Gui Zhi Fu Ling Wan
Specifically for Fibroids
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Why it works for Fibroids:
Traditional (TCM) rationale. GZFLW is a five-herb formula (Cinnamomi Ramulus, Poria, Paeoniae Radix Alba, Moutan Cortex, Persicae Semen) used to invigorate blood and resolve blood stasis—a classic TCM pattern behind pelvic masses and dysmenorrhea. Modern summaries of the formula and its composition reflect this use in gynecology. TCM Wiki
Modern/biomedical signals. Contemporary mechanistic work suggests the formula (and close variants such as Gyejibongnyeong-hwan/Guizhi-Fuling capsule) may:
- Reduce leiomyoma cell proliferation and promote apoptosis (↑ cleaved caspase-3, ↓ Bcl-2), and affect extracellular-matrix pathways. Frontiers
- Act on multiple signaling nodes (e.g., Ras/EGF/IGF-1, Wnt) per network-pharmacology analyses targeted to fibroids. Spandidos Publications
- Contain constituents (notably Moutan Cortex) with anticoagulant/antiplatelet activities, consistent with “blood-activating” effects (clinically relevant to both mechanism and safety—see warnings). ScienceDirect
How to use for Fibroids:
Common regimens in studies & product monographs
- Regimen length used in a randomized trial: daily administration for 16 weeks of a modified GZFLW in women with symptomatic fibroids. (The trial was dose-controlled; both low and conventional dose arms improved symptoms and MRI fibroid/uterine measures.) Read by QxMD
- Capsules (proprietary “Guizhi Fuling Jiaonang”): example labels instruct three 0.31 g capsules, three times daily after meals; some advise one 3-month course, and to avoid during menses (manufacturer specific—follow your product’s insert). Chinese Herbal Shop
- Pills/tablets (over-the-counter traditional forms): examples list 3–4 tablets, twice daily after meals, or ~1 g pills, three times daily, typically taken with warm water. (Exact strength varies by brand—check the label.) healthylicious.co.uk
General use tips
- Take after food to reduce GI upset; consistency over weeks matters more than single doses. Tcmly
- Combine with conventional care (e.g., imaging follow-up). Some evidence evaluates GZFL capsules alongside low-dose mifepristone—see “Clinical studies.” BioMed Central
Scientific Evidence for Fibroids:
Randomized, double-blind, dose-controlled trial (Hong Kong; 2021, J Ethnopharmacol). In 78 women with symptomatic fibroids, both low- and conventional-dose modified GZFLW significantly improved UF Symptom-QoL scores and reduced fibroid/uterine measures on MRI over 16 weeks, with no serious treatment-related AEs; between-group differences were not significant. Read by QxMD
Systematic review/meta-analysis (2023, 28 RCTs). Guizhi Fuling capsules + low-dose mifepristone vs mifepristone alone showed greater reductions in fibroid volume and symptom improvement in pooled Chinese RCTs; safety was generally acceptable, though authors note study quality limitations and heterogeneity. BioMed Central
Protocol evidence for fibroid-related dysmenorrhea. A BMJ Open randomized, double-blind protocol (Gyejibongnyeong-hwan = GZFLW) details TID dosing for 8 weeks in women with secondary dysmenorrhea due to fibroids (safety/efficacy endpoints prespecified). BMJ Open
Mechanistic/experimental studies. In vitro and pharmacology papers support anti-proliferative and pro-apoptotic actions relevant to leiomyoma biology; network pharmacology maps multi-target interactions linked to fibroid pathways. Frontiers
Specific Warnings for Fibroids:
Pregnancy & trying to conceive. Do not use in pregnancy (blood-activating formulas are traditionally contraindicated; contemporary clinicians echo this). Avoid when actively trying to conceive unless specifically advised by a specialist. American Dragon
Bleeding risk / Anticoagulants & antiplatelets. Because GZFLW contains Moutan Cortex and Persicae Semen (peach kernel)—herbs with anticoagulant/antiplatelet activity—use caution if you have heavy menstrual bleeding, bleeding disorders, upcoming surgery, or if you take warfarin, DOACs, aspirin, or other blood thinners/antiplatelets; interactions that increase bleeding risk are a recognized class issue for many CHMs. Coordinate with your prescriber and consider INR/bleeding monitoring. ScienceDirect
Liver safety & quality control. CHM-related herb-induced liver injury is uncommon but reported; use reputable products and stop if you develop jaundice, dark urine, severe fatigue, or RUQ pain. ScienceDirect
Allergies & intolerances. Avoid if you have known hypersensitivity to cinnamon, peach/stone-fruit kernels, or any excipients in the product. (Check labels; strengths vary by brand.) healthylicious.co.uk
General adverse effects. Trials and reviews report no serious treatment-related AEs and mostly mild GI symptoms when they occur, but safety reporting quality varies; monitor and seek care for abnormal bleeding or new symptoms. Read by QxMD
General Information (All Ailments)
What It Is
Gui Zhi Fu Ling Wan (桂枝茯苓丸) is a classical Chinese herbal formula that originated from the ancient medical text Jin Gui Yao Lue (Essentials from the Golden Cabinet) by Zhang Zhongjing. It consists of five main herbs:
- Gui Zhi (Cinnamon Twig) – Warms and unblocks the channels, promotes circulation of Qi and blood.
