Ginger
Specifically for Breast Cancer
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Why it works for Breast Cancer:
CINV relief (adjunct to antiemetics): Several randomized trials and evidence summaries suggest ginger can modestly reduce acute nausea when added to standard antiemetics around chemo days, though results are mixed across studies and benefit is not guaranteed. Authoritative summaries from NCCIH and MSKCC both characterize the evidence as inconclusive/mixed rather than definitive. academy.miloa.eu
Proposed mechanisms: Ginger’s main compounds (gingerols, shogaols) may influence gastrointestinal motility and central pathways (e.g., serotonergic) involved in nausea, which is consistent with trial benefits on nausea rather than disease control. MSKCC summarizes antiemetic activity; NCCIH notes uncertainty for chemo-related nausea. Memorial Sloan Kettering Cancer Center
Not a cancer treatment: Laboratory studies show anti-proliferative/anti-invasive effects of ginger constituents in breast-cancer cell lines, but no human trials show tumor shrinkage or improved survival from ginger. Treat these lab findings as hypothesis-generating only. Europe PMC
How to use for Breast Cancer:
Capsules around chemo days (most studied):
- A large multicenter RCT (n=744; ~70% breast-cancer patients) had participants take 0.5–1.0 g/day of ginger powder in capsules, divided into 3 × 250 mg capsules twice daily (total 6 capsules/day) for 6 days starting 3 days before chemotherapy; this reduced acute nausea versus placebo. academy.miloa.eu
General dosing range seen across trials/reviews: Many RCTs and systematic reviews evaluate ~0.5–1.5 g/day of standardized ginger preparations for several days around chemo; results vary, and some high-quality syntheses conclude effects are uncertain. MDPI
Practical tips & links
- If you and your oncology team choose to try ginger:
- Use a standardized capsule product so the dose is consistent (dietary and tea forms are often too variable for trial-like dosing). See MSKCC’s page on ginger for patient-friendly guidance and cautions. Memorial Sloan Kettering Cancer Center
- Start 3 days before chemo and continue through 2–3 days after, matching the RCT schedule above; aim for ~0.5–1.0 g/day unless your clinician suggests otherwise. academy.miloa.eu
Always clear it with your oncology team first—especially if you have surgery scheduled, a bleeding risk, gallstones, or take interacting medicines (see warnings below). Memorial Sloan Kettering Cancer Center
Scientific Evidence for Breast Cancer:
Randomized controlled trials (CINV adjunct):
- Ryan et al., 2012 (Supportive Care in Cancer): Multicenter, double-blind RCT (n=744) found 0.5–1.0 g/day ginger reduced acute chemo-day nausea versus placebo (all patients also received standard 5-HT3 antiemetics). Details include the 6-day regimen starting 3 days pre-chemo. academy.miloa.eu
- Other RCTs/meta-analyses: Mixed results overall; some show benefit, others don’t. A 2022 Nutrients systematic review concluded effects on CINV could not be confirmed and called for larger, high-quality RCTs. The Oncology Nursing Society (ONS) 2025 evidence table summarizes trial quality and the mixed findings. MDPI+1
Authoritative summaries (what major bodies say):
- NCCIH (updated Feb 2025): For chemo-related nausea, benefit is uncertain; emphasizes safety and interaction considerations. NCCIH
- MSKCC About Herbs—Ginger: Notes possible prevention of CINV in some studies, mixed evidence overall, and key contraindications/interactions (bleeding risk, perioperative avoidance, etc.). Memorial Sloan Kettering Cancer Center
Preclinical (not disease-control evidence in humans):
- 6-shogaol and related compounds show anti-invasive/anti-proliferative effects in breast-cancer cell lines (e.g., MDA-MB-231, MCF-7); these are lab studies only. Europe PMC
Specific Warnings for Breast Cancer:
Do not use ginger as a treatment for breast cancer. It has no proven tumor-control benefit in humans. Use only as a possible add-on for nausea with your care team’s approval. (NCCIH, MSKCC.) NCCIH
Bleeding risk / surgery: Ginger supplements can have antiplatelet effects. Avoid if you have a bleeding disorder, and stop 2 weeks before surgery; do not use immediately after surgery for nausea without medical guidance. Memorial Sloan Kettering Cancer Center
Drug interactions: Caution with anticoagulants/antiplatelets (e.g., warfarin, aspirin, clopidogrel) and NSAIDs due to additive bleeding risk. MSKCC also flags possible effects with tacrolimus and glucose-lowering drugs (clinically uncertain but caution advised). Always discuss with your oncology/pharmacy team. Memorial Sloan Kettering Cancer Center
Gallstones: May increase bile flow—avoid if you have gallstones unless your clinician approves. Memorial Sloan Kettering Cancer Center
Pregnancy/lactation: Use only under clinician guidance; MSKCC advises avoiding supplements during pregnancy/lactation; NCCIH notes pregnancy use may be safe but you should consult your provider. Memorial Sloan Kettering Cancer Center
Common side effects (usually mild): Heartburn, abdominal discomfort, diarrhea; rare case reports of bleeding when combined with blood thinners. Memorial Sloan Kettering Cancer Center
Quality matters: Supplements aren’t pre-approved like medicines; potency and purity vary. Use reputable brands and coordinate with your oncology team. (NCCIH explains supplement regulation.) NCCIH
General Information (All Ailments)
What It Is
Ginger is a flowering plant whose rhizome (underground stem), commonly called the ginger root, is widely used as both a spice and a medicinal ingredient. Native to Southeast Asia, it has been used in Ayurvedic, Chinese, and Middle Eastern traditional medicine for thousands of years. The bioactive compounds in ginger—especially gingerols, shogaols, and zingerone—are responsible for its distinctive aroma, pungent flavor, and therapeutic effects. It can be consumed fresh, dried, powdered, as an oil, or as a juice or extract.
