Chamomile
Specifically for Dry Eye Syndrome
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Why it works for Dry Eye Syndrome:
Chamomile contains flavonoids (e.g., apigenin) and sesquiterpenes (e.g., α-bisabolol, chamazulene) that show anti-inflammatory and antioxidant actions in non-ocular models—e.g., down-regulating NF-κB, COX-2, iNOS, and pro-inflammatory cytokines (TNF-α/IL-1β/IL-6). These mechanisms are theoretical for dry eye (ocular surface inflammation is central in DED), but they haven’t been proven to translate into clinical benefit for the eye. Taylor & Francis Online
How to use for Dry Eye Syndrome:
What NOT to do
- Don’t put chamomile tea, tea bags, essential oil, or homemade extracts in or on the eye. Risk = allergic conjunctivitis/angioedema and microbial contamination; risk is higher if you have ragweed/mugwort allergies (Asteraceae family cross-reactivity). SpringerLink
If you still wish to include chamomile (adjunct only, not a replacement)
- Prefer oral tea/capsules rather than eye application. (Oral use does not have evidence for dry eye either, but it avoids direct ocular exposure that drives most adverse reactions.) Screen for Asteraceae allergy first. spandidos-publications.com
- If considering a commercial ophthalmic product that lists chamomile among ingredients (e.g., with Euphrasia), use only sterile, labeled eye drops and follow the package directions exactly. Be aware that supportive evidence is in vitro (cell studies) and not clinical outcome trials in DED. Discontinue at the first sign of irritation. Buona
Scientific Evidence for Dry Eye Syndrome:
DED-specific or ocular evidence involving chamomile
- In vitro (lab): A commercial drop (Dacriovis™, chamomile + Euphrasia) protected corneal epithelial cells from UVB-induced oxidative/inflammatory stress; this is not a human clinical trial and cannot prove DED benefit. (Paper & manufacturer PDF.) ScienceDirect
- Blepharitis-adjacent trials: A registered/ongoing study compares tea tree oil + chamomile oil lid wipes vs baby shampoo for seborrheic blepharitis (a DED comorbidity). Results not established; cannot infer effectiveness for DED. ICHGCP
- Safety/ethnopharmacology review (2025, Frontiers): Concludes ophthalmic use of chamomile poultices lacks scientific validation and poses allergy and contamination risks. Frontiers
Broader (non-ocular) chamomile anti-inflammatory evidence
- Systematic reviews/meta-analyses report anti-inflammatory effects of chamomile in other conditions (e.g., mucositis), supporting a plausible mechanism—but not clinical efficacy for dry eye. Taylor & Francis Online
Specific Warnings for Dry Eye Syndrome:
Allergy / cross-reactivity: Chamomile can cross-react with ragweed/mugwort pollens (Asteraceae). Cases of allergic conjunctivitis and eyelid angioedema after chamomile eye use have been published. Avoid if you have seasonal allergies to these plants. Thermo Fisher Scientific
Homemade eye poultices/washes: Risk of microbial contamination and worsened inflammation; modern review advises against ophthalmic folk use. Frontiers
Essential oils near the eye: Chemical irritation and toxicity risk; do not use essential oils in the eye. (General ophthalmology safety guidance discourages unproven home remedies for eye problems.) AAO
Not a substitute for DED care: Chamomile isn’t in guideline-based DED pathways—delaying effective treatment may worsen symptoms and ocular surface damage. bnf.nice.org.uk
Product variability: Herbal products vary in composition/purity; sterility is critical for anything touching the eye. Prefer licensed, sterile ophthalmic products and check ingredients if you have allergies. European Medicines Agency (EMA)
General Information (All Ailments)
What It Is
Chamomile is a flowering herb belonging to the Asteraceae family, closely related to daisies. It is most commonly recognized for its small white and yellow flowers and its pleasant, apple-like fragrance. There are two main species used medicinally and commercially: German chamomile (Matricaria chamomilla) and Roman chamomile (Chamaemelum nobile). Both varieties are used to make teas, extracts, essential oils, and topical formulations. Chamomile has been used for thousands of years in traditional medicine systems — including ancient Egyptian, Greek, and Roman cultures — for its calming, healing, and anti-inflammatory properties.
How It Works
Chamomile’s effects are primarily due to its bioactive compounds, such as apigenin, bisabolol, chamazulene, flavonoids, and terpenoids. These constituents contribute to its soothing and therapeutic qualities through several mechanisms:
- Calming and sedative effects: Apigenin, a flavonoid found in chamomile, binds to benzodiazepine receptors in the brain, producing mild sedative and anxiolytic (anti-anxiety) effects. This is why chamomile tea is often consumed to aid relaxation and sleep.
- Anti-inflammatory properties: Compounds like chamazulene and bisabolol help reduce inflammation by inhibiting the release of prostaglandins and cytokines, which are key mediators in inflammatory responses.
- Antioxidant activity: The flavonoids and polyphenols in chamomile act as antioxidants, neutralizing free radicals that can damage cells and contribute to aging and disease.
- Digestive support: Chamomile relaxes smooth muscle in the digestive tract, which can help alleviate indigestion, bloating, gas, and stomach cramps. It also has mild antimicrobial properties that can soothe minor gastrointestinal infections.
- Skin healing: When applied topically, chamomile helps reduce skin irritation, inflammation, and redness. It is often included in ointments and creams for eczema, burns, wounds, and rashes.
