Gui Zhi Fu Ling Wan
Specifically for Menstrual cramps
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Why it works for Menstrual cramps:
Traditional rationale & composition. GZFLW is a 5-herb formula (Gui Zhi/Cinnamomi ramulus, Fu Ling/Poria, Bai Shao/Paeonia, Mu Dan Pi/Moutan cortex, Tao Ren/Persica seed) used to “invigorate blood, dispel stasis, and ease lower-abdominal pain.” This use and composition are documented in modern pharmacognosy reviews of the formula family. ScienceDirect
Biological mechanisms (modern data). Network-pharmacology and experimental work suggest multi-target actions relevant to cramps: modulation of inflammatory pathways (e.g., COX-2/prostaglandins), smooth-muscle/uterine contractility, microcirculation, and estrogen-related signaling; these mechanisms align with pain reduction in dysmenorrhea and endometriosis models. Frontiers
How to use for Menstrual cramps:
Common OTC capsule labeling (China; “Guizhi Fuling Capsule”). Typical directions on approved Chinese package inserts: 3 capsules, 3×/day, after meals; stop during menstruation; avoid in pregnancy unless prescribed. Course often 8–12 weeks depending on indication. (This is product-label guidance, not a universal rule for every brand.) 39药品通
Classical pill form / concentrated pills. Some concentrated pill products advise ~6 g per dose, 1–2×/day, taken with warm water (again: follow the actual label you buy). Tcmly
Scientific Evidence for Menstrual cramps:
Randomized, double-blind, placebo-controlled trial (primary dysmenorrhea, 2023). Patients with the heat-burning blood-stasis pattern received GZFLW or placebo twice daily for 3 cycles with 3-month follow-up. GZFLW significantly improved VAS pain and Cox Menstrual Symptom Scale (CMSS) vs placebo; no serious adverse events reported. (Journal of Ethnopharmacology.) Europe PMC
Multicenter RCT on Guizhi Fuling capsule (dose-ranging, primary dysmenorrhea). Randomized, double-blind, placebo-controlled clinical study reported efficacy and safety across doses. (Zhongguo Zhong Yao Za Zhi; indexed in Europe PMC/J-GLOBAL.) Europe PMC
Study protocol & reporting standards. Full peer-reviewed protocol describing endpoints (VAS, CMSS, SAS/SDS), dosing for 3 cycles, and follow-up—useful for understanding trial design and outcomes later reported. BioMed Central
Mechanistic reviews / systems pharmacology supporting analgesic/anti-inflammatory and uterine-regulating effects relevant to period pain. Frontiers
Specific Warnings for Menstrual cramps:
Pregnancy. Most modern labels list pregnancy as contraindicated (blood-invigorating formulas can increase risk of bleeding/miscarriage). Do not use during pregnancy unless specifically prescribed and monitored. 39药品通
During menstruation. Several licensed capsule inserts instruct stopping during active menses; resume afterward if your clinician advises. 39药品通
Bleeding risk / drug interactions. Because the formula promotes blood circulation and has antiplatelet effects in pharmacology tests, use caution with anticoagulants/antiplatelets (e.g., warfarin, DOACs, high-dose NSAIDs) and bleeding disorders; coordinate with your prescriber and monitor for bleeding. 39药品通
Adverse effects. Most reports note mild GI upset (e.g., stomach discomfort) that resolves on stopping; serious adverse events were not observed in the RCTs cited above. 39药品通
Diagnosis matters. Effectiveness in trials was greatest when patients matched a specific TCM pattern (e.g., heat-burning blood stasis); mismatch can reduce benefit. Europe PMC
General Information (All Ailments)
What It Is
Gui Zhi Fu Ling Wan (桂枝茯苓丸) is a classical Chinese herbal formula that originated from the ancient medical text Jin Gui Yao Lue (Essentials from the Golden Cabinet) by Zhang Zhongjing. It consists of five main herbs:
- Gui Zhi (Cinnamon Twig) – Warms and unblocks the channels, promotes circulation of Qi and blood.
- Fu Ling (Poria Mushroom) – Promotes urination, reduces dampness, and strengthens the spleen.
- Mu Dan Pi (Moutan Cortex / Tree Peony Bark) – Cools the blood and promotes circulation.
- Chi Shao (Red Peony Root) – Invigorates blood and removes stasis, also cools the blood.
- Tao Ren (Peach Kernel) – Breaks up blood stasis and moistens the intestines.
This formula is traditionally made into small pills or capsules and is used in TCM to address blood stasis with cold and stagnation, particularly in the lower abdomen or uterus.
