and hypertension. Its value lies in the following:

  • Supports Heart Health Naturally: Hawthorn provides gentle, long-term support for heart function, improving endurance and reducing fatigue associated with heart weakness.
  • Complementary Use in Cardiovascular Care: It is frequently used alongside conventional medications (under medical supervision) for chronic heart conditions, as it can enhance cardiac efficiency without the side effects of stronger drugs.
  • Stress and Anxiety Reduction: By improving blood flow and calming the nervous system, hawthorn may reduce heart palpitations and anxiety linked to stress or nervous tension.
  • Preventive Health: Regular use may help maintain vascular elasticity, prevent plaque buildup, and support healthy blood lipid levels, which are key factors in preventing heart disease.

Considerations

While hawthorn is generally well-tolerated, there are important considerations when using it for health purposes:

  1. Possible Interactions: Hawthorn can interact with prescription medications, particularly those for heart disease such as digoxin, beta-blockers, nitrates, and antihypertensive drugs. It may enhance or alter their effects, so professional guidance is essential.
  2. Dosage and Form: Hawthorn is available as capsules, tinctures, teas, or extracts. Standardized extracts (often containing 2–3% flavonoids or 18–20% oligomeric procyanidins) are most studied. Effects develop gradually, often requiring 6–12 weeks of consistent use for full benefit.
  3. Side Effects: Mild side effects can include dizziness, nausea, headache, or gastrointestinal upset. These are usually temporary and dose-related.
  4. Medical Conditions and Safety: Individuals with severe heart disease, low blood pressure, or arrhythmias should not self-medicate with hawthorn without a doctor’s approval. Pregnant or breastfeeding women should also avoid it due to insufficient safety data.
  5. Long-term Use: Hawthorn is considered safe for long-term use in moderate doses, but because it influences cardiovascular function, ongoing monitoring is advised if used regularly.

Helps with these conditions

Hawthorn is most effective for general wellness support with emerging research . The effectiveness varies by condition based on clinical evidence and user experiences.

High Blood Pressure 0% effective
High Cholesterol 0% effective
Poor Circulation 0% effective
Atherosclerosis 0% effective
Arrhythmia 0% effective
Peripheral Artery Disease 0% effective
6
Conditions
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Total Votes
32
Studies
0%
Avg. Effectiveness

Detailed Information by Condition

Hawthorn contains flavonoids and oligomeric procyanidins that can relax blood vessels (endothelium-dependent, nitric-oxide–mediated vasodilation) and...

0 votes Updated 2 months ago 6 studies cited

High Cholesterol

0% effective

Researchers think hawthorn could influence several atherosclerosis- and lipid-related pathways:Lipid-lowering actions (mostly preclinical): constituen...

0 votes Updated 1 month ago 5 studies cited

Poor Circulation

0% effective

Vasodilation & endothelial support. Hawthorn leaf/flower extracts are rich in oligomeric procyanidins and flavonoids that can stimulate nitric-oxi...

0 votes Updated 1 month ago 6 studies cited

Atherosclerosis

0% effective

Antioxidant + anti-inflammatory actions. Hawthorn extracts are rich in flavonoids and oligomeric procyanidins that can reduce LDL oxidation, scavenge...

0 votes Updated 1 month ago 6 studies cited

Arrhythmia

0% effective

Plausible mechanisms (but not proven for rhythm control in humans): Standardized hawthorn leaf/flower extracts (especially WS 1442) contain oligomeric...

0 votes Updated 1 month ago 6 studies cited

Hawthorn extracts (especially standardized leaf-and-flower extracts like WS® 1442 and LI 132) have vasodilatory and endothelial effects (eNOS/NO), ant...

0 votes Updated 1 month ago 3 studies cited

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