- Fu Ling (Poria Mushroom) – Promotes urination, reduces dampness, and strengthens the spleen.
- Mu Dan Pi (Moutan Cortex / Tree Peony Bark) – Cools the blood and promotes circulation.
- Chi Shao (Red Peony Root) – Invigorates blood and removes stasis, also cools the blood.
- Tao Ren (Peach Kernel) – Breaks up blood stasis and moistens the intestines.
This formula is traditionally made into small pills or capsules and is used in TCM to address blood stasis with cold and stagnation, particularly in the lower abdomen or uterus.
How It Works
Gui Zhi Fu Ling Wan works primarily by promoting blood circulation, resolving stasis, and regulating menstruation. In TCM theory, many gynecological and reproductive disorders arise from blood stasis—a condition where blood flow is sluggish or obstructed, leading to pain, clots, or palpable masses.
- Warming and moving (Gui Zhi): Warms the meridians and assists in dispersing cold-induced stagnation.
- Circulating and breaking stasis (Tao Ren, Chi Shao, Mu Dan Pi): These herbs help remove congealed blood, reduce swelling or masses, and restore normal flow of Qi and blood.
- Draining dampness and supporting fluid metabolism (Fu Ling): Balances fluid movement, helping the body to clear excess moisture that might contribute to stagnation.
In modern pharmacological studies, the formula is thought to improve uterine blood flow, modulate hormonal balance, and reduce inflammation. It has been used to support conditions such as uterine fibroids, ovarian cysts, endometriosis, dysmenorrhea (painful periods), and infertility related to blood stasis.
Why It’s Important
Gui Zhi Fu Ling Wan holds great importance in both classical and modern Chinese medicine for women’s health. It is one of the few traditional formulas that effectively addresses both cold and heat patterns simultaneously, because it includes warming (Gui Zhi) and cooling (Mu Dan Pi, Chi Shao) ingredients in balance.
Its significance lies in several areas:
- Women’s reproductive health: It is widely used to promote healthy menstruation and fertility by ensuring smooth blood flow and resolving stagnation.
- Postpartum recovery: Helps the body eliminate retained blood and restore uterine tone after childbirth.
- Chronic gynecological conditions: Provides non-invasive support for fibroids or cysts when surgery or hormonal therapy is not preferred.
- Circulatory health: Although primarily used for gynecological purposes, it can also be applied in some cases of blood stasis elsewhere in the body, such as bruising or pelvic congestion.
In essence, Gui Zhi Fu Ling Wan embodies the TCM principle of harmonizing contradictions—balancing warm and cool, moving and nourishing—to restore the natural rhythm of the body.
Considerations
While Gui Zhi Fu Ling Wan is a gentle yet potent herbal formula, several important considerations should be noted:
- Individual diagnosis: It should be prescribed based on a proper TCM assessment of blood stasis. Using it without stasis symptoms (e.g., in people with deficiency or bleeding tendencies) may worsen the condition.
- Pregnancy: The formula contains Tao Ren (Peach Kernel), which has blood-moving and stasis-breaking properties. These can potentially stimulate uterine contractions and are not recommended during pregnancy, except under close supervision by a qualified practitioner.
- Dosage and duration: Overuse can deplete the body’s energy or Yin. The formula is typically taken in moderate doses over a defined period, with reassessment every few weeks.
- Potential interactions: Herbal medicines can interact with anticoagulant or antiplatelet drugs (e.g., warfarin, aspirin). Individuals on such medications should use this formula only with professional guidance.
- Symptoms indicating caution: Avoid during active bleeding, heavy menstrual flow, or if signs of Yin deficiency (dry mouth, hot flashes, night sweats) are present.
- Quality and sourcing: Use products from reputable manufacturers to avoid contamination or adulteration, as purity and accurate formulation affect both safety and efficacy.
Helps with these conditions
Gui Zhi Fu Ling Wan is most effective for general wellness support with emerging research . The effectiveness varies by condition based on clinical evidence and user experiences.
Detailed Information by Condition
PCOS
Improves ovulation & pregnancy outcomes (as add-on therapy). A 2022/2023 systematic review and meta-analysis of 16 RCTs (1,385 women) found that G...
Endometriosis
Anti-inflammatory & immunomodulatory effects (down-regulating cytokines, COX-2/PGE2 pathways) and angiogenesis inhibition (VEGF), which could redu...
Fibroids
Traditional (TCM) rationale. GZFLW is a five-herb formula (Cinnamomi Ramulus, Poria, Paeoniae Radix Alba, Moutan Cortex, Persicae Semen) used to invig...
Ovarian Cysts
TCM pattern: The classic indication is gynecologic “masses from Blood stasis” (fixed lower-abdominal masses/pain, dysmenorrhea). The five-herb formula...
Menstrual cramps
Traditional rationale & composition. GZFLW is a 5-herb formula (Gui Zhi/Cinnamomi ramulus, Fu Ling/Poria, Bai Shao/Paeonia, Mu Dan Pi/Moutan corte...
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Helps With These Conditions
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