Why It’s Important
Chamomile is valued both for its therapeutic versatility and its gentle nature, making it suitable for a wide range of users, including children and the elderly. Its importance can be seen in several domains:
- Natural remedy for stress and sleep: In an age where anxiety and insomnia are prevalent, chamomile offers a mild, non-addictive way to support mental and emotional well-being.
- Support for holistic health: As a herbal remedy, it bridges traditional and modern medicine, offering preventive and complementary benefits without synthetic side effects.
- Widely accessible: Chamomile is inexpensive, safe for most people, and widely available as tea, capsules, or skincare products, making it one of the most approachable medicinal herbs.
- Scientific validation: Modern research supports many traditional claims, reinforcing chamomile’s credibility in clinical and wellness contexts. Studies show its potential in improving sleep quality, easing menstrual discomfort, reducing anxiety, and supporting skin health.
Considerations
While chamomile is generally regarded as safe, there are some important considerations and precautions to keep in mind:
- Allergies: Individuals allergic to plants in the Asteraceae (daisy) family—such as ragweed, marigolds, or chrysanthemums—may experience allergic reactions to chamomile.
- Drug interactions: Chamomile may enhance the effects of sedatives, anticoagulants (like warfarin), or antiplatelet medications, increasing the risk of drowsiness or bleeding. It’s best to consult a healthcare professional before combining it with prescription drugs.
- Pregnancy and breastfeeding: Although generally considered mild, large or medicinal doses of chamomile may not be recommended during pregnancy due to possible uterine-stimulating effects.
- Topical use: Essential oils or concentrated extracts should always be diluted before skin application, as undiluted chamomile oil can cause irritation in sensitive individuals.
- Quality and purity: Herbal supplements vary in concentration and purity. Choosing standardized, reputable sources ensures consistent potency and safety.
Helps with these conditions
Chamomile is most effective for general wellness support with emerging research . The effectiveness varies by condition based on clinical evidence and user experiences.
Detailed Information by Condition
Acid Reflux (GERD)
Antispasmodic & anti-inflammatory actions. Chamomile contains flavonoids (e.g., apigenin) and sesquiterpenes (e.g., α-bisabolol, chamazulene) that...
Constipation
Chamomile (Matricariarecutita or Chamaemelumnobile) is not a potent, direct laxative like senna or psyllium husk. Instead, its effectiveness for const...
Crohn's Disease
Chamomile (usually Matricaria chamomilla, “German chamomile”) is not a proven cure for Crohn’s disease, but it contains anti-inflammatory, antispasmod...
Anxiety
Flavonoid apigenin interacts with GABA receptors. Apigenin, a major chamomile flavone, has been shown in preclinical studies to bind benzodiazepine si...
PTSD
Anxiolytic / GABAergic effects (apigenin): Chamomile contains the flavonoid apigenin, which has been shown in preclinical work to interact with GABA-A...
Insomnia
Active compound: apigenin. Chamomile contains the flavonoid apigenin, which binds to benzodiazepine sites/GABA_A-related pathways and appears to produ...
Sleep Apnea
Chamomile can modestly improve sleep quality (insomnia/anxiety) — likely via its flavonoid apigenin acting on GABA and by reducing inflammation — but...
Eczema
Anti-inflammatory & soothing constituents. Chamomile contains apigenin (a flavonoid) and essential-oil components such as α-bisabolol and chamazul...
Rosacea
Anti-inflammatory constituents. Chamomile contains flavonoids (e.g., apigenin, quercetin) and terpenoids (notably α-bisabolol and chamazulene). These...
Gastritis
Anti-inflammatory effects — chamomile contains flavonoids (e.g., apigenin, luteolin) and terpenoids (e.g., α-bisabolol) that reduce inflammatory media...
Narcolepsy
Chamomile may modestly improve nighttime sleep and reduce anxiety for some people, which could indirectly help daytime sleepiness in any sleep-disorde...
Temporomandibular Joint Disorder
Chamomile can be a reasonable adjunct—mainly for anxiety-related jaw clenching, sleep, and local oral discomfort—but high-quality trials specifically...
Dry Eye Syndrome
Chamomile contains flavonoids (e.g., apigenin) and sesquiterpenes (e.g., α-bisabolol, chamazulene) that show anti-inflammatory and antioxidant actions...
Laryngitis
Anti-inflammatory constituents. Chamomile contains bisabolol, chamazulene, apigenin and luteolin—compounds with anti-inflammatory activity (e.g., COX-...
Multiple Chemical Sensitivity
There are no high-quality clinical trials showing chamomile cures or directly treats Multiple Chemical Sensitivity (MCS). What exists is indirect evid...
Colic
Antispasmodic effects on the gut. Chamomile’s flavonoids (e.g., apigenin) can relax gastrointestinal smooth muscle in animal and human tissue preparat...
Chickenpox
Anti-inflammatory & antipruritic (anti-itch) actions. Chamomile contains α-bisabolol, chamazulene, apigenin, and related flavonoids/terpenes that...
Teething
Anti-inflammatory & soothing actions (oral tissues). Chamomile flowers contain bisabolol, chamazulene, apigenin and related flavonoids with anti-i...
Menstrual cramps
Antispasmodic effects on smooth muscle (including uterus). Chamomile flavonoids—especially apigenin—relax smooth muscle through multiple pathways (e.g...
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Remedy Statistics
Helps With These Conditions
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