Gui Zhi Fu Ling Wan
Specifically for Ovarian Cysts
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Why it works for Ovarian Cysts:
TCM pattern: The classic indication is gynecologic “masses from Blood stasis” (fixed lower-abdominal masses/pain, dysmenorrhea). The five-herb formula—Cinnamomi Ramulus (Gui Zhi), Poria (Fu Ling), Moutan Cortex (Mu Dan Pi), Persicae Semen (Tao Ren), Paeoniae Radix (Chi/Bai Shao)—“invigorates blood and transforms stasis,” which historically maps to cysts/fibroids/endometriosis in modern practice. meandqi.com
Modern pharmacology (in vitro/in vivo) suggests anti-inflammatory, anti-fibrotic, pro-circulatory, and hormone-modulating effects that are plausibly relevant to cystic gynecologic disease (e.g., down-regulating uterine estrogen-related activity; modulating CGRP pathways; broad anti-inflammatory effects). tsumura.co.jp
Related gynecologic conditions: GZFLW has the most evidence in endometriosis and uterine fibroids, with some work in PCOS (which may present with multiple ovarian cysts). While this is not the same as proving efficacy for simple functional ovarian cysts, the overlap (pelvic masses, dysmenorrhea, inflammation) explains why clinicians consider it in cyst cases. BioMed Central
How to use for Ovarian Cysts:
Because products and traditions differ, dosing is typically taken from regulated Kampo labeling (Japan) or a licensed TCM practitioner’s prescription:
- Who it’s for (pattern match): Kampo labeling indicates use in patients with a relatively robust constitution with lower-abdominal resistance/tenderness, for conditions including uterine/adnexal inflammation, menstrual irregularity and dysmenorrhea—i.e., the “blood stasis” picture. tsumura.co.jp
- Adult dose (granules; TJ-25 Keishibukuryogan): 7.5 g/day in 2–3 divided doses, before or between meals. Dose may be adjusted for age, body weight, and symptoms. tsumura.co.jp
- OTC tablet equivalents (example labeling): 6 tablets/day (providing 1.15 g extract) divided across the day. (Exact strengths vary by brand—follow your product’s label.) クラシエ(Kracie)の公式ウェブサイト 株式会社クラシエ
- Form factors: classical honey pills, modern granules/capsules/tablets; composition is the same five herbs above. tsumura.co.jp
- Duration & monitoring: Kampo OTC leaflets advise reassessment if symptoms do not improve after ~1 month; for cysts specifically, continue only with clinician oversight and repeat imaging—since some cyst types (e.g., endometriomas, dermoids) need different management. tsumurakampo.jp
Scientific Evidence for Ovarian Cysts:
Endometriosis (cystic endometriomas are common in endometriosis)
- Randomized, placebo-controlled trial protocol of a modified GZFLW (Gynoclear™) for endometriosis-related pelvic pain—methods peer-reviewed; results pending/limited. Shows serious intent to test the formula rigorously. BioMed Central
- Mechanistic/target studies demonstrate inhibitory effects of GZFLW on endometriosis models and propose dose-component optimization. ScienceDirect
Uterine fibroids
- Systematic review/meta-analysis of Guizhi Fuling Capsule combined with mifepristone for fibroids suggests added benefit vs. mifepristone alone (heterogeneous, variable trial quality). BioMed Central
PCOS (may present with multiple cysts but pathophysiology differs from a simple cyst)
- Systematic review/meta-analysis of RCTs: add-on Guizhi Fuling formulations improved fertility-related outcomes in women with PCOS (improved ovulation/pregnancy rates), albeit with methodological limitations. Frontiers
- Narrative/overview papers summarize multitarget actions (hormones, inflammation, microbiome) and clinical signals in PCOS. (Again: not the same as proving efficacy for simple cysts.) SpringerLink
Case-type evidence specifically on ovarian cysts exists in Korean-medicine/TCM case reports and trend reviews, but these are not controlled trials. Treat them as hypothesis-generating only. Korea Science
Specific Warnings for Ovarian Cysts:
Pregnancy: Do not use if pregnant or possibly pregnant. The official Keishibukuryogan insert warns that Peach Kernel and Moutan “may cause premature birth or abortion.” Breastfeeding safety is not established. tsumura.co.jp
Hepatic adverse effects: Labeling reports hepatic dysfunction/jaundice as clinically significant potential adverse reactions—stop and evaluate if liver tests or symptoms become abnormal. tsumura.co.jp
General adverse effects: Possible rash, pruritus, GI upset (anorexia, nausea, diarrhea); incidence unknown. Elderly may need dose reduction. Avoid in markedly frail/“greatly declined constitution.” tsumura.co.jp
Bleeding risk & drug interactions: Because GZFLW is a blood-invigorating formula and contains Tao Ren (peach kernel), exercise caution in active bleeding, bleeding disorders, or with anticoagulants/antiplatelets; coordinate with your prescriber. (Conservative clinical warning based on traditional action and common professional guidance.) sacredlotus.com
Product quality & consistency: Use regulated brands (e.g., Kampo products such as Tsumura TJ-25) to reduce variability and contamination risk; follow official dose/leaflet. tsumura.co.jp
Stop & seek care immediately if you develop severe unilateral pelvic pain, fever, vomiting, fainting (possible torsion/rupture), or if the cyst enlarges or persists—these are standard red flags in mainstream care. nhs.uk
General Information (All Ailments)
What It Is
Gui Zhi Fu Ling Wan (桂枝茯苓丸) is a classical Chinese herbal formula that originated from the ancient medical text Jin Gui Yao Lue (Essentials from the Golden Cabinet) by Zhang Zhongjing. It consists of five main herbs:
- Gui Zhi (Cinnamon Twig) – Warms and unblocks the channels, promotes circulation of Qi and blood.