How It Works
Gui Zhi Fu Ling Wan works primarily by promoting blood circulation, resolving stasis, and regulating menstruation. In TCM theory, many gynecological and reproductive disorders arise from blood stasis—a condition where blood flow is sluggish or obstructed, leading to pain, clots, or palpable masses.
- Warming and moving (Gui Zhi): Warms the meridians and assists in dispersing cold-induced stagnation.
- Circulating and breaking stasis (Tao Ren, Chi Shao, Mu Dan Pi): These herbs help remove congealed blood, reduce swelling or masses, and restore normal flow of Qi and blood.
- Draining dampness and supporting fluid metabolism (Fu Ling): Balances fluid movement, helping the body to clear excess moisture that might contribute to stagnation.
In modern pharmacological studies, the formula is thought to improve uterine blood flow, modulate hormonal balance, and reduce inflammation. It has been used to support conditions such as uterine fibroids, ovarian cysts, endometriosis, dysmenorrhea (painful periods), and infertility related to blood stasis.
Why It’s Important
Gui Zhi Fu Ling Wan holds great importance in both classical and modern Chinese medicine for women’s health. It is one of the few traditional formulas that effectively addresses both cold and heat patterns simultaneously, because it includes warming (Gui Zhi) and cooling (Mu Dan Pi, Chi Shao) ingredients in balance.
Its significance lies in several areas:
- Women’s reproductive health: It is widely used to promote healthy menstruation and fertility by ensuring smooth blood flow and resolving stagnation.
- Postpartum recovery: Helps the body eliminate retained blood and restore uterine tone after childbirth.
- Chronic gynecological conditions: Provides non-invasive support for fibroids or cysts when surgery or hormonal therapy is not preferred.
- Circulatory health: Although primarily used for gynecological purposes, it can also be applied in some cases of blood stasis elsewhere in the body, such as bruising or pelvic congestion.
In essence, Gui Zhi Fu Ling Wan embodies the TCM principle of harmonizing contradictions—balancing warm and cool, moving and nourishing—to restore the natural rhythm of the body.
Considerations
While Gui Zhi Fu Ling Wan is a gentle yet potent herbal formula, several important considerations should be noted:
- Individual diagnosis: It should be prescribed based on a proper TCM assessment of blood stasis. Using it without stasis symptoms (e.g., in people with deficiency or bleeding tendencies) may worsen the condition.
- Pregnancy: The formula contains Tao Ren (Peach Kernel), which has blood-moving and stasis-breaking properties. These can potentially stimulate uterine contractions and are not recommended during pregnancy, except under close supervision by a qualified practitioner.
- Dosage and duration: Overuse can deplete the body’s energy or Yin. The formula is typically taken in moderate doses over a defined period, with reassessment every few weeks.
- Potential interactions: Herbal medicines can interact with anticoagulant or antiplatelet drugs (e.g., warfarin, aspirin). Individuals on such medications should use this formula only with professional guidance.
- Symptoms indicating caution: Avoid during active bleeding, heavy menstrual flow, or if signs of Yin deficiency (dry mouth, hot flashes, night sweats) are present.
- Quality and sourcing: Use products from reputable manufacturers to avoid contamination or adulteration, as purity and accurate formulation affect both safety and efficacy.
Helps with these conditions
Gui Zhi Fu Ling Wan is most effective for general wellness support with emerging research . The effectiveness varies by condition based on clinical evidence and user experiences.
Detailed Information by Condition
PCOS
Improves ovulation & pregnancy outcomes (as add-on therapy). A 2022/2023 systematic review and meta-analysis of 16 RCTs (1,385 women) found that G...
Endometriosis
Anti-inflammatory & immunomodulatory effects (down-regulating cytokines, COX-2/PGE2 pathways) and angiogenesis inhibition (VEGF), which could redu...
Fibroids
Traditional (TCM) rationale. GZFLW is a five-herb formula (Cinnamomi Ramulus, Poria, Paeoniae Radix Alba, Moutan Cortex, Persicae Semen) used to invig...
Ovarian Cysts
TCM pattern: The classic indication is gynecologic “masses from Blood stasis” (fixed lower-abdominal masses/pain, dysmenorrhea). The five-herb formula...
Menstrual cramps
Traditional rationale & composition. GZFLW is a 5-herb formula (Gui Zhi/Cinnamomi ramulus, Fu Ling/Poria, Bai Shao/Paeonia, Mu Dan Pi/Moutan corte...
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Helps With These Conditions
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