How It Works
Ginger exerts its health effects through several biochemical and physiological mechanisms:
- Anti-Inflammatory and Antioxidant Actions: Gingerols and shogaols inhibit pro-inflammatory molecules such as prostaglandins and cytokines, reducing oxidative stress and inflammation throughout the body.
- Digestive Support: Ginger enhances gastric motility and stimulates digestive enzymes, helping relieve indigestion, nausea, and bloating. It’s especially well known for easing morning sickness, motion sickness, and nausea after surgery or chemotherapy.
- Pain Relief and Circulation: Its anti-inflammatory properties may alleviate muscle soreness, joint pain (including from osteoarthritis), and menstrual cramps by reducing prostaglandin production.
- Metabolic and Cardiovascular Support: Some studies suggest ginger may lower blood sugar, reduce cholesterol, and improve lipid metabolism, thereby supporting heart health. It can also enhance blood flow and exhibit mild anticoagulant effects.
- Immune and Antimicrobial Activity: Ginger contains compounds with mild antibacterial, antiviral, and immune-modulating properties, which may help the body fight off infections and maintain immune balance.
Why It’s Important
Ginger is valued as a natural, accessible, and versatile remedy with a broad range of health benefits. It offers:
- Natural symptom relief without synthetic additives, appealing to those seeking holistic or preventive care.
- Support for digestive and metabolic health, which are key to overall well-being.
- Potential long-term benefits for chronic inflammation, which underlies many diseases such as arthritis, diabetes, and cardiovascular disorders.
- Cultural and traditional significance, with millennia of use across multiple healing systems confirming its safety and efficacy in moderation.
Considerations
While ginger is generally safe, there are important factors to keep in mind:
- Dosage and Form: Typical safe amounts are up to 4 grams per day of fresh or dried ginger. Excessive intake can lead to heartburn, stomach irritation, or diarrhea.
- Pregnancy: Small amounts can relieve morning sickness, but high doses should be avoided during late pregnancy due to potential uterine-stimulating effects.
- Medication Interactions: Ginger can interact with anticoagulants (like warfarin), antiplatelet drugs, and antidiabetic medications, potentially enhancing their effects and increasing bleeding or hypoglycemia risk.
- Individual Sensitivity: People with gallstones, bleeding disorders, or acid reflux should consult a healthcare professional before regular use.
- Supplement Quality: As with many herbal supplements, product purity and potency vary; it’s best to choose standardized, reputable brands.
Helps with these conditions
Ginger is most effective for conditions with strong anti-inflammatory components . The effectiveness varies by condition based on clinical evidence and user experiences.
Detailed Information by Condition
Acid Reflux (GERD)
Ginger is often considered helpful for managing acid reflux (GERD) because of its natural digestive and anti-inflammatory properties. Here’s why it ca...
Stomach Ulcers
Ginger contains bioactive compounds such as gingerol and shogaol, which possess anti-inflammatory, antioxidant, and antimicrobial properties. These pr...
Flu
Antiviral Properties: Ginger contains compounds like [6]-gingerol and gingerenone A that have demonstrated direct antiviral activity against influenza...
COVID-19
Ginger has plausible biologic actions that could be helpful in COVID-19 (anti-inflammatory, antioxidant, immunomodulatory, and in silico antiviral bin...
Arthritis
Ginger contains active compounds (mainly gingerols, shogaols, and related phenolics) that reduce inflammation and oxidative stress by blocking inflamm...
Back Pain
Ginger’s main phenolics (gingerols, shogaols, paradols) have anti-inflammatory and analgesic actions relevant to musculoskeletal pain:In lab and anima...
PMS
Anti-inflammatory / prostaglandin modulation. Ginger’s main actives (gingerols, shogaols) inhibit COX and LOX enzymes and dampen inflammatory mediator...