- Fu Ling (Poria Mushroom) – Promotes urination, reduces dampness, and strengthens the spleen.
- Mu Dan Pi (Moutan Cortex / Tree Peony Bark) – Cools the blood and promotes circulation.
- Chi Shao (Red Peony Root) – Invigorates blood and removes stasis, also cools the blood.
- Tao Ren (Peach Kernel) – Breaks up blood stasis and moistens the intestines.
This formula is traditionally made into small pills or capsules and is used in TCM to address blood stasis with cold and stagnation, particularly in the lower abdomen or uterus.
How It Works
Gui Zhi Fu Ling Wan works primarily by promoting blood circulation, resolving stasis, and regulating menstruation. In TCM theory, many gynecological and reproductive disorders arise from blood stasis—a condition where blood flow is sluggish or obstructed, leading to pain, clots, or palpable masses.
- Warming and moving (Gui Zhi): Warms the meridians and assists in dispersing cold-induced stagnation.
- Circulating and breaking stasis (Tao Ren, Chi Shao, Mu Dan Pi): These herbs help remove congealed blood, reduce swelling or masses, and restore normal flow of Qi and blood.
- Draining dampness and supporting fluid metabolism (Fu Ling): Balances fluid movement, helping the body to clear excess moisture that might contribute to stagnation.
In modern pharmacological studies, the formula is thought to improve uterine blood flow, modulate hormonal balance, and reduce inflammation. It has been used to support conditions such as uterine fibroids, ovarian cysts, endometriosis, dysmenorrhea (painful periods), and infertility related to blood stasis.
Why It’s Important
Gui Zhi Fu Ling Wan holds great importance in both classical and modern Chinese medicine for women’s health. It is one of the few traditional formulas that effectively addresses both cold and heat patterns simultaneously, because it includes warming (Gui Zhi) and cooling (Mu Dan Pi, Chi Shao) ingredients in balance.
Its significance lies in several areas:
- Women’s reproductive health: It is widely used to promote healthy menstruation and fertility by ensuring smooth blood flow and resolving stagnation.
- Postpartum recovery: Helps the body eliminate retained blood and restore uterine tone after childbirth.
- Chronic gynecological conditions: Provides non-invasive support for fibroids or cysts when surgery or hormonal therapy is not preferred.
- Circulatory health: Although primarily used for gynecological purposes, it can also be applied in some cases of blood stasis elsewhere in the body, such as bruising or pelvic congestion.
In essence, Gui Zhi Fu Ling Wan embodies the TCM principle of harmonizing contradictions—balancing warm and cool, moving and nourishing—to restore the natural rhythm of the body.
Considerations
While Gui Zhi Fu Ling Wan is a gentle yet potent herbal formula, several important considerations should be noted:
- Individual diagnosis: It should be prescribed based on a proper TCM assessment of blood stasis. Using it without stasis symptoms (e.g., in people with deficiency or bleeding tendencies) may worsen the condition.
- Pregnancy: The formula contains Tao Ren (Peach Kernel), which has blood-moving and stasis-breaking properties. These can potentially stimulate uterine contractions and are not recommended during pregnancy, except under close supervision by a qualified practitioner.
- Dosage and duration: Overuse can deplete the body’s energy or Yin. The formula is typically taken in moderate doses over a defined period, with reassessment every few weeks.
- Potential interactions: Herbal medicines can interact with anticoagulant or antiplatelet drugs (e.g., warfarin, aspirin). Individuals on such medications should use this formula only with professional guidance.
- Symptoms indicating caution: Avoid during active bleeding, heavy menstrual flow, or if signs of Yin deficiency (dry mouth, hot flashes, night sweats) are present.
- Quality and sourcing: Use products from reputable manufacturers to avoid contamination or adulteration, as purity and accurate formulation affect both safety and efficacy.
Helps with these conditions
Gui Zhi Fu Ling Wan is most effective for general wellness support with emerging research . The effectiveness varies by condition based on clinical evidence and user experiences.
Detailed Information by Condition
PCOS
Improves ovulation & pregnancy outcomes (as add-on therapy). A 2022/2023 systematic review and meta-analysis of 16 RCTs (1,385 women) found that G...
Endometriosis
Anti-inflammatory & immunomodulatory effects (down-regulating cytokines, COX-2/PGE2 pathways) and angiogenesis inhibition (VEGF), which could redu...
Fibroids
Traditional (TCM) rationale. GZFLW is a five-herb formula (Cinnamomi Ramulus, Poria, Paeoniae Radix Alba, Moutan Cortex, Persicae Semen) used to invig...
Ovarian Cysts
TCM pattern: The classic indication is gynecologic “masses from Blood stasis” (fixed lower-abdominal masses/pain, dysmenorrhea). The five-herb formula...
Menstrual cramps
Traditional rationale & composition. GZFLW is a 5-herb formula (Gui Zhi/Cinnamomi ramulus, Fu Ling/Poria, Bai Shao/Paeonia, Mu Dan Pi/Moutan corte...
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Helps With These Conditions
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