Gout
Ginger can help with pain and inflammation, but direct, high-quality trials in gout are scarce. It should be used as an adjunct, not a replacement for...
Sciatica
Mechanisms relevant to nerve-root pain: Ginger bioactives (6-gingerol, 6-shogaol, zingerone, paradol) inhibit NF-κB/COX-2 signaling and modulate pro-i...
Endometriosis
Targets the biology that drives endo pain. Endometriosis is an estrogen-dependent, inflammatory disease in which lesions recruit new blood vessels (an...
Anemia (Iron-Deficiency)
May enhance iron absorption (adjunct to oral iron): A narrative review collating in-vitro, animal, and limited human data concludes ginger (rich in po...
Cellular Aging
Antioxidant/Nrf2 activation. Key gingerols/shogaols activate the Nrf2 pathway and upregulate cytoprotective enzymes (e.g., HO-1), improving redox bala...
Tendonitis
Anti-inflammatory and analgesic mechanisms. Gingerols and shogaols (ginger’s main actives) can inhibit enzymes in the prostaglandin/leukotriene pathwa...
Low Testosterone
Antioxidant & anti-inflammatory effects in the testes. In animals, ginger reduces oxidative stress and lipid peroxidation in testicular tissue and...
Vertigo
Antiemetic/antinausea action (5-HT3 pathway): Key gingerols and shogaols can inhibit 5-HT3 receptors, a pathway targeted by standard antiemetics; this...
Gastritis
Ginger contains bioactive compounds (6-gingerol, shogaols, zingerone, paradol) with anti-inflammatory, antioxidant, antimicrobial, gastro-motility and...
Chronic Sinusitis
Anti-inflammatory effects: Major ginger constituents (6-gingerol, 6-shogaol, zingerone) inhibit inflammatory signalling (NF-κB, COX-2, p38 MAPK) and r...
Carpal Tunnel Syndrome
CTS is a compression/entrapment neuropathy of the median nerve, not a primarily inflammatory arthritis. Evidence-based care aims to reduce pressure on...
Atherosclerosis
Lipid effects (TG, LDL-C): Multiple meta-analyses of randomized trials report that ginger supplementation produces small but statistically significant...
Meniere’s Disease
Symptom target—not a cure: Ginger doesn’t treat the inner-ear pathology of Ménière’s. It may help during attacks by reducing nausea and the sensation...
Temporomandibular Joint Disorder
Ginger’s key compounds (6-gingerol, 6-shogaol, zingerone) dampen inflammatory pathways by inhibiting cyclo-oxygenase (COX-1/2) and 5-lipoxygenase (5-L...
Rheumatoid Osteoarthritis
Anti-inflammatory & analgesic actions. Gingerols and shogaols can down-regulate NF-κB–driven cytokines (e.g., TNF-α, IL-1β), and inhibit COX-2/5-L...
Laryngitis
Laryngitis (most often viral) is usually self-limited. Standard care is voice rest, hydration, and vocal-hygiene; antibiotics or steroids are reserved...
Food Allergies
Ginger contains compounds (gingerols, shogaols, zingerone, etc.) that are anti-inflammatory, antioxidant and can reduce mast-cell/basophil mediator re...
Gastroparesis
ginger has pharmacologic compounds (gingerols/shogaols) that stimulate antral contractions and speed gastric emptying in healthy people and in functio...
Whooping Cough
Ginger may help relieve cough symptoms (anti-inflammatory, antitussive and some antimicrobial effects in laboratory studies) but there are no good cli...
Peripheral Artery Disease
Antiplatelet effects (theoretical PAD relevance). Gingerols/shogaols can inhibit platelet aggregation in vitro and in some small human studies, which...
Chronic Pancreatitis
Ginger’s main compounds (gingerols, shogaols, zingerone, paradols) show anti-inflammatory and antioxidant actions in lab and animal research. Reported...
Pleurisy
Ginger (Zingiber officinale) has well-documented anti-inflammatory and immune-modulating properties that make it plausible as an adjunctive measure to...
Raynaud’s Disease
Small human experiments and lab studies suggest ginger can raise skin/peripheral temperature (i.e., a “warming” or mild thermogenic effect) and may pr...
Mumps
Mumps is a virus (a rubulavirus). Management is supportive and patients should be kept home for 5 days after parotitis starts; there’s no specific ant...
Menstrual cramps
Menstrual cramps are driven largely by excess uterine prostaglandins → stronger contractions and ischemic pain. Ginger’s main actives (gingerols, shog...
Morning Sickness
Active compounds (gingerols, shogaols) appear to modulate the serotonin (5-HT₃) pathway involved in the vomiting reflex. In vitro/animal work suggests...
Breast Cancer
CINV relief (adjunct to antiemetics): Several randomized trials and evidence summaries suggest ginger can modestly reduce acute nausea when added to s...
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Helps With These Conditions
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